Incidental Mutation 'R3078:Mnt'
ID 265301
Institutional Source Beutler Lab
Gene Symbol Mnt
Ensembl Gene ENSMUSG00000000282
Gene Name max binding protein
Synonyms bHLHd3, Rox
MMRRC Submission 040568-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.946) question?
Stock # R3078 (G1)
Quality Score 136
Status Not validated
Chromosome 11
Chromosomal Location 74721746-74736551 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to C at 74733936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118435 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000291] [ENSMUST00000132150]
AlphaFold O08789
Predicted Effect unknown
Transcript: ENSMUST00000000291
AA Change: Q522H
SMART Domains Protein: ENSMUSP00000000291
Gene: ENSMUSG00000000282
AA Change: Q522H

DomainStartEndE-ValueType
coiled coil region 3 53 N/A INTRINSIC
low complexity region 64 88 N/A INTRINSIC
low complexity region 100 125 N/A INTRINSIC
low complexity region 182 205 N/A INTRINSIC
HLH 228 279 2.99e-13 SMART
low complexity region 368 431 N/A INTRINSIC
low complexity region 469 481 N/A INTRINSIC
low complexity region 515 527 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132150
SMART Domains Protein: ENSMUSP00000118435
Gene: ENSMUSG00000000282

DomainStartEndE-ValueType
HLH 1 47 2.92e-7 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 93% (42/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,306,764 (GRCm39) I1981V probably benign Het
Actr3b A G 5: 26,027,440 (GRCm39) Y37C probably damaging Het
Adgrd1 A T 5: 129,206,169 (GRCm39) I248F probably benign Het
Alg10b T C 15: 90,112,139 (GRCm39) S328P probably benign Het
C5ar2 G A 7: 15,971,349 (GRCm39) R193C probably damaging Het
Cct8 A G 16: 87,285,765 (GRCm39) V231A possibly damaging Het
Clca4a C T 3: 144,674,014 (GRCm39) M240I probably damaging Het
Cmya5 A T 13: 93,185,435 (GRCm39) I3520N probably damaging Het
Dock6 G T 9: 21,757,050 (GRCm39) probably benign Het
Dynlrb1 T A 2: 155,091,865 (GRCm39) I99N probably damaging Het
Ebf4 G A 2: 130,148,419 (GRCm39) D77N probably damaging Het
Fbxw10 C T 11: 62,758,339 (GRCm39) probably benign Het
Gm10801 T C 2: 98,494,197 (GRCm39) I113T probably damaging Het
Gm5499 T C 17: 87,386,314 (GRCm39) noncoding transcript Het
Gm9913 A G 2: 125,348,459 (GRCm39) probably benign Het
Herc2 A G 7: 55,786,991 (GRCm39) N1612S probably benign Het
Ifnar2 T C 16: 91,182,889 (GRCm39) S53P possibly damaging Het
Inpp5j T A 11: 3,453,124 (GRCm39) probably null Het
Insyn2a A G 7: 134,519,750 (GRCm39) I260T probably benign Het
Iqca1l G C 5: 24,751,664 (GRCm39) T528S probably benign Het
Kif14 T G 1: 136,447,383 (GRCm39) I1396S possibly damaging Het
Med28 A G 5: 45,679,820 (GRCm39) T68A possibly damaging Het
Meis1 A T 11: 18,961,254 (GRCm39) N206K probably benign Het
Mfsd14a T C 3: 116,441,566 (GRCm39) probably benign Het
Mto1 A G 9: 78,365,310 (GRCm39) Y413C probably damaging Het
Myo7b T C 18: 32,100,237 (GRCm39) D1599G probably benign Het
Myoz1 T C 14: 20,703,685 (GRCm39) probably benign Het
Nhsl2 C T X: 101,121,201 (GRCm39) R62W probably damaging Het
Npr2 T A 4: 43,640,182 (GRCm39) Y306N probably damaging Het
Nrxn3 T G 12: 89,227,186 (GRCm39) C274G probably damaging Het
Or1e29 G A 11: 73,667,466 (GRCm39) P229L possibly damaging Het
Or5ac22 A T 16: 59,135,089 (GRCm39) M227K probably benign Het
Phldb2 T C 16: 45,645,373 (GRCm39) T403A probably benign Het
Plaa T C 4: 94,458,042 (GRCm39) I643V probably benign Het
Slc28a2b T C 2: 122,344,895 (GRCm39) L167P possibly damaging Het
Stau1 T C 2: 166,796,936 (GRCm39) I154V possibly damaging Het
Ugcg T G 4: 59,213,922 (GRCm39) V168G probably damaging Het
Vmn2r2 T C 3: 64,042,053 (GRCm39) I221V probably benign Het
Wdr93 T C 7: 79,402,241 (GRCm39) I180T possibly damaging Het
Whamm G C 7: 81,221,532 (GRCm39) G155R probably damaging Het
Wnt5a T A 14: 28,235,140 (GRCm39) Y41* probably null Het
Other mutations in Mnt
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01304:Mnt APN 11 74,733,011 (GRCm39) missense probably damaging 1.00
R0599:Mnt UTSW 11 74,733,122 (GRCm39) missense probably benign 0.09
R2100:Mnt UTSW 11 74,722,177 (GRCm39) missense probably damaging 1.00
R3076:Mnt UTSW 11 74,733,936 (GRCm39) intron probably benign
R3077:Mnt UTSW 11 74,733,936 (GRCm39) intron probably benign
R3605:Mnt UTSW 11 74,727,746 (GRCm39) missense possibly damaging 0.89
R4601:Mnt UTSW 11 74,727,285 (GRCm39) missense possibly damaging 0.76
R5766:Mnt UTSW 11 74,733,904 (GRCm39) intron probably benign
R6340:Mnt UTSW 11 74,727,242 (GRCm39) missense probably damaging 1.00
R6988:Mnt UTSW 11 74,733,635 (GRCm39) intron probably benign
R7460:Mnt UTSW 11 74,734,109 (GRCm39) missense unknown
R7970:Mnt UTSW 11 74,733,036 (GRCm39) missense probably damaging 1.00
R8145:Mnt UTSW 11 74,733,799 (GRCm39) missense unknown
R8544:Mnt UTSW 11 74,722,218 (GRCm39) missense probably damaging 0.97
R9088:Mnt UTSW 11 74,733,880 (GRCm39) missense unknown
R9388:Mnt UTSW 11 74,727,450 (GRCm39) missense probably benign 0.05
Z1176:Mnt UTSW 11 74,727,501 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGACTGTGAACCATGTTCTGC -3'
(R):5'- TGAGTGTGCTGACCGGAAAG -3'

Sequencing Primer
(F):5'- ATGTTCTGCAGGGGCCG -3'
(R):5'- CTGACCGGAAAGGAGGGC -3'
Posted On 2015-02-05