Incidental Mutation 'R3741:Zfp386'
ID 270379
Institutional Source Beutler Lab
Gene Symbol Zfp386
Ensembl Gene ENSMUSG00000042063
Gene Name zinc finger protein 386 (Kruppel-like)
Synonyms
MMRRC Submission 040727-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R3741 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 116011334-116026851 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 116023170 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 296 (L296*)
Ref Sequence ENSEMBL: ENSMUSP00000138305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073551] [ENSMUST00000183125]
AlphaFold Q1WWJ5
Predicted Effect probably null
Transcript: ENSMUST00000073551
AA Change: L261*
SMART Domains Protein: ENSMUSP00000073241
Gene: ENSMUSG00000042063
AA Change: L261*

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182566
Predicted Effect probably null
Transcript: ENSMUST00000183125
AA Change: L296*
SMART Domains Protein: ENSMUSP00000138305
Gene: ENSMUSG00000042063
AA Change: L296*

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 97% (37/38)
Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aspm T C 1: 139,406,357 (GRCm39) V1748A possibly damaging Het
Atp10b A T 11: 43,126,489 (GRCm39) S1082C probably damaging Het
Atp8b2 C G 3: 89,853,338 (GRCm39) A726P probably benign Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Bbip1 T C 19: 53,920,606 (GRCm39) M1V probably null Het
Bbox1 A G 2: 110,135,922 (GRCm39) I19T possibly damaging Het
Bclaf3 T A X: 158,334,828 (GRCm39) H41Q probably benign Het
Ctsm T A 13: 61,687,441 (GRCm39) Q107L probably benign Het
Ctso G A 3: 81,859,556 (GRCm39) V288I probably benign Het
Cyp2a4 A C 7: 26,007,969 (GRCm39) K125N probably damaging Het
Dapk1 T C 13: 60,896,014 (GRCm39) S701P probably benign Het
Dnah1 A G 14: 30,987,424 (GRCm39) probably benign Het
Dnah11 A G 12: 118,095,076 (GRCm39) M718T probably benign Het
Dnah2 C A 11: 69,339,295 (GRCm39) A3071S probably damaging Het
Epb41l4a A T 18: 33,961,155 (GRCm39) probably null Het
Fam135a A T 1: 24,053,892 (GRCm39) M1215K probably damaging Het
Gm6489 T A 1: 31,326,764 (GRCm39) noncoding transcript Het
Hhipl1 A G 12: 108,284,976 (GRCm39) Y443C probably damaging Het
Hoxc13 G A 15: 102,829,873 (GRCm39) G84D possibly damaging Het
Ifi207 T C 1: 173,555,128 (GRCm39) I851M probably damaging Het
Lipk T G 19: 33,999,107 (GRCm39) L134R probably damaging Het
Mov10l1 A G 15: 88,896,345 (GRCm39) N678D possibly damaging Het
Msrb3 A T 10: 120,620,119 (GRCm39) F67I probably damaging Het
Myo1a A G 10: 127,550,767 (GRCm39) D593G probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Nup210l A T 3: 90,114,701 (GRCm39) M1759L probably benign Het
Optn C A 2: 5,039,009 (GRCm39) M371I possibly damaging Het
Rims1 A T 1: 22,443,667 (GRCm39) V380D probably damaging Het
Rnf148 A G 6: 23,654,064 (GRCm39) C311R possibly damaging Het
Rrp12 T C 19: 41,874,167 (GRCm39) D377G probably damaging Het
Sbp T A 17: 24,164,556 (GRCm39) probably benign Het
