Incidental Mutation 'R3419:Paqr3'
ID 266952
Institutional Source Beutler Lab
Gene Symbol Paqr3
Ensembl Gene ENSMUSG00000055725
Gene Name progestin and adipoQ receptor family member III
Synonyms 6330415A20Rik, RKTG
MMRRC Submission 040637-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R3419 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 97230188-97259455 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 97247559 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 183 (L183P)
Ref Sequence ENSEMBL: ENSMUSP00000108593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069453] [ENSMUST00000112968] [ENSMUST00000112969] [ENSMUST00000196078]
AlphaFold Q6TCG8
Predicted Effect probably damaging
Transcript: ENSMUST00000069453
AA Change: L183P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000069324
Gene: ENSMUSG00000055725
AA Change: L183P

DomainStartEndE-ValueType
Pfam:HlyIII 64 289 3.4e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112968
SMART Domains Protein: ENSMUSP00000108592
Gene: ENSMUSG00000055725

DomainStartEndE-ValueType
Pfam:HlyIII 64 171 1.5e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000112969
AA Change: L183P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000108593
Gene: ENSMUSG00000055725
AA Change: L183P

DomainStartEndE-ValueType
Pfam:HlyIII 64 289 1.4e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126585
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132127
Predicted Effect probably benign
Transcript: ENSMUST00000196078
SMART Domains Protein: ENSMUSP00000142871
Gene: ENSMUSG00000055725

