Incidental Mutation 'R3082:S1pr5'
ID 265487
Institutional Source Beutler Lab
Gene Symbol S1pr5
Ensembl Gene ENSMUSG00000045087
Gene Name sphingosine-1-phosphate receptor 5
Synonyms S1P5, Edg8, lpB4
MMRRC Submission 040572-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.360) question?
Stock # R3082 (G1)
Quality Score 160
Status Validated
Chromosome 9
Chromosomal Location 21154213-21159739 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21156286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 47 (C47S)
Ref Sequence ENSEMBL: ENSMUSP00000113843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122088]
AlphaFold Q91X56
Predicted Effect probably damaging
Transcript: ENSMUST00000122088
AA Change: C47S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113843
Gene: ENSMUSG00000045087
AA Change: C47S

DomainStartEndE-ValueType
Pfam:7tm_1 53 307 9.6e-37 PFAM
low complexity region 318 327 N/A INTRINSIC
low complexity region 340 350 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215491
Meta Mutation Damage Score 0.4544 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
PHENOTYPE: Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss3 A G 10: 106,859,576 (GRCm39) V341A possibly damaging Het
Adam11 T C 11: 102,660,943 (GRCm39) probably benign Het
Aox1 G T 1: 58,322,759 (GRCm39) probably benign Het
Cdh6 T C 15: 13,044,838 (GRCm39) D428G probably damaging Het
Cep63 T C 9: 102,479,696 (GRCm39) T339A probably benign Het
Clcn1 T C 6: 42,267,112 (GRCm39) Y66H probably damaging Het
Cpsf2 C G 12: 101,955,069 (GRCm39) S280C probably damaging Het
Dcaf6 G T 1: 165,250,421 (GRCm39) probably benign Het
Ddx39a T A 8: 84,449,335 (GRCm39) N344K possibly damaging Het
Dvl1 T C 4: 155,932,316 (GRCm39) V42A possibly damaging Het
Ep400 A G 5: 110,841,096 (GRCm39) probably benign Het
Epb41l5 C T 1: 119,536,992 (GRCm39) V300I probably damaging Het
Fbln1 T G 15: 85,149,454 (GRCm39) I617S probably benign Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Grin3a G A 4: 49,665,243 (GRCm39) R1131W probably benign Het
Incenp T A 19: 9,861,143 (GRCm39) M480L unknown Het
Ints13 G T 6: 146,476,205 (GRCm39) Q99K possibly damaging Het
L2hgdh C T 12: 69,768,858 (GRCm39) D85N probably benign Het
Lct A G 1: 128,215,345 (GRCm39) Y1744H probably damaging Het
Macf1 T C 4: 123,255,236 (GRCm39) probably null Het
Mpdz A T 4: 81,203,695 (GRCm39) probably benign Het
Naa15 T C 3: 51,367,471 (GRCm39) L498P probably damaging Het
Naip6 T A 13: 100,452,925 (GRCm39) E45D probably benign Het
Nedd4l T A 18: 65,312,049 (GRCm39) N405K probably benign Het
Or4l15 A G 14: 50,198,161 (GRCm39) Y123H probably damaging Het
Or8u10 C T 2: 85,916,053 (GRCm39) V23I probably benign Het
Pitpnc1 A G 11: 107,103,350 (GRCm39) S250P possibly damaging Het
Ppp1r18 A G 17: 36,184,742 (GRCm39) D131G probably damaging Het
Prdm5 A G 6: 65,913,069 (GRCm39) D206G probably damaging Het
Pygl A G 12: 70,244,303 (GRCm39) F455S probably damaging Het
Rictor A T 15: 6,804,338 (GRCm39) Y565F probably benign Het
Ryr1 T C 7: 28,745,071 (GRCm39) N3852D probably damaging Het
Serpinf2 T C 11: 75,328,354 (GRCm39) R65G probably benign Het
Slfn14 C T 11: 83,167,519 (GRCm39) W665* probably null Het
Smu1 T C 4: 40,745,567 (GRCm39) D251G probably damaging Het
Spata18 A G 5: 73,836,423 (GRCm39) probably benign Het
Tex19.2 A G 11: 121,007,557 (GRCm39) V297A probably benign Het
Tmem131l A G 3: 83,816,457 (GRCm39) probably null Het
Trim9 T C 12: 70,301,887 (GRCm39) R584G possibly damaging Het
Trpm7 A T 2: 126,686,342 (GRCm39) N295K possibly damaging Het
Ugt2a3 A G 5: 87,473,534 (GRCm39) V461A probably benign Het
Vmn1r45 A T 6: 89,910,724 (GRCm39) M82K probably benign Het
Other mutations in S1pr5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:S1pr5 APN 9 21,155,512 (GRCm39) missense possibly damaging 0.55
IGL01719:S1pr5 APN 9 21,155,250 (GRCm39) missense probably benign 0.03
sipho UTSW 9 21,155,425 (GRCm39) missense probably benign 0.01
R0392:S1pr5 UTSW 9 21,156,277 (GRCm39) missense probably damaging 1.00
R0448:S1pr5 UTSW 9 21,155,503 (GRCm39) missense probably damaging 1.00
R1599:S1pr5 UTSW 9 21,155,230 (GRCm39) missense probably benign 0.02
R1703:S1pr5 UTSW 9 21,155,346 (GRCm39) missense possibly damaging 0.52
R1850:S1pr5 UTSW 9 21,155,425 (GRCm39) missense probably benign 0.01
R2095:S1pr5 UTSW 9 21,156,154 (GRCm39) missense probably benign 0.04
R2178:S1pr5 UTSW 9 21,155,760 (GRCm39) missense probably benign 0.36
R3430:S1pr5 UTSW 9 21,156,378 (GRCm39) missense probably benign 0.00
R5578:S1pr5 UTSW 9 21,155,847 (GRCm39) missense probably damaging 1.00
R7444:S1pr5 UTSW 9 21,156,378 (GRCm39) missense possibly damaging 0.89
R8294:S1pr5 UTSW 9 21,156,300 (GRCm39) missense possibly damaging 0.47
Predicted Primers PCR Primer
(F):5'- CTCTAAAGCAATGGCCAAGAGG -3'
(R):5'- TTTTGCACAGTGCTCCAGTG -3'

Sequencing Primer
(F):5'- AAGAGGCTCAGCACCGACG -3'
(R):5'- ACAGTGCTCCAGTGGACGAC -3'
Posted On 2015-02-05