Incidental Mutation 'R3734:Iqcg'
ID 270017
Institutional Source Beutler Lab
Gene Symbol Iqcg
Ensembl Gene ENSMUSG00000035578
Gene Name IQ motif containing G
Synonyms 2400003L07Rik, esgd12d, repro1, stubby12d, G1-374-12
MMRRC Submission 040721-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3734 (G1)
Quality Score 116
Status Validated
Chromosome 16
Chromosomal Location 32834640-32876617 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 32873996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110731 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040309] [ENSMUST00000078804] [ENSMUST00000115075] [ENSMUST00000115076] [ENSMUST00000115078] [ENSMUST00000115100] [ENSMUST00000115079]
AlphaFold Q80W32
Predicted Effect noncoding transcript
Transcript: ENSMUST00000040309
SMART Domains Protein: ENSMUSP00000041686
Gene: ENSMUSG00000035578

DomainStartEndE-ValueType
low complexity region 38 53 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000078804
SMART Domains Protein: ENSMUSP00000077857
Gene: ENSMUSG00000060636

DomainStartEndE-ValueType
Pfam:Ribosomal_L35Ae 5 104 1e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105610
Predicted Effect probably benign
Transcript: ENSMUST00000115075
SMART Domains Protein: ENSMUSP00000110727
Gene: ENSMUSG00000060636

DomainStartEndE-ValueType
Pfam:Ribosomal_L35Ae 5 104 1e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115076
SMART Domains Protein: ENSMUSP00000110728
Gene: ENSMUSG00000060636

DomainStartEndE-ValueType
Pfam:Ribosomal_L35Ae 5 104 7e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115078
SMART Domains Protein: ENSMUSP00000110730
Gene: ENSMUSG00000060636

DomainStartEndE-ValueType
Pfam:Ribosomal_L35Ae 5 104 1e-46 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000115100
AA Change: D2E
SMART Domains Protein: ENSMUSP00000110752
Gene: ENSMUSG00000035578
AA Change: D2E

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
low complexity region 101 116 N/A INTRINSIC
coiled coil region 248 329 N/A INTRINSIC
IQ 371 393 1.54e-2 SMART
low complexity region 399 419 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137720
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133785
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232188
Predicted Effect probably benign
Transcript: ENSMUST00000115079
SMART Domains Protein: ENSMUSP00000110731
Gene: ENSMUSG00000060636

