Incidental Mutation 'R3423:Or12d12'
ID 267140
Institutional Source Beutler Lab
Gene Symbol Or12d12
Ensembl Gene ENSMUSG00000092077
Gene Name olfactory receptor family 12 subfamily D member 12
Synonyms Olfr101, MOR250-2, GA_x6K02T2PSCP-1761617-1760691
MMRRC Submission 040641-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R3423 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37610337-37611375 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37610761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 184 (D184V)
Ref Sequence ENSEMBL: ENSMUSP00000149851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058046] [ENSMUST00000214376] [ENSMUST00000215392]
AlphaFold Q920Z0
Predicted Effect probably benign
Transcript: ENSMUST00000058046
AA Change: D184V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000061042
Gene: ENSMUSG00000092077
AA Change: D184V

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.3e-53 PFAM
Pfam:7tm_1 39 289 3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214376
AA Change: D184V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000215392
AA Change: D184V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap8 A G 17: 32,535,429 (GRCm39) F195S possibly damaging Het
Aldh3a1 G A 11: 61,106,362 (GRCm39) A246T probably damaging Het
Caskin1 T A 17: 24,718,539 (GRCm39) N331K probably damaging Het
Ceacam5 G A 7: 17,491,562 (GRCm39) S644N possibly damaging Het
Csmd3 A T 15: 47,710,648 (GRCm39) D1646E probably damaging Het
Cyp4a12a A C 4: 115,184,471 (GRCm39) K282T probably benign Het
Dtnb C T 12: 3,641,962 (GRCm39) R42* probably null Het
Dyrk3 A G 1: 131,057,219 (GRCm39) I318T probably damaging Het
Fhip2b G A 14: 70,824,025 (GRCm39) T535M probably damaging Het
Gm11110 T C 17: 57,410,435 (GRCm39) probably benign Het
Gm8674 T A 13: 50,055,792 (GRCm39) noncoding transcript Het
Igfn1 A G 1: 135,926,379 (GRCm39) S24P probably benign Het
Inpp4b A G 8: 82,678,890 (GRCm39) M307V possibly damaging Het
Ism2 T C 12: 87,333,871 (GRCm39) N58S probably benign Het
Kmt2a A C 9: 44,731,394 (GRCm39) probably benign Het
Limk1 A G 5: 134,701,523 (GRCm39) probably null Het
Lrrc14 T A 15: 76,597,318 (GRCm39) probably null Het
Mapt C T 11: 104,189,548 (GRCm39) R189* probably null Het
Meltf C T 16: 31,715,343 (GRCm39) R679* probably null Het
Muc6 G A 7: 141,218,313 (GRCm39) S2120F possibly damaging Het
Mug2 T C 6: 122,024,465 (GRCm39) probably benign Het
Myo15a G A 11: 60,401,126 (GRCm39) probably null Het
Nup98 T C 7: 101,834,084 (GRCm39) T293A probably benign Het
Nwd2 A T 5: 63,957,504 (GRCm39) Y278F probably damaging Het
Phactr4 A C 4: 132,097,058 (GRCm39) D496E probably benign Het
Pramel6 T A 2: 87,341,140 (GRCm39) probably null Het
Ptprq C T 10: 107,418,337 (GRCm39) A1680T probably damaging Het
Retnlb T A 16: 48,639,008 (GRCm39) C70S probably damaging Het
Ros1 C A 10: 52,004,512 (GRCm39) probably null Het
Sez6l T C 5: 112,574,615 (GRCm39) D875G probably damaging Het
Slc18b1 T G 10: 23,698,874 (GRCm39) M348R probably damaging Het
Slc36a3 G T 11: 55,033,607 (GRCm39) T137K probably benign Het
Sos2 T C 12: 69,650,327 (GRCm39) N865D probably damaging Het
Sp9 G A 2: 73,104,315 (GRCm39) A290T probably benign Het
Spg11 C T 2: 121,901,534 (GRCm39) V1469I probably benign Het
Unc13c G T 9: 73,837,935 (GRCm39) A972D possibly damaging Het
Vwa3a T C 7: 120,398,334 (GRCm39) L945P probably damaging Het
Other mutations in Or12d12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01583:Or12d12 APN 17 37,610,629 (GRCm39) missense probably benign 0.00
IGL01584:Or12d12 APN 17 37,610,629 (GRCm39) missense probably benign 0.00
IGL01609:Or12d12 APN 17 37,610,629 (GRCm39) missense probably benign 0.00
IGL01739:Or12d12 APN 17 37,610,673 (GRCm39) missense probably benign 0.00
IGL03203:Or12d12 APN 17 37,611,317 (GRCm39) splice site probably benign
R1122:Or12d12 UTSW 17 37,611,019 (GRCm39) missense probably damaging 1.00
R1132:Or12d12 UTSW 17 37,610,423 (GRCm39) missense probably benign 0.19
R1237:Or12d12 UTSW 17 37,611,156 (GRCm39) missense probably benign 0.19
R3872:Or12d12 UTSW 17 37,610,870 (GRCm39) missense probably benign 0.00
R3873:Or12d12 UTSW 17 37,610,870 (GRCm39) missense probably benign 0.00
R3874:Or12d12 UTSW 17 37,610,870 (GRCm39) missense probably benign 0.00
R4871:Or12d12 UTSW 17 37,611,095 (GRCm39) missense probably benign 0.03
R5213:Or12d12 UTSW 17 37,610,942 (GRCm39) missense probably damaging 0.98
R5974:Or12d12 UTSW 17 37,611,229 (GRCm39) missense possibly damaging 0.65
R6294:Or12d12 UTSW 17 37,610,444 (GRCm39) missense probably benign 0.02
R8784:Or12d12 UTSW 17 37,610,701 (GRCm39) missense probably benign 0.34
R9469:Or12d12 UTSW 17 37,610,956 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTAGACAGAGCTTTGTGG -3'
(R):5'- GTAGCACTGAGACCATGCTG -3'

Sequencing Primer
(F):5'- TTTGTGGAGCATGCTGCAAGAAC -3'
(R):5'- CAGTGATGGCATTTGACCGC -3'
Posted On 2015-02-18