Mutagenetix > Incidental Mutation

Incidental Mutation 'R3429:Dnah6'

267995

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

040647-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R3429 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

72994589-73198634 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 73098797 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 2034 (S2034L)

Ref Sequence

ENSEMBL: ENSMUSP00000109674 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000064948
AA Change: S2086L

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: S2086L

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000114038

SMART Domains

Protein: ENSMUSP00000109672
Gene: ENSMUSG00000052861

Domain	Start	End	E-Value	Type
Pfam:AAA_6	1	109	6.9e-45	PFAM
AAA	190	331	5.25e-1	SMART
low complexity region	407	417	N/A	INTRINSIC
AAA	533	686	1.01e-3	SMART
AAA	884	1042	3.08e0	SMART
low complexity region	1057	1068	N/A	INTRINSIC
low complexity region	1095	1106	N/A	INTRINSIC
Pfam:MT	1135	1267	1.1e-17	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000114040
AA Change: S2034L

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: S2034L

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000204053
AA Change: S2086L

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: S2086L

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 93.7%

Validation Efficiency

98% (65/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,613,249 (GRCm39)	M1K	probably null	Het
Afap1l2	C	A	19: 56,904,238 (GRCm39)	R683L	probably damaging	Het
Ankfy1	C	T	11: 72,602,980 (GRCm39)		probably benign	Het
Aoc1	A	T	6: 48,883,010 (GRCm39)	E295D	probably benign	Het
Asah1	C	T	8: 41,804,925 (GRCm39)		probably benign	Het
B4galnt4	T	C	7: 140,650,752 (GRCm39)	L842P	probably damaging	Het
Bhmt	T	C	13: 93,763,855 (GRCm39)	E62G	probably damaging	Het
Btbd10	T	A	7: 112,951,016 (GRCm39)	R25*	probably null	Het
Cdh5	T	A	8: 104,857,600 (GRCm39)	I342N	possibly damaging	Het
Clca3a2	T	A	3: 144,512,088 (GRCm39)	E109D	probably benign	Het
Cntrl	T	C	2: 35,035,112 (GRCm39)	L913S	probably damaging	Het
Col12a1	T	A	9: 79,587,593 (GRCm39)	T1183S	probably benign	Het
Col6a6	A	T	9: 105,655,166 (GRCm39)	Y852N	probably damaging	Het
Cpeb2	T	C	5: 43,438,573 (GRCm39)		probably null	Het
Cyp2c66	T	A	19: 39,151,892 (GRCm39)	N202K	probably damaging	Het
Dchs1	A	G	7: 105,405,711 (GRCm39)	V2391A	possibly damaging	Het
Dgat2	A	G	7: 98,806,300 (GRCm39)	V299A	probably benign	Het
Eps8l2	G	A	7: 140,937,832 (GRCm39)		probably null	Het
Fgg	T	A	3: 82,920,090 (GRCm39)	F290I	probably damaging	Het
Filip1	A	T	9: 79,760,952 (GRCm39)	M194K	probably damaging	Het
Foxl2	T	C	9: 98,838,035 (GRCm39)	F108L	probably damaging	Het
Fut1	T	C	7: 45,268,798 (GRCm39)	F196L	probably damaging	Het
Gm10323	A	C	13: 67,002,888 (GRCm39)	W17G	probably damaging	Het
Gstz1	T	A	12: 87,210,470 (GRCm39)		probably null	Het
Hacd1	T	C	2: 14,049,586 (GRCm39)		probably benign	Het
Hmcn2	T	A	2: 31,299,156 (GRCm39)	L2834Q	possibly damaging	Het
Hs3st3a1	C	T	11: 64,327,148 (GRCm39)	R86W	probably benign	Het
Krtap1-4	G	C	11: 99,474,020 (GRCm39)		probably benign	Het
Lmntd2	A	G	7: 140,793,910 (GRCm39)	V21A	probably benign	Het
Lonp1	T	A	17: 56,925,337 (GRCm39)	D485V	probably damaging	Het
Mia2	A	G	12: 59,236,427 (GRCm39)	T1346A	possibly damaging	Het
Mpp2	T	C	11: 101,976,141 (GRCm39)	T6A	probably benign	Het
Mycbp2	A	T	14: 103,466,866 (GRCm39)	V1299E	probably damaging	Het
Myo1d	C	T	11: 80,573,236 (GRCm39)	G197E	probably damaging	Het
Nfib	T	C	4: 82,416,532 (GRCm39)	I168V	possibly damaging	Het
Or2ak5	T	A	11: 58,611,097 (GRCm39)	Y259F	probably damaging	Het
Or2b7	A	T	13: 21,739,975 (GRCm39)	C72*	probably null	Het
Or2y1e	C	T	11: 49,218,868 (GRCm39)	A210V	probably benign	Het
Or4c121	T	A	2: 89,023,617 (GRCm39)	I254L	probably benign	Het
Or4c29	C	T	2: 88,739,810 (GRCm39)	R309Q	probably benign	Het
Parp3	A	T	9: 106,351,922 (GRCm39)	I150K	probably damaging	Het
Pnp	A	G	14: 51,185,443 (GRCm39)	D49G	probably benign	Het
Prkcq	T	C	2: 11,251,781 (GRCm39)	I206T	probably damaging	Het
Rif1	GCCACCA	GCCA	2: 52,000,336 (GRCm39)		probably benign	Het
Rlf	A	G	4: 121,007,729 (GRCm39)	L417P	probably benign	Het
Scn7a	AT	ATT	2: 66,531,239 (GRCm39)		probably null	Het
Sgce	T	A	6: 4,730,008 (GRCm39)	D72V	probably benign	Het
Sh3d21	A	G	4: 126,056,625 (GRCm39)	S66P	probably benign	Het
Sost	C	G	11: 101,854,865 (GRCm39)	G148A	probably damaging	Het
Sybu	T	C	15: 44,609,854 (GRCm39)	E138G	probably damaging	Het
Tas1r2	A	G	4: 139,396,886 (GRCm39)	T742A	probably damaging	Het
Tet3	A	G	6: 83,380,401 (GRCm39)	V589A	probably damaging	Het
Tnxb	C	A	17: 34,891,605 (GRCm39)	C649*	probably null	Het
Tnxb	A	G	17: 34,922,561 (GRCm39)	Y2458C	probably damaging	Het
Tsku	T	C	7: 98,001,746 (GRCm39)	N195S	probably damaging	Het
Vmn1r215	T	A	13: 23,260,378 (GRCm39)	N139K	probably damaging	Het
Zfp106	T	C	2: 120,357,544 (GRCm39)	H1117R	probably benign	Het
Zfp26	A	G	9: 20,352,756 (GRCm39)		probably benign	Het
Zfp764l1	T	C	7: 126,990,914 (GRCm39)	T358A	possibly damaging	Het
Zfp804b	T	A	5: 7,230,625 (GRCm39)		probably benign	Het
Zfr	T	C	15: 12,153,006 (GRCm39)	S546P	probably benign	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,172,720 (GRCm39)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,063,190 (GRCm39)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,172,744 (GRCm39)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,189,417 (GRCm39)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,100,754 (GRCm39)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,133,333 (GRCm39)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,010,509 (GRCm39)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,060,140 (GRCm39)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,150,373 (GRCm39)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,051,764 (GRCm39)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,042,708 (GRCm39)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,150,439 (GRCm39)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,069,161 (GRCm39)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,051,731 (GRCm39)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,001,235 (GRCm39)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,052,785 (GRCm39)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,053,643 (GRCm39)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,165,360 (GRCm39)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,042,759 (GRCm39)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,112,784 (GRCm39)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,009,552 (GRCm39)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,037,126 (GRCm39)	missense	probably benign
