Incidental Mutation 'R3734:Fcgr3'
ID 269986
Institutional Source Beutler Lab
Gene Symbol Fcgr3
Ensembl Gene ENSMUSG00000059498
Gene Name Fc receptor, IgG, low affinity III
Synonyms FcgammaRIII, CD16, Fcg receptor III
MMRRC Submission 040721-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3734 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 170878743-170892504 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 170885443 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 60 (M60V)
Ref Sequence ENSEMBL: ENSMUSP00000131836 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164044] [ENSMUST00000164179] [ENSMUST00000169017]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000164044
AA Change: M61V

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000131938
Gene: ENSMUSG00000059498
AA Change: M61V

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG 47 120 1.2e-1 SMART
IG 128 206 1.24e-8 SMART
transmembrane domain 219 241 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164179
AA Change: M60V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133039
Gene: ENSMUSG00000059498
AA Change: M60V

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
PDB:3WJL|C 35 74 6e-11 PDB
SCOP:d1f2qa1 39 74 8e-7 SMART
Blast:IG 46 74 4e-15 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168817
Predicted Effect probably benign
Transcript: ENSMUST00000169017
AA Change: M60V

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000131836
Gene: ENSMUSG00000059498
AA Change: M60V

DomainStartEndE-ValueType
low complexity region 18 27 N/A INTRINSIC
IG 46 119 1.2e-1 SMART
IG 127 205 1.24e-8 SMART
transmembrane domain 218 240 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.9%
Validation Efficiency 95% (41/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
PHENOTYPE: Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Ablim1 A T 19: 57,037,892 (GRCm39) probably null Het
Blvra A T 2: 126,932,175 (GRCm39) probably benign Het
Ccdc87 G T 19: 4,891,951 (GRCm39) W814C probably damaging Het
Cyp2a4 A G 7: 26,012,252 (GRCm39) D345G probably damaging Het
Dsg2 T C 18: 20,735,004 (GRCm39) V994A probably benign Het
Edem1 T C 6: 108,818,582 (GRCm39) F197L probably damaging Het
Eps8l2 A C 7: 140,937,734 (GRCm39) Y418S probably damaging Het
Ergic2 T C 6: 148,104,020 (GRCm39) D79G probably damaging Het
Gldn A G 9: 54,245,946 (GRCm39) K499R possibly damaging Het
Golga1 G T 2: 38,940,182 (GRCm39) Q141K possibly damaging Het
Ift122 A G 6: 115,902,462 (GRCm39) probably benign Het
Iqcg G T 16: 32,873,996 (GRCm39) probably benign Het
Itga1 T C 13: 115,114,175 (GRCm39) H910R probably benign Het
Jak3 C A 8: 72,129,225 (GRCm39) probably benign Het
Jrkl A G 9: 13,245,535 (GRCm39) V42A possibly damaging Het
Kif2c T C 4: 117,019,843 (GRCm39) S515G probably benign Het
Lag3 A T 6: 124,887,103 (GRCm39) S155T probably benign Het
Lsamp T C 16: 41,965,133 (GRCm39) I330T probably benign Het
Map3k6 T C 4: 132,975,707 (GRCm39) S732P possibly damaging Het
Muc5b C T 7: 141,412,774 (GRCm39) Q1907* probably null Het
Nap1l4 A C 7: 143,088,132 (GRCm39) probably benign Het
Nipal3 T C 4: 135,191,157 (GRCm39) T325A probably damaging Het
Nol4 A T 18: 22,903,921 (GRCm39) probably benign Het
Or2l13b T A 16: 19,349,398 (GRCm39) I91F probably damaging Het
Otog A G 7: 45,937,792 (GRCm39) T1834A probably benign Het
Panx1 GTTCTTCT GTTCT 9: 14,917,467 (GRCm39) probably benign Het
Pbld2 T C 10: 62,907,244 (GRCm39) L161P probably damaging Het
Pcdha6 T A 18: 37,102,454 (GRCm39) V549E probably damaging Het
Robo2 A C 16: 73,717,635 (GRCm39) L1159W possibly damaging Het
Scmh1 T A 4: 120,335,277 (GRCm39) I154N probably damaging Het
Skor1 A T 9: 63,047,350 (GRCm39) L879Q probably damaging Het
Slc1a7 G C 4: 107,834,841 (GRCm39) R69P probably damaging Het
Stk4 T A 2: 163,930,828 (GRCm39) M143K probably benign Het
Tenm1 C T X: 41,772,944 (GRCm39) V1023M probably benign Het
Tpte G A 8: 22,849,498 (GRCm39) C575Y probably damaging Het
Ulk4 T C 9: 121,091,055 (GRCm39) K216E probably benign Het
Unc5d T C 8: 29,251,826 (GRCm39) I216V probably benign Het
Vmn2r16 T C 5: 109,478,280 (GRCm39) S12P probably benign Het
Other mutations in Fcgr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Fcgr3 APN 1 170,886,849 (GRCm39) missense probably damaging 1.00
PIT4696001:Fcgr3 UTSW 1 170,885,319 (GRCm39) missense probably damaging 1.00
R1722:Fcgr3 UTSW 1 170,881,688 (GRCm39) missense possibly damaging 0.89
R4207:Fcgr3 UTSW 1 170,881,644 (GRCm39) missense probably benign 0.29
R5885:Fcgr3 UTSW 1 170,885,280 (GRCm39) missense probably damaging 1.00
R7237:Fcgr3 UTSW 1 170,886,870 (GRCm39) missense probably damaging 1.00
R7429:Fcgr3 UTSW 1 170,885,442 (GRCm39) missense probably benign
R7514:Fcgr3 UTSW 1 170,886,912 (GRCm39) missense probably benign 0.01
R7692:Fcgr3 UTSW 1 170,881,661 (GRCm39) missense probably damaging 1.00
R9496:Fcgr3 UTSW 1 170,879,386 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- AGCAGATTCTCCAGTCCTCG -3'
(R):5'- CCTTTAACTGGTCTGCGATGG -3'

Sequencing Primer
(F):5'- GGGCCAGCCTTTACTTACCAG -3'
(R):5'- ATGGTGGACTCTCTGGCC -3'
Posted On 2015-03-18