Incidental Mutation 'R3736:Or5p76'
ID 270125
Institutional Source Beutler Lab
Gene Symbol Or5p76
Ensembl Gene ENSMUSG00000058014
Gene Name olfactory receptor family 5 subfamily P member 76
Synonyms Olfr502, MOR204-8, GA_x6K02T2PBJ9-10853935-10852991
MMRRC Submission 040723-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.303) question?
Stock # R3736 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 108122211-108123155 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108122626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 177 (V177A)
Ref Sequence ENSEMBL: ENSMUSP00000151167 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078933] [ENSMUST00000216919]
AlphaFold Q8VG09
Predicted Effect possibly damaging
Transcript: ENSMUST00000078933
AA Change: V177A

PolyPhen 2 Score 0.791 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077963
Gene: ENSMUSG00000058014
AA Change: V177A

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4.8e-55 PFAM
Pfam:7tm_1 44 293 7.7e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208361
Predicted Effect possibly damaging
Transcript: ENSMUST00000216919
AA Change: V177A

PolyPhen 2 Score 0.791 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.2871 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik G A 7: 29,273,996 (GRCm39) noncoding transcript Het
Acot12 T A 13: 91,932,465 (GRCm39) I487N probably benign Het
Acox3 A G 5: 35,768,497 (GRCm39) K686R probably benign Het
Adgrf2 T C 17: 43,021,903 (GRCm39) E307G probably benign Het
Ang2 G A 14: 51,433,113 (GRCm39) R90* probably null Het
Ankrd11 A T 8: 123,618,524 (GRCm39) V1776D probably damaging Het
Atp12a G A 14: 56,611,884 (GRCm39) V353I possibly damaging Het
Bbs7 A G 3: 36,661,819 (GRCm39) Y127H possibly damaging Het
C8a T C 4: 104,674,812 (GRCm39) E509G probably benign Het
Ccdc158 A C 5: 92,780,283 (GRCm39) L930R possibly damaging Het
Ccdc162 T C 10: 41,465,564 (GRCm39) probably null Het
Cep170b A T 12: 112,707,438 (GRCm39) I395F probably damaging Het
Cimip2c A T 5: 30,639,442 (GRCm39) Y123F probably benign Het
Clcn3 T A 8: 61,436,686 (GRCm39) probably benign Het
Ctps1 T C 4: 120,400,943 (GRCm39) T459A probably benign Het
Cyp2j8 T A 4: 96,332,836 (GRCm39) R503S probably damaging Het
Dync1h1 G A 12: 110,598,109 (GRCm39) V1767I probably benign Het
Evi5 A T 5: 107,966,849 (GRCm39) V224D probably damaging Het
F8 G A X: 74,254,981 (GRCm39) P2138S probably damaging Het
Helq T G 5: 100,938,054 (GRCm39) D464A possibly damaging Het
Irag1 A G 7: 110,523,170 (GRCm39) V297A probably benign Het
Irag2 G A 6: 145,106,596 (GRCm39) probably benign Het
Kcnk10 A G 12: 98,456,171 (GRCm39) V203A probably benign Het
Lef1 C T 3: 130,984,715 (GRCm39) P160S possibly damaging Het
Lyn G T 4: 3,745,330 (GRCm39) W78C probably damaging Het
Med12l T A 3: 58,998,916 (GRCm39) H614Q probably damaging Het
Mogs C A 6: 83,093,757 (GRCm39) T242K possibly damaging Het
Morc3 T A 16: 93,671,700 (GRCm39) V910E probably damaging Het
Ncapg A T 5: 45,853,469 (GRCm39) Q906L probably benign Het
Nup210l A G 3: 90,027,320 (GRCm39) Y234C probably damaging Het
Olr1 T A 6: 129,476,838 (GRCm39) probably benign Het
Osmr A T 15: 6,851,561 (GRCm39) Y656N probably damaging Het
Pde4dip A T 3: 97,631,427 (GRCm39) F1161I probably damaging Het
Poc5 A G 13: 96,533,324 (GRCm39) S151G probably damaging Het
Rmnd5a T C 6: 71,373,846 (GRCm39) D316G possibly damaging Het
Shroom3 T C 5: 93,112,303 (GRCm39) V1888A possibly damaging Het
Shtn1 A T 19: 59,010,700 (GRCm39) S256T probably benign Het
Sptlc2 G A 12: 87,388,339 (GRCm39) A381V probably benign Het
Suclg2 T A 6: 95,474,677 (GRCm39) I363F probably damaging Het
Tas2r134 C A 2: 51,517,786 (GRCm39) N88K probably damaging Het
Tbc1d32 A G 10: 56,005,189 (GRCm39) Y815H probably damaging Het
Tnrc6b G C 15: 80,773,364 (GRCm39) probably benign Het
Vti1a T A 19: 55,369,364 (GRCm39) probably null Het
Zfp273 T A 13: 67,973,626 (GRCm39) C251* probably null Het
Zfp683 C A 4: 133,784,742 (GRCm39) Q330K probably benign Het
Zfpm1 G A 8: 123,050,475 (GRCm39) C117Y possibly damaging Het
Zscan4d T C 7: 10,896,803 (GRCm39) N189S probably benign Het
Other mutations in Or5p76
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02260:Or5p76 APN 7 108,122,492 (GRCm39) missense probably benign 0.00
R0007:Or5p76 UTSW 7 108,122,420 (GRCm39) missense probably damaging 1.00
R0650:Or5p76 UTSW 7 108,122,289 (GRCm39) missense probably damaging 1.00
R1448:Or5p76 UTSW 7 108,122,525 (GRCm39) missense probably benign
R1469:Or5p76 UTSW 7 108,122,411 (GRCm39) missense probably benign 0.14
R1469:Or5p76 UTSW 7 108,122,411 (GRCm39) missense probably benign 0.14
R1701:Or5p76 UTSW 7 108,122,731 (GRCm39) missense probably benign 0.01
R5030:Or5p76 UTSW 7 108,122,384 (GRCm39) missense possibly damaging 0.66
R5315:Or5p76 UTSW 7 108,123,097 (GRCm39) missense probably damaging 1.00
R6052:Or5p76 UTSW 7 108,122,945 (GRCm39) missense probably benign 0.34
R6548:Or5p76 UTSW 7 108,122,423 (GRCm39) missense probably benign 0.00
R6866:Or5p76 UTSW 7 108,122,377 (GRCm39) missense probably damaging 0.96
R6946:Or5p76 UTSW 7 108,122,528 (GRCm39) missense probably benign 0.02
R7582:Or5p76 UTSW 7 108,123,058 (GRCm39) missense probably benign 0.00
R8771:Or5p76 UTSW 7 108,122,632 (GRCm39) missense possibly damaging 0.62
R8824:Or5p76 UTSW 7 108,122,350 (GRCm39) missense probably benign 0.28
R8854:Or5p76 UTSW 7 108,122,936 (GRCm39) missense probably benign 0.00
R9398:Or5p76 UTSW 7 108,123,035 (GRCm39) missense probably damaging 0.98
Z1088:Or5p76 UTSW 7 108,122,605 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCAGTGGAGCGCATCTTCAG -3'
(R):5'- ATCCAGCTTGGTTCAGCTG -3'

Sequencing Primer
(F):5'- CATCTTCAGGATGGTGATAAGGATG -3'
(R):5'- ACAGTTGAATGTTTCCTTCTGGC -3'
Posted On 2015-03-18