Mutagenetix > Incidental Mutation

Incidental Mutation 'R3023:Vmn2r78'

265754

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r78

Ensembl Gene

ENSMUSG00000091962

Gene Name

vomeronasal 2, receptor 78

Synonyms

MMRRC Submission

040539-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R3023 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86564557-86604385 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 86604174 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Isoleucine at position 784 (S784I)

Ref Sequence

ENSEMBL: ENSMUSP00000126698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170835]

AlphaFold

K7N6U5

Predicted Effect

probably damaging
Transcript: ENSMUST00000170835
AA Change: S784I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962
AA Change: S784I

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	5.9e-31	PFAM
Pfam:NCD3G	507	559	8.1e-21	PFAM
Pfam:7tm_3	592	827	1e-52	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 93.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,646,531 (GRCm39)	E1060D	probably benign	Het
Abca15	A	T	7: 119,982,002 (GRCm39)	I1106F	probably benign	Het
Arl5a	A	G	2: 52,306,209 (GRCm39)	V41A	probably benign	Het
Atp8b5	A	G	4: 43,311,957 (GRCm39)	D190G	possibly damaging	Het
Cc2d2a	T	A	5: 43,842,593 (GRCm39)		probably null	Het
Ckap2	T	C	8: 22,665,877 (GRCm39)	N390S	possibly damaging	Het
Dtx3l	A	G	16: 35,752,806 (GRCm39)	I600T	probably benign	Het
Epb41l1	A	C	2: 156,356,129 (GRCm39)	E555A	probably damaging	Het
Fxr1	G	A	3: 34,118,373 (GRCm39)	R503H	probably damaging	Het
Igf1r	A	G	7: 67,833,147 (GRCm39)	N436D	probably benign	Het
Kif26b	G	A	1: 178,692,433 (GRCm39)	C11Y	probably damaging	Het
Or4a78	A	G	2: 89,497,990 (GRCm39)	I80T	possibly damaging	Het
Osbpl6	A	T	2: 76,417,077 (GRCm39)	I703F	probably damaging	Het
Plcd4	A	G	1: 74,587,351 (GRCm39)	Y37C	probably damaging	Het
Plekhm3	CCTGCTGCTGCTGCTGCTGCTGCTGC	CCTGCTGCTGCTGCTGCTGCTGC	1: 64,976,940 (GRCm39)		probably benign	Het
Pwwp2b	G	A	7: 138,836,110 (GRCm39)	R517H	probably damaging	Het
Rp1	G	A	1: 4,422,898 (GRCm39)	R61W	probably damaging	Het
Sdk1	C	G	5: 142,031,991 (GRCm39)	T1022S	probably benign	Het
Slc12a7	T	A	13: 73,948,541 (GRCm39)	S669T	probably benign	Het
Sstr3	G	A	15: 78,424,187 (GRCm39)	R187W	probably damaging	Het
Tlr2	C	T	3: 83,745,178 (GRCm39)	V302I	probably benign	Het
Trav7-6	A	G	14: 53,954,701 (GRCm39)	K77R	probably benign	Het
Vmn2r18	T	C	5: 151,485,148 (GRCm39)	N782S	probably benign	Het

