Incidental Mutation 'R1871:Letm2'
ID 271597
Institutional Source Beutler Lab
Gene Symbol Letm2
Ensembl Gene ENSMUSG00000037363
Gene Name leucine zipper-EF-hand containing transmembrane protein 2
Synonyms D030041N04Rik
MMRRC Submission 039893-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R1871 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 26068506-26087598 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 26086460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147507 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079160] [ENSMUST00000210234] [ENSMUST00000210616] [ENSMUST00000210810] [ENSMUST00000211422]
AlphaFold Q7TNU7
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059474
Predicted Effect probably benign
Transcript: ENSMUST00000079160
SMART Domains Protein: ENSMUSP00000078160
Gene: ENSMUSG00000037363

DomainStartEndE-ValueType
low complexity region 106 117 N/A INTRINSIC
Pfam:LETM1 120 384 1.2e-102 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209734
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209982
Predicted Effect probably benign
Transcript: ENSMUST00000210234
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210321
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211001
Predicted Effect probably benign
Transcript: ENSMUST00000210616
Predicted Effect probably benign
Transcript: ENSMUST00000210810
Predicted Effect probably benign
Transcript: ENSMUST00000211422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211137
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210914
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210582
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.6%
  • 20x: 93.2%
Validation Efficiency 97% (87/90)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930009A15Rik A G 10: 115,415,699 (GRCm39) probably null Het
Abca13 A T 11: 9,242,134 (GRCm39) E1332D probably benign Het
Abce1 G A 8: 80,411,897 (GRCm39) Q588* probably null Het
Acads A T 5: 115,255,701 (GRCm39) C45S probably damaging Het
Adam34l A T 8: 44,078,132 (GRCm39) Y697* probably null Het
Adamts12 T C 15: 11,311,240 (GRCm39) S1166P probably benign Het
Ano4 T A 10: 88,828,889 (GRCm39) I517F probably damaging Het
Arpc1a T A 5: 145,043,901 (GRCm39) C344S possibly damaging Het
Blk A T 14: 63,613,364 (GRCm39) S381R possibly damaging Het
Capn15 C A 17: 26,183,203 (GRCm39) W426L probably damaging Het
Chd6 T C 2: 160,832,176 (GRCm39) T999A probably damaging Het
Clca3a2 A G 3: 144,503,398 (GRCm39) Y851H probably benign Het
Crp T A 1: 172,526,172 (GRCm39) W86R possibly damaging Het
Ctnnal1 G A 4: 56,812,534 (GRCm39) L705F probably benign Het
Cyp2c66 A G 19: 39,151,858 (GRCm39) D191G possibly damaging Het
Cyp4f37 A G 17: 32,853,639 (GRCm39) D441G probably damaging Het
D130040H23Rik T A 8: 69,755,354 (GRCm39) I253N probably benign Het
Dnah5 T A 15: 28,331,859 (GRCm39) Y2148* probably null Het
Eef1g A T 19: 8,955,330 (GRCm39) D393V possibly damaging Het
Elapor2 A G 5: 9,468,007 (GRCm39) E225G probably damaging Het
Ephx2 A T 14: 66,322,183 (GRCm39) I538N probably damaging Het
Fat4 T A 3: 39,035,221 (GRCm39) S2958T possibly damaging Het
Foxi1 A T 11: 34,157,937 (GRCm39) N29K possibly damaging Het
Gm10287 G T 3: 148,930,373 (GRCm39) noncoding transcript Het
Gm10801 G T 2: 98,494,185 (GRCm39) S109I probably benign Het
Gmcl1 T C 6: 86,674,498 (GRCm39) D460G probably benign Het
Gpr158 A G 2: 21,820,426 (GRCm39) D641G probably damaging Het
Heph C A X: 95,542,690 (GRCm39) S561Y probably benign Het
Hgfac A G 5: 35,200,257 (GRCm39) *90W probably null Het
Hp1bp3 C G 4: 137,949,497 (GRCm39) P65R probably damaging Het
Ighv6-4 T A 12: 114,370,221 (GRCm39) Y58F probably benign Het
Jrk T C 15: 74,578,412 (GRCm39) D291G possibly damaging Het
Kdm4d A G 9: 14,375,679 (GRCm39) Y60H probably damaging Het
Khdrbs3 T C 15: 68,921,291 (GRCm39) Y203H probably damaging Het
Klhl6 A T 16: 19,775,793 (GRCm39) V255D possibly damaging Het
Krt9 C T 11: 100,081,614 (GRCm39) R305H probably damaging Het
Lama2 T G 10: 26,860,490 (GRCm39) N2999T probably damaging Het
Lipa A T 19: 34,488,328 (GRCm39) L106Q probably damaging Het
Llph A T 10: 120,067,141 (GRCm39) N86I probably damaging Het
Lyst T A 13: 13,826,297 (GRCm39) N1601K probably benign Het
Mc1r T A 8: 124,134,275 (GRCm39) S9R probably benign Het
Mfsd14a A G 3: 116,434,969 (GRCm39) I249T probably benign Het
Mtfp1 G A 11: 4,044,012 (GRCm39) R73C probably benign Het
Myo1a A G 10: 127,555,540 (GRCm39) Q877R probably benign Het
