Incidental Mutation 'R3436:Vsig4'
ID 267214
Institutional Source Beutler Lab
Gene Symbol Vsig4
Ensembl Gene ENSMUSG00000044206
Gene Name V-set and immunoglobulin domain containing 4
Synonyms CRIg, Z39IG
MMRRC Submission 040654-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3436 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 95290809-95337044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 95334422 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 29 (V29A)
Ref Sequence ENSEMBL: ENSMUSP00000051521 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050707]
AlphaFold F6TUL9
PDB Structure Structure or murine CRIg [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000050707
AA Change: V29A

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000051521
Gene: ENSMUSG00000044206
AA Change: V29A

DomainStartEndE-ValueType
IG 26 136 3.04e-3 SMART
transmembrane domain 188 210 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146830
Meta Mutation Damage Score 0.3496 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele fail to exhibit complement-dependent clearance of Staphylococcus aureus from the circulation and are more susceptible to Listeria monocytogenes infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambp T C 4: 63,067,721 (GRCm39) E163G probably benign Het
Angptl3 A T 4: 98,921,540 (GRCm39) K219N probably benign Het
Atp6v1g1 A G 4: 63,468,255 (GRCm39) N86S probably benign Het
Cadps A T 14: 12,616,158 (GRCm38) probably null Het
Ccdc146 A G 5: 21,502,003 (GRCm39) S804P possibly damaging Het
Cdc20b T C 13: 113,215,233 (GRCm39) I267T probably damaging Het
Cdh8 A G 8: 100,127,350 (GRCm39) probably benign Het
Dse G T 10: 34,028,470 (GRCm39) N873K probably benign Het
Ehd1 G T 19: 6,327,044 (GRCm39) E14* probably null Het
F8 A G X: 74,311,030 (GRCm39) probably benign Het
Flnb T C 14: 7,942,057 (GRCm38) V2345A probably damaging Het
Fndc1 T C 17: 7,969,189 (GRCm39) K1559E probably damaging Het
Ighg1 T C 12: 113,293,180 (GRCm39) E170G probably damaging Het
Kmt2b G T 7: 30,276,117 (GRCm39) P1794Q probably damaging Het
Lama2 C T 10: 26,877,231 (GRCm39) E2652K probably benign Het
Med25 C A 7: 44,535,314 (GRCm39) R37L possibly damaging Het
Optc T C 1: 133,825,617 (GRCm39) D303G probably damaging Het
Or2n1d A G 17: 38,646,323 (GRCm39) I92V probably damaging Het
Or2n1e G A 17: 38,586,421 (GRCm39) G253D probably damaging Het
Or4c102 T A 2: 88,422,448 (GRCm39) F100Y probably damaging Het
Pkd1l2 T C 8: 117,767,478 (GRCm39) N1271D probably benign Het
Plpp2 A T 10: 79,363,647 (GRCm39) probably null Het
Polq A T 16: 36,882,699 (GRCm39) N1342I probably damaging Het
Prr16 A G 18: 51,436,195 (GRCm39) N225D probably benign Het
Pwwp2a C T 11: 43,597,015 (GRCm39) Q452* probably null Het
Slfn2 A T 11: 82,960,390 (GRCm39) H123L probably benign Het
Sort1 T A 3: 108,245,123 (GRCm39) I325N probably damaging Het
Tmem132e A G 11: 82,335,156 (GRCm39) Y654C probably damaging Het
Tmprss11b A T 5: 86,815,443 (GRCm39) Y48* probably null Het
Tpp2 T C 1: 43,979,304 (GRCm39) I67T probably damaging Het
Trdn G A 10: 33,344,191 (GRCm39) probably null Het
Trim14 C T 4: 46,523,739 (GRCm39) V100I possibly damaging Het
Trim17 T C 11: 58,856,059 (GRCm39) C39R probably damaging Het
Trim52 C T 14: 106,344,741 (GRCm39) P133L possibly damaging Het
Unc13b T C 4: 43,097,028 (GRCm39) probably benign Het
Vmn2r94 G A 17: 18,478,650 (GRCm39) probably benign Het
Washc4 T A 10: 83,405,866 (GRCm39) I454N probably benign Het
Wnk3 T A X: 150,069,300 (GRCm39) F886I probably benign Het
Ylpm1 T C 12: 85,096,644 (GRCm39) probably null Het
Zfp507 A T 7: 35,487,195 (GRCm39) Y234N probably damaging Het
Other mutations in Vsig4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02632:Vsig4 APN X 95,291,378 (GRCm39) missense probably benign 0.18
R4254:Vsig4 UTSW X 95,334,107 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- CTCCTGGAACTTTGTGGCTC -3'
(R):5'- AAAGTCTTTGTCGTAGGGACTG -3'

Sequencing Primer
(F):5'- GAACTTTGTGGCTCACTTTCAGGC -3'
(R):5'- CGTAGGGACTGACTCACATTG -3'
Posted On 2015-02-18