IGL02126:Dnah6	APN	6	73,080,149 (GRCm39)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	72,994,780 (GRCm39)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,110,633 (GRCm39)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,145,894 (GRCm39)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,078,881 (GRCm39)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,053,623 (GRCm39)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,004,431 (GRCm39)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	72,998,210 (GRCm39)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,072,087 (GRCm39)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,098,806 (GRCm39)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,185,582 (GRCm39)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,115,698 (GRCm39)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,009,570 (GRCm39)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,126,123 (GRCm39)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,121,987 (GRCm39)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,018,037 (GRCm39)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,121,683 (GRCm39)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,030,630 (GRCm39)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,060,068 (GRCm39)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,052,833 (GRCm39)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,140,487 (GRCm39)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,042,738 (GRCm39)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,185,624 (GRCm39)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,078,863 (GRCm39)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,091,565 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,037,243 (GRCm39)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,015,717 (GRCm39)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,165,518 (GRCm39)	splice site	probably benign
R0165:Dnah6	UTSW	6	72,998,306 (GRCm39)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,059,906 (GRCm39)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,136,098 (GRCm39)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,150,541 (GRCm39)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,046,382 (GRCm39)	splice site	probably benign
R0345:Dnah6	UTSW	6	72,998,240 (GRCm39)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,165,342 (GRCm39)	missense	probably benign
R0362:Dnah6	UTSW	6	73,185,592 (GRCm39)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,060,107 (GRCm39)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,021,757 (GRCm39)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	72,999,395 (GRCm39)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,100,794 (GRCm39)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,106,457 (GRCm39)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,189,605 (GRCm39)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,064,585 (GRCm39)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,012,276 (GRCm39)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,101,740 (GRCm39)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,136,176 (GRCm39)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,121,948 (GRCm39)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,136,118 (GRCm39)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,101,692 (GRCm39)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,185,528 (GRCm39)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,168,602 (GRCm39)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,004,425 (GRCm39)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,026,031 (GRCm39)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,128,536 (GRCm39)	missense	probably benign
R1557:Dnah6	UTSW	6	73,026,114 (GRCm39)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,053,583 (GRCm39)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,044,452 (GRCm39)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,121,946 (GRCm39)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,077,095 (GRCm39)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,021,735 (GRCm39)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,132,279 (GRCm39)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,182,715 (GRCm39)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,106,523 (GRCm39)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,021,744 (GRCm39)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,137,965 (GRCm39)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,001,941 (GRCm39)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,158,780 (GRCm39)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,077,071 (GRCm39)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,158,745 (GRCm39)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,061,704 (GRCm39)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,098,953 (GRCm39)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,072,027 (GRCm39)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,069,175 (GRCm39)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,044,449 (GRCm39)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,150,402 (GRCm39)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,004,405 (GRCm39)	missense	probably benign
