Incidental Mutation 'R2971:Ces1c'
ID 265678
Institutional Source Beutler Lab
Gene Symbol Ces1c
Ensembl Gene ENSMUSG00000057400
Gene Name carboxylesterase 1C
Synonyms Ces-N, Es-N, Es-1, Ee-1, Es-4, Es1
MMRRC Submission 040525-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R2971 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 93825643-93857911 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93830821 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 445 (D445V)
Ref Sequence ENSEMBL: ENSMUSP00000034189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034189] [ENSMUST00000211843]
AlphaFold P23953
Predicted Effect probably benign
Transcript: ENSMUST00000034189
AA Change: D445V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000034189
Gene: ENSMUSG00000057400
AA Change: D445V

DomainStartEndE-ValueType
Pfam:COesterase 1 534 4e-167 PFAM
Pfam:Abhydrolase_3 136 235 6.2e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212091
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.6%
Validation Efficiency 100% (35/35)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 78,749,447 (GRCm39) D1406G possibly damaging Het
Aebp2 T C 6: 140,579,624 (GRCm39) probably null Het
Ap5m1 T A 14: 49,321,339 (GRCm39) Y49* probably null Het
Atp8b5 T C 4: 43,361,953 (GRCm39) probably benign Het
Baz1a A G 12: 54,970,224 (GRCm39) S518P probably damaging Het
Ctnnbl1 C T 2: 157,713,106 (GRCm39) H464Y probably benign Het
Cyp2j6 T C 4: 96,420,018 (GRCm39) K238E probably benign Het
Gdf10 G A 14: 33,646,148 (GRCm39) R99H probably damaging Het
Gm4779 G A X: 100,836,568 (GRCm39) P116L possibly damaging Het
Gucy2g A G 19: 55,198,708 (GRCm39) S812P probably damaging Het
Ifit3b C T 19: 34,589,417 (GRCm39) Q198* probably null Het
Irgm1 A T 11: 48,757,417 (GRCm39) Y131* probably null Het
Man1c1 G C 4: 134,430,749 (GRCm39) P11R probably damaging Het
Myh7b A G 2: 155,474,175 (GRCm39) N1630S probably benign Het
Myo5a T C 9: 75,023,484 (GRCm39) I15T probably damaging Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Nme6 A G 9: 109,671,159 (GRCm39) probably benign Het
Or11g25 T A 14: 50,723,065 (GRCm39) I50N probably damaging Het
Or5al6 T C 2: 85,976,908 (GRCm39) T57A probably damaging Het
Plch2 T G 4: 155,075,224 (GRCm39) M797L probably benign Het
Plscr2 G T 9: 92,172,724 (GRCm39) E128* probably null Het
Plxna2 T A 1: 194,480,039 (GRCm39) D1403E probably damaging Het
Pou6f2 T C 13: 18,556,552 (GRCm39) T25A unknown Het
Psmb11 T C 14: 54,862,800 (GRCm39) V6A possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptprd T G 4: 76,025,561 (GRCm39) S546R probably benign Het
Rbp3 A G 14: 33,676,411 (GRCm39) N120D probably benign Het
Skint1 C A 4: 111,878,527 (GRCm39) P153H possibly damaging Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Tmem201 A G 4: 149,806,902 (GRCm39) probably benign Het
Ube2v1 T C 2: 167,452,256 (GRCm39) N89D probably damaging Het
Zfp282 A T 6: 47,874,866 (GRCm39) probably null Het
Zfp560 C A 9: 20,260,240 (GRCm39) M207I probably benign Het
Zfp697 T C 3: 98,335,617 (GRCm39) Y461H probably damaging Het
Other mutations in Ces1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Ces1c APN 8 93,833,301 (GRCm39) missense probably benign 0.02
IGL00558:Ces1c APN 8 93,825,899 (GRCm39) missense probably benign 0.03
IGL00787:Ces1c APN 8 93,846,994 (GRCm39) missense possibly damaging 0.90
IGL00851:Ces1c APN 8 93,849,745 (GRCm39) missense probably benign 0.00
IGL01598:Ces1c APN 8 93,845,041 (GRCm39) missense probably benign
IGL02616:Ces1c APN 8 93,833,243 (GRCm39) missense probably benign 0.01
IGL03087:Ces1c APN 8 93,845,042 (GRCm39) missense probably benign
IGL03203:Ces1c APN 8 93,851,216 (GRCm39) missense probably damaging 1.00
R0119:Ces1c UTSW 8 93,834,238 (GRCm39) missense probably benign 0.00
R0119:Ces1c UTSW 8 93,833,345 (GRCm39) unclassified probably benign
R0255:Ces1c UTSW 8 93,854,152 (GRCm39) missense probably benign
R0759:Ces1c UTSW 8 93,857,492 (GRCm39) nonsense probably null
R1499:Ces1c UTSW 8 93,854,233 (GRCm39) missense probably benign 0.01
R1926:Ces1c UTSW 8 93,854,232 (GRCm39) missense possibly damaging 0.69
R2087:Ces1c UTSW 8 93,834,230 (GRCm39) missense probably benign 0.00
R2142:Ces1c UTSW 8 93,857,468 (GRCm39) missense probably benign
R2442:Ces1c UTSW 8 93,849,840 (GRCm39) missense probably damaging 1.00
R3079:Ces1c UTSW 8 93,846,975 (GRCm39) missense probably damaging 1.00
R3080:Ces1c UTSW 8 93,846,975 (GRCm39) missense probably damaging 1.00
R3609:Ces1c UTSW 8 93,846,960 (GRCm39) missense probably damaging 1.00
R4131:Ces1c UTSW 8 93,827,312 (GRCm39) missense probably damaging 1.00
R4633:Ces1c UTSW 8 93,845,014 (GRCm39) missense probably benign 0.00
R4988:Ces1c UTSW 8 93,827,336 (GRCm39) missense probably damaging 1.00
R5081:Ces1c UTSW 8 93,854,197 (GRCm39) missense probably damaging 1.00
R5497:Ces1c UTSW 8 93,857,343 (GRCm39) missense possibly damaging 0.91
R5586:Ces1c UTSW 8 93,854,227 (GRCm39) missense probably benign 0.00
R7013:Ces1c UTSW 8 93,857,392 (GRCm39) missense probably damaging 1.00
R7137:Ces1c UTSW 8 93,857,470 (GRCm39) missense probably benign 0.02
R7611:Ces1c UTSW 8 93,851,139 (GRCm39) missense probably benign 0.00
R7882:Ces1c UTSW 8 93,833,231 (GRCm39) missense probably benign
R8280:Ces1c UTSW 8 93,825,809 (GRCm39) missense possibly damaging 0.53
R8705:Ces1c UTSW 8 93,857,518 (GRCm39) missense probably benign
R8752:Ces1c UTSW 8 93,846,964 (GRCm39) missense probably damaging 1.00
R8896:Ces1c UTSW 8 93,833,254 (GRCm39) missense probably benign
R9470:Ces1c UTSW 8 93,830,746 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCAGTTCTGCTATAGAATGCCAGG -3'
(R):5'- AACCAGATCATCAGGCTTTCCC -3'

Sequencing Primer
(F):5'- TCTGCTATAGAATGCCAGGAAACAAG -3'
(R):5'- CAAAGCTGCCTCTGTCCTACACTAG -3'
Posted On 2015-02-05