Incidental Mutation 'IGL00913:Ogfrl1'
| ID |
26627 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ogfrl1
|
| Ensembl Gene |
ENSMUSG00000026158 |
| Gene Name |
opioid growth factor receptor-like 1 |
| Synonyms |
2210417C17Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
IGL00913
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
23405505-23422282 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23409171 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 352
(I352V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000027343
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027343]
[ENSMUST00000188677]
|
| AlphaFold |
Q8VE52 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027343
AA Change: I352V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000027343
Gene: ENSMUSG00000026158
AA Change: I352V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
44 |
N/A |
INTRINSIC |
|
low complexity region
|
72 |
86 |
N/A |
INTRINSIC |
|
Pfam:OGFr_N
|
114 |
320 |
1.7e-104 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186064
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188677
|
| SMART Domains |
Protein: ENSMUSP00000139453
Gene: ENSMUSG00000026158
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:OGFr_N
|
1 |
92 |
1.6e-38 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrf4 |
A |
G |
17: 42,977,793 (GRCm39) |
S517P |
possibly damaging |
Het |
| Arl4c |
T |
C |
1: 88,629,106 (GRCm39) |
D94G |
probably damaging |
Het |
| Bag5 |
T |
C |
12: 111,677,766 (GRCm39) |
E19G |
probably damaging |
Het |
| Carf |
T |
A |
1: 60,187,114 (GRCm39) |
D537E |
probably benign |
Het |
| Cd177 |
C |
A |
7: 24,455,620 (GRCm39) |
D301Y |
probably damaging |
Het |
| Csmd1 |
C |
T |
8: 16,121,301 (GRCm39) |
V1799I |
probably benign |
Het |
| Cyp4x1 |
T |
A |
4: 114,970,060 (GRCm39) |
I356F |
probably benign |
Het |
| F5 |
A |
T |
1: 164,032,465 (GRCm39) |
H1804L |
probably damaging |
Het |
| Fras1 |
G |
T |
5: 96,842,935 (GRCm39) |
G1718C |
probably damaging |
Het |
| Ganc |
T |
C |
2: 120,269,933 (GRCm39) |
|
probably benign |
Het |
| Hs3st5 |
A |
G |
10: 36,708,846 (GRCm39) |
D127G |
probably damaging |
Het |
| Inpp5a |
A |
G |
7: 139,096,637 (GRCm39) |
D154G |
probably benign |
Het |
| Kif16b |
T |
A |
2: 142,545,927 (GRCm39) |
R1134* |
probably null |
Het |
| Lrrc66 |
C |
T |
5: 73,765,499 (GRCm39) |
A515T |
possibly damaging |
Het |
| Map3k10 |
C |
T |
7: 27,362,640 (GRCm39) |
|
probably benign |
Het |
| Mideas |
T |
A |
12: 84,219,632 (GRCm39) |
I441L |
probably benign |
Het |
| Mrpl12 |
G |
A |
11: 120,376,202 (GRCm39) |
D71N |
possibly damaging |
Het |
| Nfix |
A |
T |
8: 85,453,106 (GRCm39) |
V316E |
probably damaging |
Het |
| Nop2 |
A |
G |
6: 125,116,784 (GRCm39) |
Y346C |
probably damaging |
Het |
| Nrbp1 |
A |
G |
5: 31,408,403 (GRCm39) |
E513G |
possibly damaging |
Het |
| Or7a35 |
A |
G |
10: 78,854,085 (GRCm39) |
T310A |
probably benign |
Het |
| Or8b48 |
T |
A |
9: 38,492,672 (GRCm39) |
V33E |
probably damaging |
Het |
| Oxr1 |
G |
A |
15: 41,683,539 (GRCm39) |
V15I |
possibly damaging |
Het |
| Pik3r6 |
T |
G |
11: 68,442,147 (GRCm39) |
F697C |
probably damaging |
Het |
| Ptk2 |
A |
G |
15: 73,167,238 (GRCm39) |
|
probably benign |
Het |
| Rnft2 |
G |
A |
5: 118,339,280 (GRCm39) |
T380M |
probably damaging |
Het |
| Scel |
A |
G |
14: 103,819,245 (GRCm39) |
N346S |
probably benign |
Het |
| Sema4a |
T |
A |
3: 88,357,117 (GRCm39) |
T153S |
probably damaging |
Het |
| Serinc2 |
A |
T |
4: 130,158,201 (GRCm39) |
L82Q |
possibly damaging |
Het |
| Sin3a |
A |
G |
9: 57,005,402 (GRCm39) |
T392A |
probably benign |
Het |
| Slc25a38 |
T |
A |
9: 119,949,373 (GRCm39) |
Y108* |
probably null |
Het |
| Tmc8 |
G |
A |
11: 117,677,330 (GRCm39) |
G317R |
probably damaging |
Het |
| Trpc3 |
A |
G |
3: 36,694,788 (GRCm39) |
V722A |
possibly damaging |
Het |
| Unc93a2 |
A |
T |
17: 7,637,138 (GRCm39) |
V130D |
probably damaging |
Het |
|
| Other mutations in Ogfrl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02200:Ogfrl1
|
APN |
1 |
23,409,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4508001:Ogfrl1
|
UTSW |
1 |
23,409,351 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ogfrl1
|
UTSW |
1 |
23,409,206 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0735:Ogfrl1
|
UTSW |
1 |
23,414,835 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R1474:Ogfrl1
|
UTSW |
1 |
23,414,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3837:Ogfrl1
|
UTSW |
1 |
23,409,041 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4037:Ogfrl1
|
UTSW |
1 |
23,418,045 (GRCm39) |
splice site |
probably benign |
|
|
R4039:Ogfrl1
|
UTSW |
1 |
23,418,045 (GRCm39) |
splice site |
probably benign |
|
|
R4332:Ogfrl1
|
UTSW |
1 |
23,414,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4780:Ogfrl1
|
UTSW |
1 |
23,409,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5056:Ogfrl1
|
UTSW |
1 |
23,418,130 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Ogfrl1
|
UTSW |
1 |
23,418,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6167:Ogfrl1
|
UTSW |
1 |
23,415,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6341:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6342:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6343:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6363:Ogfrl1
|
UTSW |
1 |
23,409,194 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6584:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6586:Ogfrl1
|
UTSW |
1 |
23,408,944 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7419:Ogfrl1
|
UTSW |
1 |
23,422,063 (GRCm39) |
nonsense |
probably null |
|
|
R8364:Ogfrl1
|
UTSW |
1 |
23,414,824 (GRCm39) |
nonsense |
probably null |
|
|
R8749:Ogfrl1
|
UTSW |
1 |
23,409,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9539:Ogfrl1
|
UTSW |
1 |
23,415,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-04-17 |
Incidental Mutation