Mutagenetix > Incidental Mutation

Incidental Mutation 'R3700:Vmn1r10'

269951

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r10

Ensembl Gene

ENSMUSG00000115181

Gene Name

vomeronasal 1 receptor 10

Synonyms

V1rc1

MMRRC Submission

040693-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.290) question?

Stock #

R3700 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57090410-57091345 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57091287 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 293 (N293S)

Ref Sequence

ENSEMBL: ENSMUSP00000154213 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176073] [ENSMUST00000228270]

AlphaFold

W4VSP8

Predicted Effect

probably benign
Transcript: ENSMUST00000176073
AA Change: N293S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000134901
Gene: ENSMUSG00000115181
AA Change: N293S

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.1e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228270
AA Change: N293S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 94.2%

Validation Efficiency

98% (51/52)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alpk2	G	A	18: 65,438,222 (GRCm39)	T1524I	probably damaging	Het
Ankrd29	G	A	18: 12,387,757 (GRCm39)	A275V	possibly damaging	Het
Arhgap26	T	A	18: 39,253,237 (GRCm39)	F221L	probably damaging	Het
Arhgap28	T	C	17: 68,208,361 (GRCm39)	S36G	probably damaging	Het
Bcl11a	A	G	11: 24,113,890 (GRCm39)	D411G	probably damaging	Het
Cdh23	C	A	10: 60,163,149 (GRCm39)		probably null	Het
Cnnm2	T	A	19: 46,750,990 (GRCm39)	I260N	probably damaging	Het
Coro6	T	C	11: 77,358,129 (GRCm39)	F238S	probably damaging	Het
Ddah1	G	A	3: 145,597,250 (GRCm39)	M162I	probably benign	Het
Dnah5	T	C	15: 28,387,937 (GRCm39)	I3132T	possibly damaging	Het
Drgx	A	T	14: 32,350,818 (GRCm39)	E218V	probably damaging	Het
Dync2i1	C	T	12: 116,175,462 (GRCm39)	W905*	probably null	Het
Eif3f	A	T	7: 108,539,482 (GRCm39)	I251F	probably benign	Het
Ephx4	T	C	5: 107,550,673 (GRCm39)	F11L	probably benign	Het
Esp1	T	C	17: 41,041,998 (GRCm39)	S97P	unknown	Het
Fbxw10	A	T	11: 62,759,983 (GRCm39)		probably null	Het
Hsp90ab1	T	C	17: 45,882,440 (GRCm39)	T85A	possibly damaging	Het
Idh2	T	C	7: 79,748,895 (GRCm39)	K129E	probably damaging	Het
Kcnj6	A	G	16: 94,633,865 (GRCm39)	I64T	probably damaging	Het
Klk1b5	T	A	7: 43,500,251 (GRCm39)	C280S	probably damaging	Het
Lhx2	T	A	2: 38,250,111 (GRCm39)	L269H	probably damaging	Het
Lrrc71	T	A	3: 87,653,185 (GRCm39)		probably null	Het
Lss	T	A	10: 76,382,026 (GRCm39)	L484Q	probably damaging	Het
Mmp14	G	A	14: 54,669,389 (GRCm39)		probably benign	Het
Muc5b	A	G	7: 141,400,986 (GRCm39)	T534A	unknown	Het
Mysm1	T	C	4: 94,858,889 (GRCm39)	K87E	probably benign	Het
Or6d13	T	A	6: 116,517,489 (GRCm39)	V25E	probably benign	Het
Or6f2	C	G	7: 139,756,127 (GRCm39)	F37L	possibly damaging	Het
Pcolce	T	C	5: 137,607,309 (GRCm39)	T61A	probably damaging	Het
Phc3	C	A	3: 30,968,277 (GRCm39)	D920Y	probably damaging	Het
Pi4kb	T	C	3: 94,901,599 (GRCm39)	I422T	probably benign	Het
Piezo1	C	T	8: 123,221,642 (GRCm39)	R584H	probably damaging	Het
Plce1	T	A	19: 38,693,781 (GRCm39)	F768Y	probably damaging	Het
Ppp1r21	T	C	17: 88,889,882 (GRCm39)	S709P	possibly damaging	Het
Prdx6	T	C	1: 161,074,858 (GRCm39)	D74G	probably damaging	Het
Rlf	A	G	4: 121,008,060 (GRCm39)	F307L	possibly damaging	Het
Skic2	T	C	17: 35,068,879 (GRCm39)	E40G	probably benign	Het
Snapin	G	A	3: 90,397,499 (GRCm39)	R91*	probably null	Het
Sort1	T	A	3: 108,263,955 (GRCm39)	L838*	probably null	Het
Sstr4	A	G	2: 148,238,273 (GRCm39)	I295V	possibly damaging	Het
Stk39	T	A	2: 68,222,462 (GRCm39)	I201F	probably damaging	Het
Tasp1	T	C	2: 139,752,474 (GRCm39)	T322A	probably benign	Het
Tepsin	C	T	11: 119,982,579 (GRCm39)	C491Y	possibly damaging	Het
Tlr9	G	A	9: 106,101,278 (GRCm39)	V190M	probably damaging	Het
Ttf2	A	G	3: 100,858,324 (GRCm39)	L755P	probably damaging	Het
Txn2	G	A	15: 77,811,976 (GRCm39)	T60M	possibly damaging	Het
Vmn1r232	A	G	17: 21,134,465 (GRCm39)	L45P	probably benign	Het
Vmn2r111	C	T	17: 22,790,142 (GRCm39)	W288*	probably null	Het
Vmn2r118	T	C	17: 55,915,421 (GRCm39)	S510G	possibly damaging	Het
Zgpat	T	A	2: 181,007,439 (GRCm39)		probably benign	Het
Zzef1	G	T	11: 72,777,598 (GRCm39)	G1810C	probably null	Het

