Incidental Mutation 'R1465:Loxhd1'
| ID |
265957 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Loxhd1
|
| Ensembl Gene |
ENSMUSG00000032818 |
| Gene Name |
lipoxygenase homology domains 1 |
| Synonyms |
1700096C21Rik, sba |
| MMRRC Submission |
039519-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R1465 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
77369654-77530626 bp(+) (GRCm39) |
| Type of Mutation |
splice site (17 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 77468269 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114988
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035501]
[ENSMUST00000096547]
[ENSMUST00000123410]
[ENSMUST00000148341]
|
| AlphaFold |
C8YR32 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000035501
|
| SMART Domains |
Protein: ENSMUSP00000045450
Gene: ENSMUSG00000032818
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PLAT
|
1 |
53 |
3.2e-7 |
PFAM |
|
LH2
|
63 |
176 |
1.1e-4 |
SMART |
|
LH2
|
192 |
306 |
4.02e-4 |
SMART |
|
LH2
|
320 |
442 |
3.79e-6 |
SMART |
|
LH2
|
451 |
567 |
5.92e-6 |
SMART |
|
LH2
|
581 |
696 |
7.67e-3 |
SMART |
|
LH2
|
793 |
913 |
1.47e-11 |
SMART |
|
low complexity region
|
922 |
931 |
N/A |
INTRINSIC |
|
SCOP:d1lox_2
|
949 |
974 |
1e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000096547
|
| SMART Domains |
Protein: ENSMUSP00000094294
Gene: ENSMUSG00000032818
| Domain | Start | End | E-Value | Type |
|---|
|
LH2
|
43 |
158 |
5.64e-5 |
SMART |
|
LH2
|
172 |
290 |
1.64e-9 |
SMART |
|
LH2
|
296 |
409 |
1.1e-4 |
SMART |
|
LH2
|
425 |
539 |
4.02e-4 |
SMART |
|
LH2
|
553 |
675 |
3.79e-6 |
SMART |
|
LH2
|
684 |
800 |
5.92e-6 |
SMART |
|
LH2
|
814 |
936 |
6.91e-8 |
SMART |
|
low complexity region
|
945 |
954 |
N/A |
INTRINSIC |
|
LH2
|
970 |
1086 |
4.81e-7 |
SMART |
|
LH2
|
1101 |
1228 |
5.73e-3 |
SMART |
|
LH2
|
1255 |
1375 |
8.82e-5 |
SMART |
|
Pfam:PLAT
|
1424 |
1540 |
5.4e-10 |
PFAM |
|
LH2
|
1553 |
1666 |
6.41e-3 |
SMART |
|
LH2
|
1680 |
1799 |
6.76e-6 |
SMART |
|
Pfam:PLAT
|
1813 |
1929 |
3.8e-9 |
PFAM |
|
LH2
|
1949 |
2067 |
7.23e-11 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000123410
|
| SMART Domains |
Protein: ENSMUSP00000120991
Gene: ENSMUSG00000032818
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PLAT
|
1 |
67 |
4.4e-15 |
PFAM |
|
low complexity region
|
79 |
88 |
N/A |
INTRINSIC |
|
LH2
|
104 |
220 |
4.81e-7 |
SMART |
|
LH2
|
235 |
362 |
5.73e-3 |
SMART |
|
LH2
|
389 |
509 |
8.82e-5 |
SMART |
|
Pfam:PLAT
|
558 |
674 |
9.9e-12 |
PFAM |
|
LH2
|
687 |
800 |
6.41e-3 |
SMART |
|
LH2
|
814 |
933 |
6.76e-6 |
SMART |
|
Pfam:PLAT
|
947 |
1065 |
8.8e-9 |
PFAM |
|
Pfam:PLAT
|
1085 |
1174 |
4.2e-11 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000148341
|
| SMART Domains |
Protein: ENSMUSP00000114988
Gene: ENSMUSG00000032818
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PLAT
|
1 |
91 |
1.7e-11 |
PFAM |
|
LH2
|
106 |
220 |
4.02e-4 |
SMART |
|
LH2
|
234 |
356 |
3.79e-6 |
SMART |
|
LH2
|
365 |
481 |
5.92e-6 |
SMART |
|
LH2
|
495 |
610 |
7.67e-3 |
SMART |
|
LH2
|
707 |
827 |
1.47e-11 |
SMART |
|
low complexity region
|
836 |
845 |
N/A |
INTRINSIC |
|
LH2
|
861 |
977 |
4.81e-7 |
SMART |
|
LH2
|
992 |
1119 |
5.73e-3 |
SMART |
|
LH2
|
1146 |
1266 |
8.82e-5 |
SMART |
|
Pfam:PLAT
|
1384 |
1469 |
8.9e-14 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.5%
