Incidental Mutation 'IGL00980:Vmn2r2'
ID27164
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r2
Ensembl Gene ENSMUSG00000043897
Gene Namevomeronasal 2, receptor 2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL00980
Quality Score
Status
Chromosome3
Chromosomal Location64116432-64140543 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 64117180 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 660 (M660K)
Ref Sequence ENSEMBL: ENSMUSP00000135110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]
Predicted Effect probably benign
Transcript: ENSMUST00000077958
AA Change: M576K

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: M576K

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 4.5e-80 PFAM
Pfam:NCD3G 458 511 8.3e-18 PFAM
Pfam:7tm_3 542 779 1.3e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177151
AA Change: M660K

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: M660K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 83 500 1.6e-84 PFAM
Pfam:NCD3G 542 595 2.6e-17 PFAM
Pfam:7tm_3 628 862 1.9e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik C T 3: 37,000,041 T3103I probably damaging Het
Adam2 A T 14: 66,056,528 Y283* probably null Het
Bend3 C A 10: 43,511,566 Q652K probably damaging Het
Ccdc136 G A 6: 29,420,258 S992N probably damaging Het
Cct6a T C 5: 129,791,793 probably benign Het
Cd74 A T 18: 60,811,326 I203F probably benign Het
Cd8b1 C A 6: 71,332,479 C182* probably null Het
Cmtr1 T A 17: 29,691,284 D454E probably benign Het
Cyp2b13 T A 7: 26,081,727 F188Y probably benign Het
Dppa2 T C 16: 48,311,686 S49P possibly damaging Het
Fhl5 G T 4: 25,207,181 L196I possibly damaging Het
Gimap4 T A 6: 48,690,938 V81D probably damaging Het
Gm4884 T G 7: 41,043,726 M373R probably damaging Het
Gnrhr C T 5: 86,197,303 probably null Het
H2-Oa T G 17: 34,094,563 L196R probably damaging Het
Icosl T C 10: 78,071,971 S122P probably damaging Het
Itpr3 A G 17: 27,110,956 T1575A probably benign Het
Krt80 T C 15: 101,349,998 K373E possibly damaging Het
Lamp1 G A 8: 13,171,195 probably benign Het
Npvf T C 6: 50,650,885 K185E probably damaging Het
Nuf2 A G 1: 169,510,434 M258T probably damaging Het
Olfr1416 T C 1: 92,479,680 probably null Het
Olfr883 G A 9: 38,025,811 V2I probably benign Het
Smurf2 A C 11: 106,836,095 I469S probably damaging Het
Soat1 T A 1: 156,441,341 H180L probably benign Het
Spink5 G T 18: 44,007,710 D659Y probably damaging Het
Sprtn T C 8: 124,900,298 M139T probably damaging Het
Tas2r137 T C 6: 40,491,418 S61P possibly damaging Het
Tec G A 5: 72,786,798 L89F probably damaging Het
Trav21-dv12 A T 14: 53,876,650 M76L probably benign Het
Ttc7 A C 17: 87,321,446 T271P possibly damaging Het
Tyk2 G A 9: 21,120,588 T397I probably benign Het
Ugt1a6b T A 1: 88,107,605 Y222N possibly damaging Het
Vmn2r52 T A 7: 10,171,090 Y274F probably damaging Het
Wscd1 A C 11: 71,788,942 N547T possibly damaging Het
Zfp335 C A 2: 164,902,674 E394* probably null Het
