Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00486:Zmym6'

27185

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym6

Ensembl Gene

ENSMUSG00000042408

Gene Name

zinc finger, MYM-type 6

Synonyms

9330177P20Rik, Zfp258, D4Wsu24e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00486

Quality Score

Status

Chromosome

Chromosomal Location

126971176-127018165 bp(+) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 127017978 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000101703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046751] [ENSMUST00000094712] [ENSMUST00000094713] [ENSMUST00000106097]

AlphaFold

Q8BS54

Predicted Effect

probably benign
Transcript: ENSMUST00000046751

SMART Domains

Protein: ENSMUSP00000045366
Gene: ENSMUSG00000042408

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	241	277	4.01e1	SMART
TRASH	349	385	2.46e1	SMART
TRASH	391	426	3.32e2	SMART
TRASH	434	472	2.91e-1	SMART
TRASH	478	513	9.99e0	SMART
low complexity region	602	612	N/A	INTRINSIC
low complexity region	642	656	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000094712

SMART Domains

Protein: ENSMUSP00000092302
Gene: ENSMUSG00000070737

Domain	Start	End	E-Value	Type
Pfam:DoxX	5	103	9e-9	PFAM
Pfam:DoxX_2	7	124	4.8e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000094713

SMART Domains

Protein: ENSMUSP00000092303
Gene: ENSMUSG00000042408

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	262	293	6.03e2	SMART
TRASH	299	334	3.32e2	SMART
TRASH	342	380	2.91e-1	SMART
TRASH	386	421	9.99e0	SMART
low complexity region	510	520	N/A	INTRINSIC
low complexity region	550	564	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106097

SMART Domains

Protein: ENSMUSP00000101703
Gene: ENSMUSG00000070737

Domain	Start	End	E-Value	Type
Pfam:DoxX_2	27	111	8.1e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	A	G	7: 119,846,076 (GRCm39)	T576A	probably damaging	Het
As3mt	A	G	19: 46,708,864 (GRCm39)	E286G	probably benign	Het
Baiap3	G	T	17: 25,467,351 (GRCm39)		probably benign	Het
C1qc	T	C	4: 136,617,445 (GRCm39)	E217G	probably damaging	Het
Ccser2	A	G	14: 36,662,021 (GRCm39)	Y388H	probably damaging	Het
Clcn7	C	A	17: 25,370,097 (GRCm39)	A328D	probably damaging	Het
Clstn1	G	A	4: 149,719,700 (GRCm39)	R415Q	probably damaging	Het
Hcn4	T	C	9: 58,767,336 (GRCm39)	S966P	unknown	Het
Heph	A	T	X: 95,571,284 (GRCm39)	D748V	probably damaging	Het
Herc1	C	T	9: 66,383,402 (GRCm39)	T3691I	probably benign	Het
Hsd17b14	A	G	7: 45,216,137 (GRCm39)	T236A	possibly damaging	Het
Kif28	C	A	1: 179,530,081 (GRCm39)	L693F	probably damaging	Het
Mnd1	T	C	3: 84,045,505 (GRCm39)	E33G	possibly damaging	Het
Nbas	T	G	12: 13,503,076 (GRCm39)	D1520E	probably benign	Het
Poli	C	T	18: 70,658,561 (GRCm39)	G81R	probably damaging	Het
Pou6f2	G	A	13: 18,314,170 (GRCm39)	S401F	probably damaging	Het
Ppp1r3c	G	A	19: 36,711,324 (GRCm39)	R149W	probably damaging	Het
Ptprc	C	A	1: 138,043,359 (GRCm39)	C64F	probably damaging	Het
Ptprz1	T	C	6: 22,973,053 (GRCm39)	Y274H	probably damaging	Het
Ranbp2	T	A	10: 58,313,434 (GRCm39)	L1385I	probably benign	Het
Sgms1	A	T	19: 32,137,025 (GRCm39)	F180L	probably damaging	Het
Slc7a9	T	A	7: 35,160,312 (GRCm39)	M396K	probably damaging	Het
Syt17	T	C	7: 118,033,513 (GRCm39)	D165G	probably damaging	Het
Tnxb	T	C	17: 34,911,356 (GRCm39)	L1553P	probably damaging	Het
Trim31	C	A	17: 37,220,133 (GRCm39)	Q350K	probably benign	Het
Wnk3	A	G	X: 150,016,025 (GRCm39)	R494G	probably damaging	Het