- 10x: 93.6%
- 20x: 86.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice honozygous for an ENU-induced mutation exhibit hearing loss associated with hair cell and spiral ganglion degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310030G06Rik |
A |
G |
9: 50,651,866 (GRCm39) |
Y121H |
probably damaging |
Het |
| Abca13 |
G |
T |
11: 9,349,303 (GRCm39) |
G3626W |
probably damaging |
Het |
| Acvr1c |
A |
G |
2: 58,174,973 (GRCm39) |
Y192H |
probably damaging |
Het |
| Afm |
A |
T |
5: 90,698,200 (GRCm39) |
D534V |
probably damaging |
Het |
| Agl |
T |
C |
3: 116,565,021 (GRCm39) |
E1076G |
probably benign |
Het |
| Ahcyl |
T |
C |
16: 45,974,211 (GRCm39) |
K389E |
probably benign |
Het |
| Angptl3 |
A |
T |
4: 98,925,757 (GRCm39) |
H361L |
probably benign |
Het |
| Apob |
T |
C |
12: 8,061,421 (GRCm39) |
F3301S |
possibly damaging |
Het |
| Arhgef33 |
T |
A |
17: 80,674,730 (GRCm39) |
C376S |
possibly damaging |
Het |
| Ass1 |
A |
G |
2: 31,410,428 (GRCm39) |
*413W |
probably null |
Het |
| Atp6v1h |
T |
A |
1: 5,165,911 (GRCm39) |
L127Q |
probably damaging |
Het |
| Bcl2l1 |
G |
A |
2: 152,671,870 (GRCm39) |
S14F |
probably damaging |
Het |
| Bhmt1b |
T |
G |
18: 87,775,382 (GRCm39) |
F302V |
probably damaging |
Het |
| Birc6 |
G |
A |
17: 74,930,853 (GRCm39) |
A2477T |
probably benign |
Het |
| Bpifb9a |
G |
A |
2: 154,112,941 (GRCm39) |
A589T |
possibly damaging |
Het |
| Casp9 |
C |
A |
4: 141,533,151 (GRCm39) |
T252K |
probably benign |
Het |
| Cct4 |
G |
A |
11: 22,952,922 (GRCm39) |
D533N |
probably damaging |
Het |
| Clcn6 |
A |
C |
4: 148,098,358 (GRCm39) |
I555S |
probably damaging |
Het |
| Col4a4 |
A |
T |
1: 82,475,543 (GRCm39) |
|
probably null |
Het |
| Cyp2d10 |
A |
T |
15: 82,288,129 (GRCm39) |
|
probably null |
Het |
| D930048N14Rik |
A |
G |
11: 51,545,740 (GRCm39) |
|
probably benign |
Het |
| Dhfr |
A |
G |
13: 92,504,815 (GRCm39) |
|
probably benign |
Het |
| Dlg5 |
T |
C |
14: 24,204,764 (GRCm39) |
|
probably null |
Het |
| Dnah11 |
T |
C |
12: 118,002,430 (GRCm39) |
E2240G |
probably damaging |
Het |
| Dnmt3a |
A |
G |
12: 3,916,088 (GRCm39) |
E17G |
probably damaging |
Het |
| Dock1 |
A |
G |
7: 134,384,138 (GRCm39) |
T670A |
probably benign |
Het |
| Dpy19l2 |
A |
G |
9: 24,580,618 (GRCm39) |
M241T |
probably benign |
Het |
| Dpy19l4 |
A |
G |
4: 11,296,034 (GRCm39) |
S212P |
probably damaging |
Het |
| Ephb6 |
T |
C |
6: 41,593,040 (GRCm39) |
F426S |
probably damaging |
Het |
| F5 |
A |
T |
1: 164,026,402 (GRCm39) |
D1658V |
probably benign |
Het |
| Faah |
A |
T |
4: 115,856,755 (GRCm39) |
V469E |
probably damaging |
Het |
| Fas |
T |
C |
19: 34,294,013 (GRCm39) |
C123R |
probably damaging |
Het |
| Fhod1 |
T |
C |
8: 106,065,546 (GRCm39) |
|
probably benign |
Het |
| Filip1 |
A |
G |
9: 79,805,589 (GRCm39) |
V55A |
probably benign |
Het |
| Frmpd1 |
G |
A |
4: 45,273,197 (GRCm39) |
R372Q |
probably damaging |
Het |
| Glyctk |
C |
T |
9: 106,034,806 (GRCm39) |
G87S |
probably damaging |
Het |
| Golga3 |
T |
C |
5: 110,357,744 (GRCm39) |
L1080P |
probably damaging |
Het |
| Gpr137 |
T |
C |
19: 6,915,812 (GRCm39) |
T281A |
probably benign |
Het |
| Grap2 |
T |
A |
15: 80,532,612 (GRCm39) |
|
probably null |
Het |
| Hlcs |
T |
C |
16: 94,069,151 (GRCm39) |
D170G |
probably damaging |
Het |
| Hook1 |
A |
G |
4: 95,901,493 (GRCm39) |