Other mutations in Vmn2r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Vmn2r78	APN	7	86,564,569 (GRCm39)	missense	unknown
IGL01473:Vmn2r78	APN	7	86,569,520 (GRCm39)	missense	possibly damaging	0.61
IGL01767:Vmn2r78	APN	7	86,603,643 (GRCm39)	missense	probably benign	0.28
IGL02322:Vmn2r78	APN	7	86,570,687 (GRCm39)	missense	probably damaging	0.96
IGL02537:Vmn2r78	APN	7	86,603,496 (GRCm39)	missense	probably damaging	0.99
IGL03297:Vmn2r78	APN	7	86,569,969 (GRCm39)	nonsense	probably null
ANU74:Vmn2r78	UTSW	7	86,570,273 (GRCm39)	missense	possibly damaging	0.62
R0035:Vmn2r78	UTSW	7	86,569,413 (GRCm39)	missense	probably benign	0.22
R0081:Vmn2r78	UTSW	7	86,572,235 (GRCm39)	missense	probably benign	0.35
R0401:Vmn2r78	UTSW	7	86,570,519 (GRCm39)	missense	probably benign	0.04
R0751:Vmn2r78	UTSW	7	86,603,588 (GRCm39)	missense	possibly damaging	0.77
R1341:Vmn2r78	UTSW	7	86,571,477 (GRCm39)	missense	possibly damaging	0.71
R1386:Vmn2r78	UTSW	7	86,564,615 (GRCm39)	missense	unknown
R1526:Vmn2r78	UTSW	7	86,571,465 (GRCm39)	splice site	probably null
R1712:Vmn2r78	UTSW	7	86,604,132 (GRCm39)	missense	probably damaging	1.00
R1739:Vmn2r78	UTSW	7	86,569,997 (GRCm39)	missense	probably benign
R1812:Vmn2r78	UTSW	7	86,569,995 (GRCm39)	missense	probably benign	0.38
R2011:Vmn2r78	UTSW	7	86,604,287 (GRCm39)	missense	possibly damaging	0.52
R2144:Vmn2r78	UTSW	7	86,603,690 (GRCm39)	missense	probably damaging	1.00
R2197:Vmn2r78	UTSW	7	86,570,535 (GRCm39)	missense	probably damaging	0.96
R2291:Vmn2r78	UTSW	7	86,569,362 (GRCm39)	missense	probably damaging	1.00
R2409:Vmn2r78	UTSW	7	86,569,953 (GRCm39)	splice site	probably benign
R4486:Vmn2r78	UTSW	7	86,569,959 (GRCm39)	critical splice acceptor site	probably null
R4512:Vmn2r78	UTSW	7	86,569,452 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r78	UTSW	7	86,603,466 (GRCm39)	missense	probably damaging	0.99
R4544:Vmn2r78	UTSW	7	86,570,399 (GRCm39)	missense	probably benign
R4546:Vmn2r78	UTSW	7	86,603,811 (GRCm39)	missense	probably damaging	1.00
R4872:Vmn2r78	UTSW	7	86,603,916 (GRCm39)	missense	possibly damaging	0.87
R4928:Vmn2r78	UTSW	7	86,603,835 (GRCm39)	missense	probably damaging	1.00
R5101:Vmn2r78	UTSW	7	86,571,563 (GRCm39)	missense	probably damaging	1.00
R5265:Vmn2r78	UTSW	7	86,569,332 (GRCm39)	missense	probably damaging	1.00
R5328:Vmn2r78	UTSW	7	86,570,238 (GRCm39)	missense	probably damaging	0.98
R5442:Vmn2r78	UTSW	7	86,569,330 (GRCm39)	missense	possibly damaging	0.95
R5567:Vmn2r78	UTSW	7	86,570,737 (GRCm39)	missense	probably benign	0.17
R5572:Vmn2r78	UTSW	7	86,564,720 (GRCm39)	missense	probably benign	0.01
R5636:Vmn2r78	UTSW	7	86,603,637 (GRCm39)	missense	probably damaging	0.99
R5901:Vmn2r78	UTSW	7	86,603,796 (GRCm39)	missense	probably damaging	1.00
R5977:Vmn2r78	UTSW	7	86,604,115 (GRCm39)	missense	probably benign	0.00
R5977:Vmn2r78	UTSW	7	86,569,541 (GRCm39)	missense	possibly damaging	0.74
R6276:Vmn2r78	UTSW	7	86,570,318 (GRCm39)	missense	probably benign	0.00
R6386:Vmn2r78	UTSW	7	86,571,545 (GRCm39)	nonsense	probably null
R6724:Vmn2r78	UTSW	7	86,603,466 (GRCm39)	missense	probably damaging	0.99
R6852:Vmn2r78	UTSW	7	86,603,811 (GRCm39)	missense	probably damaging	1.00
R6896:Vmn2r78	UTSW	7	86,571,558 (GRCm39)	missense	probably benign	0.10
R7385:Vmn2r78	UTSW	7	86,571,633 (GRCm39)	missense	probably benign	0.18
R7578:Vmn2r78	UTSW	7	86,603,552 (GRCm39)	nonsense	probably null
R7680:Vmn2r78	UTSW	7	86,604,149 (GRCm39)	missense	probably damaging	1.00
R7748:Vmn2r78	UTSW	7	86,570,343 (GRCm39)	missense	probably benign	0.00
R7852:Vmn2r78	UTSW	7	86,569,378 (GRCm39)	nonsense	probably null
R8031:Vmn2r78	UTSW	7	86,604,075 (GRCm39)	missense	probably damaging	1.00
R8070:Vmn2r78	UTSW	7	86,571,695 (GRCm39)	missense	probably benign	0.01
R8085:Vmn2r78	UTSW	7	86,603,998 (GRCm39)	missense	probably benign	0.00
R8163:Vmn2r78	UTSW	7	86,603,660 (GRCm39)	missense	probably damaging	1.00
R8501:Vmn2r78	UTSW	7	86,570,094 (GRCm39)	missense	probably damaging	0.99
R8749:Vmn2r78	UTSW	7	86,603,513 (GRCm39)	missense	possibly damaging	0.81
R9209:Vmn2r78	UTSW	7	86,569,431 (GRCm39)	missense	probably benign	0.08
RF018:Vmn2r78	UTSW	7	86,603,639 (GRCm39)	nonsense	probably null
Z1177:Vmn2r78	UTSW	7	86,603,982 (GRCm39)	missense	probably benign	0.02
Z1177:Vmn2r78	UTSW	7	86,570,415 (GRCm39)	missense	probably benign	0.44

Predicted Primers

PCR Primer
(F):5'- CCATTTGTTGATGCTGATCTACAC -3'
(R):5'- AGTAAGCAGTATGGTGATCATGC -3'

Sequencing Primer
(F):5'- GCTGATCTACACATGATACATGAAC -3'
(R):5'- TCATGCTGATATGTTTGGTGTAATAG -3'

Posted On

2015-02-05