Incidental Mutation 'R3760:Fhad1'
ID 270499
Institutional Source Beutler Lab
Gene Symbol Fhad1
Ensembl Gene ENSMUSG00000051435
Gene Name forkhead-associated phosphopeptide binding domain 1
Synonyms 2900090M10Rik
MMRRC Submission 040740-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R3760 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 141617749-141742393 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 141637124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 1114 (E1114G)
Ref Sequence ENSEMBL: ENSMUSP00000101406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105779] [ENSMUST00000105780]
AlphaFold A6PWD2
Predicted Effect probably damaging
Transcript: ENSMUST00000105779
AA Change: E1114G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101405
Gene: ENSMUSG00000051435
AA Change: E1114G

DomainStartEndE-ValueType
FHA 17 69 8.41e-8 SMART
low complexity region 111 124 N/A INTRINSIC
coiled coil region 307 434 N/A INTRINSIC
coiled coil region 640 915 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
coiled coil region 1111 1140 N/A INTRINSIC
coiled coil region 1255 1339 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105780
AA Change: E1114G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101406
Gene: ENSMUSG00000051435
AA Change: E1114G

DomainStartEndE-ValueType
FHA 17 69 8.41e-8 SMART
low complexity region 111 124 N/A INTRINSIC
coiled coil region 307 434 N/A INTRINSIC
coiled coil region 640 915 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
coiled coil region 1111 1140 N/A INTRINSIC
coiled coil region 1255 1339 N/A INTRINSIC
Meta Mutation Damage Score 0.0814 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl2 T C 3: 148,522,871 (GRCm39) E1448G probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Ct45a C T X: 55,590,568 (GRCm39) V78I probably benign Het
Ell2 A T 13: 75,910,281 (GRCm39) Q163L probably benign Het
Epha6 T A 16: 60,041,347 (GRCm39) T423S possibly damaging Het
Gpr83 A T 9: 14,772,034 (GRCm39) T69S probably benign Het
Gramd1c A T 16: 43,818,154 (GRCm39) M342K probably damaging Het
H3c7 T C 13: 23,728,985 (GRCm39) C111R probably damaging Het
Idua T C 5: 108,817,978 (GRCm39) probably benign Het
Kcnh1 T C 1: 192,188,332 (GRCm39) L931P probably damaging Het
Map2 T A 1: 66,478,077 (GRCm39) S470T probably damaging Het
Map7 T C 10: 20,152,027 (GRCm39) probably benign Het
Obscn A G 11: 58,919,406 (GRCm39) L6213P probably damaging Het
Or5b109 T C 19: 13,212,250 (GRCm39) L212P probably damaging Het
Or8k38 G A 2: 86,488,232 (GRCm39) S190L possibly damaging Het
Pcnx4 C T 12: 72,613,780 (GRCm39) T575M probably damaging Het
Ppp1r12a A G 10: 108,100,595 (GRCm39) D348G probably damaging Het
Prrc2c T C 1: 162,520,420 (GRCm39) N730S probably damaging Het
Serpinb3d C T 1: 107,009,304 (GRCm39) probably benign Het
Skint6 T C 4: 112,794,655 (GRCm39) T705A possibly damaging Het
Slc6a20a A G 9: 123,492,054 (GRCm39) I50T probably damaging Het
Taf13 T C 3: 108,485,424 (GRCm39) probably benign Het
Tlr11 A T 14: 50,599,700 (GRCm39) E562V probably damaging Het
Uhrf2 T C 19: 30,051,331 (GRCm39) S302P probably benign Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Unc79 T A 12: 103,058,964 (GRCm39) L1036Q probably damaging Het
Vmn1r85 A T 7: 12,818,932 (GRCm39) S71T probably damaging Het
Vmn2r-ps158 G A 7: 42,673,502 (GRCm39) E187K probably benign Het
Vps52 T C 17: 34,179,162 (GRCm39) F200L possibly damaging Het
Zfp521 T C 18: 13,977,686 (GRCm39) H909R possibly damaging Het