Sipa1 T C 19: 5,704,885 (GRCm39) E570G probably damaging Het
Spem2 T C 11: 69,707,556 (GRCm39) R470G possibly damaging Het
Syngr4 T C 7: 45,545,194 (GRCm39) E5G possibly damaging Het
Tmem88b A G 4: 155,869,884 (GRCm39) L59P probably damaging Het
Ttn T A 2: 76,620,703 (GRCm39) K13995* probably null Het
Vmn1r69 A G 7: 10,314,069 (GRCm39) Y221H possibly damaging Het
Other mutations in Zfp386
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Zfp386 APN 12 116,022,788 (GRCm39) missense probably benign
IGL02692:Zfp386 APN 12 116,022,855 (GRCm39) missense probably damaging 0.96
IGL03071:Zfp386 APN 12 116,022,760 (GRCm39) missense probably benign 0.08
F5493:Zfp386 UTSW 12 116,023,922 (GRCm39) missense probably damaging 0.99
R0098:Zfp386 UTSW 12 116,022,834 (GRCm39) nonsense probably null
R0098:Zfp386 UTSW 12 116,022,834 (GRCm39) nonsense probably null
R0372:Zfp386 UTSW 12 116,018,436 (GRCm39) missense possibly damaging 0.71
R0784:Zfp386 UTSW 12 116,023,540 (GRCm39) nonsense probably null
R0866:Zfp386 UTSW 12 116,018,329 (GRCm39) splice site probably benign
R0947:Zfp386 UTSW 12 116,023,398 (GRCm39) missense probably benign 0.11
R1080:Zfp386 UTSW 12 116,023,426 (GRCm39) nonsense probably null
R1517:Zfp386 UTSW 12 116,023,225 (GRCm39) missense possibly damaging 0.67
R1597:Zfp386 UTSW 12 116,023,709 (GRCm39) missense probably damaging 0.99
R1722:Zfp386 UTSW 12 116,023,526 (GRCm39) missense probably damaging 0.99
R2043:Zfp386 UTSW 12 116,022,781 (GRCm39) missense probably benign 0.22
R3742:Zfp386 UTSW 12 116,023,170 (GRCm39) nonsense probably null
R3902:Zfp386 UTSW 12 116,023,775 (GRCm39) missense probably damaging 1.00
R5012:Zfp386 UTSW 12 116,022,864 (GRCm39) missense probably benign
R5590:Zfp386 UTSW 12 116,023,347 (GRCm39) missense probably benign 0.41
R5709:Zfp386 UTSW 12 116,023,305 (GRCm39) missense probably benign 0.23
R6156:Zfp386 UTSW 12 116,023,526 (GRCm39) missense probably damaging 0.99
R6184:Zfp386 UTSW 12 116,024,133 (GRCm39) missense possibly damaging 0.64
R6423:Zfp386 UTSW 12 116,023,733 (GRCm39) missense probably damaging 0.96
R8015:Zfp386 UTSW 12 116,023,027 (GRCm39) missense probably damaging 0.96
R8120:Zfp386 UTSW 12 116,018,573 (GRCm39) missense unknown
R8137:Zfp386 UTSW 12 116,023,268 (GRCm39) missense possibly damaging 0.91
R9093:Zfp386 UTSW 12 116,023,878 (GRCm39) nonsense probably null
R9269:Zfp386 UTSW 12 116,023,283 (GRCm39) missense probably benign 0.01
R9320:Zfp386 UTSW 12 116,023,517 (GRCm39) missense probably damaging 1.00
R9331:Zfp386 UTSW 12 116,011,433 (GRCm39) start gained probably benign
R9536:Zfp386 UTSW 12 116,023,686 (GRCm39) missense probably damaging 1.00
R9641:Zfp386 UTSW 12 116,023,330 (GRCm39) missense probably benign 0.03
Z1088:Zfp386 UTSW 12 116,018,393 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CAGTCTCCTGTGGCCAAAAG -3'
(R):5'- ATGCTGAATTTTACGCCTAGTAACG -3'

Sequencing Primer
(F):5'- TGTGGCCAAAAGCACAATACTAATG -3'
(R):5'- ACATTGTGTCACAATCTATACTCTTG -3'
Posted On 2015-03-18