Other mutations in Zmym6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00430:Zmym6	APN	4	126,995,742 (GRCm39)	nonsense	probably null
IGL01017:Zmym6	APN	4	126,982,152 (GRCm39)	missense	probably benign	0.00
IGL01385:Zmym6	APN	4	127,017,899 (GRCm39)	missense	probably benign	0.02
IGL01577:Zmym6	APN	4	126,999,223 (GRCm39)	missense	probably damaging	1.00
IGL01654:Zmym6	APN	4	127,017,519 (GRCm39)	missense	probably damaging	1.00
IGL01736:Zmym6	APN	4	127,002,437 (GRCm39)	missense	probably damaging	1.00
IGL01824:Zmym6	APN	4	127,002,499 (GRCm39)	missense	probably damaging	0.99
IGL01916:Zmym6	APN	4	127,017,549 (GRCm39)	missense	probably damaging	0.98
IGL01985:Zmym6	APN	4	126,994,541 (GRCm39)	missense	probably damaging	1.00
IGL02056:Zmym6	APN	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
IGL02477:Zmym6	APN	4	126,972,295 (GRCm39)	nonsense	probably null
IGL02754:Zmym6	APN	4	127,003,764 (GRCm39)	splice site	probably benign
IGL03344:Zmym6	APN	4	127,014,314 (GRCm39)	missense	probably damaging	1.00
IGL03412:Zmym6	APN	4	126,986,731 (GRCm39)	missense	probably damaging	1.00
R0335:Zmym6	UTSW	4	127,016,601 (GRCm39)	missense	probably damaging	1.00
R0448:Zmym6	UTSW	4	127,002,487 (GRCm39)	missense	probably benign	0.01
R0463:Zmym6	UTSW	4	127,016,565 (GRCm39)	missense	probably damaging	0.98
R0538:Zmym6	UTSW	4	127,017,162 (GRCm39)	missense	probably benign	0.21
R0789:Zmym6	UTSW	4	127,016,615 (GRCm39)	missense	possibly damaging	0.52
R0798:Zmym6	UTSW	4	126,997,316 (GRCm39)	missense	probably benign	0.00
R1311:Zmym6	UTSW	4	127,017,151 (GRCm39)	missense	probably damaging	1.00
R1351:Zmym6	UTSW	4	127,016,798 (GRCm39)	missense	probably benign	0.00
R1429:Zmym6	UTSW	4	127,017,672 (GRCm39)	missense	probably damaging	1.00
R1636:Zmym6	UTSW	4	127,017,560 (GRCm39)	missense	probably damaging	0.99
R1666:Zmym6	UTSW	4	127,016,652 (GRCm39)	missense	probably damaging	0.98
R1919:Zmym6	UTSW	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
R2058:Zmym6	UTSW	4	126,982,208 (GRCm39)	nonsense	probably null
R3957:Zmym6	UTSW	4	127,017,089 (GRCm39)	missense	possibly damaging	0.68
R3978:Zmym6	UTSW	4	127,017,348 (GRCm39)	missense	possibly damaging	0.71
R4417:Zmym6	UTSW	4	126,986,781 (GRCm39)	missense	probably damaging	1.00
R4801:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R4802:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R5052:Zmym6	UTSW	4	127,017,767 (GRCm39)	missense	possibly damaging	0.92
R5105:Zmym6	UTSW	4	127,017,551 (GRCm39)	missense	probably benign	0.33
R5217:Zmym6	UTSW	4	126,999,167 (GRCm39)	missense	possibly damaging	0.76
R5682:Zmym6	UTSW	4	126,998,200 (GRCm39)	missense	probably damaging	1.00
R5841:Zmym6	UTSW	4	126,994,463 (GRCm39)	missense	possibly damaging	0.71
R5991:Zmym6	UTSW	4	127,002,266 (GRCm39)	splice site	probably null
R6478:Zmym6	UTSW	4	127,017,176 (GRCm39)	missense	possibly damaging	0.86
R7014:Zmym6	UTSW	4	127,017,337 (GRCm39)	nonsense	probably null
R7287:Zmym6	UTSW	4	127,016,775 (GRCm39)	missense	possibly damaging	0.50
R7290:Zmym6	UTSW	4	127,017,294 (GRCm39)	missense	possibly damaging	0.73
R7371:Zmym6	UTSW	4	126,998,106 (GRCm39)	missense	probably damaging	1.00
R7967:Zmym6	UTSW	4	127,016,453 (GRCm39)	missense	probably benign	0.03
R8237:Zmym6	UTSW	4	127,016,544 (GRCm39)	missense	probably damaging	0.99
R8306:Zmym6	UTSW	4	127,016,355 (GRCm39)	missense	probably damaging	1.00
R8312:Zmym6	UTSW	4	127,017,627 (GRCm39)	missense	probably damaging	1.00
R9090:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9216:Zmym6	UTSW	4	127,002,500 (GRCm39)	missense	probably benign	0.00
R9271:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9695:Zmym6	UTSW	4	127,016,340 (GRCm39)	missense	probably benign
X0025:Zmym6	UTSW	4	127,016,143 (GRCm39)	missense	possibly damaging	0.60
X0067:Zmym6	UTSW	4	126,998,107 (GRCm39)	missense	probably damaging	1.00
Z1177:Zmym6	UTSW	4	127,017,590 (GRCm39)	missense	not run

Posted On

2013-04-17