Incidental Mutation 'R3729:Or5p62'
ID 270878
Institutional Source Beutler Lab
Gene Symbol Or5p62
Ensembl Gene ENSMUSG00000096068
Gene Name olfactory receptor family 5 subfamily P member 62
Synonyms GA_x6K02T2PBJ9-10501920-10500976, MOR204-19, Olfr486
MMRRC Submission 040719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R3729 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107771005-107771949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107771516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 145 (I145N)
Ref Sequence ENSEMBL: ENSMUSP00000071918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072035]
AlphaFold Q8VFD0
Predicted Effect probably benign
Transcript: ENSMUST00000072035
AA Change: I145N

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000071918
Gene: ENSMUSG00000096068
AA Change: I145N

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 6.8e-51 PFAM
Pfam:7tm_1 44 293 6.6e-24 PFAM
Meta Mutation Damage Score 0.1348 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,345,409 (GRCm39) D954G probably damaging Het
Acvr1 T C 2: 58,352,925 (GRCm39) K345R probably null Het
Aldoart2 A G 12: 55,613,104 (GRCm39) Y343C probably damaging Het
Arpp21 T A 9: 111,895,047 (GRCm39) Y739F possibly damaging Het
Cachd1 C A 4: 100,832,077 (GRCm39) Y746* probably null Het
Card14 T C 11: 119,224,758 (GRCm39) V595A probably damaging Het
Dhx33 T C 11: 70,879,978 (GRCm39) D344G probably benign Het
Dnah12 T A 14: 26,427,220 (GRCm39) D171E probably benign Het
Fat3 A G 9: 16,158,337 (GRCm39) probably benign Het
Fmnl3 A G 15: 99,219,745 (GRCm39) F668L probably damaging Het
Frmpd4 G A X: 166,269,803 (GRCm39) T493M probably damaging Het
Gcn1 A T 5: 115,721,453 (GRCm39) probably benign Het
Hspbp1 G T 7: 4,680,808 (GRCm39) Q223K probably damaging Het
Ighv1-19 C A 12: 114,672,497 (GRCm39) C40F probably damaging Het
Igkv4-90 A G 6: 68,784,665 (GRCm39) F10L probably benign Het
Kctd5 T C 17: 24,278,212 (GRCm39) D146G probably benign Het
Kif4-ps A G 12: 101,112,369 (GRCm39) E166G probably damaging Het
Lemd3 T C 10: 120,763,920 (GRCm39) D780G probably damaging Het
Manba G A 3: 135,260,611 (GRCm39) V599I probably benign Het
Map2 A G 1: 66,451,605 (GRCm39) E247G possibly damaging Het
Mfsd1 T C 3: 67,490,298 (GRCm39) F50L probably benign Het
Mier2 T C 10: 79,380,876 (GRCm39) probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Nol10 A T 12: 17,474,674 (GRCm39) K622I probably benign Het
Or8d2b T C 9: 38,788,547 (GRCm39) F25S probably damaging Het
Phtf1 A G 3: 103,893,095 (GRCm39) M120V probably benign Het
Prrx1 A G 1: 163,089,446 (GRCm39) L127P probably damaging Het
Rbsn T C 6: 92,168,316 (GRCm39) M373V possibly damaging Het
Sec24b T C 3: 129,827,482 (GRCm39) K203R possibly damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Slc4a7 A T 14: 14,729,276 (GRCm38) E47D probably damaging Het
Taf12 C A 4: 132,010,265 (GRCm39) P78Q probably damaging Het
Tnn A G 1: 159,973,810 (GRCm39) C186R probably damaging Het
Trim46 T A 3: 89,142,256 (GRCm39) T721S probably benign Het
Trip4 T C 9: 65,788,224 (GRCm39) N74D possibly damaging Het
Tssk5 C T 15: 76,257,096 (GRCm39) R262H probably benign Het
Vegfa T C 17: 46,335,446 (GRCm39) I105V possibly damaging Het
Vmn2r14 T C 5: 109,364,095 (GRCm39) Y607C probably damaging Het
Wdr83 G T 8: 85,806,968 (GRCm39) H66Q probably damaging Het
Zfp280b A G 10: 75,874,936 (GRCm39) T272A probably benign Het
Zfp960 T A 17: 17,308,633 (GRCm39) L449H probably damaging Het
Other mutations in Or5p62
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0033:Or5p62 UTSW 7 107,771,134 (GRCm39) missense probably benign 0.09
R0144:Or5p62 UTSW 7 107,771,178 (GRCm39) missense probably benign 0.00
R0165:Or5p62 UTSW 7 107,771,882 (GRCm39) missense probably benign 0.03
R0739:Or5p62 UTSW 7 107,771,217 (GRCm39) missense probably benign 0.00
R1027:Or5p62 UTSW 7 107,771,348 (GRCm39) missense probably damaging 0.98
R1781:Or5p62 UTSW 7 107,771,090 (GRCm39) missense probably benign 0.06
R4505:Or5p62 UTSW 7 107,771,175 (GRCm39) missense probably benign 0.00
R5223:Or5p62 UTSW 7 107,771,915 (GRCm39) missense probably benign 0.20
R7089:Or5p62 UTSW 7 107,771,701 (GRCm39) missense probably benign 0.01
R7499:Or5p62 UTSW 7 107,771,007 (GRCm39) makesense probably null
R7894:Or5p62 UTSW 7 107,771,391 (GRCm39) missense probably benign
R7995:Or5p62 UTSW 7 107,771,207 (GRCm39) missense probably damaging 1.00
R8807:Or5p62 UTSW 7 107,771,852 (GRCm39) missense possibly damaging 0.93
R9050:Or5p62 UTSW 7 107,771,087 (GRCm39) missense probably damaging 1.00
R9244:Or5p62 UTSW 7 107,771,852 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACCCTCAGTGGAACGAATCTTC -3'
(R):5'- ATGCTTGTCAACTTCCTGACTG -3'

Sequencing Primer
(F):5'- CCTCAGTGGAACGAATCTTCAAGATG -3'
(R):5'- TGTCAACTTCCTGACTGAGAAAAAC -3'
Posted On 2015-03-18