Incidental Mutation 'R3436:Tmem132e'
ID 267198
Institutional Source Beutler Lab
Gene Symbol Tmem132e
Ensembl Gene ENSMUSG00000020701
Gene Name transmembrane protein 132E
Synonyms LOC270893
MMRRC Submission 040654-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.517) question?
Stock # R3436 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 82279726-82337158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 82335156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 654 (Y654C)
Ref Sequence ENSEMBL: ENSMUSP00000090528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054245] [ENSMUST00000092852]
AlphaFold Q6IEE6
Predicted Effect probably damaging
Transcript: ENSMUST00000054245
AA Change: Y746C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052484
Gene: ENSMUSG00000020701
AA Change: Y746C

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:TMEM132D_N 45 176 1.1e-52 PFAM
low complexity region 202 216 N/A INTRINSIC
low complexity region 241 262 N/A INTRINSIC
low complexity region 318 328 N/A INTRINSIC
Pfam:TMEM132 451 797 1.7e-136 PFAM
low complexity region 827 837 N/A INTRINSIC
low complexity region 841 854 N/A INTRINSIC
Pfam:TMEM132D_C 867 944 2e-34 PFAM
low complexity region 967 998 N/A INTRINSIC
low complexity region 1016 1027 N/A INTRINSIC
low complexity region 1036 1043 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000092852
AA Change: Y654C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000090528
Gene: ENSMUSG00000020701
AA Change: Y654C