T484A |
probably benign |
Het |
| Hoxa5 |
T |
A |
6: 52,180,771 (GRCm39) |
H187L |
probably benign |
Het |
| Inpp1 |
G |
T |
1: 52,829,253 (GRCm39) |
S255R |
probably benign |
Het |
| Inpp4b |
T |
A |
8: 82,494,786 (GRCm39) |
V67E |
probably damaging |
Het |
| Iqgap3 |
A |
G |
3: 87,994,616 (GRCm39) |
N105S |
probably damaging |
Het |
| Kcnq5 |
A |
G |
1: 21,539,692 (GRCm39) |
|
probably null |
Het |
| Klhl1 |
T |
C |
14: 96,477,649 (GRCm39) |
N473S |
probably benign |
Het |
| Klk1b24 |
C |
A |
7: 43,840,785 (GRCm39) |
T71N |
probably benign |
Het |
| Lrp1b |
C |
T |
2: 41,001,071 (GRCm39) |
R2165Q |
probably benign |
Het |
| Lrp2bp |
A |
T |
8: 46,478,272 (GRCm39) |
Q328L |
possibly damaging |
Het |
| Lrrc63 |
T |
A |
14: 75,344,829 (GRCm39) |
K419N |
possibly damaging |
Het |
| Lrrc9 |
A |
G |
12: 72,547,533 (GRCm39) |
N150S |
probably benign |
Het |
| Lrrn4 |
C |
A |
2: 132,713,995 (GRCm39) |
C317F |
probably damaging |
Het |
| Ltbp2 |
T |
C |
12: 84,860,074 (GRCm39) |
S627G |
probably damaging |
Het |
| Macf1 |
A |
T |
4: 123,386,947 (GRCm39) |
S1224T |
probably damaging |
Het |
| Meis2 |
A |
C |
2: 115,889,151 (GRCm39) |
H200Q |
probably benign |
Het |
| Mesd |
C |
A |
7: 83,544,790 (GRCm39) |
A80E |
probably benign |
Het |
| Mtor |
G |
T |
4: 148,610,450 (GRCm39) |
|
probably benign |
Het |
| Myo3a |
T |
C |
2: 22,467,939 (GRCm39) |
F398L |
probably benign |
Het |
| Nagpa |
G |
T |
16: 5,019,392 (GRCm39) |
|
probably benign |
Het |
| Nanp |
A |
G |
2: 150,872,749 (GRCm39) |
C60R |
probably benign |
Het |
| Nectin2 |
T |
G |
7: 19,464,041 (GRCm39) |
M313L |
probably benign |
Het |
| Nek4 |
C |
T |
14: 30,678,844 (GRCm39) |
H123Y |
probably damaging |
Het |
| Nploc4 |
A |
G |
11: 120,299,607 (GRCm39) |
V371A |
probably damaging |
Het |
| Ntrk3 |
T |
C |
7: 78,005,762 (GRCm39) |
|
probably benign |
Het |
| Or11g7 |
A |
G |
14: 50,690,634 (GRCm39) |
T42A |
possibly damaging |
Het |
| Or13c7b |
A |
G |
4: 43,820,723 (GRCm39) |
F213L |
probably benign |
Het |
| Or52n4 |
T |
C |
7: 104,294,153 (GRCm39) |
N140S |
probably benign |
Het |
| Or5b109 |
T |
A |
19: 13,212,265 (GRCm39) |
V217E |
possibly damaging |
Het |
| Pcdh20 |
T |
A |
14: 88,706,673 (GRCm39) |
Q209L |
probably benign |
Het |
| Pcdhb20 |
G |
A |
18: 37,637,750 (GRCm39) |
R92H |
probably damaging |
Het |
| Pgap1 |
T |
C |
1: 54,567,714 (GRCm39) |
H377R |
probably benign |
Het |
| Phyhipl |
G |
T |
10: 70,406,798 (GRCm39) |
P52Q |
probably damaging |
Het |
| Plekhg4 |
T |
C |
8: 106,107,672 (GRCm39) |
|
probably benign |
Het |
| Pwwp2a |
T |
A |
11: 43,596,383 (GRCm39) |
V516E |
possibly damaging |
Het |
| Rack1 |
T |
C |
11: 48,692,586 (GRCm39) |
V69A |
probably damaging |
Het |
| Rexo5 |
T |
A |
7: 119,400,581 (GRCm39) |
|
probably null |
Het |
| Rnf123 |
T |
C |
9: 107,948,665 (GRCm39) |
|
probably benign |
Het |
| Rock1 |
G |
T |
18: 10,072,863 (GRCm39) |
Q1161K |
possibly damaging |
Het |
| Rps6ka2 |
T |
C |
17: 7,560,266 (GRCm39) |
L568P |
probably damaging |
Het |
| Seh1l |
T |
C |
18: 67,917,054 (GRCm39) |
S78P |
probably damaging |
Het |
| Serpinb3b |
A |
T |
1: 107,083,573 (GRCm39) |
|
probably null |
Het |
| Setd1a |
T |
C |
7: 127,387,512 (GRCm39) |
|
probably benign |
Het |
| Setx |
G |
T |
2: 29,030,401 (GRCm39) |
|
probably null |
Het |
| Sh3bp1 |
T |
C |
15: 78,791,545 (GRCm39) |
|