R2041:Dnah6	UTSW	6	73,050,422 (GRCm39)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	72,998,165 (GRCm39)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,121,018 (GRCm39)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,026,149 (GRCm39)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,066,729 (GRCm39)	splice site	probably null
R2193:Dnah6	UTSW	6	73,115,623 (GRCm39)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,077,068 (GRCm39)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,090,564 (GRCm39)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	72,998,092 (GRCm39)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,133,404 (GRCm39)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,068,950 (GRCm39)	splice site	probably null
R2436:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,150,333 (GRCm39)	missense	probably benign	0.03
R3430:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,009,616 (GRCm39)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,168,481 (GRCm39)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,104,910 (GRCm39)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,066,575 (GRCm39)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,106,431 (GRCm39)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,126,467 (GRCm39)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,095,009 (GRCm39)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,106,274 (GRCm39)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,168,462 (GRCm39)	missense	probably benign
R4486:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,155,399 (GRCm39)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,169,388 (GRCm39)	missense	probably benign
R4573:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,129,695 (GRCm39)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,106,643 (GRCm39)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,047,580 (GRCm39)	missense	probably benign
R4653:Dnah6	UTSW	6	73,050,440 (GRCm39)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,014,671 (GRCm39)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,169,405 (GRCm39)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,001,995 (GRCm39)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,106,513 (GRCm39)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,072,057 (GRCm39)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,066,651 (GRCm39)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	72,999,407 (GRCm39)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,021,745 (GRCm39)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,098,771 (GRCm39)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,169,659 (GRCm39)	intron	probably benign
R4948:Dnah6	UTSW	6	73,030,672 (GRCm39)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,165,366 (GRCm39)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,121,798 (GRCm39)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,021,674 (GRCm39)	missense	probably benign
R5044:Dnah6	UTSW	6	73,014,605 (GRCm39)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,158,744 (GRCm39)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,172,617 (GRCm39)	missense	probably benign
R5186:Dnah6	UTSW	6	73,044,410 (GRCm39)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,172,715 (GRCm39)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,090,471 (GRCm39)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,104,844 (GRCm39)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,189,603 (GRCm39)	missense	probably benign
R5343:Dnah6	UTSW	6	73,189,599 (GRCm39)	missense	probably benign
R5375:Dnah6	UTSW	6	73,100,838 (GRCm39)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,014,598 (GRCm39)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,037,121 (GRCm39)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,052,717 (GRCm39)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,063,168 (GRCm39)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,069,140 (GRCm39)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,069,099 (GRCm39)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,167,402 (GRCm39)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,136,212 (GRCm39)	missense	probably benign
R5541:Dnah6	UTSW	6	73,169,971 (GRCm39)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,128,672 (GRCm39)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,126,508 (GRCm39)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	72,998,210 (GRCm39)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,037,262 (GRCm39)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,158,705 (GRCm39)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,063,149 (GRCm39)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,091,680 (GRCm39)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,165,477 (GRCm39)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,063,200 (GRCm39)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,168,588 (GRCm39)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,132,401 (GRCm39)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,051,569 (GRCm39)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,051,687 (GRCm39)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,021,715 (GRCm39)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,150,516 (GRCm39)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,030,678 (GRCm39)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,012,263 (GRCm39)	splice site	probably null
