Incidental Mutation 'R3760:Vmn1r85'
| ID |
270502 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r85
|
| Ensembl Gene |
ENSMUSG00000070817 |
| Gene Name |
vomeronasal 1 receptor 85 |
| Synonyms |
V1rj3 |
| MMRRC Submission |
040740-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
R3760 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
12818216-12819142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 12818932 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 71
(S71T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148178
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094829]
[ENSMUST00000209822]
|
| AlphaFold |
Q8VIB8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094829
AA Change: S71T
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000092424
Gene: ENSMUSG00000070817
AA Change: S71T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
296 |
8.4e-18 |
PFAM |
|
Pfam:V1R
|
24 |
298 |
2.5e-36 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000209822
AA Change: S71T
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
100% (33/33) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl2 |
T |
C |
3: 148,522,871 (GRCm39) |
E1448G |
probably damaging |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Ct45a |
C |
T |
X: 55,590,568 (GRCm39) |
V78I |
probably benign |
Het |
| Ell2 |
A |
T |
13: 75,910,281 (GRCm39) |
Q163L |
probably benign |
Het |
| Epha6 |
T |
A |
16: 60,041,347 (GRCm39) |
T423S |
possibly damaging |
Het |
| Fhad1 |
T |
C |
4: 141,637,124 (GRCm39) |
E1114G |
probably damaging |
Het |
| Gpr83 |
A |
T |
9: 14,772,034 (GRCm39) |
T69S |
probably benign |
Het |
| Gramd1c |
A |
T |
16: 43,818,154 (GRCm39) |
M342K |
probably damaging |
Het |
| H3c7 |
T |
C |
13: 23,728,985 (GRCm39) |
C111R |
probably damaging |
Het |
| Idua |
T |
C |
5: 108,817,978 (GRCm39) |
|
probably benign |
Het |
| Kcnh1 |
T |
C |
1: 192,188,332 (GRCm39) |
L931P |
probably damaging |
Het |
| Map2 |
T |
A |
1: 66,478,077 (GRCm39) |
S470T |
probably damaging |
Het |
| Map7 |
T |
C |
10: 20,152,027 (GRCm39) |
|
probably benign |
Het |
| Obscn |
A |
G |
11: 58,919,406 (GRCm39) |
L6213P |
probably damaging |
Het |
| Or5b109 |
T |
C |
19: 13,212,250 (GRCm39) |
L212P |
probably damaging |
Het |
| Or8k38 |
G |
A |
2: 86,488,232 (GRCm39) |
S190L |
possibly damaging |
Het |
| Pcnx4 |
C |
T |
12: 72,613,780 (GRCm39) |
T575M |
probably damaging |
Het |
| Ppp1r12a |
A |
G |
10: 108,100,595 (GRCm39) |
D348G |
probably damaging |
Het |
| Prrc2c |
T |
C |
1: 162,520,420 (GRCm39) |
N730S |
probably damaging |
Het |
| Serpinb3d |
C |
T |
1: 107,009,304 (GRCm39) |
|
probably benign |
Het |
| Skint6 |
T |
C |
4: 112,794,655 (GRCm39) |
T705A |
possibly damaging |
Het |
| Slc6a20a |
A |
G |
9: 123,492,054 (GRCm39) |
I50T |
probably damaging |
Het |
| Taf13 |
T |
C |
3: 108,485,424 (GRCm39) |
|
probably benign |
Het |
| Tlr11 |
A |
T |
14: 50,599,700 (GRCm39) |
E562V |
probably damaging |
Het |
| Uhrf2 |
T |
C |
19: 30,051,331 (GRCm39) |
S302P |
probably benign |
Het |
| Ulk1 |
C |
T |
5: 110,937,223 (GRCm39) |
R691Q |
probably benign |
Het |
| Unc79 |
T |
A |
12: 103,058,964 (GRCm39) |
L1036Q |
probably damaging |
Het |
| Vmn2r-ps158 |
G |
A |
7: 42,673,502 (GRCm39) |
E187K |
probably benign |
Het |
| Vps52 |
T |
C |
17: 34,179,162 (GRCm39) |
F200L |
possibly damaging |
Het |
| Zfp521 |
T |
C |
18: 13,977,686 (GRCm39) |
H909R |
possibly damaging |
Het |
|
| Other mutations in Vmn1r85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01099:Vmn1r85
|
APN |
7 |
12,818,461 (GRCm39) |
nonsense |
probably null |
|
|
IGL01520:Vmn1r85
|
APN |
7 |
12,819,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01803:Vmn1r85
|
APN |
7 |
12,818,496 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02285:Vmn1r85
|
APN |
7 |
12,818,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Vmn1r85
|
APN |
7 |
12,819,010 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL03012:Vmn1r85
|
APN |
7 |
12,818,692 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0391:Vmn1r85
|
UTSW |
7 |
12,818,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0655:Vmn1r85
|
UTSW |
7 |
12,818,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn1r85
|
UTSW |
7 |
12,818,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1452:Vmn1r85
|
UTSW |
7 |
12,818,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Vmn1r85
|
UTSW |
7 |
12,818,668 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4783:Vmn1r85
|
UTSW |
7 |
12,818,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Vmn1r85
|
UTSW |
7 |
12,818,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5373:Vmn1r85
|
UTSW |
7 |
12,818,255 (GRCm39) |
nonsense |
probably null |
|
|
R6021:Vmn1r85
|
UTSW |
7 |
12,818,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Vmn1r85
|
UTSW |
7 |
12,818,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6035:Vmn1r85
|
UTSW |
7 |
12,818,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Vmn1r85
|
UTSW |
7 |
12,818,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Vmn1r85
|
UTSW |
7 |
12,819,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7346:Vmn1r85
|
UTSW |
7 |
12,818,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7836:Vmn1r85
|
UTSW |
7 |
12,818,698 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7896:Vmn1r85
|
UTSW |
7 |
12,818,448 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9090:Vmn1r85
|
UTSW |
7 |
12,818,942 (GRCm39) |
nonsense |
probably null |
|
|
R9271:Vmn1r85
|
UTSW |
7 |
12,818,942 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Vmn1r85
|
UTSW |
7 |
12,818,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9713:Vmn1r85
|
UTSW |
7 |
12,818,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9779:Vmn1r85
|
UTSW |
7 |
12,818,308 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCATGTTGATGAACCAGGAAAAC -3'
(R):5'- TCCAAGCAACACTATCTTGGGG -3'
Sequencing Primer
(F):5'- AAAGTCCACTTAGAGAGTTTAGGC -3'
(R):5'- CAAGCAACACTATCTTGGGGGTTTTC -3'
|
| Posted On |
2015-03-18 |
Incidental Mutation