Incidental Mutation 'R3740:Syngr4'
ID 270340
Institutional Source Beutler Lab
Gene Symbol Syngr4
Ensembl Gene ENSMUSG00000040231
Gene Name synaptogyrin 4
Synonyms 1700016O14Rik
MMRRC Submission 040726-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R3740 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 45535502-45546152 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45545194 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 5 (E5G)
Ref Sequence ENSEMBL: ENSMUSP00000113955 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039049] [ENSMUST00000069772] [ENSMUST00000120299] [ENSMUST00000209350] [ENSMUST00000210503]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000039049
AA Change: E5G

PolyPhen 2 Score 0.712 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000047035
Gene: ENSMUSG00000040231
AA Change: E5G

DomainStartEndE-ValueType
Pfam:MARVEL 18 163 2e-27 PFAM
low complexity region 184 201 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000069772
SMART Domains Protein: ENSMUSP00000070405
Gene: ENSMUSG00000002781

DomainStartEndE-ValueType
Pfam:DUF3754 182 349 3.6e-12 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000120299
AA Change: E5G

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000113955
Gene: ENSMUSG00000040231
AA Change: E5G

DomainStartEndE-ValueType
Pfam:MARVEL 18 110 2.3e-12 PFAM
low complexity region 113 129 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150842
AA Change: K71E
Predicted Effect probably benign
Transcript: ENSMUST00000209292
Predicted Effect probably benign
Transcript: ENSMUST00000209350
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209395
Predicted Effect probably benign
Transcript: ENSMUST00000210503
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211254
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209580
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 94% (29/31)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein. The gene belongs to the synaptogyrin gene family. Like other members of the family the protein contains four transmembrane regions. The exact function of this protein is unclear. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T C 1: 25,865,535 (GRCm39) R103G probably benign Het
Atp8b2 C G 3: 89,853,338 (GRCm39) A726P probably benign Het
Bbox1 A G 2: 110,135,922 (GRCm39) I19T possibly damaging Het
Ctso G A 3: 81,859,556 (GRCm39) V288I probably benign Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Fam135a A T 1: 24,053,892 (GRCm39) M1215K probably damaging Het
Fam174b T C 7: 73,390,578 (GRCm39) probably null Het
Fgfr1op2 A G 6: 146,496,731 (GRCm39) I190V possibly damaging Het
Flt1 G A 5: 147,536,403 (GRCm39) R813W probably damaging Het
Gm6489 T A 1: 31,326,764 (GRCm39) noncoding transcript Het
Hacd3 T C 9: 64,928,755 (GRCm39) E24G possibly damaging Het
Kat6b T G 14: 21,720,112 (GRCm39) M1488R probably damaging Het
Kcnk3 T C 5: 30,779,274 (GRCm39) V108A possibly damaging Het
Kif5a A G 10: 127,079,337 (GRCm39) I287T probably damaging Het
Mical1 A C 10: 41,355,067 (GRCm39) D192A probably benign Het
Mov10l1 A G 15: 88,896,345 (GRCm39) N678D possibly damaging Het
Nup210l A T 3: 90,114,701 (GRCm39) M1759L probably benign Het
Optn C A 2: 5,039,009 (GRCm39) M371I possibly damaging Het
Pik3cg T C 12: 32,255,223 (GRCm39) K255E probably damaging Het
Rims1 A T 1: 22,443,667 (GRCm39) V380D probably damaging Het
Serpinb6e T A 13: 34,022,943 (GRCm39) I147F probably benign Het
Slc13a1 T C 6: 24,134,476 (GRCm39) M136V probably damaging Het
Tiam2 A G 17: 3,464,388 (GRCm39) D39G possibly damaging Het
Tmem88b A G 4: 155,869,884 (GRCm39) L59P probably damaging Het
Ttn T A 2: 76,620,703 (GRCm39) K13995* probably null Het
Vmn1r225 A G 17: 20,723,261 (GRCm39) Q234R possibly damaging Het
Vmn2r107 A G 17: 20,595,151 (GRCm39) N568S probably benign Het
Zfp605 G T 5: 110,276,564 (GRCm39) G561W probably damaging Het
Zfp69 T A 4: 120,788,071 (GRCm39) probably null Het
Other mutations in Syngr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Syngr4 APN 7 45,536,390 (GRCm39) missense probably benign
R1739:Syngr4 UTSW 7 45,538,146 (GRCm39) missense possibly damaging 0.95
R2143:Syngr4 UTSW 7 45,536,464 (GRCm39) missense probably benign 0.01
R2144:Syngr4 UTSW 7 45,536,464 (GRCm39) missense probably benign 0.01
R2145:Syngr4 UTSW 7 45,536,464 (GRCm39) missense probably benign 0.01
R3741:Syngr4 UTSW 7 45,545,194 (GRCm39) missense possibly damaging 0.94
R3742:Syngr4 UTSW 7 45,545,194 (GRCm39) missense possibly damaging 0.94
R4627:Syngr4 UTSW 7 45,536,452 (GRCm39) missense probably damaging 1.00
R6709:Syngr4 UTSW 7 45,538,122 (GRCm39) missense probably benign 0.02
R6767:Syngr4 UTSW 7 45,536,915 (GRCm39) missense possibly damaging 0.58
R7207:Syngr4 UTSW 7 45,538,101 (GRCm39) missense possibly damaging 0.56
Predicted Primers PCR Primer
(F):5'- CAGTGGCTAGTGACCAGATAC -3'
(R):5'- AAAGGAAGGGCCAGTACTCC -3'

Sequencing Primer
(F):5'- CCAGATACTCAGTAAAAGGTGGCTTC -3'
(R):5'- AGGGCCAGTACTCCCCACTC -3'
Posted On 2015-03-18