Incidental Mutation 'R3734:Iqcg'
ID |
270017 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Iqcg
|
Ensembl Gene |
ENSMUSG00000035578 |
Gene Name |
IQ motif containing G |
Synonyms |
2400003L07Rik, esgd12d, repro1, stubby12d, G1-374-12 |
MMRRC Submission |
040721-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R3734 (G1)
|
Quality Score |
116 |
Status
|
Validated
|
Chromosome |
16 |
Chromosomal Location |
32834640-32876617 bp(-) (GRCm39) |
Type of Mutation |
unclassified |
DNA Base Change (assembly) |
G to T
at 32873996 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000110731
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040309]
[ENSMUST00000078804]
[ENSMUST00000115075]
[ENSMUST00000115076]
[ENSMUST00000115078]
[ENSMUST00000115100]
[ENSMUST00000115079]
|
AlphaFold |
Q80W32 |
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000040309
|
SMART Domains |
Protein: ENSMUSP00000041686 Gene: ENSMUSG00000035578
Domain | Start | End | E-Value | Type |
low complexity region
|
38 |
53 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000078804
|
SMART Domains |
Protein: ENSMUSP00000077857 Gene: ENSMUSG00000060636
Domain | Start | End | E-Value | Type |
Pfam:Ribosomal_L35Ae
|
5 |
104 |
1e-46 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000105610
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115075
|
SMART Domains |
Protein: ENSMUSP00000110727 Gene: ENSMUSG00000060636
Domain | Start | End | E-Value | Type |
Pfam:Ribosomal_L35Ae
|
5 |
104 |
1e-46 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115076
|
SMART Domains |
Protein: ENSMUSP00000110728 Gene: ENSMUSG00000060636
Domain | Start | End | E-Value | Type |
Pfam:Ribosomal_L35Ae
|
5 |
104 |
7e-51 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115078
|
SMART Domains |
Protein: ENSMUSP00000110730 Gene: ENSMUSG00000060636
Domain | Start | End | E-Value | Type |
Pfam:Ribosomal_L35Ae
|
5 |
104 |
1e-46 |
PFAM |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000115100
AA Change: D2E
|
SMART Domains |
Protein: ENSMUSP00000110752 Gene: ENSMUSG00000035578 AA Change: D2E
Domain | Start | End | E-Value | Type |
low complexity region
|
3 |
50 |
N/A |
INTRINSIC |
low complexity region
|
101 |
116 |
N/A |
INTRINSIC |
coiled coil region
|
248 |
329 |
N/A |
INTRINSIC |
IQ
|
371 |
393 |
1.54e-2 |
SMART |
low complexity region
|
399 |
419 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126793
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137720
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133785
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232188
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115079
|
SMART Domains |
Protein: ENSMUSP00000110731 Gene: ENSMUSG00000060636
Domain | Start | End | E-Value | Type |
Pfam:Ribosomal_L35Ae
|
5 |
104 |
1e-46 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231235
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.9%
|
Validation Efficiency |
95% (41/43) |
MGI Phenotype |
