Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00971:Zfp451'

26746

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp451

Ensembl Gene

ENSMUSG00000042197

Gene Name

zinc finger protein 451

Synonyms

4930515K21Rik, Kiaa0576-hp, 4933435G09Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00971

Quality Score

Status

Chromosome

Chromosomal Location

33800626-33853676 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 33822234 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 155 (S155P)

Ref Sequence

ENSEMBL: ENSMUSP00000019861 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019861] [ENSMUST00000115167] [ENSMUST00000139143] [ENSMUST00000151055] [ENSMUST00000194656]

AlphaFold

Q8C0P7

Predicted Effect

probably benign
Transcript: ENSMUST00000019861
AA Change: S155P

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000019861
Gene: ENSMUSG00000042197
AA Change: S155P

Domain	Start	End	E-Value	Type
coiled coil region	81	109	N/A	INTRINSIC
ZnF_C2H2	169	195	1.63e1	SMART
ZnF_C2H2	212	232	1.18e2	SMART
ZnF_C2H2	253	277	1.73e0	SMART
ZnF_C2H2	315	335	2.03e2	SMART
ZnF_C2H2	362	385	3.75e1	SMART
ZnF_C2H2	494	517	2.91e-2	SMART
ZnF_C2H2	527	550	5.4e1	SMART
low complexity region	558	577	N/A	INTRINSIC
ZnF_C2H2	604	629	1.55e1	SMART
ZnF_C2H2	634	657	2.29e0	SMART
ZnF_C2H2	665	687	1.64e-1	SMART
ZnF_C2H2	751	774	6.75e0	SMART
ZnF_C2H2	787	810	4.94e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000115167

SMART Domains

Protein: ENSMUSP00000110821
Gene: ENSMUSG00000042197

Domain	Start	End	E-Value	Type
coiled coil region	81	109	N/A	INTRINSIC
ZnF_C2H2	169	195	1.63e1	SMART
ZnF_C2H2	212	232	1.18e2	SMART
ZnF_C2H2	253	277	1.73e0	SMART
ZnF_C2H2	315	335	2.03e2	SMART
ZnF_C2H2	362	385	3.75e1	SMART
ZnF_C2H2	494	517	2.91e-2	SMART
ZnF_C2H2	527	550	5.4e1	SMART
low complexity region	558	577	N/A	INTRINSIC
ZnF_C2H2	604	629	1.55e1	SMART
ZnF_C2H2	634	657	2.29e0	SMART
ZnF_C2H2	665	687	1.64e-1	SMART
ZnF_C2H2	751	774	6.75e0	SMART
ZnF_C2H2	787	810	4.94e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130376

SMART Domains

Protein: ENSMUSP00000118047
Gene: ENSMUSG00000042197

Domain	Start	End	E-Value	Type
ZnF_C2H2	30	56	1.63e1	SMART

Predicted Effect

silent
Transcript: ENSMUST00000139143

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140163

Predicted Effect

probably benign
Transcript: ENSMUST00000151055

Predicted Effect

probably benign
Transcript: ENSMUST00000194656
AA Change: S113P

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000141813
Gene: ENSMUSG00000042197
AA Change: S113P

