Incidental Mutation 'R3724:Vmn2r20'
ID 270673
Institutional Source Beutler Lab
Gene Symbol Vmn2r20
Ensembl Gene ENSMUSG00000094145
Gene Name vomeronasal 2, receptor 20
Synonyms EG667180
MMRRC Submission 040715-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.598) question?
Stock # R3724 (G1)
Quality Score 205
Status Validated
Chromosome 6
Chromosomal Location 123362221-123395020 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 123362706 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 693 (T693S)
Ref Sequence ENSEMBL: ENSMUSP00000129145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172199]
AlphaFold L7N2B1
Predicted Effect probably benign
Transcript: ENSMUST00000172199
AA Change: T693S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129145
Gene: ENSMUSG00000094145
AA Change: T693S

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 5e-33 PFAM
Pfam:NCD3G 517 570 9.6e-24 PFAM
Pfam:7tm_3 601 838 1.4e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik G T 8: 120,876,099 (GRCm39) R133L probably damaging Het
Abhd8 G A 8: 71,914,136 (GRCm39) A164V probably benign Het
Api5 C T 2: 94,255,958 (GRCm39) R243Q possibly damaging Het
Atl1 A G 12: 70,006,154 (GRCm39) T487A probably damaging Het
C2cd6 C T 1: 59,105,394 (GRCm39) probably benign Het
Ccdc88c G A 12: 100,896,783 (GRCm39) A1389V possibly damaging Het
Ccna1 T C 3: 54,958,353 (GRCm39) E110G probably damaging Het
Ccne2 T C 4: 11,203,039 (GRCm39) C386R probably benign Het
Cfap53 A G 18: 74,492,640 (GRCm39) I455V probably benign Het
Ctdp1 C T 18: 80,502,482 (GRCm39) V143I probably benign Het
Cyp11a1 A T 9: 57,926,605 (GRCm39) M47L probably benign Het
Dnah5 T C 15: 28,270,566 (GRCm39) L956P probably benign Het
Enkd1 A T 8: 106,430,557 (GRCm39) V326E possibly damaging Het
Epha4 A G 1: 77,403,180 (GRCm39) probably benign Het
Etv5 T C 16: 22,254,662 (GRCm39) D66G probably damaging Het
Evi5l A G 8: 4,228,080 (GRCm39) probably benign Het
Foxf2 A G 13: 31,814,513 (GRCm39) K409R probably damaging Het
Frem3 A G 8: 81,341,900 (GRCm39) T1398A probably benign Het
Galm A G 17: 80,490,709 (GRCm39) T289A probably benign Het
Gtdc1 T C 2: 44,646,319 (GRCm39) E44G probably damaging Het
Hmcn1 T A 1: 150,565,269 (GRCm39) Y2286F possibly damaging Het
Iars1 A G 13: 49,840,860 (GRCm39) probably null Het
Ifna5 A G 4: 88,754,171 (GRCm39) E137G probably damaging Het
Itih4 G A 14: 30,614,541 (GRCm39) E468K possibly damaging Het
Kat6a A T 8: 23,352,804 (GRCm39) H196L probably damaging Het
Kctd16 A G 18: 40,391,912 (GRCm39) T167A possibly damaging Het
Klhl29 C T 12: 5,140,603 (GRCm39) V680I probably damaging Het
Marchf7 T C 2: 60,060,089 (GRCm39) I72T probably benign Het
Mbd6 C T 10: 127,119,760 (GRCm39) probably benign Het
Mefv A G 16: 3,526,058 (GRCm39) probably null Het
Mindy3 T A 2: 12,360,165 (GRCm39) M6L probably damaging Het
Mrpl9 T A 3: 94,355,073 (GRCm39) probably null Het
Nlrp4e A T 7: 23,020,802 (GRCm39) T430S probably benign Het
Or4ac1-ps1 T G 2: 88,370,630 (GRCm39) noncoding transcript Het
Pcdh15 A T 10: 74,481,680 (GRCm39) T342S probably benign Het
Prkce A T 17: 86,476,051 (GRCm39) K11* probably null Het
Pros1 T C 16: 62,720,692 (GRCm39) I117T possibly damaging Het
Prpf38b T C 3: 108,811,656 (GRCm39) probably benign Het
Sh3rf1 T C 8: 61,825,756 (GRCm39) S584P probably benign Het
Slit2 T C 5: 48,414,225 (GRCm39) probably null Het
Srsf4 C T 4: 131,627,413 (GRCm39) probably benign Het
Stambp C T 6: 83,534,448 (GRCm39) E280K probably damaging Het
Tenm3 A G 8: 48,730,781 (GRCm39) I1329T probably damaging Het
Tex2 G A 11: 106,420,156 (GRCm39) T869I unknown Het
Tlk2 A G 11: 105,138,390 (GRCm39) T281A probably benign Het
Tpm1 G A 9: 66,939,227 (GRCm39) probably benign Het
Trim3 A G 7: 105,260,396 (GRCm39) F702L probably damaging Het
Uba6 T C 5: 86,282,906 (GRCm39) D559G probably damaging Het
Zfand2b A G 1: 75,146,499 (GRCm39) K125E possibly damaging Het
Zfp422 C T 6: 116,603,340 (GRCm39) A220T probably benign Het
Zfp747 A T 7: 126,973,762 (GRCm39) V136D probably benign Het
Other mutations in Vmn2r20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01915:Vmn2r20 APN 6 123,370,924 (GRCm39) missense possibly damaging 0.89
IGL02653:Vmn2r20 APN 6 123,362,324 (GRCm39) missense probably damaging 1.00
IGL02686:Vmn2r20 APN 6 123,362,585 (GRCm39) missense probably benign 0.00
R0309:Vmn2r20 UTSW 6 123,363,063 (GRCm39) missense probably benign 0.18
R6502:Vmn2r20 UTSW 6 123,373,342 (GRCm39) missense possibly damaging 0.51
R7039:Vmn2r20 UTSW 6 123,363,082 (GRCm39) missense probably damaging 0.98
R7218:Vmn2r20 UTSW 6 123,363,074 (GRCm39) missense probably damaging 1.00
R7372:Vmn2r20 UTSW 6 123,362,468 (GRCm39) missense probably damaging 1.00
R7509:Vmn2r20 UTSW 6 123,362,382 (GRCm39) missense probably benign 0.00
R7832:Vmn2r20 UTSW 6 123,362,882 (GRCm39) missense probably damaging 1.00
R8011:Vmn2r20 UTSW 6 123,373,369 (GRCm39) missense possibly damaging 0.71
R8118:Vmn2r20 UTSW 6 123,373,429 (GRCm39) missense probably damaging 1.00
R8839:Vmn2r20 UTSW 6 123,373,515 (GRCm39) missense possibly damaging 0.95
R9275:Vmn2r20 UTSW 6 123,362,394 (GRCm39) missense probably damaging 1.00
R9743:Vmn2r20 UTSW 6 123,373,369 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGGATCCCTCATTACACCAG -3'
(R):5'- TTTATCCACTATCGGGACACAC -3'

Sequencing Primer
(F):5'- CAGAGGATGATTTGCCCAAACTCTG -3'
(R):5'- AGAAATCTCAGCTATGTCCTCCTAG -3'
Posted On 2015-03-18