probably benign |
Het |
| Shc2 |
G |
T |
10: 79,467,136 (GRCm39) |
R146S |
probably damaging |
Het |
| Skap2 |
T |
C |
6: 51,886,348 (GRCm39) |
T5A |
probably benign |
Het |
| Skor2 |
A |
T |
18: 76,964,340 (GRCm39) |
|
probably benign |
Het |
| Slc35a3 |
T |
C |
3: 116,480,983 (GRCm39) |
I93M |
probably benign |
Het |
| Sohlh1 |
C |
T |
2: 25,733,359 (GRCm39) |
G295D |
probably damaging |
Het |
| Speg |
A |
G |
1: 75,405,128 (GRCm39) |
|
probably benign |
Het |
| Sult2a8 |
A |
C |
7: 14,150,208 (GRCm39) |
C168G |
probably benign |
Het |
| Tax1bp1 |
T |
C |
6: 52,704,179 (GRCm39) |
|
probably benign |
Het |
| Tbc1d4 |
T |
C |
14: 101,685,124 (GRCm39) |
I1176V |
possibly damaging |
Het |
| Tcof1 |
A |
G |
18: 60,952,026 (GRCm39) |
|
probably benign |
Het |
| Thada |
A |
T |
17: 84,744,104 (GRCm39) |
F735I |
possibly damaging |
Het |
| Tle1 |
A |
C |
4: 72,058,068 (GRCm39) |
H52Q |
probably damaging |
Het |
| Tmem101 |
A |
T |
11: 102,044,155 (GRCm39) |
V244E |
probably damaging |
Het |
| Tnfrsf26 |
C |
A |
7: 143,171,668 (GRCm39) |
C95F |
probably damaging |
Het |
| Uspl1 |
T |
C |
5: 149,150,842 (GRCm39) |
S482P |
probably benign |
Het |
| Vmn2r118 |
G |
T |
17: 55,917,935 (GRCm39) |
N192K |
probably benign |
Het |
| Vmn2r14 |
C |
T |
5: 109,368,195 (GRCm39) |
V266I |
possibly damaging |
Het |
| Vmn2r51 |
A |
G |
7: 9,834,249 (GRCm39) |
I263T |
probably damaging |
Het |
| Zfp937 |
T |
A |
2: 150,080,967 (GRCm39) |
C332* |
probably null |
Het |
| Zscan21 |
T |
A |
5: 138,123,470 (GRCm39) |
S50T |
probably benign |
Het |
|
| Other mutations in Loxhd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00330:Loxhd1
|
APN |
18 |
77,483,146 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00490:Loxhd1
|
APN |
18 |
77,518,770 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00507:Loxhd1
|
APN |
18 |
77,420,263 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00546:Loxhd1
|
APN |
18 |
77,493,672 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01369:Loxhd1
|
APN |
18 |
77,416,897 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01767:Loxhd1
|
APN |
18 |
77,374,120 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02245:Loxhd1
|
APN |
18 |
77,427,797 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02388:Loxhd1
|
APN |
18 |
77,456,833 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02410:Loxhd1
|
APN |
18 |
77,490,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02593:Loxhd1
|
APN |
18 |
77,498,235 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02632:Loxhd1
|
APN |
18 |
77,493,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02692:Loxhd1
|
APN |
18 |
77,444,609 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02796:Loxhd1
|
APN |
18 |
77,456,811 (GRCm39) |
splice site |
probably benign |
|
|
IGL03032:Loxhd1
|
APN |
18 |
77,374,169 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03074:Loxhd1
|
APN |
18 |
77,529,480 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03094:Loxhd1
|
APN |
18 |
77,518,809 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03118:Loxhd1
|
APN |
18 |
77,468,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03232:Loxhd1
|
APN |
18 |
77,496,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03377:Loxhd1
|
APN |
18 |
77,529,369 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
H8562:Loxhd1
|
UTSW |
