Incidental Mutation 'R3620:Gcg'
ID 268580
Institutional Source Beutler Lab
Gene Symbol Gcg
Ensembl Gene ENSMUSG00000000394
Gene Name glucagon
Synonyms Glu, GLP-1, glucagon-like peptide I, PPG
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R3620 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 62304874-62313994 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62307279 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 94 (E94G)
Ref Sequence ENSEMBL: ENSMUSP00000115892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102733] [ENSMUST00000136686]
AlphaFold P55095
Predicted Effect possibly damaging
Transcript: ENSMUST00000102733
AA Change: E94G

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000099794
Gene: ENSMUSG00000000394
AA Change: E94G

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
GLUCA 53 79 7.5e-15 SMART
GLUCA 98 124 4.06e-11 SMART
GLUCA 146 172 1.97e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000136686
AA Change: E94G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000115892
Gene: ENSMUSG00000000394
AA Change: E94G

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
GLUCA 53 79 7.5e-15 SMART
GLUCA 98 124 4.06e-11 SMART
GLUCA 146 172 1.97e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155624
Meta Mutation Damage Score 0.0955 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit islet alpha cell hyperplasia and increased body weight. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 9,226,864 (GRCm39) M473T probably benign Het
Asxl1 C A 2: 153,199,075 (GRCm39) R76S probably damaging Het
Bhlhe41 C A 6: 145,808,733 (GRCm39) G360C possibly damaging Het
Ccdc88a T C 11: 29,380,227 (GRCm39) I201T probably benign Het
Ccng1 T C 11: 40,642,992 (GRCm39) T152A probably benign Het
Cep192 T C 18: 67,962,928 (GRCm39) V648A probably benign Het
Cldn16 T A 16: 26,296,302 (GRCm39) F93I possibly damaging Het
Csmd1 T C 8: 16,042,684 (GRCm39) S2350G probably benign Het
Enpp6 T C 8: 47,518,540 (GRCm39) W223R probably benign Het
Fah T C 7: 84,238,159 (GRCm39) probably null Het
Fat2 A T 11: 55,147,521 (GRCm39) V3907D probably damaging Het
Fsip2 C A 2: 82,810,602 (GRCm39) T2307K probably benign Het
Gramd1b C A 9: 40,366,842 (GRCm39) R42L probably benign Het
H2bc9 C A 13: 23,727,324 (GRCm39) V67L probably benign Het
Hdc T A 2: 126,458,187 (GRCm39) Y45F possibly damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igsf10 T G 3: 59,243,752 (GRCm39) D194A probably damaging Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Lrpprc A T 17: 85,077,452 (GRCm39) C412S probably benign Het
Mga T A 2: 119,747,149 (GRCm39) D433E probably damaging Het
Myo15a A T 11: 60,369,468 (GRCm39) S743C possibly damaging Het
Myo15b T G 11: 115,762,013 (GRCm39) L1176R possibly damaging Het
Ndor1 T C 2: 25,138,047 (GRCm39) Q526R probably damaging Het
Nipbl A G 15: 8,362,508 (GRCm39) I1429T probably damaging Het
Or1d2 T A 11: 74,256,050 (GRCm39) L185Q probably damaging Het
Or4c126 T C 2: 89,824,196 (GRCm39) I153T probably damaging Het
Or4k38 T A 2: 111,165,689 (GRCm39) I245L probably benign Het
Otogl T C 10: 107,710,232 (GRCm39) D619G probably damaging Het
Pa2g4 C G 10: 128,399,464 (GRCm39) E67Q probably damaging Het
Pnpla1 C T 17: 29,096,362 (GRCm39) A147V probably damaging Het
Prdm13 A G 4: 21,683,532 (GRCm39) Y143H unknown Het
Rad23a A G 8: 85,567,193 (GRCm39) M1T probably null Het
Rpl31-ps17 C T 12: 54,748,397 (GRCm39) noncoding transcript Het
Slc10a2 A T 8: 5,154,909 (GRCm39) I92N probably damaging Het
Slc24a4 T C 12: 102,185,222 (GRCm39) F111L probably damaging Het
Sox11 T C 12: 27,391,735 (GRCm39) T225A probably benign Het
Thbs1 T C 2: 117,951,640 (GRCm39) V820A probably benign Het
Unc45a G T 7: 79,983,799 (GRCm39) N332K possibly damaging Het
Vmn1r159 A C 7: 22,542,258 (GRCm39) I258S possibly damaging Het
Wdr31 A T 4: 62,375,701 (GRCm39) F251L possibly damaging Het
Wdr43 C T 17: 71,957,601 (GRCm39) T530M probably benign Het
Zfp445 C T 9: 122,681,833 (GRCm39) A703T probably benign Het
Other mutations in Gcg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Gcg APN 2 62,310,827 (GRCm39) missense possibly damaging 0.86
IGL02582:Gcg APN 2 62,308,922 (GRCm39) nonsense probably null
R0466:Gcg UTSW 2 62,307,282 (GRCm39) missense probably damaging 0.99
R3621:Gcg UTSW 2 62,307,279 (GRCm39) missense probably damaging 0.96
R4744:Gcg UTSW 2 62,308,975 (GRCm39) missense probably damaging 1.00
R4859:Gcg UTSW 2 62,307,189 (GRCm39) missense probably damaging 0.96
R5807:Gcg UTSW 2 62,306,069 (GRCm39) missense possibly damaging 0.54
R5971:Gcg UTSW 2 62,306,148 (GRCm39) missense probably damaging 1.00
R6138:Gcg UTSW 2 62,306,148 (GRCm39) missense probably damaging 1.00
R7191:Gcg UTSW 2 62,307,183 (GRCm39) missense probably damaging 1.00
R7522:Gcg UTSW 2 62,306,103 (GRCm39) missense probably benign 0.32
R8188:Gcg UTSW 2 62,309,004 (GRCm39) missense probably damaging 0.96
R8746:Gcg UTSW 2 62,305,325 (GRCm39) missense probably damaging 1.00
R9261:Gcg UTSW 2 62,306,408 (GRCm39) intron probably benign
R9273:Gcg UTSW 2 62,306,133 (GRCm39) missense probably null 0.44
U15987:Gcg UTSW 2 62,306,148 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAACATTGTGTGGCTAGCTC -3'
(R):5'- TTTCCCCACAAAGTTTCAATCCAG -3'

Sequencing Primer
(F):5'- CGGTACAGTTTTTCCCATCGGATAG -3'
(R):5'- TCAATCCAGATCATTAACAGAACTTC -3'
Posted On 2015-02-19