Mutagenetix > Incidental Mutation

Incidental Mutation 'R2411:Ifitm1'

266167

Institutional Source

Beutler Lab

Gene Symbol

Ifitm1

Ensembl Gene

ENSMUSG00000025491

Gene Name

interferon induced transmembrane protein 1

Synonyms

1110036C17Rik, fragilis2, Mil2

MMRRC Submission

040376-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2411 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

140547342-140549740 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 140549711 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000101657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026564] [ENSMUST00000106040] [ENSMUST00000106042]

AlphaFold

Q9D103

Predicted Effect

probably null
Transcript: ENSMUST00000026564

SMART Domains

Protein: ENSMUSP00000026564
Gene: ENSMUSG00000025491

Domain	Start	End	E-Value	Type
Pfam:Dispanin	18	101	1.3e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000106040

SMART Domains

Protein: ENSMUSP00000101655
Gene: ENSMUSG00000025491

Domain	Start	End	E-Value	Type
Pfam:Dispanin	18	101	1.3e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000106042

SMART Domains

Protein: ENSMUSP00000101657
Gene: ENSMUSG00000025491

Domain	Start	End	E-Value	Type
Pfam:CD225	24	101	2.9e-31	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 93.9%

Validation Efficiency

98% (42/43)

MGI Phenotype

PHENOTYPE: Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing when compared with that of their wild-type littermates. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	G	T	11: 109,684,980 (GRCm39)	C172*	probably null	Het
4933402D24Rik	A	G	1: 63,795,373 (GRCm39)		probably benign	Het
9030612E09Rik	G	T	10: 43,050,796 (GRCm39)	R30L	possibly damaging	Het
Aadacl2	A	G	3: 59,924,844 (GRCm39)	D137G	possibly damaging	Het
Acad11	T	G	9: 103,963,222 (GRCm39)		probably benign	Het
Acap1	A	T	11: 69,776,311 (GRCm39)	N229K	probably damaging	Het
Agbl1	A	G	7: 76,369,898 (GRCm39)	T666A	probably damaging	Het
Btbd16	T	C	7: 130,391,954 (GRCm39)	F160L	probably damaging	Het
Clock	A	C	5: 76,379,360 (GRCm39)	H525Q	probably benign	Het
Col6a1	G	T	10: 76,546,922 (GRCm39)	Q767K	unknown	Het
Creld1	A	G	6: 113,466,737 (GRCm39)	H240R	probably benign	Het
Dlg4	G	A	11: 69,932,755 (GRCm39)		probably null	Het
Fam204a	A	T	19: 60,187,870 (GRCm39)	*237R	probably null	Het
Filip1	T	A	9: 79,805,715 (GRCm39)	N13I	probably damaging	Het
Gm14295	G	T	2: 176,499,206 (GRCm39)	A19S	probably benign	Het
Hddc3	A	T	7: 79,993,341 (GRCm39)	Q56L	probably damaging	Het
Hes6	A	C	1: 91,340,986 (GRCm39)		probably null	Het
Hormad1	A	G	3: 95,487,326 (GRCm39)	D270G	probably benign	Het
Igbp1b	A	C	6: 138,634,871 (GRCm39)	V191G	probably damaging	Het
Impg2	T	A	16: 56,072,517 (GRCm39)	N316K	probably damaging	Het
Kalrn	C	T	16: 33,810,180 (GRCm39)	D2525N	possibly damaging	Het
Lilra6	T	C	7: 3,914,453 (GRCm39)	Y566C	probably damaging	Het
Map4k4	A	G	1: 40,046,656 (GRCm39)	D775G	probably damaging	Het
Mtmr10	A	T	7: 63,947,245 (GRCm39)	K53N	probably damaging	Het
Mybpc2	G	A	7: 44,155,662 (GRCm39)	R864W	probably damaging	Het
Nckap1l	C	A	15: 103,391,995 (GRCm39)	P810Q	probably damaging	Het
Nsf	C	T	11: 103,821,578 (GRCm39)	E26K	possibly damaging	Het
Or14c44	T	C	7: 86,062,290 (GRCm39)	V281A	possibly damaging	Het
Or1ad1	A	G	11: 50,875,758 (GRCm39)	T77A	probably damaging	Het
Or4a27	C	T	2: 88,559,741 (GRCm39)	M67I	probably benign	Het
Ppp2r3c	T	C	12: 55,345,269 (GRCm39)	K73R	probably benign	Het
Ptpru	A	T	4: 131,498,780 (GRCm39)	F1311Y	probably damaging	Het
Ror2	G	A	13: 53,284,980 (GRCm39)	P144L	possibly damaging	Het
Setd2	A	G	9: 110,379,497 (GRCm39)	E1104G	possibly damaging	Het
St14	G	A	9: 31,019,530 (GRCm39)	T97I	probably benign	Het
Stag3	A	G	5: 138,281,290 (GRCm39)		probably benign	Het
Sytl3	T	C	17: 7,003,892 (GRCm39)	S326P	probably damaging	Het
Tor1b	G	T	2: 30,845,824 (GRCm39)	S167I	probably damaging	Het
Ttn	T	A	2: 76,568,359 (GRCm39)	E27511D	probably damaging	Het
Uso1	T	A	5: 92,306,258 (GRCm39)		probably benign	Het
Vmn1r10	G	T	6: 57,091,124 (GRCm39)	V239F	probably benign	Het
Vps35l	G	C	7: 118,391,818 (GRCm39)	A410P	probably damaging	Het
Zfp160	C	T	17: 21,246,007 (GRCm39)	R186C	possibly damaging	Het
Zfp869	A	G	8: 70,159,179 (GRCm39)	C465R	probably damaging	Het
Zfp957	T	C	14: 79,451,782 (GRCm39)	K6E	unknown	Het

Other mutations in Ifitm1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Ifitm1	APN	7	140,549,537 (GRCm39)	makesense	probably null
IGL00931:Ifitm1	APN	7	140,548,169 (GRCm39)	start codon destroyed	probably damaging	1.00
IGL02048:Ifitm1	APN	7	140,548,205 (GRCm39)	missense	probably benign
IGL02822:Ifitm1	APN	7	140,548,191 (GRCm39)	missense	possibly damaging	0.80
R0332:Ifitm1	UTSW	7	140,548,366 (GRCm39)	splice site	probably benign
R0445:Ifitm1	UTSW	7	140,548,354 (GRCm39)	splice site	probably null
R0595:Ifitm1	UTSW	7	140,548,242 (GRCm39)	missense	possibly damaging	0.88
R0655:Ifitm1	UTSW	7	140,549,449 (GRCm39)	missense	probably benign	0.01
R1344:Ifitm1	UTSW	7	140,548,263 (GRCm39)	missense	probably benign	0.02
R2092:Ifitm1	UTSW	7	140,549,427 (GRCm39)	missense	probably damaging	1.00
R6481:Ifitm1	UTSW	7	140,549,519 (GRCm39)	missense	probably benign	0.00
R7805:Ifitm1	UTSW	7	140,548,282 (GRCm39)	nonsense	probably null
R8888:Ifitm1	UTSW	7	140,549,499 (GRCm39)	missense	probably damaging	0.98
R8895:Ifitm1	UTSW	7	140,549,499 (GRCm39)	missense	probably damaging	0.98
R9604:Ifitm1	UTSW	7	140,548,227 (GRCm39)	missense	probably benign	0.00
Z1176:Ifitm1	UTSW	7	140,549,430 (GRCm39)	missense	probably benign	0.01

Predicted Primers

Posted On

2015-02-05