18 |
77,429,627 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4494001:Loxhd1
|
UTSW |
18 |
77,529,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0003:Loxhd1
|
UTSW |
18 |
77,427,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0003:Loxhd1
|
UTSW |
18 |
77,427,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0048:Loxhd1
|
UTSW |
18 |
77,496,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0049:Loxhd1
|
UTSW |
18 |
77,468,256 (GRCm39) |
splice site |
probably benign |
|
|
R0049:Loxhd1
|
UTSW |
18 |
77,468,256 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0206:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0208:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0323:Loxhd1
|
UTSW |
18 |
77,456,833 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0332:Loxhd1
|
UTSW |
18 |
77,471,526 (GRCm39) |
splice site |
probably null |
|
|
R0367:Loxhd1
|
UTSW |
18 |
77,513,453 (GRCm39) |
splice site |
probably benign |
|
|
R0709:Loxhd1
|
UTSW |
18 |
77,492,665 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0783:Loxhd1
|
UTSW |
18 |
77,517,680 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1132:Loxhd1
|
UTSW |
18 |
77,517,639 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1232:Loxhd1
|
UTSW |
18 |
77,493,699 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1331:Loxhd1
|
UTSW |
18 |
77,490,632 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1465:Loxhd1
|
UTSW |
18 |
77,468,269 (GRCm39) |
splice site |
probably null |
|
|
R1501:Loxhd1
|
UTSW |
18 |
77,444,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Loxhd1
|
UTSW |
18 |
77,490,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Loxhd1
|
UTSW |
18 |
77,409,364 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1671:Loxhd1
|
UTSW |
18 |
77,492,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Loxhd1
|
UTSW |
18 |
77,380,937 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1735:Loxhd1
|
UTSW |
18 |
77,492,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1796:Loxhd1
|
UTSW |
18 |
77,513,335 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1796:Loxhd1
|
UTSW |
18 |
77,493,603 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1800:Loxhd1
|
UTSW |
18 |
77,490,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1848:Loxhd1
|
UTSW |
18 |
77,369,667 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1912:Loxhd1
|
UTSW |
18 |
77,427,833 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1945:Loxhd1
|
UTSW |
18 |
77,492,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1978:Loxhd1
|
UTSW |
18 |
77,409,338 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1997:Loxhd1
|
UTSW |
18 |
77,383,465 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2086:Loxhd1
|
UTSW |
18 |
77,472,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Loxhd1
|
UTSW |
18 |
77,443,862 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R3124:Loxhd1
|
UTSW |
18 |
77,518,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3896:Loxhd1
|
UTSW |
18 |
77,469,719 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3907:Loxhd1
|
UTSW |
18 |
77,496,464 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3980:Loxhd1
|
UTSW |
18 |
77,501,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4165:Loxhd1
|
UTSW |
18 |
77,460,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4166:Loxhd1
