Incidental Mutation 'R3692:Zswim6'
ID |
268833 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zswim6
|
Ensembl Gene |
ENSMUSG00000032846 |
Gene Name |
zinc finger SWIM-type containing 6 |
Synonyms |
2900036G02Rik |
MMRRC Submission |
040687-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.436)
|
Stock # |
R3692 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
107861152-108026598 bp(-) (GRCm39) |
Type of Mutation |
exon |
DNA Base Change (assembly) |
A to G
at 107863076 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
|
AlphaFold |
no structure available at present |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000105097
|
SMART Domains |
Protein: ENSMUSP00000100724 Gene: ENSMUSG00000032846
Domain | Start | End | E-Value | Type |
low complexity region
|
19 |
39 |
N/A |
INTRINSIC |
low complexity region
|
43 |
71 |
N/A |
INTRINSIC |
low complexity region
|
132 |
193 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224719
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225197
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225822
|
Meta Mutation Damage Score |
0.1564 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
Validation Efficiency |
98% (42/43) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam1a |
T |
C |
5: 121,657,385 (GRCm39) |
D636G |
probably damaging |
Het |
Adgrv1 |
A |
G |
13: 81,672,719 (GRCm39) |
V2218A |
possibly damaging |
Het |
Ano5 |
T |
A |
7: 51,240,327 (GRCm39) |
Y752N |
probably damaging |
Het |
Bltp2 |
A |
G |
11: 78,160,335 (GRCm39) |
D598G |
probably damaging |
Het |
Calca |
T |
C |
7: 114,233,796 (GRCm39) |
E45G |
probably damaging |
Het |
Cdk8 |
C |
T |
5: 146,220,478 (GRCm39) |
R166* |
probably null |
Het |
Chsy1 |
T |
A |
7: 65,821,001 (GRCm39) |
M412K |
probably damaging |
Het |
Cic |
T |
A |
7: 24,988,338 (GRCm39) |
Y1675* |
probably null |
Het |
Col1a2 |
T |
A |
6: 4,510,710 (GRCm39) |
D53E |
possibly damaging |
Het |
Dennd6b |
A |
G |
15: 89,071,030 (GRCm39) |
|
probably benign |
Het |
Fut10 |
T |
A |
8: 31,726,048 (GRCm39) |
Y268N |
possibly damaging |
Het |
Glrx3 |
T |
C |
7: 137,060,846 (GRCm39) |
|
probably benign |
Het |
Gucy1b2 |
T |
A |
14: 62,642,076 (GRCm39) |
N697I |
probably damaging |
Het |
Ifi208 |
T |
C |
1: 173,510,438 (GRCm39) |
S198P |
possibly damaging |
Het |
Krt34 |
A |
G |
11: 99,929,857 (GRCm39) |
V213A |
probably damaging |
Het |
Lats2 |
T |
C |
14: 57,928,998 (GRCm39) |
N959S |
probably damaging |
Het |
Mat1a |
A |
G |
14: 40,843,338 (GRCm39) |
Y288C |
probably damaging |
Het |
Mtif2 |
A |
T |
11: 29,490,718 (GRCm39) |
H474L |
probably benign |
Het |
Myh8 |
A |
G |
11: 67,192,744 (GRCm39) |
I1512V |
probably damaging |
Het |
Nkx2-6 |
T |
C |
14: 69,409,476 (GRCm39) |
S76P |
probably benign |
Het |
Noxred1 |
G |
A |
12: 87,280,240 (GRCm39) |
R31W |
probably benign |
Het |
Or14c46 |
T |
A |
7: 85,918,703 (GRCm39) |
Q98L |
probably damaging |
Het |
Or4a69 |
T |
A |
2: 89,313,240 (GRCm39) |
M80L |
probably benign |
Het |
Pcdhb16 |
C |
A |
18: 37,611,340 (GRCm39) |
T100K |
probably benign |
Het |
Pcdhga10 |
T |
C |
18: 37,881,384 (GRCm39) |
C382R |
probably damaging |
Het |
Pdgfra |
A |
T |
5: 75,349,948 (GRCm39) |
Y944F |
possibly damaging |
Het |
Pkhd1 |
A |
G |