DomainStartEndE-ValueType
Pfam:Ribosomal_L35Ae 5 104 1e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231235
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.9%
Validation Efficiency 95% (41/43)
MGI Phenotype PHENOTYPE: Homozygous male mice are infertile and have very low epididymal sperm concentration with low motility, predominantly appearing as sperm heads without tails or with short tails. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Ablim1 A T 19: 57,037,892 (GRCm39) probably null Het
Blvra A T 2: 126,932,175 (GRCm39) probably benign Het
Ccdc87 G T 19: 4,891,951 (GRCm39) W814C probably damaging Het
Cyp2a4 A G 7: 26,012,252 (GRCm39) D345G probably damaging Het
Dsg2 T C 18: 20,735,004 (GRCm39) V994A probably benign Het
Edem1 T C 6: 108,818,582 (GRCm39) F197L probably damaging Het
Eps8l2 A C 7: 140,937,734 (GRCm39) Y418S probably damaging Het
Ergic2 T C 6: 148,104,020 (GRCm39) D79G probably damaging Het
Fcgr3 T C 1: 170,885,443 (GRCm39) M60V probably benign Het
Gldn A G 9: 54,245,946 (GRCm39) K499R possibly damaging Het
Golga1 G T 2: 38,940,182 (GRCm39) Q141K possibly damaging Het
Ift122 A G 6: 115,902,462 (GRCm39) probably benign Het
Itga1 T C 13: 115,114,175 (GRCm39) H910R probably benign Het
Jak3 C A 8: 72,129,225 (GRCm39) probably benign Het
Jrkl A G 9: 13,245,535 (GRCm39) V42A possibly damaging Het
Kif2c T C 4: 117,019,843 (GRCm39) S515G probably benign Het
Lag3 A T 6: 124,887,103 (GRCm39) S155T probably benign Het
Lsamp T C 16: 41,965,133 (GRCm39) I330T probably benign Het
Map3k6 T C 4: 132,975,707 (GRCm39) S732P possibly damaging Het
Muc5b C T 7: 141,412,774 (GRCm39) Q1907* probably null Het
Nap1l4 A C 7: 143,088,132 (GRCm39) probably benign Het
Nipal3 T C 4: 135,191,157 (GRCm39) T325A probably damaging Het
Nol4 A T 18: 22,903,921 (GRCm39) probably benign Het
Or2l13b T A 16: 19,349,398 (GRCm39) I91F probably damaging Het
Otog A G 7: 45,937,792 (GRCm39) T1834A probably benign Het
Panx1 GTTCTTCT GTTCT 9: 14,917,467 (GRCm39) probably benign Het
Pbld2 T C 10: 62,907,244 (GRCm39) L161P probably damaging Het
Pcdha6 T A 18: 37,102,454 (GRCm39) V549E probably damaging Het
Robo2 A C 16: 73,717,635 (GRCm39) L1159W possibly damaging Het
Scmh1 T A 4: 120,335,277 (GRCm39) I154N probably damaging Het
Skor1 A T 9: 63,047,350 (GRCm39) L879Q probably damaging Het
Slc1a7 G C 4: 107,834,841 (GRCm39) R69P probably damaging Het
Stk4 T A 2: 163,930,828 (GRCm39) M143K probably benign Het
Tenm1 C T X: 41,772,944 (GRCm39) V1023M probably benign Het
Tpte G A 8: 22,849,498 (GRCm39) C575Y probably damaging Het
Ulk4 T C 9: 121,091,055 (GRCm39) K216E probably benign Het
Unc5d T C 8: 29,251,826 (GRCm39) I216V probably benign Het
Vmn2r16 T C 5: 109,478,280 (GRCm39) S12P probably benign Het
Other mutations in Iqcg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01106:Iqcg APN 16 32,855,970 (GRCm39) missense possibly damaging 0.90
IGL01155:Iqcg APN 16 32,861,245 (GRCm39) missense probably damaging 0.99
IGL01602:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL01605:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL02243:Iqcg APN 16 32,865,962 (GRCm39) missense probably damaging 1.00
IGL02328:Iqcg APN 16 32,839,876 (GRCm39) missense probably benign 0.00
IGL02490:Iqcg APN 16 32,855,937 (GRCm39) nonsense probably null
IGL03297:Iqcg APN 16 32,856,002 (GRCm39) splice site probably benign
R0038:Iqcg UTSW 16 32,866,012 (GRCm39) missense probably benign 0.03
R0453:Iqcg UTSW 16 32,870,213 (GRCm39) splice site probably benign
R0719:Iqcg UTSW 16 32,861,215 (GRCm39) missense probably benign 0.26
R1191:Iqcg UTSW 16 32,870,313 (GRCm39) missense probably benign 0.43
R1544:Iqcg UTSW 16 32,865,895 (GRCm39) missense probably benign 0.01
R2292:Iqcg UTSW 16 32,870,253 (GRCm39) missense probably benign 0.25
R3725:Iqcg UTSW 16 32,840,909 (GRCm39) splice site probably null
R3726:Iqcg UTSW 16 32,849,411 (GRCm39) missense probably damaging 1.00
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3733:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3770:Iqcg UTSW 16 32,870,378 (GRCm39) synonymous silent
R4296:Iqcg UTSW 16 32,837,345 (GRCm39) unclassified probably benign
R4409:Iqcg UTSW 16 32,865,888 (GRCm39) critical splice donor site probably null
R4410:Iqcg UTSW 16 32,851,186 (GRCm39) missense possibly damaging 0.95
R4429:Iqcg UTSW 16 32,839,860 (GRCm39) missense probably benign 0.02
R4603:Iqcg UTSW 16 32,861,133 (GRCm39) critical splice donor site probably null
R4603:Iqcg UTSW 16 32,861,134 (GRCm39) missense probably null 0.68
R4979:Iqcg UTSW 16 32,839,884 (GRCm39) missense probably damaging 1.00
R5672:Iqcg UTSW 16 32,839,878 (GRCm39) missense probably damaging 0.99
R6183:Iqcg UTSW 16 32,851,293 (GRCm39) missense probably damaging 1.00
R6965:Iqcg UTSW 16 32,851,174 (GRCm39) missense probably benign 0.06
R8135:Iqcg UTSW 16 32,849,394 (GRCm39) missense probably benign 0.20
R9260:Iqcg UTSW 16 32,855,973 (GRCm39) nonsense probably null
R9505:Iqcg UTSW 16 32,861,247 (GRCm39) missense probably benign 0.42
Z1177:Iqcg UTSW 16 32,849,390 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTCACTTGCTAAACGCCCTC -3'
(R):5'- TTCCCTAAGCAGGAGGAGAC -3'

Sequencing Primer
(F):5'- TCAAGCGCCCACCCCAC -3'
(R):5'- CTATAGATAGCTCTTGGGATTCTGTG -3'
Posted On 2015-03-18