Mutagenetix > Incidental Mutation

Incidental Mutation 'R2420:Or4k42'

266150

Institutional Source

Beutler Lab

Gene Symbol

Or4k42

Ensembl Gene

ENSMUSG00000095809

Gene Name

olfactory receptor family 4 subfamily K member 42

Synonyms

Olfr1290, MOR248-9, GA_x6K02T2Q125-72541649-72540711

MMRRC Submission

040382-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R2420 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

111319563-111324160 bp(-) (GRCm39)

Type of Mutation

splice site (575 bp from exon)

DNA Base Change (assembly)

T to C at 111319602 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000146756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099616] [ENSMUST00000120021] [ENSMUST00000207494] [ENSMUST00000208695] [ENSMUST00000208881] [ENSMUST00000217611]

AlphaFold

Q7TQX8

Predicted Effect

probably null
Transcript: ENSMUST00000099616

SMART Domains

Protein: ENSMUSP00000097211
Gene: ENSMUSG00000095809

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	3.5e-52	PFAM
Pfam:7tm_1	41	287	1e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120021

Predicted Effect

probably benign
Transcript: ENSMUST00000207494

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207707

Predicted Effect

probably null
Transcript: ENSMUST00000208695

Predicted Effect

probably null
Transcript: ENSMUST00000208881

Predicted Effect

silent
Transcript: ENSMUST00000217611

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225425

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.9%
20x: 93.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6820408C15Rik	A	G	2: 152,270,921 (GRCm39)	K48R	probably damaging	Het
Acsm2	T	C	7: 119,162,857 (GRCm39)	F44L	probably damaging	Het
Actr5	T	C	2: 158,478,001 (GRCm39)	F457S	probably damaging	Het
Adamts3	A	G	5: 89,831,034 (GRCm39)	S1007P	probably damaging	Het
Ahnak	C	T	19: 8,986,620 (GRCm39)	P2635S	possibly damaging	Het
Ankrd17	A	T	5: 90,437,179 (GRCm39)	D555E	possibly damaging	Het
Arhgap29	A	G	3: 121,767,629 (GRCm39)	I24V	probably benign	Het
Atxn2	A	T	5: 121,940,142 (GRCm39)		probably null	Het
Birc6	T	A	17: 74,967,609 (GRCm39)	L301Q	probably damaging	Het
Ccdc137	G	A	11: 120,353,090 (GRCm39)		probably null	Het
Ccdc18	A	C	5: 108,376,454 (GRCm39)	E1298D	probably damaging	Het
Chst9	A	T	18: 15,585,341 (GRCm39)	N407K	probably damaging	Het
Cwf19l2	A	G	9: 3,411,341 (GRCm39)	K73E	possibly damaging	Het
Dhcr24	G	T	4: 106,418,291 (GRCm39)		probably benign	Het
Dnajc21	A	G	15: 10,462,021 (GRCm39)	S127P	probably benign	Het
Egln1	T	C	8: 125,674,985 (GRCm39)	N270S	probably benign	Het
Eme1	A	G	11: 94,536,640 (GRCm39)		probably null	Het
Emilin2	A	G	17: 71,581,274 (GRCm39)	I484T	possibly damaging	Het
Entpd2	T	C	2: 25,289,295 (GRCm39)	I259T	probably benign	Het
Fbp1	T	C	13: 63,019,120 (GRCm39)	K24E	probably benign	Het
Fga	A	T	3: 82,940,461 (GRCm39)	N705I	possibly damaging	Het
Gas1	G	T	13: 60,324,744 (GRCm39)		probably benign	Het
Glrb	A	G	3: 80,767,542 (GRCm39)	I226T	probably damaging	Het
Gm17421	T	A	12: 113,333,107 (GRCm39)		noncoding transcript	Het
Gm44501	A	T	17: 40,889,600 (GRCm39)	H38L	possibly damaging	Het
H2-M10.5	A	G	17: 37,085,891 (GRCm39)	I308V	probably benign	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Jcad	T	C	18: 4,675,952 (GRCm39)	M1238T	probably damaging	Het
Kank1	T	C	19: 25,387,821 (GRCm39)	L498S	probably damaging	Het
Krt10	G	A	11: 99,277,933 (GRCm39)	T338I	possibly damaging	Het
Krt13	A	T	11: 100,010,877 (GRCm39)	L159Q	probably benign	Het
Lama1	A	T	17: 68,057,548 (GRCm39)	M541L	probably benign	Het
Lilra6	A	G	7: 3,917,857 (GRCm39)	Y96H	probably damaging	Het
Ltc4s	A	G	11: 50,128,166 (GRCm39)		probably null	Het
Ly6g6e	G	A	17: 35,297,122 (GRCm39)	R121Q	probably benign	Het
Mfn1	A	G	3: 32,623,664 (GRCm39)	I263V	probably benign	Het
Mmaa	T	A	8: 80,008,061 (GRCm39)	R59W	probably damaging	Het
Mug2	C	A	6: 122,060,419 (GRCm39)	T1385K	probably damaging	Het
Mypn	G	T	10: 63,028,648 (GRCm39)	Y138*	probably null	Het
Nav3	A	C	10: 109,699,674 (GRCm39)	S273R	probably damaging	Het
Ndufaf1	T	C	2: 119,486,218 (GRCm39)	E298G	probably damaging	Het
Or10d5	A	G	9: 39,861,824 (GRCm39)	L81P	possibly damaging	Het
Or4c114	T	C	2: 88,905,336 (GRCm39)	Y33C	possibly damaging	Het
Or5k15	T	C	16: 58,710,328 (GRCm39)	E85G	probably benign	Het
Or5p51	T	C	7: 107,444,025 (GRCm39)	K305R	probably benign	Het
Pak1	A	T	7: 97,503,686 (GRCm39)	D7V	probably benign	Het
Pax3	A	T	1: 78,173,501 (GRCm39)		probably null	Het
Plekhg1	G	A	10: 3,908,048 (GRCm39)	M988I	probably benign	Het
Prickle1	A	G	15: 93,401,518 (GRCm39)	F322S	probably damaging	Het
Prl8a2	A	G	13: 27,532,896 (GRCm39)	E36G	possibly damaging	Het
Prss45	A	G	9: 110,668,160 (GRCm39)	I118V	possibly damaging	Het
Psd4	T	G	2: 24,291,253 (GRCm39)	V597G	probably damaging	Het
Psmb10	A	G	8: 106,663,934 (GRCm39)	S108P	probably benign	Het
Pttg1ip2	T	C	5: 5,505,912 (GRCm39)	Y123C	probably benign	Het
Shank3	A	T	15: 89,405,413 (GRCm39)	K455*	probably null	Het
Spag17	T	A	3: 99,934,935 (GRCm39)	W714R	probably benign	Het
Synrg	A	G	11: 83,900,050 (GRCm39)	E674G	probably damaging	Het
Tep1	T	A	14: 51,071,480 (GRCm39)	H2055L	probably benign	Het
Terb1	T	C	8: 105,225,227 (GRCm39)	T14A	probably damaging	Het
Tmub2	T	A	11: 102,178,581 (GRCm39)	D161E	probably benign	Het
Ttc23l	CT	CTTGGATT	15: 10,537,648 (GRCm39)		probably benign	Het
Ttc23l	G	A	15: 10,537,652 (GRCm39)	S206L	probably benign	Het
Tyr	T	A	7: 87,078,397 (GRCm39)	I488F	probably benign	Het
Uba6	A	G	5: 86,280,475 (GRCm39)		probably null	Het
Unc13c	T	C	9: 73,838,829 (GRCm39)	Y674C	probably damaging	Het
Vmn2r105	T	A	17: 20,448,097 (GRCm39)	R242S	probably benign	Het
Vmn2r12	A	G	5: 109,234,398 (GRCm39)	Y605H	probably benign	Het
Wnk1	A	G	6: 119,913,328 (GRCm39)		probably null	Het
Zfhx4	C	A	3: 5,455,465 (GRCm39)	A1153E	probably benign	Het
Zfp13	A	C	17: 23,795,186 (GRCm39)	Y462D	probably damaging	Het
Zfp644	A	G	5: 106,785,110 (GRCm39)	M479T	possibly damaging	Het

