Incidental Mutation 'R3429:Cyp2c66'
ID 268037
Institutional Source Beutler Lab
Gene Symbol Cyp2c66
Ensembl Gene ENSMUSG00000067229
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms 2010301M18Rik
MMRRC Submission 040647-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R3429 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 39102342-39175200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39151892 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 202 (N202K)
Ref Sequence ENSEMBL: ENSMUSP00000084487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087234] [ENSMUST00000146494]
AlphaFold Q5GLZ0
Predicted Effect probably damaging
Transcript: ENSMUST00000087234
AA Change: N202K

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229
AA Change: N202K

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 1e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146494
SMART Domains Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
SCOP:d1cpt__ 26 55 4e-9 SMART
Meta Mutation Damage Score 0.1583 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 98% (65/66)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,613,249 (GRCm39) M1K probably null Het
Afap1l2 C A 19: 56,904,238 (GRCm39) R683L probably damaging Het
Ankfy1 C T 11: 72,602,980 (GRCm39) probably benign Het
Aoc1 A T 6: 48,883,010 (GRCm39) E295D probably benign Het
Asah1 C T 8: 41,804,925 (GRCm39) probably benign Het
B4galnt4 T C 7: 140,650,752 (GRCm39) L842P probably damaging Het
Bhmt T C 13: 93,763,855 (GRCm39) E62G probably damaging Het
Btbd10 T A 7: 112,951,016 (GRCm39) R25* probably null Het
Cdh5 T A 8: 104,857,600 (GRCm39) I342N possibly damaging Het
Clca3a2 T A 3: 144,512,088 (GRCm39) E109D probably benign Het
Cntrl T C 2: 35,035,112 (GRCm39) L913S probably damaging Het
Col12a1 T A 9: 79,587,593 (GRCm39) T1183S probably benign Het
Col6a6 A T 9: 105,655,166 (GRCm39) Y852N probably damaging Het
Cpeb2 T C 5: 43,438,573 (GRCm39) probably null Het
Dchs1 A G 7: 105,405,711 (GRCm39) V2391A possibly damaging Het
Dgat2 A G 7: 98,806,300 (GRCm39) V299A probably benign Het
Dnah6 G A 6: 73,098,797 (GRCm39) S2034L possibly damaging Het
Eps8l2 G A 7: 140,937,832 (GRCm39) probably null Het
Fgg T A 3: 82,920,090 (GRCm39) F290I probably damaging Het
Filip1 A T 9: 79,760,952 (GRCm39) M194K probably damaging Het
Foxl2 T C 9: 98,838,035 (GRCm39) F108L probably damaging Het
Fut1 T C 7: 45,268,798 (GRCm39) F196L probably damaging Het
Gm10323 A C 13: 67,002,888 (GRCm39) W17G probably damaging Het
Gstz1 T A 12: 87,210,470 (GRCm39) probably null Het
Hacd1 T C 2: 14,049,586 (GRCm39) probably benign Het
Hmcn2 T A 2: 31,299,156 (GRCm39) L2834Q possibly damaging Het
Hs3st3a1 C T 11: 64,327,148 (GRCm39) R86W probably benign Het
Krtap1-4 G C 11: 99,474,020 (GRCm39) probably benign Het
Lmntd2 A G 7: 140,793,910 (GRCm39) V21A probably benign Het
Lonp1 T A 17: 56,925,337 (GRCm39) D485V probably damaging Het
Mia2 A G 12: 59,236,427 (GRCm39) T1346A possibly damaging Het
Mpp2 T C 11: 101,976,141 (GRCm39) T6A probably benign Het
Mycbp2 A T 14: 103,466,866 (GRCm39) V1299E probably damaging Het
Myo1d C T 11: 80,573,236 (GRCm39) G197E probably damaging Het
Nfib T C 4: 82,416,532 (GRCm39) I168V possibly damaging Het
Or2ak5 T A 11: 58,611,097 (GRCm39) Y259F probably damaging Het
Or2b7 A T 13: 21,739,975 (GRCm39) C72* probably null Het
Or2y1e C T 11: 49,218,868 (GRCm39) A210V probably benign Het
Or4c121 T A 2: 89,023,617 (GRCm39) I254L probably benign Het
Or4c29 C T 2: 88,739,810 (GRCm39) R309Q probably benign Het
Parp3 A T 9: 106,351,922 (GRCm39) I150K probably damaging Het
Pnp A G 14: 51,185,443 (GRCm39) D49G probably benign Het
Prkcq T C 2: 11,251,781 (GRCm39) I206T probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rlf A G 4: 121,007,729 (GRCm39) L417P probably benign Het
Scn7a AT ATT 2: 66,531,239 (GRCm39) probably null Het
Sgce T A 6: 4,730,008 (GRCm39) D72V probably benign Het
Sh3d21 A G 4: 126,056,625 (GRCm39) S66P probably benign Het
Sost C G 11: 101,854,865 (GRCm39) G148A probably damaging Het
Sybu T C 15: 44,609,854 (GRCm39) E138G probably damaging Het
Tas1r2 A G 4: 139,396,886 (GRCm39) T742A probably damaging Het
Tet3 A G 6: 83,380,401 (GRCm39) V589A probably damaging Het
Tnxb C A 17: 34,891,605 (GRCm39) C649* probably null Het