Nalcn A C 14: 123,831,965 (GRCm39) V103G possibly damaging Het
Ndst3 A T 3: 123,355,673 (GRCm39) F119I probably damaging Het
Or8k16 A G 2: 85,520,655 (GRCm39) N294S probably damaging Het
Patl1 T C 19: 11,902,596 (GRCm39) probably benign Het
Pcdhb2 A T 18: 37,430,408 (GRCm39) probably null Het
Pcdhb22 A C 18: 37,652,200 (GRCm39) T223P probably damaging Het
Pcdhga1 T A 18: 37,973,143 (GRCm39) N907K probably damaging Het
Pfas T C 11: 68,882,795 (GRCm39) D782G probably damaging Het
Plpp6 T C 19: 28,941,684 (GRCm39) F95S probably damaging Het
Polr2b T A 5: 77,474,374 (GRCm39) probably benign Het
Qars1 T G 9: 108,391,315 (GRCm39) probably null Het
Ranbp2 A G 10: 58,328,383 (GRCm39) I2800V probably damaging Het
Rnf213 T C 11: 119,340,955 (GRCm39) V3532A probably benign Het
Rubcnl T C 14: 75,279,849 (GRCm39) S411P possibly damaging Het
Scn1a C A 2: 66,148,369 (GRCm39) G1059W probably damaging Het
Sgms1 C T 19: 32,137,282 (GRCm39) V95I probably benign Het
Siglecf A G 7: 43,004,967 (GRCm39) N399S probably benign Het
Slc29a4 T C 5: 142,707,243 (GRCm39) *529R probably null Het
Slfn9 G T 11: 82,872,402 (GRCm39) T778N probably benign Het
Sorl1 G A 9: 41,881,021 (GRCm39) Q2167* probably null Het
Stkld1 A G 2: 26,827,985 (GRCm39) probably benign Het
Taar8b T C 10: 23,967,900 (GRCm39) Y98C probably damaging Het
Tecta G A 9: 42,248,472 (GRCm39) L1977F probably damaging Het
Tecta G C 9: 42,248,636 (GRCm39) T1917R probably damaging Het
Topaz1 T A 9: 122,628,544 (GRCm39) S1544T probably benign Het
Tpx2 T C 2: 152,735,523 (GRCm39) I717T probably damaging Het
Tyk2 A T 9: 21,032,737 (GRCm39) V342E probably damaging Het
Ube4a A T 9: 44,856,235 (GRCm39) probably null Het
Unc80 A T 1: 66,549,876 (GRCm39) R711S possibly damaging Het
Ush2a C A 1: 188,558,665 (GRCm39) D3631E probably benign Het
Usp34 A G 11: 23,314,479 (GRCm39) H807R probably benign Het
Vps13a T C 19: 16,642,028 (GRCm39) T2200A probably benign Het
Wif1 A G 10: 120,920,824 (GRCm39) I215M probably benign Het
Wnk1 T C 6: 119,928,050 (GRCm39) T1134A probably damaging Het
Xxylt1 A G 16: 30,776,235 (GRCm39) V367A probably damaging Het
Zfp735 A T 11: 73,601,412 (GRCm39) K119* probably null Het
Other mutations in Letm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02738:Letm2 APN 8 26,076,789 (GRCm39) missense probably damaging 1.00
selbstlob UTSW 8 26,083,977 (GRCm39) missense probably benign 0.03
IGL03098:Letm2 UTSW 8 26,071,745 (GRCm39) missense possibly damaging 0.73
R0062:Letm2 UTSW 8 26,077,464 (GRCm39) splice site probably benign
R0062:Letm2 UTSW 8 26,077,464 (GRCm39) splice site probably benign
R0207:Letm2 UTSW 8 26,068,786 (GRCm39) missense probably damaging 0.96
R0485:Letm2 UTSW 8 26,082,574 (GRCm39) missense probably damaging 1.00
R1869:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R1870:Letm2 UTSW 8 26,086,460 (GRCm39) splice site probably benign
R3881:Letm2 UTSW 8 26,083,884 (GRCm39) nonsense probably null
R4115:Letm2 UTSW 8 26,070,343 (GRCm39) nonsense probably null
R4459:Letm2 UTSW 8 26,076,715 (GRCm39) missense probably damaging 1.00
R4461:Letm2 UTSW 8 26,076,715 (GRCm39) missense probably damaging 1.00
R4961:Letm2 UTSW 8 26,084,108 (GRCm39) missense possibly damaging 0.86
R5063:Letm2 UTSW 8 26,071,795 (GRCm39) missense probably benign 0.26
R5069:Letm2 UTSW 8 26,083,980 (GRCm39) nonsense probably null
R5732:Letm2 UTSW 8 26,077,341 (GRCm39) missense possibly damaging 0.51
R6527:Letm2 UTSW 8 26,082,522 (GRCm39) utr 3 prime probably benign
R6706:Letm2 UTSW 8 26,083,977 (GRCm39) missense probably benign 0.03
R7624:Letm2 UTSW 8 26,082,553 (GRCm39) nonsense probably null
R7968:Letm2 UTSW 8 26,083,766 (GRCm39) missense probably damaging 1.00
R8272:Letm2 UTSW 8 26,076,672 (GRCm39) missense probably damaging 1.00
R8356:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R8456:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R8481:Letm2 UTSW 8 26,070,375 (GRCm39) missense possibly damaging 0.86
R9023:Letm2 UTSW 8 26,077,236 (GRCm39) missense
R9234:Letm2 UTSW 8 26,084,102 (GRCm39) missense probably benign 0.03
R9366:Letm2 UTSW 8 26,084,165 (GRCm39) missense probably damaging 1.00
R9636:Letm2 UTSW 8 26,083,719 (GRCm39) missense probably benign 0.33
R9690:Letm2 UTSW 8 26,077,435 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGCAAGGTTTTCTGTACTAAGCC -3'
(R):5'- GAACCCATTTCTGTGTGTTTGGATC -3'

Sequencing Primer
(F):5'- GCTGGGACTAAACGCATTTGTCAC -3'
(R):5'- CTGTGTGTTTGGATCGAAAAAGTACC -3'
Posted On 2015-03-23