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 226 236 N/A INTRINSIC
low complexity region 471 489 N/A INTRINSIC
low complexity region 735 745 N/A INTRINSIC
low complexity region 749 762 N/A INTRINSIC
transmembrane domain 798 820 N/A INTRINSIC
low complexity region 875 906 N/A INTRINSIC
low complexity region 924 935 N/A INTRINSIC
low complexity region 944 951 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202598
Meta Mutation Damage Score 0.6213 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambp T C 4: 63,067,721 (GRCm39) E163G probably benign Het
Angptl3 A T 4: 98,921,540 (GRCm39) K219N probably benign Het
Atp6v1g1 A G 4: 63,468,255 (GRCm39) N86S probably benign Het
Cadps A T 14: 12,616,158 (GRCm38) probably null Het
Ccdc146 A G 5: 21,502,003 (GRCm39) S804P possibly damaging Het
Cdc20b T C 13: 113,215,233 (GRCm39) I267T probably damaging Het
Cdh8 A G 8: 100,127,350 (GRCm39) probably benign Het
Dse G T 10: 34,028,470 (GRCm39) N873K probably benign Het
Ehd1 G T 19: 6,327,044 (GRCm39) E14* probably null Het
F8 A G X: 74,311,030 (GRCm39) probably benign Het
Flnb T C 14: 7,942,057 (GRCm38) V2345A probably damaging Het
Fndc1 T C 17: 7,969,189 (GRCm39) K1559E probably damaging Het
Ighg1 T C 12: 113,293,180 (GRCm39) E170G probably damaging Het
Kmt2b G T 7: 30,276,117 (GRCm39) P1794Q probably damaging Het
Lama2 C T 10: 26,877,231 (GRCm39) E2652K probably benign Het
Med25 C A 7: 44,535,314 (GRCm39) R37L possibly damaging Het
Optc T C 1: 133,825,617 (GRCm39) D303G probably damaging Het
Or2n1d A G 17: 38,646,323 (GRCm39) I92V probably damaging Het
Or2n1e G A 17: 38,586,421 (GRCm39) G253D probably damaging Het
Or4c102 T A 2: 88,422,448 (GRCm39) F100Y probably damaging Het
Pkd1l2 T C 8: 117,767,478 (GRCm39) N1271D probably benign Het
Plpp2 A T 10: 79,363,647 (GRCm39) probably null Het
Polq A T 16: 36,882,699 (GRCm39) N1342I probably damaging Het
Prr16 A G 18: 51,436,195 (GRCm39) N225D probably benign Het
Pwwp2a C T 11: 43,597,015 (GRCm39) Q452* probably null Het
Slfn2 A T 11: 82,960,390 (GRCm39) H123L probably benign Het
Sort1 T A 3: 108,245,123 (GRCm39) I325N probably damaging Het
Tmprss11b A T 5: 86,815,443 (GRCm39) Y48* probably null Het
Tpp2 T C 1: 43,979,304 (GRCm39) I67T probably damaging Het
Trdn G A 10: 33,344,191 (GRCm39) probably null Het
Trim14 C T 4: 46,523,739 (GRCm39) V100I possibly damaging Het
Trim17 T C 11: 58,856,059 (GRCm39) C39R probably damaging Het
Trim52 C T 14: 106,344,741 (GRCm39) P133L possibly damaging Het
Unc13b T C 4: 43,097,028 (GRCm39) probably benign Het
Vmn2r94 G A 17: 18,478,650 (GRCm39) probably benign Het
Vsig4 A G X: 95,334,422 (GRCm39) V29A probably benign Het
Washc4 T A 10: 83,405,866 (GRCm39) I454N probably benign Het
Wnk3 T A X: 150,069,300 (GRCm39) F886I probably benign Het
Ylpm1 T C 12: 85,096,644 (GRCm39) probably null Het
Zfp507 A T 7: 35,487,195 (GRCm39) Y234N probably damaging Het
Other mutations in Tmem132e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01576:Tmem132e APN 11 82,329,200 (GRCm39) missense probably damaging 1.00
IGL01586:Tmem132e APN 11 82,325,495 (GRCm39) missense probably damaging 1.00
IGL01729:Tmem132e APN 11 82,325,942 (GRCm39) missense possibly damaging 0.89
IGL02592:Tmem132e APN 11 82,325,462 (GRCm39) missense probably damaging 1.00
R0029:Tmem132e UTSW 11 82,335,587 (GRCm39) missense probably damaging 1.00
R0501:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.90
R0612:Tmem132e UTSW 11 82,334,198 (GRCm39) missense probably damaging 1.00
R0613:Tmem132e UTSW 11 82,329,164 (GRCm39) missense probably damaging 1.00
R1311:Tmem132e UTSW 11 82,335,122 (GRCm39) missense probably damaging 1.00
R1430:Tmem132e UTSW 11 82,329,122 (GRCm39) missense probably damaging 1.00
R1607:Tmem132e UTSW 11 82,328,196 (GRCm39) missense probably benign 0.39
R1710:Tmem132e UTSW 11 82,334,343 (GRCm39) missense probably damaging 1.00
R1913:Tmem132e UTSW 11 82,334,243 (GRCm39) missense probably damaging 1.00
R1951:Tmem132e UTSW 11 82,335,908 (GRCm39) missense possibly damaging 0.84
R2018:Tmem132e UTSW 11 82,335,989 (GRCm39) missense probably benign 0.26
R2051:Tmem132e UTSW 11 82,331,264 (GRCm39) missense probably damaging 1.00
R2076:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.90
R2100:Tmem132e UTSW 11 82,335,357 (GRCm39) missense probably damaging 1.00
R2325:Tmem132e UTSW 11 82,325,341 (GRCm39) missense probably damaging 1.00
R2924:Tmem132e UTSW 11 82,335,149 (GRCm39) missense probably damaging 1.00
R3437:Tmem132e UTSW 11 82,335,156 (GRCm39) missense probably damaging 1.00
R4594:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.83
R4704:Tmem132e UTSW 11 82,334,357 (GRCm39) missense probably damaging 0.97
R4754:Tmem132e UTSW 11 82,335,677 (GRCm39) nonsense probably null
R4764:Tmem132e UTSW 11 82,325,338 (GRCm39) missense probably damaging 0.99
R5245:Tmem132e UTSW 11 82,333,464 (GRCm39) missense probably damaging 0.96
R5720:Tmem132e UTSW 11 82,333,276 (GRCm39) splice site probably null
R5793:Tmem132e UTSW 11 82,335,684 (GRCm39) missense probably damaging 1.00
R5984:Tmem132e UTSW 11 82,335,923 (GRCm39) missense probably damaging 1.00
R6980:Tmem132e UTSW 11 82,329,212 (GRCm39) critical splice donor site probably null
R7052:Tmem132e UTSW 11 82,328,189 (GRCm39) missense probably damaging 0.99
R7637:Tmem132e UTSW 11 82,325,342 (GRCm39) missense probably damaging 1.00
R7918:Tmem132e UTSW 11 82,336,116 (GRCm39) missense probably damaging 1.00
R8262:Tmem132e UTSW 11 82,325,666 (GRCm39) missense probably benign 0.33
R8772:Tmem132e UTSW 11 82,325,137 (GRCm39) missense probably damaging 0.99
R9248:Tmem132e UTSW 11 82,335,308 (GRCm39) missense probably damaging 1.00
Z1177:Tmem132e UTSW 11 82,335,930 (GRCm39) missense probably damaging 0.97
Z1177:Tmem132e UTSW 11 82,326,004 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGAGTCTCAGCTAGCACCTAG -3'
(R):5'- GAGTAGTAGCCAGCACACTCTTG -3'

Sequencing Primer
(F):5'- GCACCTAGCATTTCCAGTGTAAGG -3'
(R):5'- GCACACTCTTGCGCTTGG -3'
Posted On 2015-02-18