R6640:Dnah6	UTSW	6	73,001,276 (GRCm39)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,115,743 (GRCm39)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,014,532 (GRCm39)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,110,591 (GRCm39)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,110,525 (GRCm39)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,189,505 (GRCm39)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,158,738 (GRCm39)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,021,756 (GRCm39)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	72,998,161 (GRCm39)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,064,545 (GRCm39)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,112,663 (GRCm39)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,158,688 (GRCm39)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,150,528 (GRCm39)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,061,743 (GRCm39)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,121,705 (GRCm39)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,189,595 (GRCm39)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,169,300 (GRCm39)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,189,475 (GRCm39)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,104,887 (GRCm39)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,095,082 (GRCm39)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,004,423 (GRCm39)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,126,413 (GRCm39)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,069,151 (GRCm39)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,072,189 (GRCm39)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,101,742 (GRCm39)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,146,063 (GRCm39)	splice site	probably null
R7735:Dnah6	UTSW	6	73,046,412 (GRCm39)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,002,703 (GRCm39)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,104,902 (GRCm39)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,112,450 (GRCm39)	splice site	probably null
R8034:Dnah6	UTSW	6	73,106,208 (GRCm39)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,137,896 (GRCm39)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,002,769 (GRCm39)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,037,208 (GRCm39)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,014,549 (GRCm39)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,021,711 (GRCm39)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,145,810 (GRCm39)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,172,664 (GRCm39)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,053,582 (GRCm39)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,001,983 (GRCm39)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,051,634 (GRCm39)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,115,757 (GRCm39)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,155,440 (GRCm39)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,072,171 (GRCm39)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,145,850 (GRCm39)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,052,873 (GRCm39)	intron	probably benign
R8737:Dnah6	UTSW	6	73,044,428 (GRCm39)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,156,811 (GRCm39)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,042,756 (GRCm39)	missense	probably benign
R8809:Dnah6	UTSW	6	73,009,546 (GRCm39)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,104,937 (GRCm39)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,121,156 (GRCm39)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	72,998,131 (GRCm39)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,155,481 (GRCm39)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,121,734 (GRCm39)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,119,275 (GRCm39)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,061,640 (GRCm39)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,121,029 (GRCm39)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,044,469 (GRCm39)	missense	probably benign
R9106:Dnah6	UTSW	6	73,121,752 (GRCm39)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,037,186 (GRCm39)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,098,882 (GRCm39)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,121,924 (GRCm39)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,121,688 (GRCm39)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,004,497 (GRCm39)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,060,040 (GRCm39)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	72,998,261 (GRCm39)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,189,513 (GRCm39)	missense	probably benign
R9439:Dnah6	UTSW	6	73,012,330 (GRCm39)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,119,299 (GRCm39)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,115,750 (GRCm39)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,168,589 (GRCm39)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,078,872 (GRCm39)	missense	probably benign
RF020:Dnah6	UTSW	6	73,095,040 (GRCm39)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,155,501 (GRCm39)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,168,483 (GRCm39)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,014,656 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,110,542 (GRCm39)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,064,766 (GRCm39)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,009,509 (GRCm39)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	72,998,220 (GRCm39)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,132,255 (GRCm39)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,018,121 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATCCCAGGGTCAGTGTGGATTC -3'
(R):5'- TGGAGATCTGTGGAGCATTC -3'

Sequencing Primer
(F):5'- CCAGGGTCAGTGTGGATTCTGAAG -3'
(R):5'- GGAGCATTCATATAGACTTTGACACC -3'

Posted On

2015-02-18