Incidental Mutation 'R3547:Gstcd'
ID 268239
Institutional Source Beutler Lab
Gene Symbol Gstcd
Ensembl Gene ENSMUSG00000028018
Gene Name glutathione S-transferase, C-terminal domain containing
Synonyms 4933434L15Rik
MMRRC Submission 040666-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3547 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 132687513-132797794 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 132790599 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 56 (T56K)
Ref Sequence ENSEMBL: ENSMUSP00000079421 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029651] [ENSMUST00000080583]
AlphaFold Q5RL51
Predicted Effect possibly damaging
Transcript: ENSMUST00000029651
AA Change: T56K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000029651
Gene: ENSMUSG00000028018
AA Change: T56K

DomainStartEndE-ValueType
low complexity region 52 62 N/A INTRINSIC
low complexity region 168 181 N/A INTRINSIC
low complexity region 195 205 N/A INTRINSIC
low complexity region 208 229 N/A INTRINSIC
Pfam:GidB 417 515 9e-9 PFAM
Pfam:Methyltransf_32 424 548 1.1e-15 PFAM
Pfam:MTS 430 508 5.3e-6 PFAM
Pfam:Methyltransf_31 440 571 2.6e-11 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000080583
AA Change: T56K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000079421
Gene: ENSMUSG00000028018
AA Change: T56K