PHENOTYPE: Homozygous male mice are infertile and have very low epididymal sperm concentration with low motility, predominantly appearing as sperm heads without tails or with short tails. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
Ablim1 |
A |
T |
19: 57,037,892 (GRCm39) |
|
probably null |
Het |
Blvra |
A |
T |
2: 126,932,175 (GRCm39) |
|
probably benign |
Het |
Ccdc87 |
G |
T |
19: 4,891,951 (GRCm39) |
W814C |
probably damaging |
Het |
Cyp2a4 |
A |
G |
7: 26,012,252 (GRCm39) |
D345G |
probably damaging |
Het |
Dsg2 |
T |
C |
18: 20,735,004 (GRCm39) |
V994A |
probably benign |
Het |
Edem1 |
T |
C |
6: 108,818,582 (GRCm39) |
F197L |
probably damaging |
Het |
Eps8l2 |
A |
C |
7: 140,937,734 (GRCm39) |
Y418S |
probably damaging |
Het |
Ergic2 |
T |
C |
6: 148,104,020 (GRCm39) |
D79G |
probably damaging |
Het |
Fcgr3 |
T |
C |
1: 170,885,443 (GRCm39) |
M60V |
probably benign |
Het |
Gldn |
A |
G |
9: 54,245,946 (GRCm39) |
K499R |
possibly damaging |
Het |
Golga1 |
G |
T |
2: 38,940,182 (GRCm39) |
Q141K |
possibly damaging |
Het |
Ift122 |
A |
G |
6: 115,902,462 (GRCm39) |
|
probably benign |
Het |
Itga1 |
T |
C |
13: 115,114,175 (GRCm39) |
H910R |
probably benign |
Het |
Jak3 |
C |
A |
8: 72,129,225 (GRCm39) |
|
probably benign |
Het |
Jrkl |
A |
G |
9: 13,245,535 (GRCm39) |
V42A |
possibly damaging |
Het |
Kif2c |
T |
C |
4: 117,019,843 (GRCm39) |
S515G |
probably benign |
Het |
Lag3 |
A |
T |
6: 124,887,103 (GRCm39) |
S155T |
probably benign |
Het |
Lsamp |
T |
C |
16: 41,965,133 (GRCm39) |
I330T |
probably benign |
Het |
Map3k6 |
T |
C |
4: 132,975,707 (GRCm39) |
S732P |
possibly damaging |
Het |
Muc5b |
C |
T |
7: 141,412,774 (GRCm39) |
Q1907* |
probably null |
Het |
Nap1l4 |
A |
C |
7: 143,088,132 (GRCm39) |
|
probably benign |
Het |
Nipal3 |
T |
C |
4: 135,191,157 (GRCm39) |
T325A |
probably damaging |
Het |
Nol4 |
A |
T |
18: 22,903,921 (GRCm39) |
|
probably benign |
Het |
Or2l13b |
T |
A |
16: 19,349,398 (GRCm39) |
I91F |
probably damaging |
Het |
Otog |
A |
G |
7: 45,937,792 (GRCm39) |
T1834A |
probably benign |
Het |
Panx1 |
GTTCTTCT |
GTTCT |
9: 14,917,467 (GRCm39) |
|
probably benign |
Het |
Pbld2 |
T |
C |
10: 62,907,244 (GRCm39) |
L161P |
probably damaging |
Het |
Pcdha6 |
T |
A |
18: 37,102,454 (GRCm39) |
V549E |
probably damaging |
Het |
Robo2 |
A |
C |
16: 73,717,635 (GRCm39) |
L1159W |
possibly damaging |
Het |
Scmh1 |
T |
A |
4: 120,335,277 (GRCm39) |
I154N |
probably damaging |
Het |
Skor1 |
A |
T |
9: 63,047,350 (GRCm39) |
L879Q |
probably damaging |
Het |
Slc1a7 |
G |
C |
4: 107,834,841 (GRCm39) |
R69P |
probably damaging |
Het |
Stk4 |
T |
A |
2: 163,930,828 (GRCm39) |
M143K |
probably benign |
Het |
Tenm1 |
C |
T |
X: 41,772,944 (GRCm39) |
V1023M |
probably benign |
Het |
Tpte |
G |
A |
8: 22,849,498 (GRCm39) |
C575Y |
probably damaging |
Het |
Ulk4 |
T |
C |
9: 121,091,055 (GRCm39) |
K216E |
probably benign |
Het |
Unc5d |
T |
C |
8: 29,251,826 (GRCm39) |
I216V |
probably benign |
Het |
Vmn2r16 |
T |
C |
5: 109,478,280 (GRCm39) |
S12P |
probably benign |
Het |
|
Other mutations in Iqcg |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01106:Iqcg