Other mutations in Fhad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Fhad1 APN 4 141,632,923 (GRCm39) missense probably benign 0.02
IGL01478:Fhad1 APN 4 141,678,949 (GRCm39) missense possibly damaging 0.84
IGL01752:Fhad1 APN 4 141,700,210 (GRCm39) missense possibly damaging 0.82
IGL01788:Fhad1 APN 4 141,660,113 (GRCm39) missense probably benign 0.00
IGL01919:Fhad1 APN 4 141,691,906 (GRCm39) missense probably damaging 0.96
IGL02489:Fhad1 APN 4 141,684,931 (GRCm39) missense probably damaging 0.97
IGL02568:Fhad1 APN 4 141,660,105 (GRCm39) missense probably null 1.00
IGL02583:Fhad1 APN 4 141,738,955 (GRCm39) utr 5 prime probably benign
IGL02716:Fhad1 APN 4 141,645,642 (GRCm39) missense possibly damaging 0.89
IGL02819:Fhad1 APN 4 141,646,069 (GRCm39) missense probably benign 0.23
IGL02820:Fhad1 APN 4 141,646,069 (GRCm39) missense probably benign 0.23
IGL03038:Fhad1 APN 4 141,729,805 (GRCm39) missense probably benign 0.38
IGL03167:Fhad1 APN 4 141,700,108 (GRCm39) missense probably benign 0.00
IGL03255:Fhad1 APN 4 141,700,191 (GRCm39) missense possibly damaging 0.79
R4466_Fhad1_343 UTSW 4 141,684,969 (GRCm39) missense probably damaging 1.00
R4831_Fhad1_494 UTSW 4 141,643,378 (GRCm39) splice site probably null
R5504_Fhad1_818 UTSW 4 141,712,846 (GRCm39) missense probably benign
BB002:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
BB012:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
PIT1430001:Fhad1 UTSW 4 141,637,060 (GRCm39) missense probably damaging 0.99
R0014:Fhad1 UTSW 4 141,655,719 (GRCm39) missense probably damaging 1.00
R0116:Fhad1 UTSW 4 141,667,406 (GRCm39) missense probably benign 0.06
R0143:Fhad1 UTSW 4 141,656,957 (GRCm39) splice site probably benign
R0178:Fhad1 UTSW 4 141,682,651 (GRCm39) missense probably benign 0.31
R0308:Fhad1 UTSW 4 141,712,904 (GRCm39) splice site probably benign
R0384:Fhad1 UTSW 4 141,729,737 (GRCm39) missense probably benign
R0583:Fhad1 UTSW 4 141,631,301 (GRCm39) missense probably benign 0.37
R1501:Fhad1 UTSW 4 141,691,936 (GRCm39) missense probably benign
R1584:Fhad1 UTSW 4 141,712,822 (GRCm39) missense probably benign 0.22
R1615:Fhad1 UTSW 4 141,649,634 (GRCm39) missense probably damaging 0.99
R1991:Fhad1 UTSW 4 141,709,473 (GRCm39) missense possibly damaging 0.75
R2060:Fhad1 UTSW 4 141,626,560 (GRCm39) missense probably benign 0.08
R2079:Fhad1 UTSW 4 141,718,513 (GRCm39) nonsense probably null
R2133:Fhad1 UTSW 4 141,655,711 (GRCm39) missense probably damaging 1.00
R2337:Fhad1 UTSW 4 141,649,655 (GRCm39) missense possibly damaging 0.84
R2843:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2844:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2845:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2846:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2866:Fhad1 UTSW 4 141,648,099 (GRCm39) missense probably benign 0.00
R3119:Fhad1 UTSW 4 141,645,618 (GRCm39) frame shift probably null
R4180:Fhad1 UTSW 4 141,712,854 (GRCm39) missense possibly damaging 0.69
R4466:Fhad1 UTSW 4 141,684,969 (GRCm39) missense probably damaging 1.00
R4627:Fhad1 UTSW 4 141,623,779 (GRCm39) missense possibly damaging 0.47
R4680:Fhad1 UTSW 4 141,738,858 (GRCm39) nonsense probably null
R4725:Fhad1 UTSW 4 141,655,689 (GRCm39) critical splice donor site probably null
R4755:Fhad1 UTSW 4 141,655,794 (GRCm39) missense probably damaging 1.00
R4831:Fhad1 UTSW 4 141,643,378 (GRCm39) splice site probably null
R4909:Fhad1 UTSW 4 141,712,822 (GRCm39) missense probably benign 0.01
