Incidental Mutation 'R3022:Vmn1r237'
| ID |
265735 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r237
|
| Ensembl Gene |
ENSMUSG00000058030 |
| Gene Name |
vomeronasal 1 receptor 237 |
| Synonyms |
V1rf3 |
| MMRRC Submission |
040538-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R3022 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21534279-21535148 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 21534709 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 144
(I144K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076531
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077301]
|
| AlphaFold |
Q8R296 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000077301
AA Change: I144K
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000076531
Gene: ENSMUSG00000058030
AA Change: I144K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
289 |
7.1e-17 |
PFAM |
|
Pfam:V1R
|
34 |
289 |
1.9e-34 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 11 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bptf |
T |
A |
11: 107,002,463 (GRCm39) |
|
probably null |
Het |
| Dnah3 |
T |
A |
7: 119,677,704 (GRCm39) |
I406F |
possibly damaging |
Het |
| Dnah7b |
G |
A |
1: 46,221,583 (GRCm39) |
C1229Y |
probably damaging |
Het |
| Flywch1 |
T |
C |
17: 23,982,082 (GRCm39) |
R41G |
probably benign |
Het |
| Itpkb |
A |
T |
1: 180,245,888 (GRCm39) |
T802S |
probably damaging |
Het |
| Kdm1b |
C |
T |
13: 47,216,553 (GRCm39) |
R308W |
probably damaging |
Het |
| Or10aa1 |
A |
G |
1: 173,869,650 (GRCm39) |
I45V |
probably benign |
Het |
| Padi2 |
T |
A |
4: 140,665,299 (GRCm39) |
V468E |
possibly damaging |
Het |
| Prom1 |
G |
A |
5: 44,204,916 (GRCm39) |
T177I |
probably damaging |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Stx5a |
T |
C |
19: 8,732,518 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn1r237 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01300:Vmn1r237
|
APN |
17 |
21,534,337 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02746:Vmn1r237
|
APN |
17 |
21,534,480 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03112:Vmn1r237
|
APN |
17 |
21,534,368 (GRCm39) |
nonsense |
probably null |
|
|
IGL03351:Vmn1r237
|
APN |
17 |
21,535,099 (GRCm39) |
missense |
probably benign |
0.06 |
|
BB009:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
BB019:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0478:Vmn1r237
|
UTSW |
17 |
21,535,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn1r237
|
UTSW |
17 |
21,534,932 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0616:Vmn1r237
|
UTSW |
17 |
21,534,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn1r237
|
UTSW |
17 |
21,534,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1590:Vmn1r237
|
UTSW |
17 |
21,534,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4241:Vmn1r237
|
UTSW |
17 |
21,534,925 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4242:Vmn1r237
|
UTSW |
17 |
21,534,925 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4646:Vmn1r237
|
UTSW |
17 |
21,534,400 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5144:Vmn1r237
|
UTSW |
17 |
21,534,688 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5229:Vmn1r237
|
UTSW |
17 |
21,534,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5334:Vmn1r237
|
UTSW |
17 |
21,534,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5800:Vmn1r237
|
UTSW |
17 |
21,535,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5898:Vmn1r237
|
UTSW |
17 |
21,534,813 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6190:Vmn1r237
|
UTSW |
17 |
21,534,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Vmn1r237
|
UTSW |
17 |
21,534,616 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6811:Vmn1r237
|
UTSW |
17 |
21,534,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7932:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8008:Vmn1r237
|
UTSW |
17 |
21,534,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8086:Vmn1r237
|
UTSW |
17 |
21,534,509 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9568:Vmn1r237
|
UTSW |
17 |
21,534,777 (GRCm39) |
missense |
probably benign |
|
|
R9631:Vmn1r237
|
UTSW |
17 |
21,534,660 (GRCm39) |
missense |
probably benign |
0.28 |
|
X0011:Vmn1r237
|
UTSW |
17 |
21,534,317 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCATACTGTGTCTGCCTTTGGG -3'
(R):5'- AACCATGTAGCCACTGGACC -3'
Sequencing Primer
(F):5'- GGGTTGAAAAACTTCCTCGATGAC -3'
(R):5'- TGTAGCCACTGGACCAAACC -3'
|
| Posted On |
2015-02-05 |
Incidental Mutation