Incidental Mutation 'R3726:Vpreb3'
ID 270797
Institutional Source Beutler Lab
Gene Symbol Vpreb3
Ensembl Gene ENSMUSG00000000903
Gene Name V-set pre-B cell surrogate light chain 3
Synonyms 8HS-20, Vpreb-3
MMRRC Submission 040717-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3726 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 75778891-75785491 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 75779125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121151] [ENSMUST00000121151] [ENSMUST00000219979]
AlphaFold D3Z6J4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059658
SMART Domains Protein: ENSMUSP00000055979
Gene: ENSMUSG00000050157

DomainStartEndE-ValueType
Pfam:Il2rg 2 89 6.7e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117331
Predicted Effect probably null
Transcript: ENSMUST00000121151
SMART Domains Protein: ENSMUSP00000113205
Gene: ENSMUSG00000000903

DomainStartEndE-ValueType
IGv 43 124 1.81e-10 SMART
Predicted Effect probably null
Transcript: ENSMUST00000121151
SMART Domains Protein: ENSMUSP00000113205
Gene: ENSMUSG00000000903

DomainStartEndE-ValueType
IGv 43 124 1.81e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000219979
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402K13Rik AGAGGAG AGAG X: 8,971,342 (GRCm39) probably benign Het
Caap1 A T 4: 94,389,380 (GRCm39) V318D probably damaging Het
Camsap3 T C 8: 3,653,785 (GRCm39) L485P probably damaging Het
Ccsap T C 8: 124,586,100 (GRCm39) E17G possibly damaging Het
Cdk5rap2 C A 4: 70,153,674 (GRCm39) K1716N possibly damaging Het
Coq3 T C 4: 21,892,941 (GRCm39) probably benign Het
Daam2 T A 17: 49,776,766 (GRCm39) D773V probably damaging Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Fam209 T C 2: 172,315,915 (GRCm39) S97P probably benign Het
Fam50b G A 13: 34,930,869 (GRCm39) R115H probably damaging Het
Fbxo31 A G 8: 122,305,248 (GRCm39) F83L probably damaging Het
Fsip2 G T 2: 82,819,311 (GRCm39) A5015S possibly damaging Het
Galnt13 A G 2: 54,988,669 (GRCm39) H497R probably damaging Het
Ggnbp2 A G 11: 84,744,920 (GRCm39) C201R possibly damaging Het
Gm8730 T C 8: 103,591,664 (GRCm39) noncoding transcript Het
Gsr A G 8: 34,161,565 (GRCm39) K124R probably benign Het
Hdgf T C 3: 87,821,804 (GRCm39) S140P probably benign Het
Iqcg C T 16: 32,849,411 (GRCm39) E292K probably damaging Het
Lamb1 C T 12: 31,371,074 (GRCm39) A1375V probably null Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Lonp1 A G 17: 56,925,310 (GRCm39) probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Or6c212 A T 10: 129,558,984 (GRCm39) V143D probably damaging Het
Pcdhb9 T C 18: 37,534,654 (GRCm39) L216P possibly damaging Het
Ppp3cb A G 14: 20,581,010 (GRCm39) probably null Het
Ptprm G A 17: 67,263,855 (GRCm39) P464L possibly damaging Het
Rars2 A G 4: 34,645,787 (GRCm39) T235A probably benign Het
Rimkla A T 4: 119,334,986 (GRCm39) probably null Het
Rnf216 A T 5: 143,013,701 (GRCm39) I708N probably damaging Het
Six5 T A 7: 18,830,855 (GRCm39) V494E possibly damaging Het
Slc43a2 A G 11: 75,433,980 (GRCm39) probably benign Het
Slmap C A 14: 26,148,397 (GRCm39) R671S probably damaging Het
Smarcal1 T C 1: 72,665,755 (GRCm39) F751S possibly damaging Het
Sptan1 G A 2: 29,908,431 (GRCm39) D1711N possibly damaging Het
Sptssa T C 12: 54,703,180 (GRCm39) E30G probably damaging Het
Taf1c A G 8: 120,329,809 (GRCm39) F111L probably damaging Het
Thbs1 A G 2: 117,945,191 (GRCm39) I255V probably benign Het
Tmem19 A G 10: 115,195,675 (GRCm39) probably benign Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tmod1 T C 4: 46,097,026 (GRCm39) V273A probably benign Het
Trpm8 A T 1: 88,255,918 (GRCm39) Y191F probably benign Het
Ube4a T C 9: 44,844,621 (GRCm39) I934V probably damaging Het
Vwf G T 6: 125,654,911 (GRCm39) probably benign Het
Wdr53 T C 16: 32,075,538 (GRCm39) C248R probably benign Het
Zfp217 A G 2: 169,961,130 (GRCm39) V399A probably damaging Het
Zfp980 G A 4: 145,428,653 (GRCm39) G461S probably benign Het
Other mutations in Vpreb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Vpreb3 APN 10 75,784,231 (GRCm39) missense probably benign
IGL02051:Vpreb3 APN 10 75,784,244 (GRCm39) critical splice donor site probably null
IGL03162:Vpreb3 APN 10 75,785,133 (GRCm39) missense probably damaging 1.00
R2319:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2891:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2892:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2894:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3438:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3439:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3508:Vpreb3 UTSW 10 75,785,037 (GRCm39) missense probably benign 0.26
R3725:Vpreb3 UTSW 10 75,779,125 (GRCm39) critical splice donor site probably null
R3771:Vpreb3 UTSW 10 75,775,800 (GRCm39) missense probably benign 0.00
R4975:Vpreb3 UTSW 10 75,775,636 (GRCm39) missense probably damaging 1.00
Z1177:Vpreb3 UTSW 10 75,785,027 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTTGCTACCTACTGCACACAC -3'
(R):5'- GCAAACCAAGTATGCAACTGG -3'

Sequencing Primer
(F):5'- ATGCGGATCCCTCCTGTAGTG -3'
(R):5'- CTTTCCTATAAAGGGTGAGCACAC -3'
Posted On 2015-03-18