Mutagenetix > Incidental Mutation

Incidental Mutation 'R3762:Vmn2r103'

270569

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R3762 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19993625-20032798 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20032411 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 728 (E728D)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably damaging
Transcript: ENSMUST00000172203
AA Change: E728D

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: E728D

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap35	A	T	7: 16,299,000 (GRCm39)	S22T	probably damaging	Het
Atp2b1	T	C	10: 98,845,351 (GRCm39)	I718T	probably damaging	Het
Cad	T	A	5: 31,232,890 (GRCm39)		probably null	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,619,782 (GRCm39)		probably benign	Het
Defa41	C	T	8: 21,691,753 (GRCm39)	S45F	probably damaging	Het
Dhx15	G	A	5: 52,324,074 (GRCm39)	P406L	probably benign	Het
Dnah17	T	A	11: 117,995,352 (GRCm39)	M999L	probably benign	Het
Dpysl4	A	G	7: 138,676,672 (GRCm39)	E374G	probably damaging	Het
Gatad2a	T	C	8: 70,368,930 (GRCm39)		probably null	Het
Gm826	C	A	2: 160,155,423 (GRCm39)		probably benign	Het
H2-M10.1	T	A	17: 36,636,216 (GRCm39)	H117L	probably damaging	Het
Klhl9	A	T	4: 88,639,830 (GRCm39)	V137D	possibly damaging	Het
Limch1	A	G	5: 67,186,183 (GRCm39)	Y828C	probably damaging	Het
Med1	T	C	11: 98,046,341 (GRCm39)		probably benign	Het
Muc5ac	A	T	7: 141,361,212 (GRCm39)	T1507S	possibly damaging	Het
Pak6	A	T	2: 118,526,958 (GRCm39)	Q651L	probably damaging	Het
Plscr2	T	A	9: 92,173,133 (GRCm39)	V90D	probably damaging	Het
Rbbp4	G	A	4: 129,228,344 (GRCm39)	T2I	probably damaging	Het
Rnf121	G	A	7: 101,673,244 (GRCm39)	T223M	probably damaging	Het
Rsph6a	A	G	7: 18,789,256 (GRCm39)	K196R	probably damaging	Het
Tex47	A	T	5: 7,355,529 (GRCm39)	I237L	probably benign	Het
Ulk1	C	T	5: 110,937,223 (GRCm39)	R691Q	probably benign	Het
Vmn1r30	C	A	6: 58,412,278 (GRCm39)	V185L	probably benign	Het
Vmn2r14	A	T	5: 109,368,033 (GRCm39)	Y320N	probably benign	Het
Zc3h14	T	A	12: 98,724,902 (GRCm39)	F188Y	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	20,013,364 (GRCm39)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	20,015,227 (GRCm39)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	20,013,259 (GRCm39)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	20,013,229 (GRCm39)	missense	probably benign
IGL01404:Vmn2r103	APN	17	20,032,696 (GRCm39)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	20,014,330 (GRCm39)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	20,019,470 (GRCm39)	missense	probably benign
IGL02251:Vmn2r103	APN	17	20,014,231 (GRCm39)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,993,631 (GRCm39)	missense	probably benign
IGL02555:Vmn2r103	APN	17	20,031,873 (GRCm39)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	20,014,389 (GRCm39)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	20,014,218 (GRCm39)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	20,032,510 (GRCm39)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,993,782 (GRCm39)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	20,032,241 (GRCm39)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	20,031,903 (GRCm39)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	20,013,726 (GRCm39)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	20,013,121 (GRCm39)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,993,830 (GRCm39)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	20,014,189 (GRCm39)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	20,014,509 (GRCm39)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	20,013,230 (GRCm39)	missense	probably benign
R1488:Vmn2r103	UTSW	17	20,013,922 (GRCm39)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,993,662 (GRCm39)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	20,014,496 (GRCm39)	missense	probably benign
R1928:Vmn2r103	UTSW	17	20,032,029 (GRCm39)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	20,032,562 (GRCm39)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	20,014,056 (GRCm39)	missense	probably benign
R2219:Vmn2r103	UTSW	17	20,013,909 (GRCm39)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,993,793 (GRCm39)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	20,013,862 (GRCm39)	missense	probably damaging	1.00
R4014:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	20,014,495 (GRCm39)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	20,013,958 (GRCm39)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	20,032,077 (GRCm39)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	20,015,338 (GRCm39)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	20,032,031 (GRCm39)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	20,013,296 (GRCm39)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	20,032,433 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	20,013,904 (GRCm39)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	20,013,251 (GRCm39)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	20,015,201 (GRCm39)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	20,032,715 (GRCm39)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	20,014,478 (GRCm39)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	20,032,587 (GRCm39)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	20,032,406 (GRCm39)	missense	probably benign
R6292:Vmn2r103	UTSW	17	20,013,866 (GRCm39)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	20,014,344 (GRCm39)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	20,032,166 (GRCm39)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	20,032,239 (GRCm39)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,993,773 (GRCm39)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	20,013,739 (GRCm39)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	20,032,314 (GRCm39)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	20,014,476 (GRCm39)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	20,013,385 (GRCm39)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	20,019,511 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	20,013,759 (GRCm39)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	20,032,058 (GRCm39)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	20,032,205 (GRCm39)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	20,032,646 (GRCm39)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	20,032,158 (GRCm39)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	20,031,921 (GRCm39)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	20,014,027 (GRCm39)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	20,019,525 (GRCm39)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	20,032,475 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	20,015,309 (GRCm39)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GCTACTGTGTTGGCCAAAGC -3'
(R):5'- TCCCTTTAGTGCTGTGGAAGAC -3'

Sequencing Primer
(F):5'- GCTACTGTGTTGGCCAAAGCTATTAC -3'
(R):5'- CAGGCAGAAAAGTGACCCAGAC -3'

Posted On

2015-03-18