Incidental Mutation 'R2869:Nwd2'
ID 266432
Institutional Source Beutler Lab
Gene Symbol Nwd2
Ensembl Gene ENSMUSG00000090061
Gene Name NACHT and WD repeat domain containing 2
Synonyms 3110047P20Rik, B830017A01Rik
MMRRC Submission 040457-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R2869 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 63806446-63967889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63957671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 334 (I334L)
Ref Sequence ENSEMBL: ENSMUSP00000124712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159584] [ENSMUST00000162166]
AlphaFold Q6P5U7
Predicted Effect probably benign
Transcript: ENSMUST00000159584
AA Change: I334L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000124712
Gene: ENSMUSG00000090061
AA Change: I334L

DomainStartEndE-ValueType
Pfam:DUF4062 42 145 1.5e-8 PFAM
Blast:AAA 408 691 3e-29 BLAST
WD40 939 995 1.06e2 SMART
WD40 998 1037 8.96e-2 SMART
Blast:WD40 1091 1126 9e-19 BLAST
Blast:WD40 1129 1170 1e-17 BLAST
Blast:WD40 1220 1260 3e-16 BLAST
WD40 1263 1302 3.4e-2 SMART
WD40 1347 1385 2.65e1 SMART
WD40 1386 1425 1.58e2 SMART
Blast:WD40 1466 1507 3e-19 BLAST
Blast:WD40 1606 1644 4e-18 BLAST
Blast:KR 1686 1730 2e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000162166
Predicted Effect probably benign
Transcript: ENSMUST00000162757
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Als2 A G 1: 59,250,296 (GRCm39) S483P probably damaging Het
C030034I22Rik T A 17: 69,725,106 (GRCm39) noncoding transcript Het
Carmil1 G A 13: 24,229,051 (GRCm39) silent Het
Ccl27a C T 4: 41,769,640 (GRCm39) R73Q probably benign Het
Cd6 A G 19: 10,771,990 (GRCm39) I307T possibly damaging Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Eif4enif1 C T 11: 3,192,586 (GRCm39) P805S probably damaging Het
Fan1 A G 7: 64,012,938 (GRCm39) I668T probably benign Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Homo
Gbp11 C T 5: 105,478,866 (GRCm39) D191N probably benign Het
Ggt6 A T 11: 72,328,187 (GRCm39) N229I probably benign Het
Gm26902 T A 19: 34,452,210 (GRCm39) H106L probably benign Het
Gm37340 G A 2: 6,955,739 (GRCm39) probably benign Het
Gm9874 A T 17: 30,704,763 (GRCm39) probably benign Het
Gria2 G A 3: 80,609,799 (GRCm39) T670I probably damaging Het
Gsdme A T 6: 50,185,157 (GRCm39) C432* probably null Het
Habp2 T A 19: 56,276,423 (GRCm39) probably benign Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Kcnb1 A G 2: 166,947,855 (GRCm39) L331P probably damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Homo
Krt13 A G 11: 100,008,475 (GRCm39) S421P unknown Het
Lactbl1 G A 4: 136,354,097 (GRCm39) C37Y probably damaging Het
Lzts2 C A 19: 45,012,534 (GRCm39) S321* probably null Het
Marchf8 C T 6: 116,378,106 (GRCm39) probably benign Het
Meikin T C 11: 54,264,333 (GRCm39) V103A possibly damaging Het
Mki67 G A 7: 135,309,878 (GRCm39) P191L probably benign Het
Mlxip A G 5: 123,590,730 (GRCm39) M878V probably benign Het
Mpp7 G A 18: 7,461,678 (GRCm39) P65L possibly damaging Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nav1 A G 1: 135,388,495 (GRCm39) silent Het
Nbn T A 4: 15,963,810 (GRCm39) D70E probably damaging Het
Nell1 A T 7: 49,899,405 (GRCm39) probably benign Het
Nomo1 C A 7: 45,696,361 (GRCm39) T293N probably damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or4k2 T C 14: 50,423,811 (GRCm39) T288A probably benign Het
