Incidental Mutation 'R3034:Tmem181a'
ID 264802
Institutional Source Beutler Lab
Gene Symbol Tmem181a
Ensembl Gene ENSMUSG00000038141
Gene Name transmembrane protein 181A
Synonyms 5930418K15Rik, C76977, Gpr178, Tmem181
MMRRC Submission 040550-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3034 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 6307135-6358589 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6330901 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 13 (S13T)
Ref Sequence ENSEMBL: ENSMUSP00000086333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088940] [ENSMUST00000232383]
AlphaFold A0A338P7C9
Predicted Effect possibly damaging
Transcript: ENSMUST00000088940
AA Change: S13T

PolyPhen 2 Score 0.504 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000086333
Gene: ENSMUSG00000038141
AA Change: S13T

DomainStartEndE-ValueType
transmembrane domain 17 36 N/A INTRINSIC
Pfam:MIG-14_Wnt-bd 127 422 1e-100 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228334
Predicted Effect probably benign
Transcript: ENSMUST00000232383
AA Change: S54T

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0924 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12e T C 11: 70,207,079 (GRCm39) I576V probably benign Het
Apol7a T G 15: 77,273,923 (GRCm39) I180L probably benign Het
Aptx T C 4: 40,694,994 (GRCm39) N114S probably benign Het
Bltp3a T A 17: 28,113,720 (GRCm39) D1297E probably damaging Het
Cd40 T A 2: 164,904,235 (GRCm39) S65R probably benign Het
Cdh23 C T 10: 60,244,789 (GRCm39) probably benign Het
Coro7 G A 16: 4,450,155 (GRCm39) R565W probably damaging Het
Cpt1a C T 19: 3,428,390 (GRCm39) T588M probably damaging Het
Defb23 A G 2: 152,301,189 (GRCm39) S128P possibly damaging Het
Dgki G A 6: 37,064,605 (GRCm39) H250Y probably damaging Het
Fgr T C 4: 132,725,807 (GRCm39) probably null Het
Fkbp15 T C 4: 62,225,129 (GRCm39) probably null Het
Gpr137c C T 14: 45,457,733 (GRCm39) S95L probably damaging Het
Kirrel1 T C 3: 86,990,746 (GRCm39) D692G possibly damaging Het
Krt1 C A 15: 101,759,068 (GRCm39) R32L unknown Het
Lama2 C T 10: 26,877,231 (GRCm39) E2652K probably benign Het
Mbl1 C A 14: 40,880,790 (GRCm39) S226Y probably damaging Het
Mrps28 T A 3: 8,988,675 (GRCm39) D61V probably benign Het
Mthfd1 A G 12: 76,336,244 (GRCm39) K299E probably benign Het
Myo1b A G 1: 51,812,406 (GRCm39) Y738H possibly damaging Het
Myo5c A G 9: 75,193,859 (GRCm39) T1205A probably benign Het
Nfatc2 C T 2: 168,376,940 (GRCm39) G317S probably damaging Het
Nln C T 13: 104,173,947 (GRCm39) V525I possibly damaging Het
Nrap T C 19: 56,352,437 (GRCm39) E549G probably damaging Het
Nwd2 T A 5: 63,957,446 (GRCm39) Y259N probably damaging Het
Oas3 T C 5: 120,909,121 (GRCm39) D275G probably damaging Het
Or14a256 A T 7: 86,264,970 (GRCm39) D294E possibly damaging Het
Ovch2 A G 7: 107,384,699 (GRCm39) S473P probably damaging Het
Pde8b T A 13: 95,359,275 (GRCm39) Y16F probably damaging Het
Pmfbp1 A T 8: 110,247,553 (GRCm39) probably null Het
Pmvk T C 3: 89,375,824 (GRCm39) V74A probably damaging Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rbm26 T A 14: 105,390,881 (GRCm39) T202S unknown Het
Rheb C T 5: 25,008,721 (GRCm39) E166K probably damaging Het
Rnf5 A G 17: 34,822,332 (GRCm39) V39A possibly damaging Het
Scn7a T C 2: 66,513,152 (GRCm39) Y1168C probably damaging Het
Tas2r114 A G 6: 131,666,611 (GRCm39) I139T probably benign Het
Tma7 T C 9: 108,911,274 (GRCm39) probably benign Het
Tmem62 C T 2: 120,809,605 (GRCm39) probably benign Het