Domain	Start	End	E-Value	Type
ZnF_C2H2	127	153	6.9e-2	SMART
ZnF_C2H2	170	190	5e-1	SMART
ZnF_C2H2	211	235	7.2e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930596D02Rik	C	T	14: 35,532,170 (GRCm39)	C135Y	possibly damaging	Het
Afdn	T	A	17: 14,072,575 (GRCm39)		probably benign	Het
Akap10	A	G	11: 61,795,622 (GRCm39)	V347A	possibly damaging	Het
Ankrd11	A	G	8: 123,622,092 (GRCm39)	S587P	probably damaging	Het
Ces1g	T	C	8: 94,029,660 (GRCm39)	Y524C	probably damaging	Het
Cimip2b	A	G	4: 43,428,377 (GRCm39)	L51P	probably damaging	Het
Cubn	T	C	2: 13,283,219 (GRCm39)	N3573S	possibly damaging	Het
Cyp1a1	G	T	9: 57,607,990 (GRCm39)	C206F	probably damaging	Het
Fbxo30	T	C	10: 11,166,042 (GRCm39)	Y255H	probably benign	Het
Ggnbp2	T	C	11: 84,731,230 (GRCm39)	I295V	possibly damaging	Het
Gpatch8	A	G	11: 102,370,743 (GRCm39)	Y932H	unknown	Het
Gvin-ps3	G	A	7: 105,681,008 (GRCm39)		noncoding transcript	Het
Heatr6	C	T	11: 83,650,135 (GRCm39)	P197L	probably damaging	Het
Helb	T	C	10: 119,930,168 (GRCm39)	D737G	possibly damaging	Het
Helz	A	T	11: 107,554,479 (GRCm39)	I1226F	possibly damaging	Het
Ipo11	A	T	13: 106,993,277 (GRCm39)	I749N	probably damaging	Het
Ipo13	T	C	4: 117,771,564 (GRCm39)	E2G	possibly damaging	Het
Jam3	A	C	9: 27,013,188 (GRCm39)	D127E	probably damaging	Het
Kif16b	G	T	2: 142,553,664 (GRCm39)	Q1045K	probably benign	Het
Kin	T	C	2: 10,095,159 (GRCm39)	W121R	possibly damaging	Het
Man1b1	T	G	2: 25,233,337 (GRCm39)	S237A	possibly damaging	Het
Mmel1	C	T	4: 154,972,289 (GRCm39)		probably benign	Het
Morn4	T	C	19: 42,064,559 (GRCm39)	N143S	possibly damaging	Het
Nlrp4b	A	G	7: 10,448,882 (GRCm39)	T362A	possibly damaging	Het
Ntpcr	C	T	8: 126,474,501 (GRCm39)	T153M	probably damaging	Het
Or13p10	T	A	4: 118,523,475 (GRCm39)	F254I	probably damaging	Het
Pdzd2	A	G	15: 12,374,804 (GRCm39)	L1777P	probably benign	Het
Postn	A	G	3: 54,276,697 (GRCm39)	N192S	possibly damaging	Het
Prkar1a	A	T	11: 109,551,877 (GRCm39)	Y122F	probably benign	Het
Serpinb7	A	G	1: 107,355,976 (GRCm39)		probably benign	Het
Setd3	A	T	12: 108,126,496 (GRCm39)	I121N	probably damaging	Het
Slamf7	T	A	1: 171,466,810 (GRCm39)	I132L	probably benign	Het
Syt4	T	C	18: 31,580,227 (GRCm39)		probably benign	Het
Tesc	G	A	5: 118,194,504 (GRCm39)		probably null	Het
Tsc1	C	A	2: 28,560,952 (GRCm39)	S270*	probably null	Het
Wap	C	A	11: 6,586,808 (GRCm39)	C97F	probably damaging	Het
Zfp469	A	G	8: 122,996,472 (GRCm39)		probably benign	Het
Zfp51	C	T	17: 21,683,844 (GRCm39)	T153M	probably benign	Het
Zfp579	A	G	7: 4,996,390 (GRCm39)	I507T	probably damaging	Het