DomainStartEndE-ValueType
low complexity region 52 62 N/A INTRINSIC
low complexity region 168 181 N/A INTRINSIC
low complexity region 195 205 N/A INTRINSIC
low complexity region 208 229 N/A INTRINSIC
Pfam:GidB 418 516 1.5e-8 PFAM
Pfam:Methyltransf_32 424 548 1.1e-15 PFAM
Pfam:Methyltransf_31 440 569 2.5e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161577
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162926
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197381
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.9%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg5 A G 3: 54,656,736 (GRCm39) R316G probably benign Het
Anapc1 T C 2: 128,484,602 (GRCm39) N1121D possibly damaging Het
Antxr2 A T 5: 98,125,516 (GRCm39) I247N probably benign Het
Arid5b C T 10: 67,934,292 (GRCm39) G294S probably benign Het
Arl9 A G 5: 77,158,326 (GRCm39) D136G probably benign Het
Atxn1l A G 8: 110,458,981 (GRCm39) L427P possibly damaging Het
Celf3 T G 3: 94,395,845 (GRCm39) C304G probably damaging Het
Clcc1 T A 3: 108,575,429 (GRCm39) C169S probably benign Het
Clec4a3 A G 6: 122,941,239 (GRCm39) E78G probably damaging Het
Clip1 A G 5: 123,769,141 (GRCm39) L532P probably damaging Het
Col12a1 T G 9: 79,540,698 (GRCm39) K2429T probably damaging Het
Col20a1 G T 2: 180,636,704 (GRCm39) E228D probably damaging Het
Cx3cl1 A C 8: 95,504,752 (GRCm39) E56A possibly damaging Het
Eprs1 G A 1: 185,111,939 (GRCm39) probably null Het
Fap A C 2: 62,349,355 (GRCm39) L478R probably damaging Het
Fhit T C 14: 9,870,095 (GRCm38) T125A probably benign Het
Gdi1 T A X: 73,351,414 (GRCm39) F175L possibly damaging Het
Golga7b T C 19: 42,255,510 (GRCm39) M129T possibly damaging Het
Gpr149 A T 3: 62,502,549 (GRCm39) C436S probably benign Het
Grid2 T C 6: 64,297,005 (GRCm39) V456A probably damaging Het
Hydin G A 8: 111,308,699 (GRCm39) G3995D possibly damaging Het
Igkv4-50 G A 6: 69,677,765 (GRCm39) T113I probably benign Het
Igkv5-43 A G 6: 69,753,240 (GRCm39) probably benign Het
Igsf10 G A 3: 59,237,962 (GRCm39) H740Y probably benign Het
Igsf10 C A 3: 59,243,935 (GRCm39) R133L probably damaging Het
Lcmt1 A G 7: 122,999,702 (GRCm39) E94G probably benign Het
Lrp1b A T 2: 40,490,300 (GRCm39) L287H probably damaging Het
Ly6m C A 15: 74,753,463 (GRCm39) A18S probably null Het
Map3k3 C T 11: 106,033,379 (GRCm39) Q211* probably null Het
Map4 T A 9: 109,881,266 (GRCm39) F43L possibly damaging Het
Mcf2 T C X: 59,180,806 (GRCm39) K74R probably damaging Het
Mylk G A 16: 34,700,538 (GRCm39) V460I possibly damaging Het
Nat1 A G 8: 67,943,684 (GRCm39) D23G possibly damaging Het
Nbeal1 T C 1: 60,317,939 (GRCm39) F1959L probably damaging Het
Ncf1 T A 5: 134,255,463 (GRCm39) K143* probably null Het
Nlrp6 T G 7: 140,506,682 (GRCm39) V849G probably benign Het
Or52b3 A G 7: 102,203,677 (GRCm39) Y62C probably damaging Het
Pi4k2a C T 19: 42,078,987 (GRCm39) P16L probably benign Het
Pitx3 T A 19: 46,124,548 (GRCm39) Q273L possibly damaging Het
Ppp1r27 T A 11: 120,441,511 (GRCm39) I90F probably damaging Het
Prickle2 T C 6: 92,388,118 (GRCm39) Y428C probably damaging Het
Prkcq A G 2: 11,288,627 (GRCm39) K527E probably benign Het
Prune2 T A 19: 17,101,712 (GRCm39) S2405R probably damaging Het
Reln A G 5: 22,432,598 (GRCm39) V134A possibly damaging Het
Rnf167 T C 11: 70,540,507 (GRCm39) I129T possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sfxn2 T C 19: 46,578,635 (GRCm39) S217P probably damaging Het
Slc16a7 T A 10: 125,130,569 (GRCm39) K39* probably null Het
Slc22a17 A G 14: 55,144,694 (GRCm39) L573P probably damaging Het
Slc25a45 T C 19: 5,934,574 (GRCm39) Y181H probably damaging Het
Slc6a20a A G 9: 123,489,567 (GRCm39) S159P probably damaging Het
Tbc1d1 G A 5: 64,443,350 (GRCm39) R523Q probably damaging Het
Thnsl1 T G 2: 21,217,438 (GRCm39) D397E probably benign Het
Ttn T A 2: 76,575,450 (GRCm39) I25148F probably damaging Het
Ube4b T C 4: 149,419,573 (GRCm39) D1045G probably damaging Het
Ugt8a A T 3: 125,661,031 (GRCm39) L487* probably null Het
Uprt T A X: 103,526,934 (GRCm39) L123H probably damaging Het
Usp9x T C X: 12,994,629 (GRCm39) L940P probably benign Het
Utp20 T C 10: 88,618,551 (GRCm39) K1150E probably damaging Het
Uty A C Y: 1,158,512 (GRCm39) D463E possibly damaging Het
Vmn1r7 A G 6: 57,001,834 (GRCm39) I142T possibly damaging Het
Vps13d T G 4: 144,801,545 (GRCm39) T3558P probably damaging Het
Zfp319 A G 8: 96,055,445 (GRCm39) S253P probably damaging Het
Zfp831 A G 2: 174,499,476 (GRCm39) S1265G probably benign Het
Other mutations in Gstcd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01540:Gstcd APN 3 132,692,175 (GRCm39) missense probably damaging 0.96
IGL01800:Gstcd APN 3 132,790,335 (GRCm39) critical splice donor site probably null
IGL02434:Gstcd APN 3 132,701,963 (GRCm39) splice site probably benign
IGL02720:Gstcd APN 3 132,777,722 (GRCm39) missense probably benign 0.00
R0367:Gstcd UTSW 3 132,692,138 (GRCm39) splice site probably benign
R0378:Gstcd UTSW 3 132,692,169 (GRCm39) missense probably damaging 1.00
R0382:Gstcd UTSW 3 132,692,169 (GRCm39) missense probably damaging 1.00
R0465:Gstcd UTSW 3 132,688,905 (GRCm39) missense probably benign 0.04
R1295:Gstcd UTSW 3 132,711,389 (GRCm39) missense probably damaging 1.00
R1861:Gstcd UTSW 3 132,688,868 (GRCm39) missense probably damaging 1.00
R2056:Gstcd UTSW 3 132,787,814 (GRCm39) missense probably benign 0.00
R2331:Gstcd UTSW 3 132,704,641 (GRCm39) missense probably damaging 0.98
R2513:Gstcd UTSW 3 132,788,082 (GRCm39) missense possibly damaging 0.87
R2513:Gstcd UTSW 3 132,788,081 (GRCm39) missense possibly damaging 0.59
R4022:Gstcd UTSW 3 132,787,829 (GRCm39) missense probably damaging 1.00
R4713:Gstcd UTSW 3 132,688,860 (GRCm39) missense probably damaging 1.00
R4877:Gstcd UTSW 3 132,711,314 (GRCm39) splice site probably benign
R5152:Gstcd UTSW 3 132,790,717 (GRCm39) missense possibly damaging 0.95
R5165:Gstcd UTSW 3 132,790,440 (GRCm39) missense probably damaging 0.99
R6106:Gstcd UTSW 3 132,704,675 (GRCm39) missense probably benign 0.02
R6177:Gstcd UTSW 3 132,787,834 (GRCm39) missense probably damaging 1.00
R7100:Gstcd UTSW 3 132,790,704 (GRCm39) missense probably benign 0.01
R7264:Gstcd UTSW 3 132,790,540 (GRCm39) missense probably benign 0.00
R7785:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R7786:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R7972:Gstcd UTSW 3 132,777,894 (GRCm39) missense probably benign 0.10
R7975:Gstcd UTSW 3 132,777,863 (GRCm39) missense probably damaging 1.00
R8029:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8036:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8088:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8716:Gstcd UTSW 3 132,688,950 (GRCm39) missense probably damaging 1.00
R8722:Gstcd UTSW 3 132,777,822 (GRCm39) nonsense probably null
R9276:Gstcd UTSW 3 132,777,665 (GRCm39) missense probably damaging 1.00
R9575:Gstcd UTSW 3 132,704,708 (GRCm39) missense probably damaging 1.00
R9789:Gstcd UTSW 3 132,790,357 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCTTGAGGGCTCAGCTTCATAG -3'
(R):5'- TCTAGGTGACCCAATGACAACAG -3'

Sequencing Primer
(F):5'- AGGGCTCAGCTTCATAGGATTTTTG -3'
(R):5'- TGACCCAATGACAACAGAAGATG -3'
Posted On 2015-02-19