Incidental Mutation 'R3024:Slc35f5'
ID 265764
Institutional Source Beutler Lab
Gene Symbol Slc35f5
Ensembl Gene ENSMUSG00000026342
Gene Name solute carrier family 35, member F5
Synonyms 1300003P13Rik
MMRRC Submission 040540-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.177) question?
Stock # R3024 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 125488332-125523557 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 125496335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 157 (S157G)
Ref Sequence ENSEMBL: ENSMUSP00000027580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027580] [ENSMUST00000190037]
AlphaFold Q8R314
Predicted Effect probably benign
Transcript: ENSMUST00000027580
AA Change: S157G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000027580
Gene: ENSMUSG00000026342
AA Change: S157G

DomainStartEndE-ValueType
low complexity region 8 27 N/A INTRINSIC
transmembrane domain 69 86 N/A INTRINSIC
transmembrane domain 101 120 N/A INTRINSIC
Pfam:EamA 226 317 2.1e-8 PFAM
transmembrane domain 329 348 N/A INTRINSIC
transmembrane domain 360 382 N/A INTRINSIC
transmembrane domain 397 419 N/A INTRINSIC
transmembrane domain 421 443 N/A INTRINSIC
transmembrane domain 453 475 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000190037
SMART Domains Protein: ENSMUSP00000139639
Gene: ENSMUSG00000026342

DomainStartEndE-ValueType
low complexity region 34 48 N/A INTRINSIC
transmembrane domain 91 108 N/A INTRINSIC
transmembrane domain 123 142 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef37 T C 18: 61,634,959 (GRCm39) E461G probably damaging Het
Bfsp1 A T 2: 143,687,879 (GRCm39) V182D probably benign Het
Birc6 T C 17: 74,915,214 (GRCm39) S1635P possibly damaging Het
Chil6 T C 3: 106,296,086 (GRCm39) D383G probably damaging Het
Itpr2 G A 6: 146,081,808 (GRCm39) A175V probably benign Het
Kcnh7 G T 2: 62,595,007 (GRCm39) R688S probably damaging Het
Krt6a A T 15: 101,599,724 (GRCm39) C463S probably benign Het
Ksr2 T A 5: 117,693,125 (GRCm39) I191N possibly damaging Het
Lyst T C 13: 13,833,272 (GRCm39) V1698A probably benign Het
Or12d13 A T 17: 37,647,918 (GRCm39) D68E probably damaging Het
Or4c127 A T 2: 89,833,584 (GRCm39) N278I probably damaging Het
Pappa2 C T 1: 158,763,795 (GRCm39) R572Q probably benign Het
Pes1 CGGAGGAGGAGGAGGAGGAGGAGG CGGAGGAGGAGGAGGAGGAGG 11: 3,927,719 (GRCm39) probably benign Het
Phf20 A G 2: 156,129,787 (GRCm39) H453R probably damaging Het
Prex1 G T 2: 166,430,956 (GRCm39) H615Q probably benign Het
Slc25a54 T A 3: 108,987,982 (GRCm39) I41N probably damaging Het
Sstr3 G A 15: 78,424,187 (GRCm39) R187W probably damaging Het
Trim41 T C 11: 48,698,985 (GRCm39) K420E possibly damaging Het
Tsnaxip1 A G 8: 106,568,375 (GRCm39) Y353C probably damaging Het
Vmn1r238 T C 18: 3,123,305 (GRCm39) I36M probably benign Het
Xylt1 T A 7: 117,147,883 (GRCm39) V149D probably damaging Het
Zfpm2 G A 15: 40,966,355 (GRCm39) E815K probably benign Het
Other mutations in Slc35f5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00662:Slc35f5 APN 1 125,515,161 (GRCm39) missense probably damaging 1.00
IGL01844:Slc35f5 APN 1 125,517,612 (GRCm39) missense probably damaging 0.96
IGL02218:Slc35f5 APN 1 125,512,292 (GRCm39) missense probably damaging 1.00
IGL02586:Slc35f5 APN 1 125,512,273 (GRCm39) missense probably damaging 1.00
IGL03000:Slc35f5 APN 1 125,502,479 (GRCm39) missense probably damaging 1.00
IGL03160:Slc35f5 APN 1 125,502,472 (GRCm39) missense probably damaging 1.00
IGL03181:Slc35f5 APN 1 125,512,922 (GRCm39) missense probably damaging 1.00
IGL02984:Slc35f5 UTSW 1 125,490,250 (GRCm39) missense probably benign 0.28
R0127:Slc35f5 UTSW 1 125,503,942 (GRCm39) missense probably damaging 1.00
R0390:Slc35f5 UTSW 1 125,512,832 (GRCm39) missense probably damaging 1.00
R0513:Slc35f5 UTSW 1 125,503,906 (GRCm39) splice site probably benign
R1701:Slc35f5 UTSW 1 125,498,330 (GRCm39) missense possibly damaging 0.77
R1716:Slc35f5 UTSW 1 125,512,269 (GRCm39) missense possibly damaging 0.65
R2211:Slc35f5 UTSW 1 125,507,001 (GRCm39) missense possibly damaging 0.74
R3870:Slc35f5 UTSW 1 125,490,098 (GRCm39) missense probably benign 0.00
R4239:Slc35f5 UTSW 1 125,500,211 (GRCm39) missense possibly damaging 0.94
R4547:Slc35f5 UTSW 1 125,500,119 (GRCm39) missense probably benign 0.00
R5622:Slc35f5 UTSW 1 125,517,693 (GRCm39) missense probably damaging 1.00
R5688:Slc35f5 UTSW 1 125,518,775 (GRCm39) missense probably benign 0.23
R5876:Slc35f5 UTSW 1 125,515,100 (GRCm39) critical splice acceptor site probably null
R6701:Slc35f5 UTSW 1 125,490,347 (GRCm39) missense probably damaging 1.00
R7292:Slc35f5 UTSW 1 125,500,222 (GRCm39) missense probably damaging 0.99
R7368:Slc35f5 UTSW 1 125,512,256 (GRCm39) missense probably damaging 1.00
R7530:Slc35f5 UTSW 1 125,512,275 (GRCm39) missense probably damaging 1.00
R7807:Slc35f5 UTSW 1 125,512,278 (GRCm39) missense probably damaging 1.00
R8004:Slc35f5 UTSW 1 125,517,624 (GRCm39) missense probably damaging 0.98
R8289:Slc35f5 UTSW 1 125,490,252 (GRCm39) nonsense probably null
R8435:Slc35f5 UTSW 1 125,488,994 (GRCm39) nonsense probably null
R9011:Slc35f5 UTSW 1 125,490,050 (GRCm39) missense probably benign 0.03
R9339:Slc35f5 UTSW 1 125,517,628 (GRCm39) missense probably benign 0.34
R9365:Slc35f5 UTSW 1 125,496,333 (GRCm39) missense probably benign 0.08
Z1177:Slc35f5 UTSW 1 125,512,971 (GRCm39) critical splice donor site probably null
Z1177:Slc35f5 UTSW 1 125,488,442 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ATCCAGGCTCGGCTACTTTG -3'
(R):5'- GGCTCAGCAAGTAATGACGAC -3'

Sequencing Primer
(F):5'- GGCTACTTTGATGAAATAGCCAGCC -3'
(R):5'- CGTAAGTTTCATCCTCAGTCTCC -3'
Posted On 2015-02-05