Trim71 T C 9: 114,341,912 (GRCm39) D790G probably damaging Het
Trp53tg5 T C 2: 164,313,219 (GRCm39) K152R probably benign Het
Zdbf2 C A 1: 63,343,364 (GRCm39) A581E probably damaging Het
Other mutations in Tmem181a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02071:Tmem181a APN 17 6,347,531 (GRCm39) missense probably damaging 1.00
IGL03027:Tmem181a APN 17 6,348,494 (GRCm39) missense probably damaging 1.00
a_team UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
abraham UTSW 17 6,340,874 (GRCm39) missense probably benign 0.03
PIT4651001:Tmem181a UTSW 17 6,351,170 (GRCm39) missense probably benign
R1966:Tmem181a UTSW 17 6,353,501 (GRCm39) missense probably benign
R2139:Tmem181a UTSW 17 6,348,481 (GRCm39) missense probably damaging 1.00
R2323:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R2324:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3001:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3002:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3003:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3425:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3426:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3427:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3428:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3499:Tmem181a UTSW 17 6,330,894 (GRCm39) nonsense probably null
R3683:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R3893:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4226:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4227:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4428:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4429:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4430:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4465:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4466:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4467:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4496:Tmem181a UTSW 17 6,346,061 (GRCm39) missense probably damaging 0.99
R4728:Tmem181a UTSW 17 6,340,874 (GRCm39) missense probably benign 0.03
R4822:Tmem181a UTSW 17 6,330,940 (GRCm39) missense probably benign 0.00
R5301:Tmem181a UTSW 17 6,346,070 (GRCm39) missense possibly damaging 0.52
R5991:Tmem181a UTSW 17 6,339,312 (GRCm39) missense probably damaging 1.00
R6052:Tmem181a UTSW 17 6,330,890 (GRCm39) missense probably damaging 1.00
R6222:Tmem181a UTSW 17 6,351,192 (GRCm39) missense probably benign 0.29
R7131:Tmem181a UTSW 17 6,348,247 (GRCm39) missense probably damaging 0.98
R7231:Tmem181a UTSW 17 6,348,195 (GRCm39) missense possibly damaging 0.81
R7374:Tmem181a UTSW 17 6,354,533 (GRCm39) missense possibly damaging 0.85
R7437:Tmem181a UTSW 17 6,353,540 (GRCm39) missense possibly damaging 0.70
R7592:Tmem181a UTSW 17 6,339,295 (GRCm39) missense probably benign 0.00
R8175:Tmem181a UTSW 17 6,346,075 (GRCm39) missense probably benign 0.00
R8327:Tmem181a UTSW 17 6,351,680 (GRCm39) missense probably damaging 1.00
R8385:Tmem181a UTSW 17 6,339,274 (GRCm39) missense probably benign 0.10
R9144:Tmem181a UTSW 17 6,346,048 (GRCm39) missense possibly damaging 0.94
R9221:Tmem181a UTSW 17 6,307,265 (GRCm39) missense probably damaging 0.99
R9327:Tmem181a UTSW 17 6,346,048 (GRCm39) missense possibly damaging 0.94
RF010:Tmem181a UTSW 17 6,330,978 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TGATCCGTTCCAGAGGTGAC -3'
(R):5'- ACAAGGTGCAGGGTGTAACC -3'

Sequencing Primer
(F):5'- TTCCAGAGGTGACCAAGCC -3'
(R):5'- GGTGTAACCACGCTCTGC -3'
Posted On 2015-02-05