Incidental Mutation 'R3756:Poldip3'
ID 271456
Institutional Source Beutler Lab
Gene Symbol Poldip3
Ensembl Gene ENSMUSG00000041815
Gene Name polymerase (DNA-directed), delta interacting protein 3
Synonyms 1110008P04Rik, PDIP46
Accession Numbers
Essential gene? Probably non essential (E-score: 0.185) question?
Stock # R3756 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 83010177-83033585 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 83015676 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058793] [ENSMUST00000100375] [ENSMUST00000129372]
AlphaFold Q8BG81
Predicted Effect probably benign
Transcript: ENSMUST00000058793
SMART Domains Protein: ENSMUSP00000054548
Gene: ENSMUSG00000041815

DomainStartEndE-ValueType
low complexity region 183 196 N/A INTRINSIC
low complexity region 214 223 N/A INTRINSIC
low complexity region 260 272 N/A INTRINSIC
RRM 281 347 5.05e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100375
SMART Domains Protein: ENSMUSP00000097944
Gene: ENSMUSG00000041815

DomainStartEndE-ValueType
low complexity region 154 167 N/A INTRINSIC
low complexity region 185 194 N/A INTRINSIC
low complexity region 231 243 N/A INTRINSIC
RRM 252 318 5.05e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129372
SMART Domains Protein: ENSMUSP00000120859
Gene: ENSMUSG00000041815

DomainStartEndE-ValueType
low complexity region 153 162 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135013
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149802
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atad2 A G 15: 57,963,119 (GRCm39) C805R probably benign Het
Atf7ip T A 6: 136,537,815 (GRCm39) N357K probably benign Het
Atp7a T A X: 105,145,449 (GRCm39) probably null Het
Cdc16 T C 8: 13,827,609 (GRCm39) probably null Het
Cdh26 T A 2: 178,111,794 (GRCm39) probably benign Het
Ctdp1 A T 18: 80,495,566 (GRCm39) S273T probably damaging Het
Cyb5d1 G T 11: 69,284,658 (GRCm39) R165S probably damaging Het
Ddhd1 T C 14: 45,848,030 (GRCm39) K546R probably benign Het
Ddhd1 A T 14: 45,894,720 (GRCm39) V250E probably damaging Het
Dnm1l G T 16: 16,139,476 (GRCm39) A406D possibly damaging Het
Efs G A 14: 55,157,879 (GRCm39) probably benign Het
Ephb1 A C 9: 101,918,238 (GRCm39) S424A probably benign Het
Erich3 A G 3: 154,470,215 (GRCm39) T83A possibly damaging Het
Erich3 A G 3: 154,469,958 (GRCm39) probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Gm9970 G C 5: 31,398,117 (GRCm39) probably benign Het
H2az2 A G 11: 6,383,761 (GRCm39) V53A possibly damaging Het
Inpp5d G A 1: 87,629,130 (GRCm39) probably benign Het
Lhcgr A G 17: 89,061,284 (GRCm39) S256P possibly damaging Het
Lrch4 T A 5: 137,635,992 (GRCm39) D348E probably damaging Het
Mettl13 T C 1: 162,371,789 (GRCm39) E360G probably damaging Het
Mtss2 C T 8: 111,456,692 (GRCm39) S192L probably damaging Het
Myh8 G A 11: 67,175,443 (GRCm39) probably benign Het
Myom2 T A 8: 15,152,650 (GRCm39) Y666N probably benign Het
Pcdha8 G A 18: 37,126,741 (GRCm39) V408M probably damaging Het
Pcdhb3 T C 18: 37,435,878 (GRCm39) F615L probably damaging Het
Pitrm1 T C 13: 6,608,271 (GRCm39) L333P probably damaging Het
Plxnb1 G T 9: 108,942,526 (GRCm39) probably benign Het
Rbmx2 T A X: 47,797,890 (GRCm39) S143T possibly damaging Het
Rgl2 C A 17: 34,151,571 (GRCm39) A205D probably benign Het
Rundc3a A G 11: 102,290,085 (GRCm39) I175V possibly damaging Het
Rxra A C 2: 27,631,923 (GRCm39) Q198P probably damaging Het
Slc25a36 A T 9: 96,982,208 (GRCm39) Y42* probably null Het
Slc4a5 A G 6: 83,265,285 (GRCm39) D693G probably benign Het
Tmem86b A G 7: 4,631,623 (GRCm39) L138P probably damaging Het
Trappc13 C T 13: 104,305,068 (GRCm39) D40N probably benign Het
Vmn1r39 T C 6: 66,781,863 (GRCm39) S152G probably damaging Het
Zbbx C T 3: 75,012,978 (GRCm39) G151E probably damaging Het
Zfp35 T C 18: 24,135,982 (GRCm39) C109R possibly damaging Het
Other mutations in Poldip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00780:Poldip3 APN 15 83,022,680 (GRCm39) missense probably damaging 1.00
IGL02887:Poldip3 APN 15 83,013,469 (GRCm39) unclassified probably benign
R0143:Poldip3 UTSW 15 83,012,144 (GRCm39) missense probably damaging 1.00
R0201:Poldip3 UTSW 15 83,019,497 (GRCm39) missense probably benign 0.00
R0511:Poldip3 UTSW 15 83,022,436 (GRCm39) missense probably damaging 1.00
R1560:Poldip3 UTSW 15 83,022,527 (GRCm39) missense probably damaging 1.00
R2302:Poldip3 UTSW 15 83,013,469 (GRCm39) unclassified probably benign
R3755:Poldip3 UTSW 15 83,015,676 (GRCm39) unclassified probably benign
R4785:Poldip3 UTSW 15 83,015,702 (GRCm39) missense probably damaging 1.00
R4917:Poldip3 UTSW 15 83,016,776 (GRCm39) critical splice donor site probably null
R4965:Poldip3 UTSW 15 83,021,706 (GRCm39) missense possibly damaging 0.80
R5009:Poldip3 UTSW 15 83,017,395 (GRCm39) missense probably damaging 1.00
R5030:Poldip3 UTSW 15 83,022,392 (GRCm39) missense possibly damaging 0.67
R5992:Poldip3 UTSW 15 83,013,430 (GRCm39) missense probably damaging 0.96
R6638:Poldip3 UTSW 15 83,017,401 (GRCm39) missense probably damaging 1.00
R7028:Poldip3 UTSW 15 83,015,698 (GRCm39) missense probably damaging 1.00
R9377:Poldip3 UTSW 15 83,019,589 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTTCCCAACCAGACCCTTTAAG -3'
(R):5'- GCAGTGCAGTCTTTGGAGAG -3'

Sequencing Primer
(F):5'- GACCCTTTAAGAGACTCATCCACTG -3'
(R):5'- GGCAAGTGGTCTGCATGTCC -3'
Posted On 2015-03-18