Incidental Mutation 'R1761:Arhgap33'
ID 265942
Institutional Source Beutler Lab
Gene Symbol Arhgap33
Ensembl Gene ENSMUSG00000036882
Gene Name Rho GTPase activating protein 33
Synonyms Snx26, Tcgap, NOMA-GAP
MMRRC Submission 039793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.187) question?
Stock # R1761 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 30221651-30234485 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 30232488 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146767 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044338] [ENSMUST00000207858] [ENSMUST00000207860] [ENSMUST00000208491] [ENSMUST00000208522] [ENSMUST00000208538]
AlphaFold Q80YF9
Predicted Effect probably null
Transcript: ENSMUST00000044338
SMART Domains Protein: ENSMUSP00000038412
Gene: ENSMUSG00000036882

DomainStartEndE-ValueType
low complexity region 45 58 N/A INTRINSIC
SH3 213 271 5.32e-12 SMART
low complexity region 318 335 N/A INTRINSIC
RhoGAP 350 531 4.05e-67 SMART
low complexity region 582 595 N/A INTRINSIC
low complexity region 597 609 N/A INTRINSIC
low complexity region 675 686 N/A INTRINSIC
low complexity region 694 733 N/A INTRINSIC
low complexity region 770 798 N/A INTRINSIC
low complexity region 832 850 N/A INTRINSIC
low complexity region 894 940 N/A INTRINSIC
low complexity region 979 988 N/A INTRINSIC
low complexity region 1076 1086 N/A INTRINSIC
low complexity region 1158 1166 N/A INTRINSIC
low complexity region 1194 1216 N/A INTRINSIC
low complexity region 1284 1291 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207637
Predicted Effect probably null
Transcript: ENSMUST00000207858
Predicted Effect probably null
Transcript: ENSMUST00000207860
Predicted Effect probably null
Transcript: ENSMUST00000208491
Predicted Effect probably null
Transcript: ENSMUST00000208522
Predicted Effect probably null
Transcript: ENSMUST00000208538
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208723
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a null mutation display region specific thinning of the cerebral cortex with reduced dendritic complexity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,488,672 (GRCm39) H1268Y possibly damaging Het
Acan T A 7: 78,743,833 (GRCm39) Y621* probably null Het
Aig1 T C 10: 13,566,328 (GRCm39) Y152C probably damaging Het
Bcl6 G T 16: 23,796,292 (GRCm39) A45D probably damaging Het
Cbx5 T C 15: 103,121,607 (GRCm39) D10G possibly damaging Het
Ccdc191 A G 16: 43,763,873 (GRCm39) I445V probably benign Het
Cdk4 T A 10: 126,900,546 (GRCm39) probably benign Het
Chil6 A G 3: 106,301,654 (GRCm39) F149L probably damaging Het
Cntn5 T C 9: 10,172,059 (GRCm39) T42A probably benign Het
Cpn2 A T 16: 30,079,014 (GRCm39) I229N probably damaging Het
Cpne8 A G 15: 90,532,821 (GRCm39) V62A probably damaging Het
Cr2 A G 1: 194,837,431 (GRCm39) probably null Het
Crnn A T 3: 93,055,958 (GRCm39) H248L probably benign Het
Csn1s1 A G 5: 87,826,894 (GRCm39) S254G probably benign Het
Cubn A G 2: 13,494,128 (GRCm39) probably null Het
Dnah8 A G 17: 30,998,890 (GRCm39) N3525S probably damaging Het
Dpp3 A G 19: 4,971,177 (GRCm39) L220P probably benign Het
Fam110a T C 2: 151,812,125 (GRCm39) E215G probably benign Het
Fam20a A T 11: 109,568,664 (GRCm39) N287K probably damaging Het
Fat4 T C 3: 38,941,638 (GRCm39) V177A possibly damaging Het
