Incidental Mutation 'R3623:Strn3'
ID 268746
Institutional Source Beutler Lab
Gene Symbol Strn3
Ensembl Gene ENSMUSG00000020954
Gene Name striatin, calmodulin binding protein 3
Synonyms SG2NA
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3623 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 51656415-51738680 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 51707999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 132 (Y132C)
Ref Sequence ENSEMBL: ENSMUSP00000130184 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013130] [ENSMUST00000169503]
AlphaFold Q9ERG2
Predicted Effect probably benign
Transcript: ENSMUST00000013130
AA Change: Y132C

PolyPhen 2 Score 0.305 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000013130
Gene: ENSMUSG00000020954
AA Change: Y132C

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
low complexity region 31 55 N/A INTRINSIC
Pfam:Striatin 64 194 1.3e-50 PFAM
low complexity region 252 263 N/A INTRINSIC
low complexity region 349 367 N/A INTRINSIC
low complexity region 429 446 N/A INTRINSIC
WD40 468 507 7.05e-9 SMART
WD40 521 560 2.42e-7 SMART
WD40 574 613 1.62e-8 SMART
WD40 617 659 8.25e0 SMART
WD40 670 708 2.65e1 SMART
WD40 711 750 2.32e-9 SMART
WD40 753 796 4.95e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000169503
AA Change: Y132C

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000130184
Gene: ENSMUSG00000020954
AA Change: Y132C

