Incidental Mutation 'R3551:Slco1a7'
ID 268337
Institutional Source Beutler Lab
Gene Symbol Slco1a7
Ensembl Gene ENSMUSG00000084927
Gene Name solute carrier organic anion transporter family, member 1a7
Synonyms Gm5724
MMRRC Submission 040668-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R3551 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 141653844-141719536 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 141654322 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 647 (K647E)
Ref Sequence ENSEMBL: ENSMUSP00000117177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000148411]
AlphaFold L7N264
Predicted Effect probably benign
Transcript: ENSMUST00000148411
AA Change: K647E

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000117177
Gene: ENSMUSG00000084927
AA Change: K647E

DomainStartEndE-ValueType
Pfam:MFS_1 22 405 3.4e-26 PFAM
KAZAL 438 484 1.71e0 SMART
Meta Mutation Damage Score 0.0831 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,152,450 (GRCm39) Y866N probably damaging Het
Adam24 G C 8: 41,132,632 (GRCm39) W33C probably benign Het
Adgrl2 A T 3: 148,564,599 (GRCm39) V327E probably damaging Het
Aqp7 T A 4: 41,045,329 (GRCm39) N17I probably benign Het
Bicra T A 7: 15,713,658 (GRCm39) Q848L probably benign Het
C4b T C 17: 34,960,846 (GRCm39) E240G possibly damaging Het
Ccni T C 5: 93,335,620 (GRCm39) S173G probably benign Het
Clca3a2 T A 3: 144,508,842 (GRCm39) N50I probably damaging Het
Dcaf7 A G 11: 105,945,622 (GRCm39) T324A probably benign Het
Dnah12 G A 14: 26,492,929 (GRCm39) R1230H probably benign Het
Dsg4 G A 18: 20,584,813 (GRCm39) V176M probably damaging Het
Ect2l A G 10: 18,039,141 (GRCm39) I339T probably damaging Het
Edc4 A T 8: 106,612,126 (GRCm39) I138F probably damaging Het
Ercc6l2 T A 13: 63,992,409 (GRCm39) V401E probably damaging Het
Gm3269 T A 14: 16,033,003 (GRCm39) V260D possibly damaging Het
Gm4076 C T 13: 85,275,269 (GRCm39) noncoding transcript Het
Gm4922 A T 10: 18,660,244 (GRCm39) N159K probably benign Het
Gm5134 G T 10: 75,836,281 (GRCm39) A421S probably benign Het
Hrc G C 7: 44,985,757 (GRCm39) E303Q possibly damaging Het
Ipo4 A G 14: 55,870,560 (GRCm39) V288A probably benign Het
Kng2 A G 16: 22,830,745 (GRCm39) probably null Het
Lrfn1 T C 7: 28,159,479 (GRCm39) L466P possibly damaging Het
Magi1 T A 6: 93,676,610 (GRCm39) K916N probably damaging Het
Mms19 T C 19: 41,938,237 (GRCm39) T720A probably benign Het
Muc5b A G 7: 141,415,072 (GRCm39) T2673A possibly damaging Het
Myo15a C T 11: 60,400,489 (GRCm39) A1767V possibly damaging Het
Npas2 A T 1: 39,326,643 (GRCm39) M43L probably benign Het
Nup43 A G 10: 7,550,778 (GRCm39) D216G possibly damaging Het
Or1e19 T C 11: 73,316,678 (GRCm39) I44V probably benign Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pcdhga6 G T 18: 37,841,270 (GRCm39) R330L probably benign Het
Pear1 A G 3: 87,665,439 (GRCm39) F145L probably benign Het
Pgap1 A G 1: 54,569,302 (GRCm39) S355P possibly damaging Het
Prr14l A T 5: 32,985,963 (GRCm39) probably null Het
Ptpn12 T C 5: 21,194,047 (GRCm39) K742E possibly damaging Het
Ryr1 T A 7: 28,756,422 (GRCm39) Q3464L probably damaging Het
Sema4c G C 1: 36,592,804 (GRCm39) T138S probably benign Het
Slc4a2 C T 5: 24,635,099 (GRCm39) T168M probably benign Het
Spice1 G T 16: 44,178,232 (GRCm39) S85I probably damaging Het
Thrb T A 14: 17,963,214 (GRCm38) I59N probably damaging Het
Trav7-1 A G 14: 52,892,756 (GRCm39) D103G probably damaging Het
Ubap2l G T 3: 89,922,758 (GRCm39) T766N unknown Het
Zfp692 C T 11: 58,200,254 (GRCm39) T170I possibly damaging Het
Zfp704 A G 3: 9,539,585 (GRCm39) V255A probably damaging Het
Zfp759 T C 13: 67,287,031 (GRCm39) V194A probably benign Het