Fzd8 C T 18: 9,213,643 (GRCm39) R242C probably damaging Het
Gimap5 A T 6: 48,730,195 (GRCm39) Q255L probably damaging Het
Gm4787 A G 12: 81,423,950 (GRCm39) L736S probably benign Het
Gmeb1 G A 4: 131,962,198 (GRCm39) Q154* probably null Het
Gpr156 T C 16: 37,807,929 (GRCm39) L192P probably damaging Het
Gpr179 A C 11: 97,225,932 (GRCm39) S2074R probably benign Het
Hddc2 G T 10: 31,202,135 (GRCm39) D161Y probably damaging Het
Hlcs T C 16: 94,068,866 (GRCm39) D265G probably benign Het
Hspg2 A T 4: 137,241,984 (GRCm39) I573F possibly damaging Het
Il1b T C 2: 129,207,101 (GRCm39) K220E probably damaging Het
Il5 T C 11: 53,614,557 (GRCm39) I66T probably damaging Het
Irf6 G A 1: 192,851,609 (GRCm39) R400H probably damaging Het
Klra1 A T 6: 130,349,836 (GRCm39) Y201N probably damaging Het
Lmf2 A G 15: 89,236,916 (GRCm39) V442A possibly damaging Het
Mcm2 T C 6: 88,866,770 (GRCm39) I412M possibly damaging Het
Mlkl T A 8: 112,060,355 (GRCm39) L18F possibly damaging Het
Mug2 C A 6: 122,051,664 (GRCm39) H949N probably benign Het
Nf1 T C 11: 79,275,091 (GRCm39) F51L probably damaging Het
Or52j3 T G 7: 102,836,325 (GRCm39) C172W probably damaging Het
Or7d10 A T 9: 19,832,445 (GRCm39) *313C probably null Het
Or8k18 T G 2: 86,085,383 (GRCm39) Y218S probably damaging Het
P3h2 T C 16: 25,803,800 (GRCm39) E322G probably damaging Het
Pramel21 T C 4: 143,342,438 (GRCm39) Y182H probably benign Het
Psmg2 CTTCAGTT CTTCAGTTCAGTT 18: 67,779,095 (GRCm39) probably null Het
Ptdss1 T C 13: 67,104,476 (GRCm39) V116A possibly damaging Het
Ranbp2 T C 10: 58,321,563 (GRCm39) V2620A probably benign Het
Robo2 A G 16: 73,831,912 (GRCm39) V256A probably damaging Het
Scg3 T A 9: 75,584,040 (GRCm39) I154F probably damaging Het
Scgn A T 13: 24,143,689 (GRCm39) F225Y probably damaging Het
Sec61b T C 4: 47,480,137 (GRCm39) C58R possibly damaging Het
Slc25a46 G T 18: 31,740,315 (GRCm39) Q96K possibly damaging Het
Spmip6 G A 4: 41,507,223 (GRCm39) P109L probably damaging Het
Sptb A G 12: 76,659,382 (GRCm39) F1173L probably damaging Het
Srcap T A 7: 127,134,017 (GRCm39) C893S probably damaging Het
Tet3 T C 6: 83,380,641 (GRCm39) E509G probably damaging Het
Timm10b C T 7: 105,332,915 (GRCm39) R897* probably null Het
Tln2 C T 9: 67,193,796 (GRCm39) A1773T probably benign Het
Tom1 T C 8: 75,778,179 (GRCm39) V87A probably benign Het
Tti1 T C 2: 157,849,617 (GRCm39) I541V probably benign Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Tubb1 A G 2: 174,298,689 (GRCm39) S124G probably benign Het
Vgll3 A T 16: 65,636,614 (GRCm39) D310V probably damaging Het
Vmac A G 17: 57,022,788 (GRCm39) L74P probably damaging Het
Zbtb1 A T 12: 76,432,595 (GRCm39) K194* probably null Het
Zfp429 A G 13: 67,544,195 (GRCm39) M76T probably benign Het
Zfp808 T A 13: 62,319,460 (GRCm39) C230S possibly damaging Het
Zfp980 A G 4: 145,428,612 (GRCm39) Y447C probably damaging Het
Zfp985 A G 4: 147,668,502 (GRCm39) T457A probably benign Het
Other mutations in Arhgap33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01092:Arhgap33 APN 7 30,229,371 (GRCm39) missense probably damaging 0.99
IGL02176:Arhgap33 APN 7 30,223,476 (GRCm39) missense possibly damaging 0.76
IGL02430:Arhgap33 APN 7 30,222,185 (GRCm39) missense probably benign 0.07
IGL03091:Arhgap33 APN 7 30,227,718 (GRCm39) missense probably damaging 1.00
R0276:Arhgap33 UTSW 7 30,222,669 (GRCm39) missense probably benign 0.01