|
UTSW |
18 |
77,460,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Loxhd1
|
UTSW |
18 |
77,418,755 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4345:Loxhd1
|
UTSW |
18 |
77,486,697 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4354:Loxhd1
|
UTSW |
18 |
77,483,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Loxhd1
|
UTSW |
18 |
77,460,607 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4402:Loxhd1
|
UTSW |
18 |
77,529,456 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4404:Loxhd1
|
UTSW |
18 |
77,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4456:Loxhd1
|
UTSW |
18 |
77,486,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4525:Loxhd1
|
UTSW |
18 |
77,444,608 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4605:Loxhd1
|
UTSW |
18 |
77,493,642 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4661:Loxhd1
|
UTSW |
18 |
77,490,581 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4698:Loxhd1
|
UTSW |
18 |
77,459,987 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4725:Loxhd1
|
UTSW |
18 |
77,483,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4820:Loxhd1
|
UTSW |
18 |
77,472,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5163:Loxhd1
|
UTSW |
18 |
77,449,432 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5288:Loxhd1
|
UTSW |
18 |
77,451,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5328:Loxhd1
|
UTSW |
18 |
77,498,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Loxhd1
|
UTSW |
18 |
77,420,378 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5347:Loxhd1
|
UTSW |
18 |
77,454,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5589:Loxhd1
|
UTSW |
18 |
77,429,751 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5616:Loxhd1
|
UTSW |
18 |
77,492,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5703:Loxhd1
|
UTSW |
18 |
77,444,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5837:Loxhd1
|
UTSW |
18 |
77,374,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5888:Loxhd1
|
UTSW |
18 |
77,490,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6021:Loxhd1
|
UTSW |
18 |
77,499,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6032:Loxhd1
|
UTSW |
18 |
77,469,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6032:Loxhd1
|
UTSW |
18 |
77,469,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Loxhd1
|
UTSW |
18 |
77,383,454 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6174:Loxhd1
|
UTSW |
18 |
77,499,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Loxhd1
|
UTSW |
18 |
77,449,426 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6377:Loxhd1
|
UTSW |
18 |
77,468,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Loxhd1
|
UTSW |
18 |
77,499,847 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6555:Loxhd1
|
UTSW |
18 |
77,380,965 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6782:Loxhd1
|
UTSW |
18 |
77,518,873 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6834:Loxhd1
|
UTSW |
18 |
77,529,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7000:Loxhd1
|
UTSW |
18 |
77,460,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7112:Loxhd1
|
UTSW |
18 |
77,476,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Loxhd1
|
UTSW |
18 |
77,501,892 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7206:Loxhd1
|
UTSW |
18 |