Or6c211 A T 10: 129,505,628 (GRCm39) C253* probably null Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Otud4 T A 8: 80,387,702 (GRCm39) N300K possibly damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pes1 C A 11: 3,926,834 (GRCm39) T372K probably benign Het
Plcl1 A T 1: 55,736,309 (GRCm39) D550V probably benign Het
Ppp1r7 T A 1: 93,285,585 (GRCm39) probably null Het
Prdx4 A G X: 154,123,460 (GRCm39) V15A probably benign Homo
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Psmd13 A T 7: 140,466,968 (GRCm39) T116S probably damaging Het
Pzp A T 6: 128,462,519 (GRCm39) probably null Het
Serinc2 A G 4: 130,159,005 (GRCm39) S29P probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Stx3 A T 19: 11,766,938 (GRCm39) V91D probably damaging Het
Taf6l A G 19: 8,755,992 (GRCm39) probably benign Het
Tafa2 A T 10: 123,540,270 (GRCm39) H42L possibly damaging Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Tprg1 T C 16: 25,231,590 (GRCm39) W189R probably damaging Het
Trim32 A G 4: 65,532,694 (GRCm39) D417G probably damaging Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Ybx3 G A 6: 131,347,376 (GRCm39) A253V probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Zzz3 T A 3: 152,152,481 (GRCm39) silent Het
Other mutations in Nwd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Nwd2 APN 5 63,962,818 (GRCm39) missense probably benign
IGL01111:Nwd2 APN 5 63,964,643 (GRCm39) missense probably damaging 1.00
IGL01152:Nwd2 APN 5 63,963,872 (GRCm39) missense possibly damaging 0.74
IGL01307:Nwd2 APN 5 63,965,626 (GRCm39) missense possibly damaging 0.95
IGL01449:Nwd2 APN 5 63,962,937 (GRCm39) missense probably damaging 1.00
IGL01624:Nwd2 APN 5 63,964,153 (GRCm39) missense probably damaging 1.00
IGL01997:Nwd2 APN 5 63,961,938 (GRCm39) missense probably damaging 0.99
IGL02007:Nwd2 APN 5 63,962,042 (GRCm39) missense possibly damaging 0.87
IGL02143:Nwd2 APN 5 63,948,996 (GRCm39) splice site probably null
IGL02184:Nwd2 APN 5 63,963,020 (GRCm39) missense probably damaging 1.00
IGL02379:Nwd2 APN 5 63,962,644 (GRCm39) missense probably damaging 1.00
IGL02489:Nwd2 APN 5 63,962,570 (GRCm39) missense probably damaging 1.00
IGL02580:Nwd2 APN 5 63,965,512 (GRCm39) missense probably damaging 0.99
IGL02682:Nwd2 APN 5 63,962,021 (GRCm39) missense probably damaging 1.00
IGL02682:Nwd2 APN 5 63,962,020 (GRCm39) missense probably benign 0.03
IGL02891:Nwd2 APN 5 63,882,570 (GRCm39) missense possibly damaging 0.91
IGL03135:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
IGL03149:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
R0113:Nwd2 UTSW 5 63,965,241 (GRCm39) missense probably damaging 1.00
R0172:Nwd2 UTSW 5 63,963,712 (GRCm39) missense probably benign 0.44
R0196:Nwd2 UTSW 5 63,963,694 (GRCm39) missense probably benign 0.37
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0309:Nwd2 UTSW 5 63,964,561 (GRCm39) missense probably damaging 1.00
R0311:Nwd2 UTSW 5 63,962,341 (GRCm39) missense probably damaging 0.99
R0335:Nwd2 UTSW 5 63,962,116 (GRCm39) missense probably benign 0.00
R0384:Nwd2 UTSW 5 63,963,025 (GRCm39) missense probably benign 0.11
R0496:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0497:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0498:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0505:Nwd2 UTSW 5 63,962,454 (GRCm39) missense probably damaging 1.00
