Incidental Mutation 'R3740:Vmn1r225'
| ID |
270349 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r225
|
| Ensembl Gene |
ENSMUSG00000043537 |
| Gene Name |
vomeronasal 1 receptor 225 |
| Synonyms |
V1re5 |
| MMRRC Submission |
040726-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R3740 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20722561-20723457 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20723261 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 234
(Q234R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056068
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061660]
|
| AlphaFold |
Q8R2A5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000061660
AA Change: Q234R
PolyPhen 2
Score 0.564 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000056068
Gene: ENSMUSG00000043537
AA Change: Q234R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
287 |
8.9e-15 |
PFAM |
|
Pfam:V1R
|
11 |
291 |
3.1e-24 |
PFAM |
|
| Meta Mutation Damage Score |
0.2714 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
94% (29/31) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb3 |
T |
C |
1: 25,865,535 (GRCm39) |
R103G |
probably benign |
Het |
| Atp8b2 |
C |
G |
3: 89,853,338 (GRCm39) |
A726P |
probably benign |
Het |
| Bbox1 |
A |
G |
2: 110,135,922 (GRCm39) |
I19T |
possibly damaging |
Het |
| Ctso |
G |
A |
3: 81,859,556 (GRCm39) |
V288I |
probably benign |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Fam135a |
A |
T |
1: 24,053,892 (GRCm39) |
M1215K |
probably damaging |
Het |
| Fam174b |
T |
C |
7: 73,390,578 (GRCm39) |
|
probably null |
Het |
| Fgfr1op2 |
A |
G |
6: 146,496,731 (GRCm39) |
I190V |
possibly damaging |
Het |
| Flt1 |
G |
A |
5: 147,536,403 (GRCm39) |
R813W |
probably damaging |
Het |
| Gm6489 |
T |
A |
1: 31,326,764 (GRCm39) |
|
noncoding transcript |
Het |
| Hacd3 |
T |
C |
9: 64,928,755 (GRCm39) |
E24G |
possibly damaging |
Het |
| Kat6b |
T |
G |
14: 21,720,112 (GRCm39) |
M1488R |
probably damaging |
Het |
| Kcnk3 |
T |
C |
5: 30,779,274 (GRCm39) |
V108A |
possibly damaging |
Het |
| Kif5a |
A |
G |
10: 127,079,337 (GRCm39) |
I287T |
probably damaging |
Het |
| Mical1 |
A |
C |
10: 41,355,067 (GRCm39) |
D192A |
probably benign |
Het |
| Mov10l1 |
A |
G |
15: 88,896,345 (GRCm39) |
N678D |
possibly damaging |
Het |
| Nup210l |
A |
T |
3: 90,114,701 (GRCm39) |
M1759L |
probably benign |
Het |
| Optn |
C |
A |
2: 5,039,009 (GRCm39) |
M371I |
possibly damaging |
Het |
| Pik3cg |
T |
C |
12: 32,255,223 (GRCm39) |
K255E |
probably damaging |
Het |
| Rims1 |
A |
T |
1: 22,443,667 (GRCm39) |
V380D |
probably damaging |
Het |
| Serpinb6e |
T |
A |
13: 34,022,943 (GRCm39) |
I147F |
probably benign |
Het |
| Slc13a1 |
T |
C |
6: 24,134,476 (GRCm39) |
M136V |
probably damaging |
Het |
| Syngr4 |
T |
C |
7: 45,545,194 (GRCm39) |
E5G |
possibly damaging |
Het |
| Tiam2 |
A |
G |
17: 3,464,388 (GRCm39) |
D39G |
possibly damaging |
Het |
| Tmem88b |
A |
G |
4: 155,869,884 (GRCm39) |
L59P |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,620,703 (GRCm39) |
K13995* |
probably null |
Het |
| Vmn2r107 |
A |
G |
17: 20,595,151 (GRCm39) |
N568S |
probably benign |
Het |
| Zfp605 |
G |
T |
5: 110,276,564 (GRCm39) |
G561W |
probably damaging |
Het |
| Zfp69 |
T |
A |
4: 120,788,071 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r225 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01093:Vmn1r225
|
APN |
17 |
20,723,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01830:Vmn1r225
|
APN |
17 |
20,722,717 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02943:Vmn1r225
|
APN |
17 |
20,722,567 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0544:Vmn1r225
|
UTSW |
17 |
20,722,718 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1126:Vmn1r225
|
UTSW |
17 |
20,722,588 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1809:Vmn1r225
|
UTSW |
17 |
20,722,918 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1928:Vmn1r225
|
UTSW |
17 |
20,723,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2044:Vmn1r225
|
UTSW |
17 |
20,722,852 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2191:Vmn1r225
|
UTSW |
17 |
20,723,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2206:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2207:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2680:Vmn1r225
|
UTSW |
17 |
20,723,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3807:Vmn1r225
|
UTSW |
17 |
20,723,114 (GRCm39) |
nonsense |
probably null |
|
|
R4196:Vmn1r225
|
UTSW |
17 |
20,723,237 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4970:Vmn1r225
|
UTSW |
17 |
20,722,831 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5129:Vmn1r225
|
UTSW |
17 |
20,723,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5130:Vmn1r225
|
UTSW |
17 |
20,723,047 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5187:Vmn1r225
|
UTSW |
17 |
20,723,177 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5580:Vmn1r225
|
UTSW |
17 |
20,723,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6563:Vmn1r225
|
UTSW |
17 |
20,722,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6674:Vmn1r225
|
UTSW |
17 |
20,723,377 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7003:Vmn1r225
|
UTSW |
17 |
20,723,416 (GRCm39) |
missense |
probably null |
0.01 |
|
R7143:Vmn1r225
|
UTSW |
17 |
20,722,646 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7422:Vmn1r225
|
UTSW |
17 |
20,723,059 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7651:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7952:Vmn1r225
|
UTSW |
17 |
20,722,589 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8097:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8696:Vmn1r225
|
UTSW |
17 |
20,723,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8823:Vmn1r225
|
UTSW |
17 |
20,722,823 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9007:Vmn1r225
|
UTSW |
17 |
20,723,449 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9041:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9147:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9148:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9312:Vmn1r225
|
UTSW |
17 |
20,722,960 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9401:Vmn1r225
|
UTSW |
17 |
20,722,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9401:Vmn1r225
|
UTSW |
17 |
20,722,911 (GRCm39) |
nonsense |
probably null |
|
|
R9488:Vmn1r225
|
UTSW |
17 |
20,722,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn1r225
|
UTSW |
17 |
20,722,753 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCAAGGTCGTGACAAAGTAG -3'
(R):5'- AACTGGTGAAGATCCTGTGAC -3'
Sequencing Primer
(F):5'- TCGTGACAAAGTAGTAGATACAGTG -3'
(R):5'- CTGGTGAAGATCCTGTGACTATAGAC -3'
|
| Posted On |
2015-03-18 |
Incidental Mutation