Incidental Mutation 'R3690:Vmn2r59'
ID 269723
Institutional Source Beutler Lab
Gene Symbol Vmn2r59
Ensembl Gene ENSMUSG00000092032
Gene Name vomeronasal 2, receptor 59
Synonyms EG628444
MMRRC Submission 040685-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3690 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 41661216-41708405 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41661370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 815 (F815S)
Ref Sequence ENSEMBL: ENSMUSP00000131856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168489]
AlphaFold E9PUT5
Predicted Effect possibly damaging
Transcript: ENSMUST00000168489
AA Change: F815S

PolyPhen 2 Score 0.773 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: F815S

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-44 PFAM
Pfam:NCD3G 514 567 4.3e-23 PFAM
Pfam:7tm_3 600 835 5.4e-53 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,091,328 (GRCm39) Y629F probably benign Het
Abcb5 T A 12: 118,836,668 (GRCm39) D1081V probably damaging Het
Afdn A G 17: 14,108,671 (GRCm39) E1398G probably damaging Het
Atp8b5 T C 4: 43,368,055 (GRCm39) C893R probably damaging Het
Avl9 C T 6: 56,713,812 (GRCm39) H357Y probably benign Het
Bclaf1 C T 10: 20,201,143 (GRCm39) T423I possibly damaging Het
Btbd19 A T 4: 116,977,789 (GRCm39) probably benign Het
Cap1 A G 4: 122,758,419 (GRCm39) S254P probably damaging Het
Cdc42ep1 T C 15: 78,731,629 (GRCm39) S25P probably benign Het
Cln6 T C 9: 62,754,252 (GRCm39) I98T possibly damaging Het
Cul9 T C 17: 46,814,957 (GRCm39) probably null Het
Dcx T C X: 142,660,240 (GRCm39) E268G possibly damaging Het
Ddias G A 7: 92,509,366 (GRCm39) P183L probably benign Het
Dnase2b A T 3: 146,299,326 (GRCm39) Y42* probably null Het
Dusp16 C T 6: 134,738,082 (GRCm39) probably benign Het
Egfr T C 11: 16,821,881 (GRCm39) probably benign Het
Fam171a1 T C 2: 3,227,393 (GRCm39) V842A probably benign Het
Folr1 T C 7: 101,507,745 (GRCm39) S232G probably benign Het
Foxj3 T C 4: 119,473,839 (GRCm39) probably benign Het
Fpr-rs6 T C 17: 20,403,137 (GRCm39) M75V probably benign Het
Fxyd5 G T 7: 30,735,864 (GRCm39) L128M possibly damaging Het
Gigyf2 T C 1: 87,349,238 (GRCm39) S500P possibly damaging Het
Inppl1 A G 7: 101,481,275 (GRCm39) L268P probably damaging Het
Klk1b24 A T 7: 43,841,243 (GRCm39) H192L probably benign Het
Llgl1 T G 11: 60,597,828 (GRCm39) Y316D probably damaging Het
Lmbrd1 T A 1: 24,801,374 (GRCm39) *143R probably null Het
Map3k15 T A X: 158,905,568 (GRCm39) N1295K possibly damaging Het
Mcm3ap A G 10: 76,318,513 (GRCm39) E678G probably damaging Het
Mrpl44 T A 1: 79,757,366 (GRCm39) Y270* probably null Het
Nav1 T A 1: 135,395,382 (GRCm39) I996L probably benign Het
Neb T C 2: 52,027,397 (GRCm39) E6868G probably damaging Het
Nexmif A T X: 103,131,213 (GRCm39) Y235N probably damaging Het
Nup50 C T 15: 84,823,994 (GRCm39) T449M probably damaging Het
Or14a256 G A 7: 86,265,686 (GRCm39) P56S probably damaging Het
Or2b6 A G 13: 21,823,508 (GRCm39) F62L probably damaging Het
Or51aa2 T C 7: 103,188,274 (GRCm39) T56A probably benign Het
Or52e8b A G 7: 104,673,902 (GRCm39) L95P probably damaging Het
Or52n2 T C 7: 104,542,724 (GRCm39) Y37C possibly damaging Het
Pald1 A T 10: 61,191,587 (GRCm39) probably null Het
Pde11a T A 2: 76,121,510 (GRCm39) K357I probably damaging Het
Ric3 A G 7: 108,637,817 (GRCm39) V312A possibly damaging Het
Scaper C T 9: 55,791,205 (GRCm39) G231D probably benign Het
