Incidental Mutation 'R3684:Lrrn1'
ID 269464
Institutional Source Beutler Lab
Gene Symbol Lrrn1
Ensembl Gene ENSMUSG00000034648
Gene Name leucine rich repeat protein 1, neuronal
Synonyms 2810047E21Rik, NLRR-1
MMRRC Submission 040682-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.339) question?
Stock # R3684 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 107506729-107547175 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107544910 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 236 (V236A)
Ref Sequence ENSEMBL: ENSMUSP00000037096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049285]
AlphaFold Q61809
Predicted Effect probably benign
Transcript: ENSMUST00000049285
AA Change: V236A

PolyPhen 2 Score 0.133 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000037096
Gene: ENSMUSG00000034648
AA Change: V236A

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 31 76 2.89e-1 SMART
LRR 94 117 1.06e1 SMART
LRR 118 141 1.89e-1 SMART
LRR_TYP 142 165 4.3e-5 SMART
LRR 166 189 1.76e-1 SMART
LRR 214 237 4.09e1 SMART
LRR 238 261 1.53e1 SMART
LRR 262 285 2.63e0 SMART
LRR 311 335 1.45e2 SMART
LRR 336 359 4.21e1 SMART
LRRCT 371 423 2.14e-10 SMART
IGc2 438 506 6.34e-15 SMART
FN3 523 605 8.71e-2 SMART
transmembrane domain 631 653 N/A INTRINSIC
low complexity region 690 701 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibited decreased exploratory activity and the female mutants exhibited an increased anxiety-like response during open field testing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 C T 14: 68,819,447 (GRCm39) V17I probably benign Het
Ahdc1 T C 4: 132,793,013 (GRCm39) L1418P possibly damaging Het
Atr T C 9: 95,802,453 (GRCm39) S1782P probably damaging Het
Btbd9 T A 17: 30,553,281 (GRCm39) N394Y probably damaging Het
Calb2 A G 8: 110,883,620 (GRCm39) Y35H probably benign Het
Cdon A G 9: 35,400,328 (GRCm39) E1014G possibly damaging Het
Cep83 A G 10: 94,622,687 (GRCm39) T588A probably benign Het
Cfap126 T C 1: 170,941,600 (GRCm39) S32P possibly damaging Het
Clcn7 T C 17: 25,369,567 (GRCm39) L301P possibly damaging Het
Corin T C 5: 72,488,198 (GRCm39) D610G probably damaging Het
Dok3 A G 13: 55,672,306 (GRCm39) S154P probably damaging Het
Ggta1 T A 2: 35,298,000 (GRCm39) T162S probably benign Het
Gldn G A 9: 54,245,624 (GRCm39) E392K possibly damaging Het
Gls A T 1: 52,205,452 (GRCm39) D447E probably damaging Het
Itih5 A T 2: 10,243,435 (GRCm39) N391Y possibly damaging Het
Jchain G A 5: 88,670,398 (GRCm39) P74S probably damaging Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Mcm3ap T C 10: 76,325,260 (GRCm39) S954P possibly damaging Het
Myh11 T C 16: 14,021,098 (GRCm39) N1725S probably benign Het
Ppcdc C T 9: 57,328,408 (GRCm39) probably null Het
Rhobtb3 A G 13: 76,087,600 (GRCm39) I129T probably damaging Het
Sfxn2 A G 19: 46,579,592 (GRCm39) R252G probably benign Het
Sh2d2a C A 3: 87,759,027 (GRCm39) probably null Het
Sh3gl1 T C 17: 56,325,953 (GRCm39) K159E possibly damaging Het
Slc7a9 A G 7: 35,152,926 (GRCm39) T115A probably benign Het
Spmap1 A T 11: 97,666,525 (GRCm39) Y54N probably damaging Het
Synj2 A T 17: 6,078,718 (GRCm39) D1020V probably damaging Het
Tenm2 C A 11: 35,942,644 (GRCm39) V1342L probably benign Het
Tmem127 T A 2: 127,090,652 (GRCm39) I56N possibly damaging Het
Traj7 A G 14: 54,448,938 (GRCm39) probably benign Het
Unc5d A G 8: 29,184,620 (GRCm39) F627L probably damaging Het
Unc79 T A 12: 103,041,062 (GRCm39) N698K probably benign Het
