Incidental Mutation 'IGL00903:Fcrl6'
ID26605
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcrl6
Ensembl Gene ENSMUSG00000070504
Gene NameFc receptor-like 6
SynonymsENSMUSG00000070504, mIFGP6, moFcRH6, FcRH6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.028) question?
Stock #IGL00903
Quality Score
Status
Chromosome1
Chromosomal Location172596642-172602551 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 172599107 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 91 (T91S)
Ref Sequence ENSEMBL: ENSMUSP00000091861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094303]
Predicted Effect probably benign
Transcript: ENSMUST00000094303
AA Change: T91S

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000091861
Gene: ENSMUSG00000070504
AA Change: T91S

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Ig_3 19 91 1.2e-4 PFAM
Pfam:Ig_2 20 106 8e-9 PFAM
Pfam:Ig_3 113 187 1.9e-9 PFAM
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193431
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193566
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500012F01Rik G T 2: 167,065,486 probably benign Het
Arsk A G 13: 76,098,368 probably null Het
As3mt A G 19: 46,712,234 I159V probably benign Het
Ctsll3 C A 13: 60,800,261 V201L probably benign Het
Dapk1 T C 13: 60,761,397 Y1275H probably damaging Het
Erap1 G A 13: 74,673,707 R727H probably benign Het
Fam173b T C 15: 31,606,115 V73A possibly damaging Het
Gvin1 T C 7: 106,158,170 E2364G probably benign Het
Hacd3 T C 9: 65,004,253 probably benign Het
Hcls1 T A 16: 36,956,021 probably null Het
Igf2r C T 17: 12,683,867 R2432H possibly damaging Het
Kif27 C A 13: 58,344,672 V218F possibly damaging Het
Klhl20 T C 1: 161,090,506 Y70C probably benign Het
Krt86 C T 15: 101,473,860 H104Y probably benign Het
Lcn12 G T 2: 25,493,320 N15K possibly damaging Het
Mrgpra1 T C 7: 47,335,578 M118V probably benign Het
Nacad G T 11: 6,600,632 T853K probably damaging Het
Nos3 A T 5: 24,369,862 Q293L probably damaging Het
Prkca C T 11: 107,983,974 V381M probably damaging Het
Ptcd3 A G 6: 71,907,844 F37S possibly damaging Het
Ptgs2 A G 1: 150,104,424 Y371C probably damaging Het
Pygl T C 12: 70,207,742 Y143C probably damaging Het
Samhd1 A G 2: 157,107,423 probably benign Het
Scube1 T A 15: 83,703,501 H89L probably damaging Het
Tmem59l G A 8: 70,485,665 probably benign Het
Vmn2r108 A G 17: 20,462,512 V810A probably damaging Het
Vmn2r61 T G 7: 42,300,511 F785C probably damaging Het
Other mutations in Fcrl6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01074:Fcrl6 APN 1 172599113 missense possibly damaging 0.89
IGL02146:Fcrl6 APN 1 172598697 missense probably benign 0.01
IGL02277:Fcrl6 APN 1 172599119 missense probably damaging 1.00
IGL03162:Fcrl6 APN 1 172598253 missense probably damaging 1.00
IGL03303:Fcrl6 APN 1 172597688 missense probably damaging 0.99
K3955:Fcrl6 UTSW 1 172597684 missense probably benign 0.00
R0051:Fcrl6 UTSW 1 172598753 missense probably benign 0.24
R0051:Fcrl6 UTSW 1 172598753 missense probably benign 0.24
R1336:Fcrl6 UTSW 1 172599224 nonsense probably null
R2125:Fcrl6 UTSW 1 172599248 missense probably benign 0.41
R2126:Fcrl6 UTSW 1 172599248 missense probably benign 0.41
R5376:Fcrl6 UTSW 1 172599280 missense probably damaging 1.00
R5395:Fcrl6 UTSW 1 172598720 missense possibly damaging 0.55
R6314:Fcrl6 UTSW 1 172598619 splice site probably null
U24488:Fcrl6 UTSW 1 172598870 missense probably damaging 0.99
Posted On2013-04-17