77,529,513 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7260:Loxhd1
|
UTSW |
18 |
77,420,338 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7432:Loxhd1
|
UTSW |
18 |
77,383,547 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7475:Loxhd1
|
UTSW |
18 |
77,500,001 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7555:Loxhd1
|
UTSW |
18 |
77,483,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Loxhd1
|
UTSW |
18 |
77,409,330 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7612:Loxhd1
|
UTSW |
18 |
77,517,671 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7626:Loxhd1
|
UTSW |
18 |
77,518,882 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7768:Loxhd1
|
UTSW |
18 |
77,472,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7791:Loxhd1
|
UTSW |
18 |
77,471,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7829:Loxhd1
|
UTSW |
18 |
77,496,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7884:Loxhd1
|
UTSW |
18 |
77,518,909 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7960:Loxhd1
|
UTSW |
18 |
77,472,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7986:Loxhd1
|
UTSW |
18 |
77,462,890 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8042:Loxhd1
|
UTSW |
18 |
77,518,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8084:Loxhd1
|
UTSW |
18 |
77,427,845 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8088:Loxhd1
|
UTSW |
18 |
77,429,709 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8100:Loxhd1
|
UTSW |
18 |
77,492,512 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8139:Loxhd1
|
UTSW |
18 |
77,468,192 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8152:Loxhd1
|
UTSW |
18 |
77,476,095 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8199:Loxhd1
|
UTSW |
18 |
77,469,334 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8246:Loxhd1
|
UTSW |
18 |
77,451,242 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8263:Loxhd1
|
UTSW |
18 |
77,462,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8324:Loxhd1
|
UTSW |
18 |
77,427,275 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8342:Loxhd1
|
UTSW |
18 |
77,493,681 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8401:Loxhd1
|
UTSW |
18 |
77,468,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Loxhd1
|
UTSW |
18 |
77,518,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8490:Loxhd1
|
UTSW |
18 |
77,529,162 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8807:Loxhd1
|
UTSW |
18 |
77,444,468 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8961:Loxhd1
|
UTSW |
18 |
77,472,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Loxhd1
|
UTSW |
18 |
77,518,899 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9079:Loxhd1
|
UTSW |
18 |
77,490,593 (GRCm39) |
missense |
probably benign |
|
|
R9284:Loxhd1
|
UTSW |
18 |
77,501,826 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9312:Loxhd1
|
UTSW |
18 |
77,498,285 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9619:Loxhd1
|
UTSW |
18 |
77,443,871 (GRCm39) |
missense |
probably benign |
0.32 |
|
X0020:Loxhd1
|
UTSW |
18 |
77,427,258 (GRCm39) |
nonsense |
probably null |
|
|
X0024:Loxhd1
|
UTSW |
18 |
77,483,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Loxhd1
|
UTSW |
18 |
77,529,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2015-02-05 |
Incidental Mutation