Usp17la A T 7: 104,510,937 (GRCm39) N514I possibly damaging Het
Uvrag A T 7: 98,637,427 (GRCm39) C341S probably damaging Het
Zfp810 T C 9: 22,189,531 (GRCm39) D459G probably benign Het
Other mutations in Lrrn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Lrrn1 APN 6 107,545,269 (GRCm39) missense probably benign 0.06
IGL00949:Lrrn1 APN 6 107,546,261 (GRCm39) missense probably benign 0.15
IGL01594:Lrrn1 APN 6 107,544,454 (GRCm39) missense probably damaging 0.99
IGL02814:Lrrn1 APN 6 107,544,313 (GRCm39) missense probably damaging 1.00
IGL02824:Lrrn1 APN 6 107,545,495 (GRCm39) missense possibly damaging 0.57
IGL02931:Lrrn1 APN 6 107,544,709 (GRCm39) missense probably damaging 1.00
R0399:Lrrn1 UTSW 6 107,546,081 (GRCm39) missense probably benign
R1109:Lrrn1 UTSW 6 107,544,225 (GRCm39) missense probably benign
R1620:Lrrn1 UTSW 6 107,545,327 (GRCm39) missense probably damaging 1.00
R1826:Lrrn1 UTSW 6 107,544,529 (GRCm39) missense probably benign 0.05
R1893:Lrrn1 UTSW 6 107,545,083 (GRCm39) missense possibly damaging 0.82
R2327:Lrrn1 UTSW 6 107,545,794 (GRCm39) missense probably benign 0.05
R3757:Lrrn1 UTSW 6 107,546,169 (GRCm39) missense possibly damaging 0.81
R4538:Lrrn1 UTSW 6 107,545,598 (GRCm39) missense probably benign 0.21
R4922:Lrrn1 UTSW 6 107,545,311 (GRCm39) missense probably damaging 1.00
R4946:Lrrn1 UTSW 6 107,545,851 (GRCm39) missense probably benign 0.16
R4970:Lrrn1 UTSW 6 107,546,305 (GRCm39) missense probably benign 0.06
R4977:Lrrn1 UTSW 6 107,545,668 (GRCm39) missense probably benign
R5121:Lrrn1 UTSW 6 107,546,168 (GRCm39) missense possibly damaging 0.89
R5186:Lrrn1 UTSW 6 107,546,185 (GRCm39) missense probably damaging 1.00
R5625:Lrrn1 UTSW 6 107,544,315 (GRCm39) missense probably damaging 0.99
R5736:Lrrn1 UTSW 6 107,544,345 (GRCm39) missense probably damaging 1.00
R5873:Lrrn1 UTSW 6 107,545,936 (GRCm39) missense probably damaging 0.98
R5949:Lrrn1 UTSW 6 107,544,465 (GRCm39) missense probably benign 0.00
R6046:Lrrn1 UTSW 6 107,545,488 (GRCm39) missense probably benign 0.00
R6370:Lrrn1 UTSW 6 107,546,185 (GRCm39) missense probably damaging 1.00
R7138:Lrrn1 UTSW 6 107,545,336 (GRCm39) missense probably damaging 1.00
R7169:Lrrn1 UTSW 6 107,544,565 (GRCm39) missense probably damaging 1.00
R7413:Lrrn1 UTSW 6 107,546,083 (GRCm39) missense probably benign 0.00
R7449:Lrrn1 UTSW 6 107,545,482 (GRCm39) missense possibly damaging 0.91
R7969:Lrrn1 UTSW 6 107,544,811 (GRCm39) missense probably damaging 1.00
R8077:Lrrn1 UTSW 6 107,545,783 (GRCm39) missense probably damaging 0.99
R8288:Lrrn1 UTSW 6 107,543,955 (GRCm39) start gained probably benign
R8420:Lrrn1 UTSW 6 107,546,294 (GRCm39) missense probably benign 0.00
R8725:Lrrn1 UTSW 6 107,544,303 (GRCm39) nonsense probably null
R9007:Lrrn1 UTSW 6 107,544,820 (GRCm39) missense probably damaging 0.99
R9133:Lrrn1 UTSW 6 107,544,568 (GRCm39) missense probably damaging 1.00
R9367:Lrrn1 UTSW 6 107,545,093 (GRCm39) missense probably damaging 0.98
R9373:Lrrn1 UTSW 6 107,545,465 (GRCm39) missense possibly damaging 0.82
R9475:Lrrn1 UTSW 6 107,545,261 (GRCm39) missense probably damaging 1.00
R9513:Lrrn1 UTSW 6 107,545,505 (GRCm39) missense probably benign 0.04
R9516:Lrrn1 UTSW 6 107,545,505 (GRCm39) missense probably benign 0.04
R9549:Lrrn1 UTSW 6 107,545,978 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAAGTGATCGATAGCCGCTGG -3'
(R):5'- CTGGCAAGTTATCCAGGGCATAG -3'

Sequencing Primer
(F):5'- GATAGCCGCTGGTTTGATTCCAC -3'
(R):5'- GGAAACCAGCTCTCCCATGTTG -3'
Posted On 2015-02-19