Smc1b T A 15: 85,001,464 (GRCm39) probably benign Het
Smcr8 A G 11: 60,668,854 (GRCm39) M1V probably null Het
Smtn T C 11: 3,477,687 (GRCm39) probably benign Het
Spatc1 A T 15: 76,152,495 (GRCm39) K42* probably null Het
Taf7l A T X: 133,365,074 (GRCm39) I449K probably damaging Het
Tex47 A G 5: 7,354,777 (GRCm39) probably benign Het
Tram2 T A 1: 21,075,824 (GRCm39) Y198F probably damaging Het
Ttn C G 2: 76,629,588 (GRCm39) W14284C probably damaging Het
Ube3a A G 7: 58,926,547 (GRCm39) K442E probably damaging Het
Vmn2r116 T A 17: 23,603,798 (GRCm39) F8I unknown Het
Zap70 T C 1: 36,820,493 (GRCm39) C563R probably damaging Het
Zfp579 T C 7: 4,997,719 (GRCm39) H64R probably damaging Het
Other mutations in Vmn2r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Vmn2r59 APN 7 41,661,488 (GRCm39) missense possibly damaging 0.91
IGL01432:Vmn2r59 APN 7 41,661,983 (GRCm39) missense possibly damaging 0.82
IGL02119:Vmn2r59 APN 7 41,695,593 (GRCm39) missense probably benign 0.36
IGL02216:Vmn2r59 APN 7 41,661,817 (GRCm39) missense probably damaging 1.00
IGL02327:Vmn2r59 APN 7 41,661,655 (GRCm39) missense probably benign
IGL03346:Vmn2r59 APN 7 41,693,253 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r59 APN 7 41,708,340 (GRCm39) missense probably benign 0.43
IGL03412:Vmn2r59 APN 7 41,661,862 (GRCm39) missense probably benign
PIT4366001:Vmn2r59 UTSW 7 41,695,205 (GRCm39) missense possibly damaging 0.91
R0068:Vmn2r59 UTSW 7 41,695,725 (GRCm39) missense probably damaging 0.99
R0094:Vmn2r59 UTSW 7 41,661,722 (GRCm39) missense probably benign 0.07
R0179:Vmn2r59 UTSW 7 41,696,432 (GRCm39) nonsense probably null
R0370:Vmn2r59 UTSW 7 41,662,150 (GRCm39) missense probably benign 0.23
R0412:Vmn2r59 UTSW 7 41,695,916 (GRCm39) splice site probably benign
R0465:Vmn2r59 UTSW 7 41,696,332 (GRCm39) missense probably benign
R0487:Vmn2r59 UTSW 7 41,696,528 (GRCm39) nonsense probably null
R0576:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R0632:Vmn2r59 UTSW 7 41,708,308 (GRCm39) missense probably damaging 1.00
R1356:Vmn2r59 UTSW 7 41,661,218 (GRCm39) makesense probably null
R1387:Vmn2r59 UTSW 7 41,695,521 (GRCm39) missense probably damaging 1.00
R1388:Vmn2r59 UTSW 7 41,695,133 (GRCm39) missense probably benign 0.01
R1435:Vmn2r59 UTSW 7 41,695,629 (GRCm39) missense possibly damaging 0.50
R1750:Vmn2r59 UTSW 7 41,695,251 (GRCm39) missense possibly damaging 0.50
R2020:Vmn2r59 UTSW 7 41,693,203 (GRCm39) missense probably damaging 1.00
R2249:Vmn2r59 UTSW 7 41,708,326 (GRCm39) missense probably benign 0.00
R2256:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2257:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2441:Vmn2r59 UTSW 7 41,695,570 (GRCm39) missense probably benign 0.00
R2511:Vmn2r59 UTSW 7 41,693,190 (GRCm39) missense probably damaging 1.00
R2860:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R2861:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R3912:Vmn2r59 UTSW 7 41,695,744 (GRCm39) missense probably benign 0.00
R4167:Vmn2r59 UTSW 7 41,670,732 (GRCm39) intron probably benign
R4357:Vmn2r59 UTSW 7 41,661,644 (GRCm39) missense probably damaging 1.00
R4445:Vmn2r59 UTSW 7 41,691,874 (GRCm39) missense probably damaging 1.00
R4542:Vmn2r59 UTSW 7 41,695,497 (GRCm39) missense possibly damaging 0.93
R4587:Vmn2r59 UTSW 7 41,695,648 (GRCm39) missense probably benign 0.00
R4616:Vmn2r59 UTSW 7 41,661,862 (GRCm39) missense probably benign
R4653:Vmn2r59 UTSW 7 41,693,228 (GRCm39) missense probably benign 0.19