Other mutations in Vmn2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Vmn2r2 APN 3 64133898 splice site probably benign
IGL01389:Vmn2r2 APN 3 64117009 missense probably damaging 0.97
IGL01804:Vmn2r2 APN 3 64134256 missense possibly damaging 0.91
IGL02750:Vmn2r2 APN 3 64117402 missense probably damaging 1.00
IGL02829:Vmn2r2 APN 3 64118751 splice site probably benign
IGL03036:Vmn2r2 APN 3 64116900 missense probably benign 0.01
IGL03174:Vmn2r2 APN 3 64117123 nonsense probably null
PIT4151001:Vmn2r2 UTSW 3 64116913 missense possibly damaging 0.67
R0029:Vmn2r2 UTSW 3 64116944 missense probably benign 0.00
R0310:Vmn2r2 UTSW 3 64134618 missense probably damaging 1.00
R0357:Vmn2r2 UTSW 3 64133899 splice site probably null
R0637:Vmn2r2 UTSW 3 64126578 missense probably benign 0.00
R1626:Vmn2r2 UTSW 3 64134500 missense possibly damaging 0.61
R1662:Vmn2r2 UTSW 3 64117130 missense probably benign 0.00
R1710:Vmn2r2 UTSW 3 64117399 missense probably benign 0.19
R1797:Vmn2r2 UTSW 3 64134707 missense probably benign 0.00
R1862:Vmn2r2 UTSW 3 64134521 missense possibly damaging 0.79
R1971:Vmn2r2 UTSW 3 64126700 missense probably damaging 1.00
R2051:Vmn2r2 UTSW 3 64117345 missense possibly damaging 0.77
R2099:Vmn2r2 UTSW 3 64117053 missense probably damaging 1.00
R2275:Vmn2r2 UTSW 3 64116509 missense probably benign 0.00
R3078:Vmn2r2 UTSW 3 64134632 missense probably benign 0.22
R3418:Vmn2r2 UTSW 3 64116899 missense probably benign 0.00
R3419:Vmn2r2 UTSW 3 64116899 missense probably benign 0.00
R3959:Vmn2r2 UTSW 3 64140526 missense probably benign
R4230:Vmn2r2 UTSW 3 64134491 missense probably benign 0.00
R4258:Vmn2r2 UTSW 3 64134697 missense probably damaging 1.00
R4810:Vmn2r2 UTSW 3 64137462 missense probably damaging 1.00
R4822:Vmn2r2 UTSW 3 64134539 missense probably damaging 0.99
R4919:Vmn2r2 UTSW 3 64117157 missense possibly damaging 0.56
R4925:Vmn2r2 UTSW 3 64137471 start codon destroyed probably null 0.03
R4954:Vmn2r2 UTSW 3 64140484 missense probably benign 0.00
R5071:Vmn2r2 UTSW 3 64116900 missense probably benign 0.01
R5315:Vmn2r2 UTSW 3 64116956 missense probably benign 0.37
R5450:Vmn2r2 UTSW 3 64126590 missense probably benign
R5577:Vmn2r2 UTSW 3 64116995 missense probably benign 0.00
R5595:Vmn2r2 UTSW 3 64126615 missense possibly damaging 0.74
R5727:Vmn2r2 UTSW 3 64117187 missense probably benign 0.41
R5810:Vmn2r2 UTSW 3 64117394 missense probably damaging 1.00
R5919:Vmn2r2 UTSW 3 64137302 missense probably benign 0.39
R6052:Vmn2r2 UTSW 3 64117361 missense possibly damaging 0.56
R6084:Vmn2r2 UTSW 3 64117046 missense probably benign 0.01
R6299:Vmn2r2 UTSW 3 64116653 nonsense probably null
R6762:Vmn2r2 UTSW 3 64134449 missense probably damaging 1.00
R6858:Vmn2r2 UTSW 3 64137494 missense probably damaging 1.00
R6889:Vmn2r2 UTSW 3 64117267 missense probably damaging 0.99
R6990:Vmn2r2 UTSW 3 64117187 missense probably benign 0.02
R7195:Vmn2r2 UTSW 3 64116479 missense probably benign 0.01
R7269:Vmn2r2 UTSW 3 64126577 missense probably benign 0.32
X0024:Vmn2r2 UTSW 3 64137286 nonsense probably null
Posted On2013-04-17