Incidental Mutation 'R3758:Mill1'
ID 271522
Institutional Source Beutler Lab
Gene Symbol Mill1
Ensembl Gene ENSMUSG00000054005
Gene Name MHC I like leukocyte 1
Synonyms 5530400I18Rik
MMRRC Submission 040739-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R3758 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 17979272-18000017 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 17996628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000069083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066780]
AlphaFold Q8HWE7
Predicted Effect probably null
Transcript: ENSMUST00000066780
SMART Domains Protein: ENSMUSP00000069083
Gene: ENSMUSG00000054005

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Pfam:MHC_I 60 236 3.8e-33 PFAM
IGc1 255 327 3.53e-4 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 93% (28/30)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat3 A G 17: 13,146,354 (GRCm39) probably benign Het
Bcat1 T A 6: 144,978,598 (GRCm39) I208F probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cd200r3 T G 16: 44,784,991 (GRCm39) probably null Het
Coq8b C T 7: 26,941,652 (GRCm39) Q246* probably null Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Fbln2 T C 6: 91,233,363 (GRCm39) S616P probably damaging Het
Fkbp10 G A 11: 100,313,451 (GRCm39) probably null Het
Gabra1 G T 11: 42,066,763 (GRCm39) D50E probably benign Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Hmgcs2 A G 3: 98,198,406 (GRCm39) N103S probably damaging Het
Htt A G 5: 35,053,314 (GRCm39) H2549R probably damaging Het
Lrba A G 3: 86,683,356 (GRCm39) E2726G probably damaging Het
Lrrc7 T C 3: 157,869,602 (GRCm39) N706D probably damaging Het
Mtcl2 T C 2: 156,862,558 (GRCm39) N1457S possibly damaging Het
Nipa2 T C 7: 55,585,689 (GRCm39) Y102C probably damaging Het
Nmd3 T A 3: 69,631,641 (GRCm39) C32* probably null Het
Or11h6 A G 14: 50,880,493 (GRCm39) K252E possibly damaging Het
Or4a78 A G 2: 89,497,916 (GRCm39) F105L probably benign Het
Or52r1b A G 7: 102,691,177 (GRCm39) S159G probably benign Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Pcdhb7 A G 18: 37,476,079 (GRCm39) D405G possibly damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Serpinb9b A G 13: 33,219,571 (GRCm39) Y166C probably damaging Het
Sprr1a T G 3: 92,391,704 (GRCm39) K99T probably damaging Het
Spsb4 A G 9: 96,877,924 (GRCm39) V133A probably damaging Het
Suz12 A G 11: 79,915,768 (GRCm39) T391A probably benign Het
Tor1aip2 A G 1: 155,941,035 (GRCm39) E447G probably damaging Het
Ube4a G A 9: 44,861,198 (GRCm39) probably benign Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Mill1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Mill1 APN 7 17,998,566 (GRCm39) missense possibly damaging 0.91
IGL01313:Mill1 APN 7 17,998,558 (GRCm39) missense possibly damaging 0.82
IGL01417:Mill1 APN 7 17,998,708 (GRCm39) missense probably benign 0.18
IGL01997:Mill1 APN 7 17,989,814 (GRCm39) missense probably damaging 1.00
IGL02282:Mill1 APN 7 17,997,129 (GRCm39) critical splice donor site probably null
IGL03126:Mill1 APN 7 17,989,832 (GRCm39) missense probably benign 0.33
IGL03197:Mill1 APN 7 17,998,590 (GRCm39) missense probably benign 0.02
R0513:Mill1 UTSW 7 17,998,802 (GRCm39) nonsense probably null
R0515:Mill1 UTSW 7 17,998,798 (GRCm39) missense probably benign 0.12
R1460:Mill1 UTSW 7 17,996,595 (GRCm39) missense probably damaging 1.00
R1589:Mill1 UTSW 7 17,979,572 (GRCm39) missense probably benign 0.01
R2192:Mill1 UTSW 7 17,998,544 (GRCm39) nonsense probably null
R3704:Mill1 UTSW 7 17,996,978 (GRCm39) missense possibly damaging 0.91
R4685:Mill1 UTSW 7 17,989,853 (GRCm39) missense probably damaging 0.98
R4753:Mill1 UTSW 7 17,996,472 (GRCm39) missense probably benign 0.28
R5763:Mill1 UTSW 7 17,979,587 (GRCm39) missense probably benign 0.03
R5938:Mill1 UTSW 7 17,996,613 (GRCm39) missense probably benign 0.00
R7757:Mill1 UTSW 7 17,996,391 (GRCm39) missense probably benign 0.02
R8094:Mill1 UTSW 7 17,989,835 (GRCm39) missense probably benign 0.01
R8972:Mill1 UTSW 7 17,996,982 (GRCm39) missense probably benign 0.00
R9620:Mill1 UTSW 7 17,997,027 (GRCm39) missense probably benign 0.01
R9694:Mill1 UTSW 7 17,997,027 (GRCm39) missense probably benign 0.01
Z1176:Mill1 UTSW 7 17,979,424 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CTTCGATGATGAGCCCTTCCTG -3'
(R):5'- CCCAGGCAATGACCTGTTATC -3'

Sequencing Primer
(F):5'- GATGAGCCCTTCCTGCCCTATAAG -3'
(R):5'- GACTTAATCTCTCAGTGGGGC -3'
Posted On 2015-03-18