R4703:Vmn2r59 UTSW 7 41,661,686 (GRCm39) missense probably benign 0.01
R4895:Vmn2r59 UTSW 7 41,695,218 (GRCm39) missense probably damaging 0.98
R4910:Vmn2r59 UTSW 7 41,693,077 (GRCm39) missense probably benign
R5045:Vmn2r59 UTSW 7 41,695,496 (GRCm39) missense possibly damaging 0.93
R5105:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R5153:Vmn2r59 UTSW 7 41,691,834 (GRCm39) critical splice donor site probably null
R5566:Vmn2r59 UTSW 7 41,696,247 (GRCm39) missense possibly damaging 0.92
R5586:Vmn2r59 UTSW 7 41,695,105 (GRCm39) missense probably benign 0.12
R5606:Vmn2r59 UTSW 7 41,695,318 (GRCm39) missense probably benign 0.27
R5616:Vmn2r59 UTSW 7 41,708,191 (GRCm39) splice site probably null
R5625:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R5696:Vmn2r59 UTSW 7 41,695,468 (GRCm39) missense probably benign 0.00
R5982:Vmn2r59 UTSW 7 41,695,491 (GRCm39) missense probably benign 0.00
R6106:Vmn2r59 UTSW 7 41,661,749 (GRCm39) nonsense probably null
R6196:Vmn2r59 UTSW 7 41,661,679 (GRCm39) missense probably benign 0.36
R6228:Vmn2r59 UTSW 7 41,691,835 (GRCm39) critical splice donor site probably null
R6590:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6625:Vmn2r59 UTSW 7 41,693,177 (GRCm39) missense probably benign 0.02
R6690:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6768:Vmn2r59 UTSW 7 41,661,392 (GRCm39) missense probably benign 0.17
R6830:Vmn2r59 UTSW 7 41,693,171 (GRCm39) missense probably benign 0.10
R6859:Vmn2r59 UTSW 7 41,693,277 (GRCm39) missense probably damaging 1.00
R7034:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7036:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7145:Vmn2r59 UTSW 7 41,695,188 (GRCm39) missense probably damaging 1.00
R7556:Vmn2r59 UTSW 7 41,695,233 (GRCm39) missense probably damaging 1.00
R7733:Vmn2r59 UTSW 7 41,661,443 (GRCm39) missense probably benign 0.17
R7770:Vmn2r59 UTSW 7 41,708,336 (GRCm39) missense probably damaging 1.00
R7812:Vmn2r59 UTSW 7 41,695,196 (GRCm39) nonsense probably null
R7867:Vmn2r59 UTSW 7 41,661,707 (GRCm39) missense probably damaging 1.00
R7975:Vmn2r59 UTSW 7 41,693,199 (GRCm39) missense probably damaging 1.00
R7999:Vmn2r59 UTSW 7 41,696,256 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r59 UTSW 7 41,661,521 (GRCm39) missense probably damaging 0.97
R8367:Vmn2r59 UTSW 7 41,661,247 (GRCm39) missense probably benign 0.44
R9106:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R9135:Vmn2r59 UTSW 7 41,693,127 (GRCm39) missense
R9135:Vmn2r59 UTSW 7 41,693,125 (GRCm39) missense probably benign 0.33
R9234:Vmn2r59 UTSW 7 41,661,907 (GRCm39) missense possibly damaging 0.67
R9273:Vmn2r59 UTSW 7 41,695,286 (GRCm39) nonsense probably null
R9432:Vmn2r59 UTSW 7 41,696,254 (GRCm39) missense probably damaging 1.00
R9433:Vmn2r59 UTSW 7 41,695,590 (GRCm39) missense probably damaging 0.99
R9616:Vmn2r59 UTSW 7 41,661,299 (GRCm39) missense probably damaging 1.00
R9654:Vmn2r59 UTSW 7 41,693,217 (GRCm39) missense probably benign 0.10
R9741:Vmn2r59 UTSW 7 41,708,209 (GRCm39) missense probably damaging 0.99
X0025:Vmn2r59 UTSW 7 41,695,365 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r59 UTSW 7 41,661,838 (GRCm39) missense possibly damaging 0.85
Z1176:Vmn2r59 UTSW 7 41,691,941 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACGCATTATACCTGAATGTGAC -3'
(R):5'- TTAGCACTTGGGAGCTACACC -3'

Sequencing Primer
(F):5'- GAATGTGACATTCAGAATACTGTGAC -3'
(R):5'- ACTTGGGAGCTACACCATGGC -3'
Posted On 2015-02-19