Incidental Mutation 'R3779:Map3k9'
ID 271973
Institutional Source Beutler Lab
Gene Symbol Map3k9
Ensembl Gene ENSMUSG00000042724
Gene Name mitogen-activated protein kinase kinase kinase 9
Synonyms Mlk1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3779 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 81767784-81827949 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 81790565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035987] [ENSMUST00000222322]
AlphaFold Q3U1V8
Predicted Effect probably benign
Transcript: ENSMUST00000035987
SMART Domains Protein: ENSMUSP00000041819
Gene: ENSMUSG00000042724

DomainStartEndE-ValueType
low complexity region 14 40 N/A INTRINSIC
SH3 48 108 1.61e-20 SMART
TyrKc 137 396 6.72e-89 SMART
low complexity region 449 469 N/A INTRINSIC
low complexity region 573 590 N/A INTRINSIC
low complexity region 644 657 N/A INTRINSIC
low complexity region 722 736 N/A INTRINSIC
low complexity region 749 765 N/A INTRINSIC
low complexity region 772 783 N/A INTRINSIC
low complexity region 799 811 N/A INTRINSIC
low complexity region 901 915 N/A INTRINSIC
low complexity region 1020 1036 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000222322
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223292
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 98% (47/48)
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik A G 16: 88,424,273 (GRCm39) C73R probably damaging Het
Acot10 A G 15: 20,665,628 (GRCm39) V371A probably damaging Het
Ambn C A 5: 88,613,201 (GRCm39) probably benign Het
Ankrd34a T C 3: 96,506,247 (GRCm39) F484L possibly damaging Het
Bcl11a A G 11: 24,114,568 (GRCm39) K637R probably damaging Het
Cenpe T C 3: 134,962,337 (GRCm39) S1968P possibly damaging Het
Cfap61 T C 2: 145,792,714 (GRCm39) I52T probably damaging Het
Cit A T 5: 115,997,400 (GRCm39) M128L probably benign Het
Cnga1 G T 5: 72,762,126 (GRCm39) L463I probably damaging Het
Dnah11 C T 12: 118,094,448 (GRCm39) probably benign Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Ep400 A G 5: 110,839,515 (GRCm39) I1853T unknown Het
Flg2 C T 3: 93,109,730 (GRCm39) S586L unknown Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably benign Het
Gm21886 G T 18: 80,132,649 (GRCm39) Q170K possibly damaging Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Gm9376 T C 14: 118,504,727 (GRCm39) V53A probably benign Het
H2-T3 T C 17: 36,500,574 (GRCm39) T90A probably damaging Het
Hif1an A G 19: 44,557,847 (GRCm39) D243G probably damaging Het
Hmgcs2 C T 3: 98,206,428 (GRCm39) probably benign Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Jak1 G A 4: 101,013,687 (GRCm39) H1014Y probably benign Het
Klrb1c T C 6: 128,757,306 (GRCm39) D253G probably damaging Het
Lpin1 G A 12: 16,614,569 (GRCm39) T404M probably damaging Het
Mtrex A T 13: 113,039,926 (GRCm39) probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Or6c38 A G 10: 128,929,165 (GRCm39) F226S possibly damaging Het
Pdgfrb T A 18: 61,205,738 (GRCm39) S575T probably damaging Het
Phldb2 T C 16: 45,569,118 (GRCm39) Y1247C probably damaging Het
Pinlyp T A 7: 24,241,260 (GRCm39) T181S probably benign Het
Pkn2 A G 3: 142,499,741 (GRCm39) V928A possibly damaging Het
Skint5 C T 4: 113,636,237 (GRCm39) probably benign Het
Slc24a1 A G 9: 64,855,579 (GRCm39) Y443H unknown Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syncrip A C 9: 88,358,992 (GRCm39) D172E probably damaging Het
Tex26 T C 5: 149,369,316 (GRCm39) I48T probably damaging Het
Trpm6 A C 19: 18,853,403 (GRCm39) I1808L possibly damaging Het
Uba2 T C 7: 33,854,071 (GRCm39) probably null Het
Vwa8 T A 14: 79,339,762 (GRCm39) probably benign Het
Wfs1 C A 5: 37,125,968 (GRCm39) V308L probably benign Het
Wrn T A 8: 33,731,048 (GRCm39) R1095W probably damaging Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Map3k9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00640:Map3k9 APN 12 81,776,472 (GRCm39) missense probably benign 0.00
IGL01098:Map3k9 APN 12 81,770,928 (GRCm39) missense probably damaging 1.00
IGL01122:Map3k9 APN 12 81,778,900 (GRCm39) missense possibly damaging 0.94