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
low complexity region 31 55 N/A INTRINSIC
Pfam:Striatin 64 198 3.2e-51 PFAM
low complexity region 252 263 N/A INTRINSIC
low complexity region 345 362 N/A INTRINSIC
WD40 384 423 7.05e-9 SMART
WD40 437 476 2.42e-7 SMART
WD40 490 529 1.62e-8 SMART
WD40 533 575 8.25e0 SMART
WD40 586 624 2.65e1 SMART
WD40 627 666 2.32e-9 SMART
WD40 669 712 4.95e-4 SMART
Meta Mutation Damage Score 0.8418 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (69/69)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 A G 11: 7,080,348 (GRCm39) T364A probably benign Het
Adpgk G A 9: 59,221,036 (GRCm39) V281I probably benign Het
Akap9 C A 5: 4,026,235 (GRCm39) Q1297K possibly damaging Het
Ankrd13d T C 19: 4,331,968 (GRCm39) E110G probably damaging Het
Ankrd53 A G 6: 83,740,244 (GRCm39) E104G possibly damaging Het
Becn2 T C 1: 175,748,197 (GRCm39) C88R possibly damaging Het
Bscl2 T A 19: 8,818,514 (GRCm39) C40S probably benign Het
Btaf1 A G 19: 36,958,486 (GRCm39) T668A probably benign Het
Camk2g G A 14: 20,805,775 (GRCm39) probably benign Het
Cd109 A T 9: 78,574,639 (GRCm39) D541V probably damaging Het
Cep135 G A 5: 76,772,586 (GRCm39) G657D probably benign Het
Coch A G 12: 51,649,609 (GRCm39) I307V probably benign Het
D17H6S53E A G 17: 35,346,512 (GRCm39) E141G probably benign Het
Ddias T C 7: 92,508,800 (GRCm39) T372A probably benign Het
Dffb T C 4: 154,049,976 (GRCm39) T296A probably damaging Het
Dock8 A G 19: 25,057,241 (GRCm39) Q216R probably benign Het
Ep400 T C 5: 110,867,102 (GRCm39) Y1014C unknown Het
Ephx1 A G 1: 180,817,498 (GRCm39) I391T probably benign Het
Fcgbp A G 7: 27,800,701 (GRCm39) Y1249C probably damaging Het
Gm5592 T C 7: 40,807,052 (GRCm39) probably benign Het
Gm7964 A G 7: 83,405,629 (GRCm39) N149S probably benign Het
Greb1l T A 18: 10,542,380 (GRCm39) I1325N probably damaging Het
H2-T3 T C 17: 36,500,957 (GRCm39) T20A possibly damaging Het
Htr1d T C 4: 136,170,815 (GRCm39) I348T probably damaging Het
Hyal4 A T 6: 24,765,737 (GRCm39) S364C probably damaging Het
Igkv1-133 A T 6: 67,701,944 (GRCm39) Q16L probably benign Het
Irs2 C T 8: 11,057,643 (GRCm39) G263D probably damaging Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Kmt2a A G 9: 44,760,263 (GRCm39) Y529H probably damaging Het
Mdfic T A 6: 15,770,319 (GRCm39) N108K probably damaging Het
Met A T 6: 17,549,085 (GRCm39) D979V probably damaging Het
Mettl21e T A 1: 44,245,857 (GRCm39) I130F probably damaging Het
Mlh3 C T 12: 85,315,169 (GRCm39) C339Y probably damaging Het
Mog T C 17: 37,323,338 (GRCm39) H200R possibly damaging Het
Msrb3 C T 10: 120,620,103 (GRCm39) R72H probably damaging Het
Mtmr11 A G 3: 96,072,583 (GRCm39) H324R probably damaging Het
Myh7 T C 14: 55,210,838 (GRCm39) E1693G probably damaging Het
Nadk2 T A 15: 9,084,303 (GRCm39) W139R probably damaging Het
Ndufa9 A T 6: 126,821,362 (GRCm39) M76K possibly damaging Het
Nr1i2 A G 16: 38,086,269 (GRCm39) probably benign Het
Nsd3 A G 8: 26,152,835 (GRCm39) T392A probably damaging Het
Or14a259 A G 7: 86,013,308 (GRCm39) F79S probably benign Het
Or52d3 T C 7: 104,229,149 (GRCm39) S99P probably damaging Het
P2ry2 A T 7: 100,647,706 (GRCm39) S200T probably benign Het
Pcnt T A 10: 76,269,584 (GRCm39) E228V probably benign Het
Phka2 T A X: 159,327,291 (GRCm39) Y334* probably null Het
Pkhd1l1 A T 15: 44,390,265 (GRCm39) K1460N probably damaging Het
Rpl7a-ps3 G A 15: 36,308,429 (GRCm39) noncoding transcript Het
Rspry1 A G 8: 95,376,405 (GRCm39) D309G probably damaging Het
Scap A G 9: 110,209,271 (GRCm39) Y648C probably damaging Het
Sgcz T C 8: 38,420,201 (GRCm39) E17G probably damaging Het
Slc17a5 A T 9: 78,445,556 (GRCm39) V433D probably damaging Het
Smad9 C T 3: 54,696,705 (GRCm39) R257W probably damaging Het
Srcap T C 7: 127,141,319 (GRCm39) S1639P probably damaging Het
Tas2r110 A T 6: 132,845,433 (GRCm39) M155L probably benign Het
Tasor2 T C 13: 3,645,556 (GRCm39) T98A probably benign Het
Thbd A G 2: 148,248,893 (GRCm39) V325A probably damaging Het
Trpd52l3 T A 19: 29,981,333 (GRCm39) C29* probably null Het
Trpm1 A G 7: 63,894,601 (GRCm39) Y951C probably damaging Het
Ube3a T A 7: 58,921,860 (GRCm39) N77K probably damaging Het
Upp2 G A 2: 58,680,128 (GRCm39) R300Q possibly damaging Het
Usp35 T C 7: 96,961,827 (GRCm39) H533R probably damaging Het
Veph1 C T 3: 66,122,858 (GRCm39) V224I probably benign Het
