Mutagenetix > Incidental Mutation

Incidental Mutation 'R2204:Or10j2'

266106

Institutional Source

Beutler Lab

Gene Symbol

Or10j2

Ensembl Gene

ENSMUSG00000049605

Gene Name

olfactory receptor family 10 subfamily J member 2

Synonyms

MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364

MMRRC Submission

040206-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R2204 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

173097714-173098704 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 173097703 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000052418 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]

AlphaFold

A0A140T8J6

Predicted Effect

probably null
Transcript: ENSMUST00000059754

SMART Domains

Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.6e-55	PFAM
Pfam:7tm_1	41	289	5.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000111224

SMART Domains

Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
PTX	20	219	1.93e-94	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000213420

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630076J17Rik	A	G	3: 107,140,943 (GRCm39)		probably benign	Het
Abca1	G	A	4: 53,090,291 (GRCm39)	T386I	probably damaging	Het
Acsf3	C	T	8: 123,540,383 (GRCm39)	S527F	probably damaging	Het
Adamts7	A	T	9: 90,062,729 (GRCm39)	K394N	probably damaging	Het
Ankrd2	C	A	19: 42,032,558 (GRCm39)	A273E	probably damaging	Het
Ankrd26	T	A	6: 118,500,843 (GRCm39)	H876L	possibly damaging	Het
Atg16l1	A	C	1: 87,694,737 (GRCm39)	Q138P	probably benign	Het
Bap1	T	C	14: 30,978,658 (GRCm39)	V23A	probably benign	Het
Cartpt	A	T	13: 100,037,133 (GRCm39)	S4T	probably benign	Het
Cdan1	C	A	2: 120,551,241 (GRCm39)	C1093F	probably damaging	Het
Ceacam11	C	T	7: 17,709,273 (GRCm39)	T157I	possibly damaging	Het
Cfap45	T	C	1: 172,359,728 (GRCm39)	V76A	probably benign	Het
Chil3	T	C	3: 106,071,562 (GRCm39)	D34G	probably benign	Het
Chrnb4	G	A	9: 54,951,132 (GRCm39)	R44C	probably damaging	Het
Col6a4	T	C	9: 105,937,331 (GRCm39)	D1395G	probably damaging	Het
Cpa1	A	G	6: 30,641,818 (GRCm39)	D214G	probably damaging	Het
Cttnbp2	T	G	6: 18,408,693 (GRCm39)	D976A	probably benign	Het
Elapor1	C	T	3: 108,382,359 (GRCm39)	G270E	probably damaging	Het
Espl1	A	G	15: 102,214,340 (GRCm39)	E693G	probably damaging	Het
Fat1	G	T	8: 45,476,737 (GRCm39)	A1928S	probably damaging	Het
Fiz1	C	T	7: 5,011,685 (GRCm39)	E278K	probably benign	Het
Flnc	C	T	6: 29,459,507 (GRCm39)	P2536S	probably damaging	Het
Gm6370	T	A	5: 146,430,539 (GRCm39)	D241E	probably benign	Het
Hlcs	T	C	16: 94,032,011 (GRCm39)	T451A	probably benign	Het
Hmgcr	A	G	13: 96,793,141 (GRCm39)	L497P	probably damaging	Het
Hmgcs2	T	A	3: 98,198,499 (GRCm39)	I134N	probably damaging	Het
Ifit1bl1	C	T	19: 34,571,741 (GRCm39)	E239K	probably benign	Het
Ift52	G	A	2: 162,873,150 (GRCm39)	S221N	probably benign	Het
Knstrn	T	A	2: 118,661,456 (GRCm39)		probably null	Het
Map3k14	T	A	11: 103,130,280 (GRCm39)	K212N	possibly damaging	Het
Ndufb7	A	G	8: 84,297,528 (GRCm39)	H61R	probably damaging	Het
Nop56	T	A	2: 130,119,488 (GRCm39)	I51N	probably damaging	Het
Nudt5	A	T	2: 5,860,794 (GRCm39)	I22F	possibly damaging	Het
Or4p23	C	G	2: 88,576,953 (GRCm39)	G93A	probably benign	Het
Or7d11	T	C	9: 19,966,507 (GRCm39)	N84S	possibly damaging	Het
P3h4	G	A	11: 100,304,832 (GRCm39)	A185V	probably benign	Het
Pdcl	A	T	2: 37,242,056 (GRCm39)	N231K	probably benign	Het
Plcb4	T	C	2: 135,844,514 (GRCm39)	I144T	probably benign	Het
Pramel32	A	T	4: 88,546,355 (GRCm39)	L329Q	probably damaging	Het
Prrc2b	C	A	2: 32,113,476 (GRCm39)	Q1970K	probably damaging	Het
Robo4	CGG	CG	9: 37,322,786 (GRCm39)		probably null	Het
Sars2	T	C	7: 28,449,099 (GRCm39)	V302A	possibly damaging	Het
Shroom3	G	T	5: 93,090,945 (GRCm39)	V1151F	probably damaging	Het
Spata31d1d	A	G	13: 59,879,435 (GRCm39)	C34R	possibly damaging	Het
Speg	A	T	1: 75,407,121 (GRCm39)	T3137S	probably benign	Het
Ssh3	A	G	19: 4,319,101 (GRCm39)	L3P	probably damaging	Het
Stard9	GAAA	GAA	2: 120,529,012 (GRCm39)		probably null	Het
Stoml2	G	T	4: 43,030,243 (GRCm39)	Y119*	probably null	Het
Susd1	A	G	4: 59,349,843 (GRCm39)	L531P	possibly damaging	Het
Taco1	C	T	11: 105,962,760 (GRCm39)	A149V	probably benign	Het
Tenm3	T	C	8: 49,127,585 (GRCm39)	E31G	probably benign	Het
Tmc1	A	T	19: 20,918,269 (GRCm39)	L2M	probably benign	Het
Tmem39b	A	C	4: 129,587,716 (GRCm39)	S32A	probably benign	Het
Tnfsf14	T	C	17: 57,497,638 (GRCm39)	D198G	possibly damaging	Het
Trabd2b	T	C	4: 114,460,191 (GRCm39)	L443P	probably damaging	Het
Trip4	T	A	9: 65,771,547 (GRCm39)	I328F	probably damaging	Het
Trpc3	A	G	3: 36,704,298 (GRCm39)	F553S	possibly damaging	Het
Tssk2	A	G	16: 17,716,603 (GRCm39)	D2G	possibly damaging	Het
Ttn	T	C	2: 76,601,985 (GRCm39)	N18559S	possibly damaging	Het
Vmn1r23	T	C	6: 57,903,604 (GRCm39)	D58G	probably benign	Het
Zbtb47	A	G	9: 121,591,703 (GRCm39)	T8A	possibly damaging	Het
Zfyve27	C	A	19: 42,171,885 (GRCm39)	A139D	probably damaging	Het