IGL01680:Map3k9 APN 12 81,771,513 (GRCm39) missense probably benign 0.10
IGL01997:Map3k9 APN 12 81,819,471 (GRCm39) missense probably damaging 1.00
IGL02178:Map3k9 APN 12 81,790,611 (GRCm39) missense probably damaging 1.00
IGL02724:Map3k9 APN 12 81,771,516 (GRCm39) missense probably benign
PIT4366001:Map3k9 UTSW 12 81,819,535 (GRCm39) missense possibly damaging 0.95
R0530:Map3k9 UTSW 12 81,769,256 (GRCm39) missense probably benign 0.00
R0541:Map3k9 UTSW 12 81,780,997 (GRCm39) missense possibly damaging 0.79
R0550:Map3k9 UTSW 12 81,772,555 (GRCm39) missense probably damaging 1.00
R0799:Map3k9 UTSW 12 81,769,043 (GRCm39) missense probably benign 0.27
R1730:Map3k9 UTSW 12 81,769,000 (GRCm39) missense probably damaging 0.99
R1783:Map3k9 UTSW 12 81,769,000 (GRCm39) missense probably damaging 0.99
R1859:Map3k9 UTSW 12 81,771,256 (GRCm39) missense possibly damaging 0.82
R1917:Map3k9 UTSW 12 81,827,564 (GRCm39) nonsense probably null
R3121:Map3k9 UTSW 12 81,790,698 (GRCm39) missense probably damaging 1.00
R3931:Map3k9 UTSW 12 81,819,691 (GRCm39) missense probably damaging 0.99
R3951:Map3k9 UTSW 12 81,769,295 (GRCm39) missense probably benign
R4571:Map3k9 UTSW 12 81,780,865 (GRCm39) missense probably benign 0.25
R4728:Map3k9 UTSW 12 81,769,147 (GRCm39) missense probably damaging 0.96
R4857:Map3k9 UTSW 12 81,771,401 (GRCm39) missense probably benign 0.42
R4882:Map3k9 UTSW 12 81,770,936 (GRCm39) missense probably damaging 1.00
R5077:Map3k9 UTSW 12 81,780,851 (GRCm39) splice site probably null
R5369:Map3k9 UTSW 12 81,768,826 (GRCm39) missense probably damaging 0.98
R5418:Map3k9 UTSW 12 81,790,591 (GRCm39) nonsense probably null
R5540:Map3k9 UTSW 12 81,819,587 (GRCm39) missense probably damaging 1.00
R5567:Map3k9 UTSW 12 81,778,798 (GRCm39) missense possibly damaging 0.67
R5570:Map3k9 UTSW 12 81,778,798 (GRCm39) missense possibly damaging 0.67
R5696:Map3k9 UTSW 12 81,780,896 (GRCm39) missense probably benign 0.00
R6539:Map3k9 UTSW 12 81,778,966 (GRCm39) missense probably damaging 0.98
R6542:Map3k9 UTSW 12 81,769,028 (GRCm39) missense possibly damaging 0.91
R6816:Map3k9 UTSW 12 81,769,028 (GRCm39) missense possibly damaging 0.91
R6964:Map3k9 UTSW 12 81,819,777 (GRCm39) missense probably benign 0.00
R7027:Map3k9 UTSW 12 81,777,398 (GRCm39) missense probably benign 0.06
R7055:Map3k9 UTSW 12 81,770,982 (GRCm39) missense probably damaging 0.99
R7082:Map3k9 UTSW 12 81,771,476 (GRCm39) missense probably damaging 1.00
R7247:Map3k9 UTSW 12 81,772,604 (GRCm39) missense possibly damaging 0.65
R7424:Map3k9 UTSW 12 81,770,871 (GRCm39) missense probably benign 0.00
R7476:Map3k9 UTSW 12 81,790,582 (GRCm39) missense probably damaging 1.00
R7638:Map3k9 UTSW 12 81,771,506 (GRCm39) missense probably benign 0.00
R8098:Map3k9 UTSW 12 81,780,888 (GRCm39) missense probably damaging 0.99
R8249:Map3k9 UTSW 12 81,827,551 (GRCm39) missense unknown
R8356:Map3k9 UTSW 12 81,780,892 (GRCm39) missense probably damaging 0.98
R8397:Map3k9 UTSW 12 81,769,136 (GRCm39) missense probably benign 0.13
R8444:Map3k9 UTSW 12 81,768,970 (GRCm39) missense probably damaging 1.00
R8456:Map3k9 UTSW 12 81,780,892 (GRCm39) missense probably damaging 0.98
R9025:Map3k9 UTSW 12 81,819,507 (GRCm39) missense probably damaging 1.00
R9090:Map3k9 UTSW 12 81,769,261 (GRCm39) missense probably benign 0.05
R9097:Map3k9 UTSW 12 81,819,855 (GRCm39) missense possibly damaging 0.84
R9271:Map3k9 UTSW 12 81,769,261 (GRCm39) missense probably benign 0.05
R9419:Map3k9 UTSW 12 81,827,341 (GRCm39) missense probably damaging 1.00
R9549:Map3k9 UTSW 12 81,771,255 (GRCm39) missense probably benign 0.06
R9596:Map3k9 UTSW 12 81,777,404 (GRCm39) missense probably damaging 1.00
X0025:Map3k9 UTSW 12 81,771,186 (GRCm39) missense possibly damaging 0.58
Z1176:Map3k9 UTSW 12 81,819,556 (GRCm39) missense possibly damaging 0.76
Z1177:Map3k9 UTSW 12 81,827,620 (GRCm39) missense unknown
Z1177:Map3k9 UTSW 12 81,769,053 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTGAGGAGCCATCTACTACGTG -3'
(R):5'- AGGCCCTGTGACTAATGCTTATC -3'

Sequencing Primer
(F):5'- GGAGCCATCTACTACGTGCAATG -3'
(R):5'- CGCTCAGTATTGATCCTGCAGAAAG -3'
Posted On 2015-03-25