1: 20,625,353 (GRCm39) |
I741T |
possibly damaging |
Het |
Ppp1r10 |
A |
G |
17: 36,241,760 (GRCm39) |
D845G |
unknown |
Het |
Rfk |
C |
A |
19: 17,376,834 (GRCm39) |
|
probably null |
Het |
Rgs11 |
C |
T |
17: 26,423,302 (GRCm39) |
|
probably benign |
Het |
Spata31d1b |
T |
C |
13: 59,865,705 (GRCm39) |
V951A |
probably benign |
Het |
St3gal5 |
T |
C |
6: 72,126,013 (GRCm39) |
V286A |
probably benign |
Het |
St7l |
T |
C |
3: 104,798,870 (GRCm39) |
M320T |
probably benign |
Het |
Tnfrsf1b |
G |
T |
4: 144,954,092 (GRCm39) |
Q86K |
probably benign |
Het |
Tox |
T |
C |
4: 6,697,535 (GRCm39) |
I423V |
probably benign |
Het |
Tpbpa |
T |
A |
13: 61,087,827 (GRCm39) |
H88L |
probably benign |
Het |
Vmn1r236 |
A |
G |
17: 21,507,068 (GRCm39) |
Y62C |
probably benign |
Het |
Ythdc1 |
A |
G |
5: 86,970,526 (GRCm39) |
I399M |
probably damaging |
Het |
Zfp948 |
T |
G |
17: 21,807,838 (GRCm39) |
D343E |
probably benign |
Het |
|
Other mutations in Zswim6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01670:Zswim6
|
APN |
13 |
107,865,101 (GRCm39) |
splice site |
noncoding transcript |
|
IGL02367:Zswim6
|
APN |
13 |
107,880,637 (GRCm39) |
exon |
noncoding transcript |
|
IGL02622:Zswim6
|
APN |
13 |
107,884,786 (GRCm39) |
exon |
noncoding transcript |
|
IGL03000:Zswim6
|
APN |
13 |
107,863,650 (GRCm39) |
exon |
noncoding transcript |
|
IGL03000:Zswim6
|
APN |
13 |
107,863,649 (GRCm39) |
exon |
noncoding transcript |
|
R0069:Zswim6
|
UTSW |
13 |
107,875,098 (GRCm39) |
exon |
noncoding transcript |
|
R0069:Zswim6
|
UTSW |
13 |
107,875,098 (GRCm39) |
exon |
noncoding transcript |
|
R0834:Zswim6
|
UTSW |
13 |
107,862,989 (GRCm39) |
exon |
noncoding transcript |
|
R1080:Zswim6
|
UTSW |
13 |
107,924,186 (GRCm39) |
critical splice donor site |
noncoding transcript |
|
R1542:Zswim6
|
UTSW |
13 |
107,863,769 (GRCm39) |
exon |
noncoding transcript |
|
R2081:Zswim6
|
UTSW |
13 |
107,909,930 (GRCm39) |
exon |
noncoding transcript |
|
R2133:Zswim6
|
UTSW |
13 |
107,880,522 (GRCm39) |
exon |
noncoding transcript |
|
R4323:Zswim6
|
UTSW |
13 |
108,025,938 (GRCm39) |
exon |
noncoding transcript |
|
R4345:Zswim6
|
UTSW |
13 |
107,863,466 (GRCm39) |
exon |
noncoding transcript |
|
R4369:Zswim6
|
UTSW |
13 |
107,863,229 (GRCm39) |
exon |
noncoding transcript |
|
R5049:Zswim6
|
UTSW |
13 |
107,863,110 (GRCm39) |
exon |
noncoding transcript |
|
R5111:Zswim6
|
UTSW |
13 |
107,865,170 (GRCm39) |
exon |
noncoding transcript |
|
R5174:Zswim6
|
UTSW |
13 |
107,863,216 (GRCm39) |
exon |
noncoding transcript |
|
R5531:Zswim6
|
UTSW |
13 |
107,906,128 (GRCm39) |
exon |
noncoding transcript |
|
R5933:Zswim6
|
UTSW |
13 |
107,880,642 (GRCm39) |
exon |
noncoding transcript |
|
R5934:Zswim6
|
UTSW |
13 |
107,880,642 (GRCm39) |
exon |
noncoding transcript |
|
R6063:Zswim6
|
UTSW |
13 |
107,865,112 (GRCm39) |
exon |
noncoding transcript |
|
R6168:Zswim6
|
UTSW |
13 |
107,924,299 (GRCm39) |
exon |
noncoding transcript |
|
X0022:Zswim6
|
UTSW |
13 |
107,866,859 (GRCm39) |
exon |
noncoding transcript |
|
|
Predicted Primers |
PCR Primer
(F):5'- TAATACCGGTGTGGCTCTGTTC -3'
(R):5'- CATGGTGGGACTTCATGGAAGG -3'
Sequencing Primer
(F):5'- GGCTCTGTTCTTTAAGTTAAAAAGGG -3'
(R):5'- TGGGACTTCATGGAAGGAGGAAC -3'
|
Posted On |
2015-02-19 |