Vmn1r30 A T 6: 58,412,437 (GRCm39) F132I probably benign Het
Vmn2r24 A G 6: 123,792,997 (GRCm39) R775G probably damaging Het
Vps13c T A 9: 67,883,189 (GRCm39) probably null Het
Vps37c T A 19: 10,683,569 (GRCm39) probably null Het
Zap70 C T 1: 36,818,216 (GRCm39) T301I probably benign Het
Zfp341 A G 2: 154,466,801 (GRCm39) K57E probably damaging Het
Zfp60 T A 7: 27,448,753 (GRCm39) F474I probably benign Het
Zfp786 T C 6: 47,798,357 (GRCm39) N194D probably benign Het
Other mutations in Strn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Strn3 APN 12 51,707,979 (GRCm39) missense possibly damaging 0.63
IGL00690:Strn3 APN 12 51,657,221 (GRCm39) missense possibly damaging 0.96
IGL00886:Strn3 APN 12 51,656,933 (GRCm39) missense probably damaging 1.00
IGL01967:Strn3 APN 12 51,699,596 (GRCm39) missense probably damaging 1.00
IGL02507:Strn3 APN 12 51,708,410 (GRCm39) nonsense probably null
IGL03139:Strn3 APN 12 51,699,633 (GRCm39) splice site probably benign
IGL03282:Strn3 APN 12 51,673,992 (GRCm39) missense probably benign 0.00
PIT4519001:Strn3 UTSW 12 51,680,491 (GRCm39) missense probably benign 0.00
R0106:Strn3 UTSW 12 51,668,571 (GRCm39) missense probably benign 0.01
R0106:Strn3 UTSW 12 51,668,571 (GRCm39) missense probably benign 0.01
R0336:Strn3 UTSW 12 51,708,391 (GRCm39) critical splice donor site probably null
R0492:Strn3 UTSW 12 51,657,187 (GRCm39) missense probably damaging 1.00
R0512:Strn3 UTSW 12 51,673,966 (GRCm39) missense possibly damaging 0.94
R0610:Strn3 UTSW 12 51,657,231 (GRCm39) critical splice acceptor site probably null
R0707:Strn3 UTSW 12 51,657,187 (GRCm39) missense probably damaging 1.00
R0834:Strn3 UTSW 12 51,673,879 (GRCm39) splice site probably benign
R1562:Strn3 UTSW 12 51,680,401 (GRCm39) missense probably benign
R1599:Strn3 UTSW 12 51,699,549 (GRCm39) missense possibly damaging 0.78
R1663:Strn3 UTSW 12 51,699,609 (GRCm39) missense probably damaging 1.00
R1807:Strn3 UTSW 12 51,673,986 (GRCm39) missense probably benign 0.10
R2263:Strn3 UTSW 12 51,690,006 (GRCm39) splice site probably null
R2443:Strn3 UTSW 12 51,674,618 (GRCm39) missense probably damaging 1.00
R3624:Strn3 UTSW 12 51,707,999 (GRCm39) missense possibly damaging 0.87
R4154:Strn3 UTSW 12 51,673,914 (GRCm39) missense probably damaging 1.00
R4223:Strn3 UTSW 12 51,674,638 (GRCm39) missense probably damaging 1.00
R4400:Strn3 UTSW 12 51,694,883 (GRCm39) missense possibly damaging 0.85
R4564:Strn3 UTSW 12 51,680,404 (GRCm39) missense probably benign 0.00
R4585:Strn3 UTSW 12 51,696,953 (GRCm39) missense probably benign 0.02
R4755:Strn3 UTSW 12 51,656,999 (GRCm39) missense possibly damaging 0.70
R4794:Strn3 UTSW 12 51,696,954 (GRCm39) missense probably benign 0.38
R5288:Strn3 UTSW 12 51,694,803 (GRCm39) missense probably damaging 1.00
R5308:Strn3 UTSW 12 51,676,168 (GRCm39) missense probably damaging 0.99
R5765:Strn3 UTSW 12 51,680,410 (GRCm39) missense probably benign
R5893:Strn3 UTSW 12 51,690,006 (GRCm39) splice site probably null
R5945:Strn3 UTSW 12 51,676,279 (GRCm39) missense probably benign 0.00
R6244:Strn3 UTSW 12 51,656,890 (GRCm39) missense probably damaging 0.98
R6523:Strn3 UTSW 12 51,689,881 (GRCm39) splice site probably null
R7437:Strn3 UTSW 12 51,656,946 (GRCm39) missense probably damaging 1.00
R7545:Strn3 UTSW 12 51,674,543 (GRCm39) missense probably damaging 0.98
R8299:Strn3 UTSW 12 51,694,890 (GRCm39) missense probably damaging 1.00
R8337:Strn3 UTSW 12 51,707,955 (GRCm39) missense probably damaging 1.00
R9141:Strn3 UTSW 12 51,694,873 (GRCm39) missense probably damaging 1.00
R9426:Strn3 UTSW 12 51,694,873 (GRCm39) missense probably damaging 1.00
R9501:Strn3 UTSW 12 51,696,956 (GRCm39) missense probably damaging 0.99
R9503:Strn3 UTSW 12 51,656,894 (GRCm39) missense possibly damaging 0.68
R9518:Strn3 UTSW 12 51,696,956 (GRCm39) missense probably damaging 0.99
R9563:Strn3 UTSW 12 51,674,300 (GRCm39) missense possibly damaging 0.92
R9630:Strn3 UTSW 12 51,657,013 (GRCm39) missense probably damaging 1.00
R9696:Strn3 UTSW 12 51,676,286 (GRCm39) missense probably damaging 1.00
X0024:Strn3 UTSW 12 51,699,492 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGAGAGGCAGATGAAACAAATTTT -3'
(R):5'- CATACCTGTATTTGTTACTTGGGTAA -3'

Sequencing Primer
(F):5'- TTCCCAGAATCGACATTGGG -3'
(R):5'- CACATTGCTTTGTTATTGGAG -3'
Posted On 2015-02-19