Incidental Mutation 'R3754:Rpl37'
ID 271365
Institutional Source Beutler Lab
Gene Symbol Rpl37
Ensembl Gene ENSMUSG00000041841
Gene Name ribosomal protein L37
Synonyms 3110005M08Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.961) question?
Stock # R3754 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 5146127-5148622 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 5146770 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 2 (T2K)
Ref Sequence ENSEMBL: ENSMUSP00000046506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045356] [ENSMUST00000090488]
AlphaFold Q9D823
Predicted Effect possibly damaging
Transcript: ENSMUST00000045356
AA Change: T2K

PolyPhen 2 Score 0.522 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000046506
Gene: ENSMUSG00000041841
AA Change: T2K

DomainStartEndE-ValueType
Pfam:Ribosomal_L37e 2 54 3.9e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000090488
SMART Domains Protein: ENSMUSP00000087974
Gene: ENSMUSG00000068706

DomainStartEndE-ValueType
Pfam:Mt_ATP-synt_D 3 159 8.7e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104549
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226758
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227111
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227463
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227635
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227674
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap3 T C 4: 135,956,766 (GRCm39) probably null Het
Atp12a G A 14: 56,610,045 (GRCm39) V182I probably benign Het
Gad2 A T 2: 22,571,352 (GRCm39) D430V possibly damaging Het
Hr A G 14: 70,805,264 (GRCm39) E1002G probably damaging Het
Itpkc G T 7: 26,927,857 (GRCm39) P19Q probably damaging Het
Lrrc72 A G 12: 36,262,567 (GRCm39) S42P probably benign Het
Med1 A G 11: 98,057,548 (GRCm39) V318A possibly damaging Het
Myef2l G A 3: 10,153,575 (GRCm39) V115I possibly damaging Het
Nek11 A T 9: 105,191,917 (GRCm39) N164K probably damaging Het
Neurod2 A G 11: 98,218,526 (GRCm39) S213P probably damaging Het
Nhsl1 A G 10: 18,391,782 (GRCm39) N179D probably damaging Het
Nr2f2 T C 7: 70,007,769 (GRCm39) I238V probably benign Het
Slf2 A G 19: 44,961,676 (GRCm39) D1065G probably benign Het
Smim5 T C 11: 115,796,549 (GRCm39) C57R probably damaging Het
Soat2 T A 15: 102,065,513 (GRCm39) V236D probably damaging Het
Teddm3 C T 16: 20,971,898 (GRCm39) D224N possibly damaging Het
Tm2d2 G A 8: 25,510,494 (GRCm39) V118I probably damaging Het
Ttc22 C A 4: 106,496,278 (GRCm39) R443S probably damaging Het
Upf1 A G 8: 70,792,464 (GRCm39) I368T probably benign Het
Xrn1 G T 9: 95,849,841 (GRCm39) D129Y probably damaging Het
Zfp109 A G 7: 23,929,181 (GRCm39) M76T probably benign Het
Znrf1 G A 8: 112,345,843 (GRCm39) V76M probably damaging Het
Other mutations in Rpl37
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1470:Rpl37 UTSW 15 5,148,096 (GRCm39) missense probably benign 0.00
R1470:Rpl37 UTSW 15 5,148,096 (GRCm39) missense probably benign 0.00
R1887:Rpl37 UTSW 15 5,148,072 (GRCm39) missense possibly damaging 0.62
R3945:Rpl37 UTSW 15 5,147,176 (GRCm39) missense probably benign 0.01
R4959:Rpl37 UTSW 15 5,147,128 (GRCm39) missense possibly damaging 0.61
R4973:Rpl37 UTSW 15 5,147,128 (GRCm39) missense possibly damaging 0.61
R6366:Rpl37 UTSW 15 5,147,990 (GRCm39) splice site probably null
R7037:Rpl37 UTSW 15 5,147,185 (GRCm39) missense probably null 0.00
R9154:Rpl37 UTSW 15 5,147,109 (GRCm39) missense probably benign 0.26
Z1176:Rpl37 UTSW 15 5,148,074 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACCTACCCTACCTGTGTGCTAAG -3'
(R):5'- CCTCCAAAGTTGTTGCGTGC -3'

Sequencing Primer
(F):5'- CCTACCTGTGTGCTAAGATTTAAATC -3'
(R):5'- CCAAAGTTGTTGCGTGCCAAATG -3'
Posted On 2015-03-18