R0655:Nwd2 UTSW 5 63,948,928 (GRCm39) missense possibly damaging 0.73
R0762:Nwd2 UTSW 5 63,957,757 (GRCm39) missense probably benign 0.33
R0835:Nwd2 UTSW 5 63,957,473 (GRCm39) missense probably damaging 0.99
R0926:Nwd2 UTSW 5 63,965,234 (GRCm39) missense probably damaging 0.99
R0948:Nwd2 UTSW 5 63,964,655 (GRCm39) missense probably damaging 1.00
R1015:Nwd2 UTSW 5 63,964,154 (GRCm39) missense probably damaging 1.00
R1086:Nwd2 UTSW 5 63,963,917 (GRCm39) missense probably damaging 1.00
R1186:Nwd2 UTSW 5 63,807,367 (GRCm39) utr 5 prime probably benign
R1305:Nwd2 UTSW 5 63,902,540 (GRCm39) missense probably damaging 0.97
R1542:Nwd2 UTSW 5 63,964,318 (GRCm39) missense probably damaging 1.00
R1548:Nwd2 UTSW 5 63,957,525 (GRCm39) missense probably benign 0.00
R1553:Nwd2 UTSW 5 63,957,848 (GRCm39) missense probably benign 0.00
R1636:Nwd2 UTSW 5 63,964,900 (GRCm39) missense probably damaging 1.00
R1658:Nwd2 UTSW 5 63,964,589 (GRCm39) missense probably damaging 1.00
R1763:Nwd2 UTSW 5 63,965,614 (GRCm39) missense probably benign
R1800:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R1813:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1861:Nwd2 UTSW 5 63,962,197 (GRCm39) missense probably damaging 0.96
R1889:Nwd2 UTSW 5 63,965,009 (GRCm39) missense possibly damaging 0.49
R1896:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1919:Nwd2 UTSW 5 63,963,523 (GRCm39) missense probably damaging 1.00
R1922:Nwd2 UTSW 5 63,951,585 (GRCm39) missense probably benign
R2258:Nwd2 UTSW 5 63,962,499 (GRCm39) missense probably benign 0.00
R2292:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R2504:Nwd2 UTSW 5 63,961,717 (GRCm39) missense probably benign 0.02
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2958:Nwd2 UTSW 5 63,963,325 (GRCm39) missense probably benign 0.01
R3034:Nwd2 UTSW 5 63,957,446 (GRCm39) missense probably damaging 1.00
R3422:Nwd2 UTSW 5 63,882,536 (GRCm39) missense possibly damaging 0.46
R3423:Nwd2 UTSW 5 63,957,504 (GRCm39) missense probably damaging 1.00
R3439:Nwd2 UTSW 5 63,961,895 (GRCm39) missense probably benign 0.00
R4193:Nwd2 UTSW 5 63,964,808 (GRCm39) missense probably damaging 1.00
R4254:Nwd2 UTSW 5 63,963,889 (GRCm39) missense possibly damaging 0.74
R4384:Nwd2 UTSW 5 63,963,914 (GRCm39) missense probably damaging 1.00
R4707:Nwd2 UTSW 5 63,951,665 (GRCm39) missense probably damaging 1.00
R4713:Nwd2 UTSW 5 63,961,803 (GRCm39) missense probably benign 0.00
R4735:Nwd2 UTSW 5 63,965,594 (GRCm39) missense probably benign 0.34
R4744:Nwd2 UTSW 5 63,964,310 (GRCm39) missense probably damaging 1.00
R4795:Nwd2 UTSW 5 63,962,776 (GRCm39) missense probably benign 0.21
R4835:Nwd2 UTSW 5 63,965,189 (GRCm39) missense probably benign 0.00
R4839:Nwd2 UTSW 5 63,962,893 (GRCm39) missense possibly damaging 0.92
R4896:Nwd2 UTSW 5 63,962,151 (GRCm39) missense probably damaging 1.00
R5017:Nwd2 UTSW 5 63,807,484 (GRCm39) utr 5 prime probably benign
R5170:Nwd2 UTSW 5 63,963,380 (GRCm39) missense probably damaging 0.99
R5312:Nwd2 UTSW 5 63,963,415 (GRCm39) nonsense probably null
R5330:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5331:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5419:Nwd2 UTSW 5 63,965,051 (GRCm39) missense probably benign 0.11
R5434:Nwd2 UTSW 5 63,964,991 (GRCm39) missense probably benign 0.00
