Incidental Mutation 'R3730:Or8k3'
ID 270914
Institutional Source Beutler Lab
Gene Symbol Or8k3
Ensembl Gene ENSMUSG00000075196
Gene Name olfactory receptor family 8 subfamily K member 3
Synonyms GA_x6K02T2Q125-47703682-47702723, MOR188-3, Olfr1047
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R3730 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86058354-86059313 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86059195 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 40 (I40T)
Ref Sequence ENSEMBL: ENSMUSP00000150247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099901] [ENSMUST00000216056]
AlphaFold Q8VGS0
Predicted Effect probably benign
Transcript: ENSMUST00000099901
AA Change: I40T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000097485
Gene: ENSMUSG00000075196
AA Change: I40T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5e-51 PFAM
Pfam:7tm_1 41 290 4.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216056
AA Change: I40T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 90.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik A G 1: 11,615,450 (GRCm39) N141S probably damaging Het
Acbd6 T A 1: 155,434,471 (GRCm39) S30T probably benign Het
Acot12 T A 13: 91,908,145 (GRCm39) F109Y possibly damaging Het
Adamts19 G A 18: 59,033,982 (GRCm39) R319Q probably damaging Het
Akap1 T C 11: 88,736,008 (GRCm39) E218G possibly damaging Het
Atg4b T A 1: 93,695,997 (GRCm39) D45E probably damaging Het
Atoh1 A G 6: 64,706,557 (GRCm39) E84G probably benign Het
Cemip2 A G 19: 21,803,481 (GRCm39) Y838C probably damaging Het
Cfap251 A T 5: 123,464,631 (GRCm39) I1280L possibly damaging Het
Cfap54 A T 10: 92,847,335 (GRCm39) Y951* probably null Het
Col4a4 T A 1: 82,433,472 (GRCm39) probably null Het
Crlf1 A G 8: 70,952,092 (GRCm39) T95A probably benign Het
Cyp3a25 G A 5: 145,939,891 (GRCm39) P39S probably damaging Het
Dhx9 C A 1: 153,353,866 (GRCm39) A186S probably benign Het
Dusp16 A G 6: 134,695,824 (GRCm39) S336P probably benign Het
Fcgbp T C 7: 27,784,882 (GRCm39) V314A possibly damaging Het
Focad T C 4: 88,327,162 (GRCm39) I157T possibly damaging Het
Frem3 A T 8: 81,342,545 (GRCm39) T1613S probably damaging Het
Fshr C T 17: 89,309,143 (GRCm39) V222I probably benign Het
Galnt13 A G 2: 54,823,519 (GRCm39) N365S possibly damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Ice1 A T 13: 70,751,359 (GRCm39) S1576T probably damaging Het
Ighv1-19 C A 12: 114,672,497 (GRCm39) C40F probably damaging Het
Itga8 T C 2: 12,198,321 (GRCm39) T555A possibly damaging Het
Kctd5 T C 17: 24,278,212 (GRCm39) D146G probably benign Het
Ktn1 A G 14: 47,938,606 (GRCm39) E766G probably damaging Het
Ldlr C G 9: 21,643,097 (GRCm39) A41G probably benign Het
Lrp2 G A 2: 69,294,923 (GRCm39) P3465L probably damaging Het
Lrp2 A T 2: 69,365,251 (GRCm39) probably null Het
Mapk11 G A 15: 89,029,318 (GRCm39) A248V probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Npr2 T C 4: 43,640,999 (GRCm39) S402P possibly damaging Het
Olfm2 T C 9: 20,584,063 (GRCm39) N76D probably damaging Het
Or7g33 T A 9: 19,448,447 (GRCm39) I260F probably benign Het
Pias4 A T 10: 80,999,888 (GRCm39) F55Y probably damaging Het
Rgs12 G A 5: 35,189,595 (GRCm39) E658K probably damaging Het
Ripor3 C G 2: 167,834,739 (GRCm39) E251Q probably damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Slc35e4 A G 11: 3,862,577 (GRCm39) V204A possibly damaging Het
Syt4 T C 18: 31,577,189 (GRCm39) H55R probably damaging Het
Trim46 T A 3: 89,142,256 (GRCm39) T721S probably benign Het
Usf3 G T 16: 44,038,938 (GRCm39) L1139F probably benign Het
Xrn2 A T 2: 146,866,729 (GRCm39) M100L probably benign Het
Zbtb33 C A X: 37,281,822 (GRCm39) N243K probably benign Het
Zfp960 T A 17: 17,308,633 (GRCm39) L449H probably damaging Het
Other mutations in Or8k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01419:Or8k3 APN 2 86,058,973 (GRCm39) missense possibly damaging 0.78
IGL01470:Or8k3 APN 2 86,058,628 (GRCm39) missense probably benign 0.26
IGL02179:Or8k3 APN 2 86,058,591 (GRCm39) nonsense probably null
IGL02703:Or8k3 APN 2 86,059,323 (GRCm39) utr 5 prime probably benign
R0370:Or8k3 UTSW 2 86,059,057 (GRCm39) missense probably damaging 0.99
R1452:Or8k3 UTSW 2 86,058,799 (GRCm39) missense probably damaging 0.99
R1655:Or8k3 UTSW 2 86,058,424 (GRCm39) missense possibly damaging 0.95
R1866:Or8k3 UTSW 2 86,059,072 (GRCm39) missense probably damaging 0.99
R1970:Or8k3 UTSW 2 86,058,596 (GRCm39) missense probably damaging 1.00
R2385:Or8k3 UTSW 2 86,058,817 (GRCm39) nonsense probably null
R3411:Or8k3 UTSW 2 86,058,986 (GRCm39) missense probably benign 0.08
R4655:Or8k3 UTSW 2 86,059,037 (GRCm39) missense probably benign 0.26
R6168:Or8k3 UTSW 2 86,058,938 (GRCm39) missense probably damaging 0.99
R6190:Or8k3 UTSW 2 86,058,578 (GRCm39) missense possibly damaging 0.67
R6492:Or8k3 UTSW 2 86,058,731 (GRCm39) missense possibly damaging 0.91
R7419:Or8k3 UTSW 2 86,058,557 (GRCm39) missense probably damaging 1.00
R8074:Or8k3 UTSW 2 86,058,473 (GRCm39) missense possibly damaging 0.55
R8220:Or8k3 UTSW 2 86,059,309 (GRCm39) missense probably benign 0.00
R8506:Or8k3 UTSW 2 86,058,922 (GRCm39) missense possibly damaging 0.84
R8559:Or8k3 UTSW 2 86,058,988 (GRCm39) missense probably benign 0.00
R8723:Or8k3 UTSW 2 86,058,786 (GRCm39) missense probably damaging 1.00
R9037:Or8k3 UTSW 2 86,059,042 (GRCm39) missense probably benign 0.16
Z1088:Or8k3 UTSW 2 86,058,566 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGTGTGGCACAAAGTTTAAATG -3'
(R):5'- TGCACAATTAAGATACTCAGTCTGC -3'

Sequencing Primer
(F):5'- TGTGGCACAAAGTTTAAATGATATTG -3'
(R):5'- AGTCTGCTTTTGCATTTCTA -3'
Posted On 2015-03-18