Other mutations in Zfp451

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00225:Zfp451	APN	1	33,825,621 (GRCm39)	intron	probably benign
IGL00423:Zfp451	APN	1	33,816,660 (GRCm39)	missense	probably benign	0.44
IGL00925:Zfp451	APN	1	33,815,342 (GRCm39)	unclassified	probably benign
IGL01521:Zfp451	APN	1	33,816,412 (GRCm39)	splice site	probably null
IGL01672:Zfp451	APN	1	33,801,247 (GRCm39)	missense	probably benign	0.33
IGL01826:Zfp451	APN	1	33,821,243 (GRCm39)	missense	probably damaging	1.00
IGL02298:Zfp451	APN	1	33,812,002 (GRCm39)	missense	probably damaging	0.98
IGL02343:Zfp451	APN	1	33,815,574 (GRCm39)	missense	probably damaging	1.00
IGL03150:Zfp451	APN	1	33,816,535 (GRCm39)	missense	probably damaging	1.00
IGL03257:Zfp451	APN	1	33,816,129 (GRCm39)	missense	possibly damaging	0.90
R0006:Zfp451	UTSW	1	33,841,861 (GRCm39)	intron	probably benign
R0068:Zfp451	UTSW	1	33,816,706 (GRCm39)	missense	probably damaging	1.00
R0068:Zfp451	UTSW	1	33,816,706 (GRCm39)	missense	probably damaging	1.00
R0358:Zfp451	UTSW	1	33,816,810 (GRCm39)	missense	probably damaging	1.00
R0441:Zfp451	UTSW	1	33,816,126 (GRCm39)	missense	probably damaging	0.96
R0483:Zfp451	UTSW	1	33,809,991 (GRCm39)	splice site	probably benign
R0745:Zfp451	UTSW	1	33,809,929 (GRCm39)	nonsense	probably null
R1469:Zfp451	UTSW	1	33,808,894 (GRCm39)	missense	possibly damaging	0.93
R1469:Zfp451	UTSW	1	33,808,894 (GRCm39)	missense	possibly damaging	0.93
R1486:Zfp451	UTSW	1	33,816,808 (GRCm39)	missense	probably damaging	0.99
R1774:Zfp451	UTSW	1	33,852,849 (GRCm39)	missense	probably benign	0.02
R1929:Zfp451	UTSW	1	33,822,937 (GRCm39)	missense	probably benign	0.12
R1929:Zfp451	UTSW	1	33,821,274 (GRCm39)	missense	probably damaging	1.00
R1933:Zfp451	UTSW	1	33,816,903 (GRCm39)	missense	probably damaging	1.00
R2108:Zfp451	UTSW	1	33,818,248 (GRCm39)	missense	possibly damaging	0.93
R2225:Zfp451	UTSW	1	33,809,988 (GRCm39)	splice site	probably benign
R2372:Zfp451	UTSW	1	33,819,133 (GRCm39)	splice site	probably null
R3923:Zfp451	UTSW	1	33,818,126 (GRCm39)	missense	probably null	1.00
R4295:Zfp451	UTSW	1	33,816,836 (GRCm39)	missense	probably damaging	0.99
R4409:Zfp451	UTSW	1	33,816,494 (GRCm39)	missense	probably damaging	1.00
R4617:Zfp451	UTSW	1	33,841,752 (GRCm39)	intron	probably benign
R4757:Zfp451	UTSW	1	33,804,939 (GRCm39)	missense	probably damaging	0.98
R4777:Zfp451	UTSW	1	33,821,186 (GRCm39)	missense	possibly damaging	0.80
R4906:Zfp451	UTSW	1	33,844,465 (GRCm39)	missense	probably damaging	1.00
R4964:Zfp451	UTSW	1	33,816,942 (GRCm39)	missense	probably damaging	1.00
R5128:Zfp451	UTSW	1	33,842,014 (GRCm39)	intron	probably benign
R5129:Zfp451	UTSW	1	33,842,014 (GRCm39)	intron	probably benign
R5383:Zfp451	UTSW	1	33,852,887 (GRCm39)	missense	probably damaging	1.00
R5446:Zfp451	UTSW	1	33,816,609 (GRCm39)	missense	probably damaging	1.00
R6154:Zfp451	UTSW	1	33,842,627 (GRCm39)	intron	probably benign
R6228:Zfp451	UTSW	1	33,842,219 (GRCm39)	intron	probably benign
R6272:Zfp451	UTSW	1	33,842,325 (GRCm39)	intron	probably benign
R6296:Zfp451	UTSW	1	33,808,898 (GRCm39)	nonsense	probably null
R6321:Zfp451	UTSW	1	33,852,816 (GRCm39)	missense	probably damaging	1.00
R6445:Zfp451	UTSW	1	33,812,092 (GRCm39)	missense	probably damaging	1.00
R6528:Zfp451	UTSW	1	33,816,862 (GRCm39)	missense	probably damaging	1.00
R6562:Zfp451	UTSW	1	33,801,260 (GRCm39)	missense	possibly damaging	0.90
R6739:Zfp451	UTSW	1	33,842,675 (GRCm39)	intron	probably benign
R6911:Zfp451	UTSW	1	33,842,537 (GRCm39)	intron	probably benign
R7042:Zfp451	UTSW	1	33,816,474 (GRCm39)	missense	probably damaging	1.00
R7044:Zfp451	UTSW	1	33,841,248 (GRCm39)	intron	probably benign
R7071:Zfp451	UTSW	1	33,815,825 (GRCm39)	missense	possibly damaging	0.96
R7082:Zfp451	UTSW	1	33,811,972 (GRCm39)	critical splice donor site	probably null
R7123:Zfp451	UTSW	1	33,815,950 (GRCm39)	missense	probably damaging	1.00
R7149:Zfp451	UTSW	1	33,816,405 (GRCm39)	missense	probably damaging	1.00
R7179:Zfp451	UTSW	1	33,841,651 (GRCm39)	missense	unknown
R7185:Zfp451	UTSW	1	33,808,974 (GRCm39)	missense	probably damaging	1.00
R7228:Zfp451	UTSW	1	33,842,475 (GRCm39)	missense	unknown
R7402:Zfp451	UTSW	1	33,852,843 (GRCm39)	missense	probably benign
R7462:Zfp451	UTSW	1	33,816,094 (GRCm39)	missense	probably damaging	1.00
R7488:Zfp451	UTSW	1	33,818,221 (GRCm39)	missense	probably benign	0.22
R7507:Zfp451	UTSW	1	33,808,840 (GRCm39)	missense	probably damaging	1.00
R7774:Zfp451	UTSW	1	33,844,474 (GRCm39)	missense	probably benign	0.20
R7835:Zfp451	UTSW	1	33,812,060 (GRCm39)	missense	probably damaging	1.00
R7979:Zfp451	UTSW	1	33,821,219 (GRCm39)	missense	probably benign	0.01
R8123:Zfp451	UTSW	1	33,801,248 (GRCm39)	missense	possibly damaging	0.92
R8137:Zfp451	UTSW	1	33,821,156 (GRCm39)	missense	possibly damaging	0.57
R8938:Zfp451	UTSW	1	33,842,063 (GRCm39)	intron	probably benign
R8974:Zfp451	UTSW	1	33,816,535 (GRCm39)	missense	probably damaging	1.00
R9036:Zfp451	UTSW	1	33,815,562 (GRCm39)	missense	probably damaging	1.00
RF005:Zfp451	UTSW	1	33,815,873 (GRCm39)	nonsense	probably null

Posted On

2013-04-17