Tnxb A G 17: 34,922,561 (GRCm39) Y2458C probably damaging Het
Tsku T C 7: 98,001,746 (GRCm39) N195S probably damaging Het
Vmn1r215 T A 13: 23,260,378 (GRCm39) N139K probably damaging Het
Zfp106 T C 2: 120,357,544 (GRCm39) H1117R probably benign Het
Zfp26 A G 9: 20,352,756 (GRCm39) probably benign Het
Zfp764l1 T C 7: 126,990,914 (GRCm39) T358A possibly damaging Het
Zfp804b T A 5: 7,230,625 (GRCm39) probably benign Het
Zfr T C 15: 12,153,006 (GRCm39) S546P probably benign Het
Other mutations in Cyp2c66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Cyp2c66 APN 19 39,159,405 (GRCm39) missense probably benign 0.00
IGL01589:Cyp2c66 APN 19 39,172,379 (GRCm39) critical splice donor site probably null
IGL02098:Cyp2c66 APN 19 39,159,473 (GRCm39) missense probably damaging 1.00
IGL02114:Cyp2c66 APN 19 39,159,519 (GRCm39) splice site probably benign
IGL02567:Cyp2c66 APN 19 39,175,084 (GRCm39) utr 3 prime probably benign
IGL03181:Cyp2c66 APN 19 39,130,483 (GRCm39) missense probably benign 0.00
IGL03230:Cyp2c66 APN 19 39,172,302 (GRCm39) missense possibly damaging 0.91
R0007:Cyp2c66 UTSW 19 39,159,402 (GRCm39) nonsense probably null
R0092:Cyp2c66 UTSW 19 39,172,224 (GRCm39) splice site probably benign
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0324:Cyp2c66 UTSW 19 39,165,135 (GRCm39) missense probably benign 0.27
R0675:Cyp2c66 UTSW 19 39,175,060 (GRCm39) missense possibly damaging 0.93
R1127:Cyp2c66 UTSW 19 39,151,812 (GRCm39) missense probably damaging 1.00
R1871:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R3404:Cyp2c66 UTSW 19 39,151,771 (GRCm39) missense probably benign
R3896:Cyp2c66 UTSW 19 39,130,722 (GRCm39) missense possibly damaging 0.82
R4115:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4116:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4667:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4668:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4711:Cyp2c66 UTSW 19 39,151,843 (GRCm39) missense possibly damaging 0.74
R4960:Cyp2c66 UTSW 19 39,151,766 (GRCm39) critical splice acceptor site probably null
R5070:Cyp2c66 UTSW 19 39,151,914 (GRCm39) missense probably benign 0.15
R5113:Cyp2c66 UTSW 19 39,151,882 (GRCm39) missense probably benign 0.00
R5125:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5178:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5588:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R6011:Cyp2c66 UTSW 19 39,130,380 (GRCm39) missense probably benign 0.00
R6497:Cyp2c66 UTSW 19 39,151,821 (GRCm39) missense probably damaging 0.96
R6707:Cyp2c66 UTSW 19 39,174,944 (GRCm39) missense probably damaging 1.00
R7173:Cyp2c66 UTSW 19 39,159,401 (GRCm39) missense probably benign 0.01
R7202:Cyp2c66 UTSW 19 39,130,348 (GRCm39) missense probably damaging 1.00
R7469:Cyp2c66 UTSW 19 39,172,307 (GRCm39) missense probably damaging 1.00
R7614:Cyp2c66 UTSW 19 39,159,472 (GRCm39) missense probably damaging 0.98
R7985:Cyp2c66 UTSW 19 39,102,430 (GRCm39) missense probably null 1.00
R8012:Cyp2c66 UTSW 19 39,172,369 (GRCm39) missense probably damaging 1.00
R8056:Cyp2c66 UTSW 19 39,130,485 (GRCm39) missense probably benign 0.00
R8302:Cyp2c66 UTSW 19 39,165,078 (GRCm39) missense probably damaging 1.00
R8329:Cyp2c66 UTSW 19 39,174,906 (GRCm39) nonsense probably null
R8365:Cyp2c66 UTSW 19 39,165,048 (GRCm39) missense probably benign 0.00
R8472:Cyp2c66 UTSW 19 39,165,021 (GRCm39) missense probably benign 0.03
R8502:Cyp2c66 UTSW 19 39,130,773 (GRCm39) missense probably benign 0.01
R8688:Cyp2c66 UTSW 19 39,151,884 (GRCm39) missense probably benign 0.00
R8715:Cyp2c66 UTSW 19 39,159,388 (GRCm39) missense probably benign 0.01
R9199:Cyp2c66 UTSW 19 39,130,800 (GRCm39) missense probably benign 0.16
R9551:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9552:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9601:Cyp2c66 UTSW 19 39,175,054 (GRCm39) missense probably benign
R9777:Cyp2c66 UTSW 19 39,102,520 (GRCm39) missense probably benign 0.15
Z1177:Cyp2c66 UTSW 19 39,175,070 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CAAGACTTGCTTAAATTGTGACCAG -3'
(R):5'- AGTGAACAGTGTTCTAACAGCC -3'

Sequencing Primer
(F):5'- GTGACCAGTTTCTTTATCTGTTGAG -3'
(R):5'- AACAGTGTTCTAACAGCCTTCATTTC -3'
Posted On 2015-02-18