R4968:Fhad1 UTSW 4 141,645,618 (GRCm39) missense probably damaging 1.00
R5004:Fhad1 UTSW 4 141,729,910 (GRCm39) critical splice acceptor site probably null
R5036:Fhad1 UTSW 4 141,648,052 (GRCm39) missense probably benign 0.03
R5048:Fhad1 UTSW 4 141,691,987 (GRCm39) critical splice acceptor site probably null
R5416:Fhad1 UTSW 4 141,646,113 (GRCm39) missense probably benign 0.39
R5504:Fhad1 UTSW 4 141,712,846 (GRCm39) missense probably benign
R5586:Fhad1 UTSW 4 141,632,442 (GRCm39) missense probably benign 0.44
R5692:Fhad1 UTSW 4 141,690,768 (GRCm39) missense probably benign 0.00
R5706:Fhad1 UTSW 4 141,681,427 (GRCm39) missense probably damaging 1.00
R5773:Fhad1 UTSW 4 141,656,881 (GRCm39) missense probably damaging 0.99
R5823:Fhad1 UTSW 4 141,682,617 (GRCm39) missense possibly damaging 0.84
R5833:Fhad1 UTSW 4 141,729,838 (GRCm39) missense probably damaging 1.00
R6170:Fhad1 UTSW 4 141,618,263 (GRCm39) nonsense probably null
R6286:Fhad1 UTSW 4 141,648,209 (GRCm39) missense probably damaging 1.00
R6610:Fhad1 UTSW 4 141,643,707 (GRCm39) missense possibly damaging 0.94
R6755:Fhad1 UTSW 4 141,691,915 (GRCm39) missense probably damaging 1.00
R7006:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7008:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7012:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7014:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7058:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7059:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7060:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7159:Fhad1 UTSW 4 141,678,927 (GRCm39) missense probably benign 0.01
R7472:Fhad1 UTSW 4 141,691,937 (GRCm39) missense probably benign
R7670:Fhad1 UTSW 4 141,678,802 (GRCm39) missense probably benign 0.01
R7694:Fhad1 UTSW 4 141,632,375 (GRCm39) missense probably benign 0.41
R7745:Fhad1 UTSW 4 141,618,250 (GRCm39) missense probably benign 0.00
R7848:Fhad1 UTSW 4 141,632,913 (GRCm39) missense probably benign 0.29
R7853:Fhad1 UTSW 4 141,637,134 (GRCm39) missense probably damaging 0.99
R7867:Fhad1 UTSW 4 141,632,902 (GRCm39) missense probably benign 0.00
R7925:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
R8089:Fhad1 UTSW 4 141,684,971 (GRCm39) missense probably damaging 1.00
R8123:Fhad1 UTSW 4 141,712,836 (GRCm39) missense probably benign 0.02
R8711:Fhad1 UTSW 4 141,684,924 (GRCm39) missense probably benign 0.25
R8751:Fhad1 UTSW 4 141,646,134 (GRCm39) missense probably benign 0.04
R8783:Fhad1 UTSW 4 141,636,403 (GRCm39) missense probably benign 0.02
R8858:Fhad1 UTSW 4 141,666,339 (GRCm39) missense possibly damaging 0.87
R8867:Fhad1 UTSW 4 141,656,885 (GRCm39) missense probably damaging 0.97
R8890:Fhad1 UTSW 4 141,656,902 (GRCm39) missense probably benign 0.01
R8982:Fhad1 UTSW 4 141,729,895 (GRCm39) missense probably damaging 1.00
R9004:Fhad1 UTSW 4 141,649,735 (GRCm39) splice site probably benign
R9021:Fhad1 UTSW 4 141,709,620 (GRCm39) missense probably damaging 0.97
R9190:Fhad1 UTSW 4 141,646,058 (GRCm39) critical splice donor site probably null
R9237:Fhad1 UTSW 4 141,632,483 (GRCm39) missense probably benign 0.11
R9614:Fhad1 UTSW 4 141,678,882 (GRCm39) missense possibly damaging 0.69
R9744:Fhad1 UTSW 4 141,637,124 (GRCm39) missense probably damaging 1.00
X0018:Fhad1 UTSW 4 141,678,927 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AATGTCAGGGCGTGCACTTG -3'
(R):5'- TTTTCCAGAAGTGCCGAACG -3'

Sequencing Primer
(F):5'- GACCTGGCCCATCACTGTTAG -3'
(R):5'- TGCCGAACGACAGGGTTTC -3'
Posted On 2015-03-18