DomainStartEndE-ValueType
Pfam:HlyIII 64 179 7e-24 PFAM
transmembrane domain 181 203 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5530400C23Rik A G 6: 133,271,082 (GRCm39) Q42R probably benign Het
Ankrd26 A G 6: 118,512,068 (GRCm39) L518P probably damaging Het
Armc9 T C 1: 86,122,060 (GRCm39) L395P probably damaging Het
Baz1a T C 12: 54,993,684 (GRCm39) K181E probably benign Het
Bend3 T C 10: 43,385,978 (GRCm39) S124P probably damaging Het
Cdh5 C T 8: 104,856,002 (GRCm39) R312C probably damaging Het
Col6a3 T C 1: 90,731,813 (GRCm39) D873G probably benign Het
Dmbx1 G C 4: 115,777,873 (GRCm39) R64G probably benign Het
Dpy19l2 T C 9: 24,492,501 (GRCm39) E699G probably damaging Het
Dync2i1 C T 12: 116,188,597 (GRCm39) V666I probably benign Het
Eef2k T A 7: 120,485,093 (GRCm39) M320K probably damaging Het
Exoc5 A T 14: 49,260,735 (GRCm39) N377K probably damaging Het
Fam20c A T 5: 138,743,623 (GRCm39) N220Y probably damaging Het
Fchsd2 T A 7: 100,927,867 (GRCm39) probably null Het
Flrt2 A G 12: 95,747,378 (GRCm39) Y572C probably damaging Het
Gm17093 A G 14: 44,759,047 (GRCm39) I190V unknown Het
Gsto1 T C 19: 47,846,344 (GRCm39) F64L probably benign Het
Gucy1a1 A G 3: 82,013,440 (GRCm39) S401P probably damaging Het
Hoxd10 A G 2: 74,522,921 (GRCm39) K200E probably benign Het
Kcnj13 T C 1: 87,314,641 (GRCm39) T194A probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lacc1 T G 14: 77,272,321 (GRCm39) E158D probably benign Het
Lyn A T 4: 3,746,833 (GRCm39) I204F probably damaging Het
Mapk6 T C 9: 75,305,039 (GRCm39) E126G probably damaging Het
Mbd6 C G 10: 127,122,372 (GRCm39) R152P probably null Het
Or2h1b A T 17: 37,462,242 (GRCm39) V53E probably damaging Het
Or52e15 A G 7: 104,645,727 (GRCm39) I128T probably damaging Het
Or8g17 C T 9: 38,930,372 (GRCm39) C155Y probably benign Het
P2ry1 T C 3: 60,911,133 (GRCm39) F91L probably damaging Het
Pcdh15 C A 10: 74,420,054 (GRCm39) D1166E probably benign Het
Pik3r1 T C 13: 101,828,723 (GRCm39) D25G probably benign Het
Poc5 A T 13: 96,540,925 (GRCm39) T365S possibly damaging Het
Polr3a A G 14: 24,517,103 (GRCm39) L716P probably damaging Het
Ppp1r3a A T 6: 14,719,413 (GRCm39) D500E probably benign Het
Ptcd3 A T 6: 71,860,470 (GRCm39) I579K possibly damaging Het
Rnf168 A G 16: 32,118,010 (GRCm39) N524D probably benign Het
Scn7a AT ATT 2: 66,531,239 (GRCm39) probably null Het
Sel1l A G 12: 91,776,776 (GRCm39) W689R probably damaging Het
Serpinb13 T C 1: 106,926,657 (GRCm39) S218P probably damaging Het
Serpini1 A G 3: 75,547,589 (GRCm39) Y367C probably damaging Het
Snrnp48 G A 13: 38,405,335 (GRCm39) D248N possibly damaging Het
St6galnac4 A G 2: 32,485,743 (GRCm39) T217A probably damaging Het
Tdrd1 T A 19: 56,819,663 (GRCm39) N54K possibly damaging Het
Tmem30c A G 16: 57,098,031 (GRCm39) V130A probably benign Het
Trpa1 T C 1: 14,944,605 (GRCm39) I1046M probably benign Het
Tulp2 T A 7: 45,168,176 (GRCm39) M196K possibly damaging Het
Unc5b G A 10: 60,614,593 (GRCm39) R235W probably damaging Het
Vmn1r175 A T 7: 23,508,075 (GRCm39) M184K probably damaging Het
Vmn2r2 A T 3: 64,024,320 (GRCm39) F754I probably benign Het
Vmn2r9 A C 5: 108,994,299 (GRCm39) M450R probably damaging Het
Other mutations in Paqr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Paqr3 APN 5 97,243,796 (GRCm39) missense probably benign
IGL01966:Paqr3 APN 5 97,247,502 (GRCm39) missense probably benign 0.21
IGL02133:Paqr3 APN 5 97,243,790 (GRCm39) missense probably benign
PIT4618001:Paqr3 UTSW 5 97,251,330 (GRCm39) missense possibly damaging 0.82
R1601:Paqr3 UTSW 5 97,259,248 (GRCm39) missense probably benign 0.01
R2864:Paqr3 UTSW 5 97,247,595 (GRCm39) missense possibly damaging 0.65
R3799:Paqr3 UTSW 5 97,259,175 (GRCm39) missense probably damaging 1.00
R4352:Paqr3 UTSW 5 97,247,455 (GRCm39) missense probably benign 0.05
R4368:Paqr3 UTSW 5 97,256,150 (GRCm39) missense probably damaging 1.00
R4515:Paqr3 UTSW 5 97,251,220 (GRCm39) missense possibly damaging 0.72
R4583:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4647:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4648:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4811:Paqr3 UTSW 5 97,243,842 (GRCm39) missense probably benign 0.00
R4855:Paqr3 UTSW 5 97,256,053 (GRCm39) missense possibly damaging 0.83
R5910:Paqr3 UTSW 5 97,243,887 (GRCm39) splice site probably null
R6053:Paqr3 UTSW 5 97,259,137 (GRCm39) missense probably benign 0.12
R6156:Paqr3 UTSW 5 97,256,128 (GRCm39) missense probably damaging 1.00
R6957:Paqr3 UTSW 5 97,256,110 (GRCm39) missense possibly damaging 0.48
R6974:Paqr3 UTSW 5 97,256,146 (GRCm39) missense probably damaging 1.00
R9201:Paqr3 UTSW 5 97,245,365 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CCGATTACAGCGCTTTAACCAAG -3'
(R):5'- AGTTAACATTTGTGTGCGACG -3'

Sequencing Primer
(F):5'- TACAGCGCTTTAACCAAGGAATG -3'
(R):5'- TGCGACGCTCTTTAAAAGGG -3'
Posted On 2015-02-18