Other mutations in Slco1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Slco1a7 APN 6 141,700,155 (GRCm39) missense probably benign 0.14
IGL01347:Slco1a7 APN 6 141,700,192 (GRCm39) nonsense probably null
IGL01539:Slco1a7 APN 6 141,673,333 (GRCm39) missense possibly damaging 0.88
IGL01613:Slco1a7 APN 6 141,658,940 (GRCm39) missense possibly damaging 0.67
IGL02060:Slco1a7 APN 6 141,700,134 (GRCm39) missense probably benign 0.00
IGL02063:Slco1a7 APN 6 141,684,615 (GRCm39) missense probably benign 0.01
IGL02126:Slco1a7 APN 6 141,684,739 (GRCm39) missense probably benign 0.29
IGL02214:Slco1a7 APN 6 141,668,911 (GRCm39) missense possibly damaging 0.50
IGL02630:Slco1a7 APN 6 141,668,836 (GRCm39) missense probably damaging 1.00
R0966:Slco1a7 UTSW 6 141,673,299 (GRCm39) missense probably benign 0.00
R1082:Slco1a7 UTSW 6 141,657,859 (GRCm39) missense probably damaging 1.00
R1433:Slco1a7 UTSW 6 141,711,429 (GRCm39) missense probably benign 0.00
R1571:Slco1a7 UTSW 6 141,700,135 (GRCm39) nonsense probably null
R1765:Slco1a7 UTSW 6 141,700,084 (GRCm39) splice site probably benign
R2055:Slco1a7 UTSW 6 141,671,181 (GRCm39) missense probably benign 0.33
R2174:Slco1a7 UTSW 6 141,673,319 (GRCm39) nonsense probably null
R2495:Slco1a7 UTSW 6 141,711,503 (GRCm39) missense probably benign 0.02
R2857:Slco1a7 UTSW 6 141,690,264 (GRCm39) missense probably benign 0.35
R3824:Slco1a7 UTSW 6 141,700,100 (GRCm39) missense possibly damaging 0.50
R3912:Slco1a7 UTSW 6 141,673,362 (GRCm39) missense probably damaging 0.97
R3942:Slco1a7 UTSW 6 141,673,440 (GRCm39) missense probably damaging 0.98
R4161:Slco1a7 UTSW 6 141,654,322 (GRCm39) missense probably benign 0.20
R4168:Slco1a7 UTSW 6 141,684,673 (GRCm39) missense probably benign 0.03
R4395:Slco1a7 UTSW 6 141,657,844 (GRCm39) missense probably benign 0.02
R4720:Slco1a7 UTSW 6 141,668,948 (GRCm39) missense probably damaging 1.00
R4732:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4733:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4794:Slco1a7 UTSW 6 141,713,288 (GRCm39) missense probably benign 0.11
R5062:Slco1a7 UTSW 6 141,713,180 (GRCm39) missense possibly damaging 0.46
R5389:Slco1a7 UTSW 6 141,686,193 (GRCm39) missense probably benign 0.12
R5419:Slco1a7 UTSW 6 141,681,826 (GRCm39) splice site probably null
R5423:Slco1a7 UTSW 6 141,690,188 (GRCm39) missense probably damaging 1.00
R5704:Slco1a7 UTSW 6 141,658,980 (GRCm39) missense probably benign 0.00
R5973:Slco1a7 UTSW 6 141,700,182 (GRCm39) missense probably benign 0.01
R6041:Slco1a7 UTSW 6 141,684,764 (GRCm39) missense probably benign 0.11
R6284:Slco1a7 UTSW 6 141,671,119 (GRCm39) missense probably damaging 1.00
R6395:Slco1a7 UTSW 6 141,668,818 (GRCm39) splice site probably null
R6993:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R7149:Slco1a7 UTSW 6 141,690,178 (GRCm39) missense probably damaging 1.00
R7159:Slco1a7 UTSW 6 141,719,504 (GRCm39) start codon destroyed probably damaging 1.00
R7627:Slco1a7 UTSW 6 141,690,271 (GRCm39) missense probably damaging 1.00
R7784:Slco1a7 UTSW 6 141,658,919 (GRCm39) critical splice donor site probably null
R7873:Slco1a7 UTSW 6 141,673,448 (GRCm39) missense probably benign 0.44
R8670:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R8720:Slco1a7 UTSW 6 141,668,852 (GRCm39) missense probably benign 0.01
R9124:Slco1a7 UTSW 6 141,668,830 (GRCm39) missense possibly damaging 0.81
R9238:Slco1a7 UTSW 6 141,686,153 (GRCm39) missense probably damaging 0.98
R9381:Slco1a7 UTSW 6 141,711,490 (GRCm39) missense probably benign 0.00
X0020:Slco1a7 UTSW 6 141,700,091 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTTTCCATACAAGTCTTCCCTGGG -3'
(R):5'- AGCTTTCGCTGAACACATTAAG -3'

Sequencing Primer
(F):5'- GTCTTCCCTGGGAAAAATCTTAAGC -3'
(R):5'- AGATTTAATGCTGATGAGTTCTGTTC -3'
Posted On 2015-02-19