Other mutations in Or10j2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01413:Or10j2	APN	1	173,098,275 (GRCm39)	missense	probably damaging	1.00
IGL01418:Or10j2	APN	1	173,098,275 (GRCm39)	missense	probably damaging	1.00
IGL01930:Or10j2	APN	1	173,098,177 (GRCm39)	missense	probably benign
IGL01963:Or10j2	APN	1	173,097,919 (GRCm39)	missense	probably damaging	0.99
IGL02104:Or10j2	APN	1	173,098,603 (GRCm39)	missense	probably damaging	0.96
IGL02192:Or10j2	APN	1	173,098,417 (GRCm39)	missense	probably damaging	1.00
IGL02256:Or10j2	APN	1	173,098,194 (GRCm39)	missense	probably benign	0.04
IGL02340:Or10j2	APN	1	173,097,972 (GRCm39)	missense	probably benign	0.10
IGL02454:Or10j2	APN	1	173,098,507 (GRCm39)	missense	probably damaging	0.99
IGL02638:Or10j2	APN	1	173,097,898 (GRCm39)	missense	probably benign	0.07
FR4737:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
FR4976:Or10j2	UTSW	1	173,098,197 (GRCm39)	frame shift	probably null
R0552:Or10j2	UTSW	1	173,098,372 (GRCm39)	missense	probably benign	0.05
R0621:Or10j2	UTSW	1	173,098,242 (GRCm39)	missense	possibly damaging	0.48
R0735:Or10j2	UTSW	1	173,098,569 (GRCm39)	missense	probably benign	0.05
R1506:Or10j2	UTSW	1	173,098,336 (GRCm39)	missense	probably benign	0.04
R1670:Or10j2	UTSW	1	173,098,467 (GRCm39)	missense	probably damaging	1.00
R2111:Or10j2	UTSW	1	173,097,879 (GRCm39)	missense	probably benign
R4475:Or10j2	UTSW	1	173,098,480 (GRCm39)	missense	probably damaging	0.99
R4909:Or10j2	UTSW	1	173,098,546 (GRCm39)	missense	probably damaging	0.97
R5457:Or10j2	UTSW	1	173,098,141 (GRCm39)	missense	probably benign	0.00
R6124:Or10j2	UTSW	1	173,097,846 (GRCm39)	missense	probably damaging	1.00
R6456:Or10j2	UTSW	1	173,098,105 (GRCm39)	missense	probably damaging	1.00
R7220:Or10j2	UTSW	1	173,097,811 (GRCm39)	missense	possibly damaging	0.56
R7240:Or10j2	UTSW	1	173,098,561 (GRCm39)	missense	probably benign	0.27
R7672:Or10j2	UTSW	1	173,098,440 (GRCm39)	missense	probably benign	0.18
R8073:Or10j2	UTSW	1	173,098,552 (GRCm39)	missense	probably benign	0.42
R8116:Or10j2	UTSW	1	173,098,047 (GRCm39)	missense	possibly damaging	0.88
R8982:Or10j2	UTSW	1	173,098,306 (GRCm39)	missense	probably damaging	1.00
R9038:Or10j2	UTSW	1	173,098,147 (GRCm39)	missense	possibly damaging	0.63
R9668:Or10j2	UTSW	1	173,098,183 (GRCm39)	missense	possibly damaging	0.94
RF032:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF036:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
RF040:Or10j2	UTSW	1	173,098,276 (GRCm39)	frame shift	probably null
X0019:Or10j2	UTSW	1	173,098,124 (GRCm39)	nonsense	probably null

Predicted Primers

Posted On

2015-02-05