Other mutations in Vmn1r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01062:Vmn1r10	APN	6	57,090,821 (GRCm39)	missense	possibly damaging	0.70
IGL03255:Vmn1r10	APN	6	57,090,911 (GRCm39)	missense	probably benign	0.05
IGL03393:Vmn1r10	APN	6	57,091,042 (GRCm39)	nonsense	probably null
R0310:Vmn1r10	UTSW	6	57,090,486 (GRCm39)	missense	probably damaging	0.97
R2271:Vmn1r10	UTSW	6	57,091,088 (GRCm39)	missense	probably damaging	1.00
R2411:Vmn1r10	UTSW	6	57,091,124 (GRCm39)	missense	probably benign	0.14
R3731:Vmn1r10	UTSW	6	57,090,719 (GRCm39)	missense	probably damaging	0.99
R4805:Vmn1r10	UTSW	6	57,090,602 (GRCm39)	missense	possibly damaging	0.94
R4922:Vmn1r10	UTSW	6	57,090,811 (GRCm39)	missense	probably damaging	0.99
R5697:Vmn1r10	UTSW	6	57,090,474 (GRCm39)	missense	probably damaging	1.00
R5936:Vmn1r10	UTSW	6	57,091,302 (GRCm39)	missense	probably benign	0.01
R6119:Vmn1r10	UTSW	6	57,091,218 (GRCm39)	missense	probably benign	0.01
R7107:Vmn1r10	UTSW	6	57,090,615 (GRCm39)	missense	possibly damaging	0.90
R7531:Vmn1r10	UTSW	6	57,090,924 (GRCm39)	missense	possibly damaging	0.90
R7635:Vmn1r10	UTSW	6	57,091,026 (GRCm39)	missense	probably benign	0.00
R7860:Vmn1r10	UTSW	6	57,090,686 (GRCm39)	missense	probably benign	0.19
R8786:Vmn1r10	UTSW	6	57,091,010 (GRCm39)	missense	probably benign	0.05
R9385:Vmn1r10	UTSW	6	57,090,833 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CTTGAGAGAGTCCCCTGAGAAAAG -3'
(R):5'- ATAAGCTGCTCTATGGGCAG -3'

Sequencing Primer
(F):5'- AGACCATCGTGCTGCTGGTG -3'
(R):5'- CAGGTTCCAGGGAATTCCATG -3'

Posted On

2015-03-18