R0494:Arhgap33 UTSW 7 30,223,921 (GRCm39) missense probably damaging 0.98
R0597:Arhgap33 UTSW 7 30,225,871 (GRCm39) missense probably damaging 1.00
R0717:Arhgap33 UTSW 7 30,227,774 (GRCm39) missense probably damaging 1.00
R1661:Arhgap33 UTSW 7 30,231,748 (GRCm39) missense probably damaging 1.00
R1882:Arhgap33 UTSW 7 30,222,234 (GRCm39) missense probably damaging 1.00
R2161:Arhgap33 UTSW 7 30,228,075 (GRCm39) splice site probably null
R2566:Arhgap33 UTSW 7 30,226,654 (GRCm39) missense probably damaging 1.00
R4353:Arhgap33 UTSW 7 30,223,561 (GRCm39) missense possibly damaging 0.95
R4552:Arhgap33 UTSW 7 30,218,533 (GRCm39) unclassified probably benign
R4778:Arhgap33 UTSW 7 30,231,518 (GRCm39) missense probably benign
R4887:Arhgap33 UTSW 7 30,231,617 (GRCm39) missense probably damaging 0.99
R4957:Arhgap33 UTSW 7 30,231,786 (GRCm39) missense probably damaging 0.96
R5001:Arhgap33 UTSW 7 30,232,441 (GRCm39) missense possibly damaging 0.95
R5140:Arhgap33 UTSW 7 30,227,726 (GRCm39) missense probably damaging 1.00
R5585:Arhgap33 UTSW 7 30,223,260 (GRCm39) missense probably benign 0.00
R5704:Arhgap33 UTSW 7 30,219,045 (GRCm39) unclassified probably benign
R5805:Arhgap33 UTSW 7 30,225,839 (GRCm39) missense probably benign 0.01
R6476:Arhgap33 UTSW 7 30,223,837 (GRCm39) missense probably damaging 0.99
R6485:Arhgap33 UTSW 7 30,223,429 (GRCm39) missense probably benign
R6572:Arhgap33 UTSW 7 30,226,635 (GRCm39) missense probably damaging 1.00
R7183:Arhgap33 UTSW 7 30,225,296 (GRCm39) splice site probably null
R7205:Arhgap33 UTSW 7 30,232,434 (GRCm39) missense probably damaging 0.99
R7241:Arhgap33 UTSW 7 30,228,146 (GRCm39) missense probably damaging 1.00
R7259:Arhgap33 UTSW 7 30,231,625 (GRCm39) missense probably damaging 1.00
R7319:Arhgap33 UTSW 7 30,225,794 (GRCm39) missense probably benign
R7384:Arhgap33 UTSW 7 30,226,696 (GRCm39) missense probably damaging 1.00
R7412:Arhgap33 UTSW 7 30,222,477 (GRCm39) missense probably benign 0.00
R7693:Arhgap33 UTSW 7 30,225,537 (GRCm39) critical splice donor site probably null
R7747:Arhgap33 UTSW 7 30,223,560 (GRCm39) missense probably damaging 0.98
R7893:Arhgap33 UTSW 7 30,228,201 (GRCm39) missense probably benign 0.34
R7915:Arhgap33 UTSW 7 30,222,648 (GRCm39) missense probably benign 0.08
R8819:Arhgap33 UTSW 7 30,228,165 (GRCm39) missense probably benign 0.09
R8820:Arhgap33 UTSW 7 30,228,165 (GRCm39) missense probably benign 0.09
R8912:Arhgap33 UTSW 7 30,232,467 (GRCm39) splice site probably benign
R8922:Arhgap33 UTSW 7 30,223,417 (GRCm39) missense probably damaging 0.99
R9211:Arhgap33 UTSW 7 30,223,023 (GRCm39) missense possibly damaging 0.94
R9616:Arhgap33 UTSW 7 30,229,367 (GRCm39) missense probably damaging 0.99
R9755:Arhgap33 UTSW 7 30,227,926 (GRCm39) missense possibly damaging 0.91
R9762:Arhgap33 UTSW 7 30,230,950 (GRCm39) missense probably null 1.00
X0034:Arhgap33 UTSW 7 30,223,874 (GRCm39) small deletion probably benign
Z1176:Arhgap33 UTSW 7 30,222,142 (GRCm39) missense probably benign 0.13
Z1177:Arhgap33 UTSW 7 30,222,242 (GRCm39) missense probably damaging 1.00
Z1186:Arhgap33 UTSW 7 30,223,904 (GRCm39) small insertion probably benign
Z1186:Arhgap33 UTSW 7 30,223,860 (GRCm39) missense probably benign
Z1186:Arhgap33 UTSW 7 30,223,076 (GRCm39) missense possibly damaging 0.72
Predicted Primers
Posted On 2015-02-05