R5445:Nwd2 UTSW 5 63,962,681 (GRCm39) missense probably damaging 1.00
R5761:Nwd2 UTSW 5 63,882,573 (GRCm39) missense probably damaging 1.00
R5788:Nwd2 UTSW 5 63,965,114 (GRCm39) missense probably benign 0.00
R5907:Nwd2 UTSW 5 63,963,326 (GRCm39) missense probably damaging 0.99
R5959:Nwd2 UTSW 5 63,965,413 (GRCm39) missense probably benign 0.32
R6002:Nwd2 UTSW 5 63,962,143 (GRCm39) missense probably benign
R6027:Nwd2 UTSW 5 63,965,563 (GRCm39) missense possibly damaging 0.65
R6082:Nwd2 UTSW 5 63,962,374 (GRCm39) missense possibly damaging 0.96
R6163:Nwd2 UTSW 5 63,963,131 (GRCm39) missense probably benign 0.00
R6172:Nwd2 UTSW 5 63,964,249 (GRCm39) missense probably damaging 0.98
R6334:Nwd2 UTSW 5 63,957,596 (GRCm39) missense possibly damaging 0.95
R6447:Nwd2 UTSW 5 63,964,898 (GRCm39) missense probably benign 0.41
R6649:Nwd2 UTSW 5 63,882,527 (GRCm39) missense possibly damaging 0.89
R6855:Nwd2 UTSW 5 63,961,794 (GRCm39) missense probably benign 0.00
R7034:Nwd2 UTSW 5 63,962,258 (GRCm39) missense probably damaging 1.00
R7168:Nwd2 UTSW 5 63,964,837 (GRCm39) missense probably benign 0.04
R7326:Nwd2 UTSW 5 63,957,752 (GRCm39) missense probably damaging 1.00
R7561:Nwd2 UTSW 5 63,964,434 (GRCm39) nonsense probably null
R7576:Nwd2 UTSW 5 63,964,736 (GRCm39) missense probably benign 0.00
R7580:Nwd2 UTSW 5 63,965,624 (GRCm39) missense probably benign 0.05
R7723:Nwd2 UTSW 5 63,965,347 (GRCm39) missense possibly damaging 0.69
R7769:Nwd2 UTSW 5 63,961,847 (GRCm39) missense probably damaging 0.99
R8293:Nwd2 UTSW 5 63,962,663 (GRCm39) missense probably benign 0.05
R8517:Nwd2 UTSW 5 63,948,925 (GRCm39) missense probably damaging 1.00
R8782:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
R8792:Nwd2 UTSW 5 63,963,047 (GRCm39) missense probably damaging 0.97
R8888:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8895:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8901:Nwd2 UTSW 5 63,963,685 (GRCm39) missense probably damaging 1.00
R8913:Nwd2 UTSW 5 63,963,440 (GRCm39) missense possibly damaging 0.80
R8920:Nwd2 UTSW 5 63,948,863 (GRCm39) missense probably damaging 1.00
R9052:Nwd2 UTSW 5 63,961,773 (GRCm39) missense probably damaging 1.00
R9362:Nwd2 UTSW 5 63,961,747 (GRCm39) missense probably benign 0.23
R9368:Nwd2 UTSW 5 63,962,306 (GRCm39) missense probably damaging 0.99
R9377:Nwd2 UTSW 5 63,957,740 (GRCm39) missense probably damaging 1.00
R9430:Nwd2 UTSW 5 63,964,665 (GRCm39) missense probably damaging 1.00
R9655:Nwd2 UTSW 5 63,964,568 (GRCm39) nonsense probably null
R9661:Nwd2 UTSW 5 63,957,780 (GRCm39) missense probably damaging 0.97
R9736:Nwd2 UTSW 5 63,951,600 (GRCm39) missense probably damaging 1.00
R9793:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
R9795:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
RF020:Nwd2 UTSW 5 63,963,066 (GRCm39) nonsense probably null
X0023:Nwd2 UTSW 5 63,964,306 (GRCm39) missense probably damaging 0.99
Z1176:Nwd2 UTSW 5 63,963,500 (GRCm39) missense probably damaging 1.00
Z1176:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
Z1177:Nwd2 UTSW 5 63,964,669 (GRCm39) nonsense probably null
Z1177:Nwd2 UTSW 5 63,962,327 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- TCGTGAAAATCCCAGAGATGG -3'
(R):5'- AACGAGAGGGTTGATATGCCC -3'

Sequencing Primer
(F):5'- TGGGGAAATACATGGACATAACC -3'
(R):5'- GCTTGGAAGGATGTATTTATGCAAG -3'
Posted On 2015-02-18