Other mutations in Or4k42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00958:Or4k42	APN	2	111,319,565 (GRCm39)	makesense	probably null
IGL01418:Or4k42	APN	2	111,319,984 (GRCm39)	missense	probably benign	0.37
IGL02288:Or4k42	APN	2	111,320,065 (GRCm39)	missense	probably benign	0.09
IGL02507:Or4k42	APN	2	111,319,768 (GRCm39)	missense	possibly damaging	0.87
IGL02508:Or4k42	APN	2	111,320,180 (GRCm39)	missense	probably damaging	1.00
IGL02951:Or4k42	APN	2	111,320,465 (GRCm39)	missense	probably benign	0.00
IGL03357:Or4k42	APN	2	111,320,289 (GRCm39)	missense	probably benign	0.01
R1101:Or4k42	UTSW	2	111,319,787 (GRCm39)	missense	probably damaging	1.00
R2256:Or4k42	UTSW	2	111,320,323 (GRCm39)	missense	probably damaging	1.00
R4672:Or4k42	UTSW	2	111,319,902 (GRCm39)	missense	possibly damaging	0.66
R4715:Or4k42	UTSW	2	111,320,089 (GRCm39)	missense	probably benign
R4855:Or4k42	UTSW	2	111,320,293 (GRCm39)	missense	probably damaging	1.00
R6011:Or4k42	UTSW	2	111,320,192 (GRCm39)	missense	probably benign	0.03
R6141:Or4k42	UTSW	2	111,320,464 (GRCm39)	missense	probably benign	0.34
R6156:Or4k42	UTSW	2	111,320,095 (GRCm39)	missense	probably damaging	1.00
R6702:Or4k42	UTSW	2	111,320,454 (GRCm39)	splice site	probably null
R6703:Or4k42	UTSW	2	111,320,454 (GRCm39)	splice site	probably null
R7413:Or4k42	UTSW	2	111,319,933 (GRCm39)	missense	probably benign	0.18
R7861:Or4k42	UTSW	2	111,320,369 (GRCm39)	missense	probably damaging	0.99
R8007:Or4k42	UTSW	2	111,320,068 (GRCm39)	missense	probably damaging	1.00
R8914:Or4k42	UTSW	2	111,320,004 (GRCm39)	missense	probably damaging	1.00
R8947:Or4k42	UTSW	2	111,320,042 (GRCm39)	missense	probably benign	0.02
R9003:Or4k42	UTSW	2	111,320,411 (GRCm39)	missense	probably benign	0.11
R9396:Or4k42	UTSW	2	111,319,864 (GRCm39)	missense	probably benign	0.22
Z1176:Or4k42	UTSW	2	111,320,222 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2015-02-05