|
APN |
16 |
32,855,970 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL01155:Iqcg
|
APN |
16 |
32,861,245 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01602:Iqcg
|
APN |
16 |
32,837,348 (GRCm39) |
unclassified |
probably benign |
|
IGL01605:Iqcg
|
APN |
16 |
32,837,348 (GRCm39) |
unclassified |
probably benign |
|
IGL02243:Iqcg
|
APN |
16 |
32,865,962 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02328:Iqcg
|
APN |
16 |
32,839,876 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02490:Iqcg
|
APN |
16 |
32,855,937 (GRCm39) |
nonsense |
probably null |
|
IGL03297:Iqcg
|
APN |
16 |
32,856,002 (GRCm39) |
splice site |
probably benign |
|
R0038:Iqcg
|
UTSW |
16 |
32,866,012 (GRCm39) |
missense |
probably benign |
0.03 |
R0453:Iqcg
|
UTSW |
16 |
32,870,213 (GRCm39) |
splice site |
probably benign |
|
R0719:Iqcg
|
UTSW |
16 |
32,861,215 (GRCm39) |
missense |
probably benign |
0.26 |
R1191:Iqcg
|
UTSW |
16 |
32,870,313 (GRCm39) |
missense |
probably benign |
0.43 |
R1544:Iqcg
|
UTSW |
16 |
32,865,895 (GRCm39) |
missense |
probably benign |
0.01 |
R2292:Iqcg
|
UTSW |
16 |
32,870,253 (GRCm39) |
missense |
probably benign |
0.25 |
R3725:Iqcg
|
UTSW |
16 |
32,840,909 (GRCm39) |
splice site |
probably null |
|
R3726:Iqcg
|
UTSW |
16 |
32,849,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R3732:Iqcg
|
UTSW |
16 |
32,873,996 (GRCm39) |
unclassified |
probably benign |
|
R3732:Iqcg
|
UTSW |
16 |
32,873,996 (GRCm39) |
unclassified |
probably benign |
|
R3733:Iqcg
|
UTSW |
16 |
32,873,996 (GRCm39) |
unclassified |
probably benign |
|
R3770:Iqcg
|
UTSW |
16 |
32,870,378 (GRCm39) |
synonymous |
silent |
|
R4296:Iqcg
|
UTSW |
16 |
32,837,345 (GRCm39) |
unclassified |
probably benign |
|
R4409:Iqcg
|
UTSW |
16 |
32,865,888 (GRCm39) |
critical splice donor site |
probably null |
|
R4410:Iqcg
|
UTSW |
16 |
32,851,186 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4429:Iqcg
|
UTSW |
16 |
32,839,860 (GRCm39) |
missense |
probably benign |
0.02 |
R4603:Iqcg
|
UTSW |
16 |
32,861,133 (GRCm39) |
critical splice donor site |
probably null |
|
R4603:Iqcg
|
UTSW |
16 |
32,861,134 (GRCm39) |
missense |
probably null |
0.68 |
R4979:Iqcg
|
UTSW |
16 |
32,839,884 (GRCm39) |
missense |
probably damaging |
1.00 |
R5672:Iqcg
|
UTSW |
16 |
32,839,878 (GRCm39) |
missense |
probably damaging |
0.99 |
R6183:Iqcg
|
UTSW |
16 |
32,851,293 (GRCm39) |
missense |
probably damaging |
1.00 |
R6965:Iqcg
|
UTSW |
16 |
32,851,174 (GRCm39) |
missense |
probably benign |
0.06 |
R8135:Iqcg
|
UTSW |
16 |
32,849,394 (GRCm39) |
missense |
probably benign |
0.20 |
R9260:Iqcg
|
UTSW |
16 |
32,855,973 (GRCm39) |
nonsense |
probably null |
|
R9505:Iqcg
|
UTSW |
16 |
32,861,247 (GRCm39) |
missense |
probably benign |
0.42 |
Z1177:Iqcg
|
UTSW |
16 |
32,849,390 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AGTCACTTGCTAAACGCCCTC -3'
(R):5'- TTCCCTAAGCAGGAGGAGAC -3'
Sequencing Primer
(F):5'- TCAAGCGCCCACCCCAC -3'
(R):5'- CTATAGATAGCTCTTGGGATTCTGTG -3'
|
Posted On |
2015-03-18 |